Incidental Mutation 'IGL02677:Fcrl2'
| ID |
303197 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fcrl2
|
| Ensembl Gene |
ENSMUSG00000015852 |
| Gene Name |
Fc receptor like 2 |
| Synonyms |
Fcrls, IFGP2, 2810439C17Rik, Msr2, Fcrh2, moFcRH2sc |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.053)
|
| Stock # |
IGL02677
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
3 |
| Chromosomal Location |
87158318-87171046 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 87166694 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 100
(S100T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115780
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090986]
[ENSMUST00000146512]
|
| AlphaFold |
Q9EQY5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090986
AA Change: S100T
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000088508
Gene: ENSMUSG00000015852
AA Change: S100T
| Domain | Start | End | E-Value | Type |
|---|
|
IG
|
23 |
106 |
1.32e-3 |
SMART |
|
IGc2
|
122 |
186 |
2.77e-6 |
SMART |
|
IGc2
|
226 |
291 |
1.09e-4 |
SMART |
|
IG
|
315 |
396 |
1e-3 |
SMART |
|
SR
|
402 |
503 |
7.29e-36 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146512
AA Change: S100T
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000115780
Gene: ENSMUSG00000015852
AA Change: S100T
| Domain | Start | End | E-Value | Type |
|---|
|
IG
|
23 |
106 |
1.32e-3 |
SMART |
|
Pfam:Ig_2
|
111 |
176 |
6.1e-6 |
PFAM |
|
Pfam:Ig_3
|
111 |
176 |
1.4e-4 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Female homozygous mutant mice are larger than controls and show increased mean body weight, total tissue mass, lean body mass and total body fat. Homozygous mutant mice eshow a decreased mean percentage of CD8 cells in the peripheral blood. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 48 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931406B18Rik |
G |
T |
7: 43,150,519 (GRCm39) |
Y84* |
probably null |
Het |
| Adam5 |
A |
G |
8: 25,302,395 (GRCm39) |
|
probably benign |
Het |
| Aipl1 |
T |
C |
11: 71,920,222 (GRCm39) |
E282G |
possibly damaging |
Het |
| Akp3 |
A |
G |
1: 87,052,994 (GRCm39) |
D61G |
probably damaging |
Het |
| Anpep |
A |
G |
7: 79,488,478 (GRCm39) |
S451P |
probably damaging |
Het |
| Csnka2ip |
A |
G |
16: 64,298,675 (GRCm39) |
L119P |
probably damaging |
Het |
| Ddx19a |
T |
C |
8: 111,716,241 (GRCm39) |
E53G |
probably benign |
Het |
| Ddx50 |
C |
T |
10: 62,452,072 (GRCm39) |
R116Q |
unknown |
Het |
| Ddx60 |
A |
T |
8: 62,441,166 (GRCm39) |
E1078D |
probably damaging |
Het |
| Dpy19l1 |
T |
C |
9: 24,396,368 (GRCm39) |
D116G |
probably damaging |
Het |
| Dsg4 |
A |
G |
18: 20,597,933 (GRCm39) |
T668A |
possibly damaging |
Het |
| Dspp |
A |
G |
5: 104,323,843 (GRCm39) |
T329A |
possibly damaging |
Het |
| Eftud2 |
T |
C |
11: 102,737,440 (GRCm39) |
T554A |
probably damaging |
Het |
| Enpp1 |
T |
C |
10: 24,555,083 (GRCm39) |
|
probably benign |
Het |
| Ext2 |
A |
T |
2: 93,537,590 (GRCm39) |
F599I |
probably damaging |
Het |
| Fahd1 |
A |
T |
17: 25,068,504 (GRCm39) |
I191N |
probably damaging |
Het |
| Fras1 |
T |
A |
5: 96,692,883 (GRCm39) |
C181S |
probably damaging |
Het |
| Garre1 |
T |
A |
7: 33,941,834 (GRCm39) |
|
probably benign |
Het |
| Gcnt4 |
A |
G |
13: 97,083,741 (GRCm39) |
I346V |
probably benign |
Het |
| Gfra1 |
G |
A |
19: 58,441,787 (GRCm39) |
T48I |
probably damaging |
Het |
| Kcnma1 |
A |
G |
14: 23,513,224 (GRCm39) |
Y392H |
probably damaging |
Het |
| Klc2 |
T |
C |
19: 5,161,696 (GRCm39) |
Y298C |
probably damaging |
Het |
| Lamb3 |
G |
A |
1: 193,021,830 (GRCm39) |
V1011I |
probably benign |
Het |
| Ldb1 |
T |
C |
19: 46,024,594 (GRCm39) |
|
probably benign |
Het |
| Mcph1 |
A |
G |
8: 18,675,609 (GRCm39) |
K11E |
probably damaging |
Het |
| Myc |
A |
G |
15: 61,861,513 (GRCm39) |
H374R |
probably damaging |
Het |
| Myom1 |
A |
G |
17: 71,391,344 (GRCm39) |
Y853C |
probably damaging |
Het |
| Or4k38 |
A |
T |
2: 111,166,147 (GRCm39) |
I92N |
probably damaging |
Het |
| Pakap |
C |
T |
4: 57,856,263 (GRCm39) |
P572S |
probably benign |
Het |
| Pclo |
A |
G |
5: 14,726,943 (GRCm39) |
|
probably benign |
Het |
| Pde3a |
G |
A |
6: 141,350,898 (GRCm39) |
|
probably benign |
Het |
| Per1 |
T |
C |
11: 68,997,486 (GRCm39) |
V887A |
probably benign |
Het |
| Prokr1 |
G |
A |
6: 87,565,350 (GRCm39) |
|
probably benign |
Het |
| Rb1cc1 |
A |
G |
1: 6,319,643 (GRCm39) |
I1021V |
probably benign |
Het |
| Ryr1 |
T |
C |
7: 28,810,033 (GRCm39) |
E344G |
probably benign |
Het |
| Sec24c |
A |
T |
14: 20,739,710 (GRCm39) |
D529V |
probably damaging |
Het |
| Slc1a6 |
T |
C |
10: 78,624,898 (GRCm39) |
V101A |
probably damaging |
