Incidental Mutation 'R4178:Zfp775'
| ID |
319589 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp775
|
| Ensembl Gene |
ENSMUSG00000007216 |
| Gene Name |
zinc finger protein 775 |
| Synonyms |
C130032F08Rik |
| MMRRC Submission |
040864-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.117)
|
| Stock # |
R4178 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
48578937-48598482 bp(+) (GRCm39) |
| Type of Mutation |
splice site (3 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 48590187 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145172
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061720]
[ENSMUST00000204042]
[ENSMUST00000204095]
[ENSMUST00000204121]
[ENSMUST00000204521]
[ENSMUST00000204521]
[ENSMUST00000204521]
|
| AlphaFold |
Q8BI73 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061720
AA Change: I9V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000056290
Gene: ENSMUSG00000007216
AA Change: I9V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
102 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
104 |
126 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
4.11e-2 |
SMART |
|
ZnF_C2H2
|
279 |
301 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
307 |
329 |
4.94e-5 |
SMART |
|
ZnF_C2H2
|
335 |
357 |
2.95e-3 |
SMART |
|
ZnF_C2H2
|
364 |
386 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
446 |
468 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
474 |
496 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
502 |
524 |
5.5e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000203998
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204042
AA Change: I9V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000145369
Gene: ENSMUSG00000007216
AA Change: I9V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
102 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
104 |
126 |
3.3e-6 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
7.3e-6 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
9.9e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204095
AA Change: I9V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000145192
Gene: ENSMUSG00000007216
AA Change: I9V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
102 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
104 |
126 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
4.11e-2 |
SMART |
|
ZnF_C2H2
|
279 |
301 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
307 |
329 |
4.94e-5 |
SMART |
|
ZnF_C2H2
|
335 |
357 |
2.95e-3 |
SMART |
|
ZnF_C2H2
|
364 |
386 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
446 |
468 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
474 |
496 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
502 |
524 |
5.5e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204121
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000204521
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000204521
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000204521
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000204879
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Antxrl |
A |
G |
14: 33,776,928 (GRCm39) |
|
probably null |
Het |
| Atp2b2 |
A |
T |
6: 113,770,679 (GRCm39) |
V410E |
probably damaging |
Het |
| C6 |
G |
A |
15: 4,764,621 (GRCm39) |
V106I |
probably benign |
Het |
| Cdhr1 |
A |
C |
14: 36,804,896 (GRCm39) |
|
probably null |
Het |
| Cfap44 |
T |
A |
16: 44,272,216 (GRCm39) |
L1323Q |
possibly damaging |
Het |
| Ehd4 |
T |
A |
2: 119,984,829 (GRCm39) |
Y43F |
probably damaging |
Het |
| Eno1 |
T |
C |
4: 150,328,490 (GRCm39) |
I90T |
possibly damaging |
Het |
| Epb41l1 |
A |
G |
2: 156,363,477 (GRCm39) |
Y662C |
probably benign |
Het |
| Fkbp14 |
A |
G |
6: 54,566,299 (GRCm39) |
L103P |
probably damaging |
Het |
| Gm10322 |
C |
A |
10: 59,452,052 (GRCm39) |
N56K |
probably benign |
Het |
| Iqcd |
C |
A |
5: 120,740,476 (GRCm39) |
T269K |
probably damaging |
Het |
| Kat6b |
T |
A |
14: 21,668,972 (GRCm39) |
C249* |
probably null |
Het |
| Kcnab2 |
T |
C |
4: 152,489,058 (GRCm39) |
R109G |
probably null |
Het |
| Obox7 |
A |
G |
7: 14,398,032 (GRCm39) |
Q24R |
probably damaging |
Het |
| Obox7 |
C |
A |
7: 14,398,031 (GRCm39) |
Q24K |
probably damaging |
Het |
| Or5p1 |
A |
G |
7: 107,916,565 (GRCm39) |
N155D |
probably damaging |
Het |
| Or5p68 |
G |
A |
7: 107,945,765 (GRCm39) |
T141I |
probably benign |
Het |
| Or8g18 |
A |
C |
9: 39,149,375 (GRCm39) |
L115* |
probably null |
Het |
| Rasgrf2 |
C |
T |
13: 92,038,717 (GRCm39) |
G1043D |
probably damaging |
Het |
| Slf1 |
A |
G |
13: 77,191,688 (GRCm39) |
S1049P |
probably damaging |
Het |
| Smc1b |
A |
T |
15: 85,004,848 (GRCm39) |
F409I |
possibly damaging |
Het |
| Tab2 |
A |
G |
10: 7,795,123 (GRCm39) |
V453A |
probably damaging |
Het |
| Ubr4 |
A |
G |
4: 139,120,725 (GRCm39) |
Y338C |
probably damaging |
Het |
| Usp6nl |
A |
G |
2: 6,445,787 (GRCm39) |
E588G |
probably benign |
Het |
| Vcan |
T |
C |
13: 89,873,666 (GRCm39) |
R63G |
probably damaging |
Het |
| Zfpm2 |
T |
C |
15: 40,966,940 (GRCm39) |
C1010R |
probably damaging |
Het |
|
| Other mutations in Zfp775 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0051:Zfp775
|
UTSW |
6 |
48,597,706 (GRCm39) |
missense |
probably benign |
|
|
R1694:Zfp775
|
UTSW |
6 |
48,596,389 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5992:Zfp775
|
UTSW |
6 |
48,596,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6536:Zfp775
|
UTSW |
6 |
48,596,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6924:Zfp775
|
UTSW |
6 |
48,596,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7200:Zfp775
|
UTSW |
6 |
48,597,415 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7784:Zfp775
|
UTSW |
6 |
48,596,183 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7872:Zfp775
|
UTSW |
6 |
48,597,404 (GRCm39) |
missense |
probably benign |
|
|
R8406:Zfp775
|
UTSW |
6 |
48,597,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8766:Zfp775
|
UTSW |
6 |
48,597,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8771:Zfp775
|
UTSW |
6 |
48,596,906 (GRCm39) |
missense |
probably benign |
0.34 |
|
R9068:Zfp775
|
UTSW |
6 |
48,597,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Zfp775
|
UTSW |
6 |
48,597,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Zfp775
|
UTSW |
6 |
48,597,245 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTGAGGGAGTGGATAGAACTC -3'
(R):5'- GCTGCATACTTCTATAGCCTGG -3'
Sequencing Primer
(F):5'- TGAGGGAGTGGATAGAACTCAAAAAC -3'
(R):5'- TTACGTTTGGCTCCAAGG -3'
|
| Posted On |
2015-06-10 |
Incidental Mutation