Incidental Mutation 'IGL02677:Or4k38'
ID 303162
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4k38
Ensembl Gene ENSMUSG00000096554
Gene Name olfactory receptor family 4 subfamily K member 38
Synonyms MOR248-16, Olfr1557, MOR248-2, Olfr1282, GA_x6K02T2Q125-72387537-72386620
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL02677
Quality Score
Chromosome 2
Chromosomal Location 111165504-111166421 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 111166147 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 92 (I92N)
Ref Sequence ENSEMBL: ENSMUSP00000097213 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099618] [ENSMUST00000208176]
AlphaFold Q7TQY5
Predicted Effect probably damaging
Transcript: ENSMUST00000099618
AA Change: I92N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097213
Gene: ENSMUSG00000096554
AA Change: I92N

Pfam:7tm_4 31 305 5.5e-47 PFAM
Pfam:7tm_1 41 287 2.6e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208176
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406B18Rik G T 7: 43,150,519 (GRCm39) Y84* probably null Het
Adam5 A G 8: 25,302,395 (GRCm39) probably benign Het
Aipl1 T C 11: 71,920,222 (GRCm39) E282G possibly damaging Het
Akp3 A G 1: 87,052,994 (GRCm39) D61G probably damaging Het
Anpep A G 7: 79,488,478 (GRCm39) S451P probably damaging Het
Csnka2ip A G 16: 64,298,675 (GRCm39) L119P probably damaging Het
Ddx19a T C 8: 111,716,241 (GRCm39) E53G probably benign Het
Ddx50 C T 10: 62,452,072 (GRCm39) R116Q unknown Het
Ddx60 A T 8: 62,441,166 (GRCm39) E1078D probably damaging Het
Dpy19l1 T C 9: 24,396,368 (GRCm39) D116G probably damaging Het
Dsg4 A G 18: 20,597,933 (GRCm39) T668A possibly damaging Het
Dspp A G 5: 104,323,843 (GRCm39) T329A possibly damaging Het
Eftud2 T C 11: 102,737,440 (GRCm39) T554A probably damaging Het
Enpp1 T C 10: 24,555,083 (GRCm39) probably benign Het
Ext2 A T 2: 93,537,590 (GRCm39) F599I probably damaging Het
Fahd1 A T 17: 25,068,504 (GRCm39) I191N probably damaging Het
Fcrl2 A T 3: 87,166,694 (GRCm39) S100T probably benign Het
Fras1 T A 5: 96,692,883 (GRCm39) C181S probably damaging Het
Garre1 T A 7: 33,941,834 (GRCm39) probably benign Het
Gcnt4 A G 13: 97,083,741 (GRCm39) I346V probably benign Het
Gfra1 G A 19: 58,441,787 (GRCm39) T48I probably damaging Het
Kcnma1 A G 14: 23,513,224 (GRCm39) Y392H probably damaging Het
Klc2 T C 19: 5,161,696 (GRCm39) Y298C probably damaging Het
Lamb3 G A 1: 193,021,830 (GRCm39) V1011I probably benign Het
Ldb1 T C 19: 46,024,594 (GRCm39) probably benign Het
Mcph1 A G 8: 18,675,609 (GRCm39) K11E probably damaging Het
Myc A G 15: 61,861,513 (GRCm39) H374R probably damaging Het
Myom1 A G 17: 71,391,344 (GRCm39) Y853C probably damaging Het
Pakap C T 4: 57,856,263 (GRCm39) P572S probably benign Het
Pclo A G 5: 14,726,943 (GRCm39) probably benign Het
Pde3a G A 6: 141,350,898 (GRCm39) probably benign Het
Per1 T C 11: 68,997,486 (GRCm39) V887A probably benign Het
Prokr1 G A 6: 87,565,350 (GRCm39) probably benign Het
Rb1cc1 A G 1: 6,319,643 (GRCm39) I1021V probably benign Het
Ryr1 T C 7: 28,810,033 (GRCm39) E344G probably benign Het
Sec24c A T 14: 20,739,710 (GRCm39) D529V probably damaging Het
Slc1a6 T C 10: 78,624,898 (GRCm39) V101A probably damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Tap2 G A 17: 34,431,021 (GRCm39) V374M probably benign Het
Tex15 T A 8: 34,061,108 (GRCm39) D179E probably benign Het
Tmem8b T C 4: 43,686,092 (GRCm39) L241P probably damaging Het
Tmprss11g T C 5: 86,640,149 (GRCm39) D160G probably benign Het
Trim30a C T 7: 104,085,120 (GRCm39) C30Y probably damaging Het
Ttn A G 2: 76,601,840 (GRCm39) probably benign Het
Ush2a A G 1: 188,466,882 (GRCm39) R2849G probably damaging Het
Usp5 A G 6: 124,796,389 (GRCm39) V570A probably damaging Het
Vipr1 T C 9: 121,489,349 (GRCm39) probably benign Het
Zc2hc1c A C 12: 85,336,850 (GRCm39) D169A probably benign Het
Other mutations in Or4k38
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0798:Or4k38 UTSW 2 111,165,689 (GRCm39) missense probably benign 0.16
R0932:Or4k38 UTSW 2 111,165,543 (GRCm39) missense probably benign 0.00
R0972:Or4k38 UTSW 2 111,165,763 (GRCm39) missense probably benign 0.18
R1033:Or4k38 UTSW 2 111,166,147 (GRCm39) missense probably damaging 1.00
R1864:Or4k38 UTSW 2 111,166,052 (GRCm39) missense possibly damaging 0.95
R1879:Or4k38 UTSW 2 111,165,808 (GRCm39) missense possibly damaging 0.61
R2343:Or4k38 UTSW 2 111,166,045 (GRCm39) missense probably damaging 1.00
R2509:Or4k38 UTSW 2 111,166,076 (GRCm39) missense probably damaging 0.98
R3620:Or4k38 UTSW 2 111,165,689 (GRCm39) missense probably benign 0.06
R5589:Or4k38 UTSW 2 111,165,850 (GRCm39) missense possibly damaging 0.46
R6487:Or4k38 UTSW 2 111,166,012 (GRCm39) missense probably benign 0.00
R6818:Or4k38 UTSW 2 111,165,659 (GRCm39) missense probably benign 0.22
R7153:Or4k38 UTSW 2 111,166,246 (GRCm39) missense probably damaging 1.00
R7480:Or4k38 UTSW 2 111,165,737 (GRCm39) missense probably benign 0.22
R7589:Or4k38 UTSW 2 111,165,719 (GRCm39) missense probably damaging 1.00
R8441:Or4k38 UTSW 2 111,166,131 (GRCm39) nonsense probably null
R8774:Or4k38 UTSW 2 111,166,318 (GRCm39) missense probably damaging 1.00
R8774-TAIL:Or4k38 UTSW 2 111,166,318 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16