Het |
| Srrm1 |
G |
A |
4: 135,052,415 (GRCm39) |
P658L |
unknown |
Het |
| Tap2 |
G |
A |
17: 34,431,021 (GRCm39) |
V374M |
probably benign |
Het |
| Tex15 |
T |
A |
8: 34,061,108 (GRCm39) |
D179E |
probably benign |
Het |
| Tmem8b |
T |
C |
4: 43,686,092 (GRCm39) |
L241P |
probably damaging |
Het |
| Tmprss11g |
T |
C |
5: 86,640,149 (GRCm39) |
D160G |
probably benign |
Het |
| Trim30a |
C |
T |
7: 104,085,120 (GRCm39) |
C30Y |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,601,840 (GRCm39) |
|
probably benign |
Het |
| Ush2a |
A |
G |
1: 188,466,882 (GRCm39) |
R2849G |
probably damaging |
Het |
| Usp5 |
A |
G |
6: 124,796,389 (GRCm39) |
V570A |
probably damaging |
Het |
| Vipr1 |
T |
C |
9: 121,489,349 (GRCm39) |
|
probably benign |
Het |
| Zc2hc1c |
A |
C |
12: 85,336,850 (GRCm39) |
D169A |
probably benign |
Het |
|
| Other mutations in Fcrl2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01568:Fcrl2
|
APN |
3 |
87,163,986 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01959:Fcrl2
|
APN |
3 |
87,166,939 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02409:Fcrl2
|
APN |
3 |
87,160,030 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02957:Fcrl2
|
APN |
3 |
87,169,501 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02974:Fcrl2
|
APN |
3 |
87,164,704 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02992:Fcrl2
|
APN |
3 |
87,166,773 (GRCm39) |
missense |
probably damaging |
0.99 |
|
BB001:Fcrl2
|
UTSW |
3 |
87,166,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
BB011:Fcrl2
|
UTSW |
3 |
87,166,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0052:Fcrl2
|
UTSW |
3 |
87,164,085 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0052:Fcrl2
|
UTSW |
3 |
87,164,085 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0131:Fcrl2
|
UTSW |
3 |
87,166,266 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1171:Fcrl2
|
UTSW |
3 |
87,164,167 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1319:Fcrl2
|
UTSW |
3 |
87,169,484 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1522:Fcrl2
|
UTSW |
3 |
87,164,014 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1696:Fcrl2
|
UTSW |
3 |
87,166,825 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1742:Fcrl2
|
UTSW |
3 |
87,166,350 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2156:Fcrl2
|
UTSW |
3 |
87,164,648 (GRCm39) |
missense |
probably benign |
0.43 |
|
R2255:Fcrl2
|
UTSW |
3 |
87,164,655 (GRCm39) |
nonsense |
probably null |
|
|
R2257:Fcrl2
|
UTSW |
3 |
87,166,928 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2434:Fcrl2
|
UTSW |
3 |
87,164,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2680:Fcrl2
|
UTSW |
3 |
87,164,656 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3552:Fcrl2
|
UTSW |
3 |
87,166,717 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4866:Fcrl2
|
UTSW |
3 |
87,170,773 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4883:Fcrl2
|
UTSW |
3 |
87,166,922 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5654:Fcrl2
|
UTSW |
3 |
87,164,851 (GRCm39) |
missense |
probably benign |
|
|
R5771:Fcrl2
|
UTSW |
3 |
87,170,775 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5917:Fcrl2
|
UTSW |
3 |
87,164,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6349:Fcrl2
|
UTSW |
3 |
87,159,803 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6562:Fcrl2
|
UTSW |
3 |
87,164,635 (GRCm39) |
missense |
probably benign |
|
|
R6954:Fcrl2
|
UTSW |
3 |
87,170,983 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R7059:Fcrl2
|
UTSW |
3 |
87,164,647 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7188:Fcrl2
|
UTSW |
3 |
87,166,830 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7201:Fcrl2
|
UTSW |
3 |
87,159,934 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7369:Fcrl2
|
UTSW |
3 |
87,164,008 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7431:Fcrl2
|
UTSW |
3 |
87,166,233 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7610:Fcrl2
|
UTSW |
3 |
87,160,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Fcrl2
|
UTSW |
3 |
87,166,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8018:Fcrl2
|
UTSW |
3 |
87,166,933 (GRCm39) |
nonsense |
probably null |
|
|
R8280:Fcrl2
|
UTSW |
3 |
87,166,364 (GRCm39) |
nonsense |
probably null |
|
|
R8981:Fcrl2
|
UTSW |
3 |
87,164,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9368:Fcrl2
|
UTSW |
3 |
87,164,906 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9477:Fcrl2
|
UTSW |
3 |
87,159,803 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9522:Fcrl2
|
UTSW |
3 |
87,164,101 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Posted On |
2015-04-16 |
Incidental Mutation