Incidental Mutation 'IGL02944:Vmn1r175'
| ID |
364647 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r175
|
| Ensembl Gene |
ENSMUSG00000095632 |
| Gene Name |
vomeronasal 1 receptor 175 |
| Synonyms |
Gm6299 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
IGL02944
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
23507711-23508625 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23508591 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 12
(E12G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154170
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166141]
[ENSMUST00000228383]
|
| AlphaFold |
K7N6T9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166141
AA Change: E12G
PolyPhen 2
Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000126357
Gene: ENSMUSG00000095632
AA Change: E12G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
296 |
8.8e-15 |
PFAM |
|
Pfam:7tm_1
|
13 |
285 |
2.5e-6 |
PFAM |
|
Pfam:V1R
|
41 |
295 |
4.4e-22 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000228383
AA Change: E12G
PolyPhen 2
Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akap13 |
A |
G |
7: 75,258,405 (GRCm39) |
Q343R |
probably benign |
Het |
| Antxr1 |
T |
A |
6: 87,165,141 (GRCm39) |
N432I |
possibly damaging |
Het |
| Arhgap15 |
T |
C |
2: 44,032,362 (GRCm39) |
|
probably null |
Het |
| Atp6v1h |
T |
A |
1: 5,163,578 (GRCm39) |
|
probably benign |
Het |
| Cav2 |
T |
C |
6: 17,281,456 (GRCm39) |
Y33H |
probably damaging |
Het |
| Ccdc175 |
T |
A |
12: 72,164,667 (GRCm39) |
D585V |
probably benign |
Het |
| Coro7 |
T |
C |
16: 4,453,276 (GRCm39) |
D271G |
probably benign |
Het |
| Cylc1 |
T |
A |
X: 110,167,373 (GRCm39) |
D551E |
possibly damaging |
Het |
| Dnah1 |
A |
T |
14: 31,022,828 (GRCm39) |
I1103N |
possibly damaging |
Het |
| Gmds |
T |
A |
13: 32,522,435 (GRCm39) |
Y11F |
probably benign |
Het |
| Igkv13-54-1 |
C |
T |
6: 69,594,374 (GRCm39) |
|
noncoding transcript |
Het |
| Irf8 |
A |
G |
8: 121,481,864 (GRCm39) |
T318A |
probably benign |
Het |
| Lrrc40 |
G |
A |
3: 157,747,302 (GRCm39) |
|
probably benign |
Het |
| Mageb11 |
A |
G |
X: 89,935,868 (GRCm39) |
K41E |
probably benign |
Het |
| Mbd1 |
G |
A |
18: 74,410,481 (GRCm39) |
G428E |
probably damaging |
Het |
| Myom2 |
A |
T |
8: 15,154,065 (GRCm39) |
|
probably null |
Het |
| Nav2 |
C |
T |
7: 49,070,004 (GRCm39) |
R287W |
probably damaging |
Het |
| Nfs1 |
C |
T |
2: 155,969,688 (GRCm39) |
D320N |
probably damaging |
Het |
| Nlrp9a |
A |
T |
7: 26,258,076 (GRCm39) |
T565S |
probably benign |
Het |
| Nod1 |
A |
T |
6: 54,901,932 (GRCm39) |
I951N |
possibly damaging |
Het |
| Or1n1b |
T |
G |
2: 36,780,800 (GRCm39) |
E20A |
possibly damaging |
Het |
| Or2ag1b |
A |
G |
7: 106,288,476 (GRCm39) |
L154P |
probably damaging |
Het |
| Or52e8b |
A |
G |
7: 104,674,130 (GRCm39) |
L19P |
probably damaging |
Het |
| Or8d2 |
A |
T |
9: 38,760,048 (GRCm39) |
I213F |
possibly damaging |
Het |
| Pkhd1l1 |
T |
C |
15: 44,364,927 (GRCm39) |
Y689H |
probably damaging |
Het |
| Ppp2r5c |
A |
G |
12: 110,534,234 (GRCm39) |
I366V |
probably benign |
Het |
| Ppp3cb |
T |
C |
14: 20,578,303 (GRCm39) |
Y149C |
probably damaging |
Het |
| Prdm1 |
T |
C |
10: 44,317,807 (GRCm39) |
S354G |
probably benign |
Het |
| Ralgapa1 |
T |
A |
12: 55,804,736 (GRCm39) |
Q520L |
probably benign |
Het |
| Slc25a54 |
A |
T |
3: 108,987,931 (GRCm39) |
Y24F |
probably benign |
Het |
| Slfn3 |
T |
A |
11: 83,103,837 (GRCm39) |
V236E |
probably damaging |
Het |
| Syt6 |
A |
G |
3: 103,482,865 (GRCm39) |
|
probably benign |
Het |
| Trim30a |
G |
T |
7: 104,084,984 (GRCm39) |
N75K |
probably benign |
Het |
| Xylt1 |
A |
T |
7: 117,233,984 (GRCm39) |
T504S |
probably benign |
Het |
|
| Other mutations in Vmn1r175 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
PIT4531001:Vmn1r175
|
UTSW |
7 |
23,508,603 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1163:Vmn1r175
|
UTSW |
7 |
23,507,937 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1901:Vmn1r175
|
UTSW |
7 |
23,508,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1926:Vmn1r175
|
UTSW |
7 |
23,508,466 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1957:Vmn1r175
|
UTSW |
7 |
23,507,808 (GRCm39) |
missense |
probably benign |
0.21 |
|
R2163:Vmn1r175
|
UTSW |
7 |
23,508,352 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2381:Vmn1r175
|
UTSW |
7 |
23,508,093 (GRCm39) |
missense |
probably benign |
0.31 |
|
R3109:Vmn1r175
|
UTSW |
7 |
23,508,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3419:Vmn1r175
|
UTSW |
7 |
23,508,075 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3941:Vmn1r175
|
UTSW |
7 |
23,508,393 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4982:Vmn1r175
|
UTSW |
7 |
23,508,494 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5191:Vmn1r175
|
UTSW |
7 |
23,508,447 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5326:Vmn1r175
|
UTSW |
7 |
23,508,531 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5333:Vmn1r175
|
UTSW |
7 |
23,508,004 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5476:Vmn1r175
|
UTSW |
7 |
23,508,556 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5542:Vmn1r175
|
UTSW |
7 |
23,508,531 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5761:Vmn1r175
|
UTSW |
7 |
23,507,905 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5918:Vmn1r175
|
UTSW |
7 |
23,508,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Vmn1r175
|
UTSW |
7 |
23,508,591 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R6563:Vmn1r175
|
UTSW |
7 |
23,508,030 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7476:Vmn1r175
|
UTSW |
7 |
23,507,847 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7616:Vmn1r175
|
UTSW |
7 |
23,508,031 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8100:Vmn1r175
|
UTSW |
7 |
23,508,012 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8157:Vmn1r175
|
UTSW |
7 |
23,508,523 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8699:Vmn1r175
|
UTSW |
7 |
23,508,234 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8744:Vmn1r175
|
UTSW |
7 |
23,508,403 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9595:Vmn1r175
|
UTSW |
7 |
23,508,508 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Posted On |
2015-12-18 |
Incidental Mutation