Incidental Mutation 'R5048:Or5w16'
ID 394447
Institutional Source Beutler Lab
Gene Symbol Or5w16
Ensembl Gene ENSMUSG00000068817
Gene Name olfactory receptor family 5 subfamily W member 16
Synonyms Olfr1140, GA_x6K02T2Q125-49250025-49250960, MOR177-6
MMRRC Submission 042638-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.205) question?
Stock # R5048 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87576505-87577524 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 87576663 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 41 (A41E)
Ref Sequence ENSEMBL: ENSMUSP00000149645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111568] [ENSMUST00000214723] [ENSMUST00000217572]
AlphaFold Q7TR39
Predicted Effect probably benign
Transcript: ENSMUST00000111568
AA Change: A41E

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000107194
Gene: ENSMUSG00000068815
AA Change: A41E

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-44 PFAM
Pfam:7tm_1 41 290 2.8e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214723
AA Change: A41E

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217102
Predicted Effect probably benign
Transcript: ENSMUST00000217572
AA Change: A41E

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217634
Meta Mutation Damage Score 0.2359 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.1%
Validation Efficiency 98% (64/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 T C 2: 69,138,850 (GRCm39) I144V probably benign Het
Abhd5 T C 9: 122,206,968 (GRCm39) Y85H probably damaging Het
Acadsb G A 7: 131,039,198 (GRCm39) G323D probably damaging Het
Amotl2 A G 9: 102,600,997 (GRCm39) R322G probably benign Het
Aox1 A T 1: 58,098,641 (GRCm39) probably benign Het
Aste1 C T 9: 105,274,188 (GRCm39) R82W probably damaging Het
Atg4b T C 1: 93,703,380 (GRCm39) I139T possibly damaging Het
Btnl5-ps T A 17: 34,707,697 (GRCm39) noncoding transcript Het
Ccdc85c A G 12: 108,187,966 (GRCm39) probably null Het
Clasp1 A G 1: 118,475,340 (GRCm39) probably benign Het
Defb10 G A 8: 22,351,887 (GRCm39) C44Y probably damaging Het
Dhrs9 T C 2: 69,224,744 (GRCm39) V144A probably damaging Het
Dnhd1 G C 7: 105,342,904 (GRCm39) S1416T probably benign Het
Dok1 T A 6: 83,009,087 (GRCm39) probably benign Het
Emilin2 G A 17: 71,580,962 (GRCm39) T588M probably damaging Het
Fam181b A G 7: 92,729,147 (GRCm39) probably benign Het
Fhad1 T C 4: 141,691,987 (GRCm39) probably null Het
Foxi2 A G 7: 135,013,364 (GRCm39) E198G probably damaging Het
Fsip2 C A 2: 82,823,494 (GRCm39) A6409E probably damaging Het
Gje1 T C 10: 14,593,021 (GRCm39) Y65C probably damaging Het
Gm6401 T C 14: 41,789,724 (GRCm39) probably null Het
Gprc5c T C 11: 114,761,177 (GRCm39) *442Q probably null Het
Iars1 T A 13: 49,841,713 (GRCm39) I67N probably damaging Het
Igkv4-79 T C 6: 69,019,971 (GRCm39) S115G probably benign Het
Itga4 C A 2: 79,103,378 (GRCm39) S156R probably benign Het
Lilra6 C T 7: 3,918,440 (GRCm39) probably null Het
Majin C A 19: 6,272,684 (GRCm39) A208E probably benign Het
Megf8 A G 7: 25,030,517 (GRCm39) Q490R possibly damaging Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Mgarp G A 3: 51,298,707 (GRCm39) R88C probably damaging Het
Msh2 T C 17: 87,980,196 (GRCm39) F58S probably damaging Het
Nemp1 T C 10: 127,526,804 (GRCm39) probably null Het
Nlrp10 A T 7: 108,523,772 (GRCm39) N569K probably benign Het
Nxpe2 T C 9: 48,237,388 (GRCm39) probably null Het
Or4c106 T C 2: 88,682,807 (GRCm39) V171A possibly damaging Het
Pdcd11 C A 19: 47,095,554 (GRCm39) S625R probably benign Het
Pigb T A 9: 72,936,990 (GRCm39) probably null Het
Pitpnb T C 5: 111,530,869 (GRCm39) F221L possibly damaging Het
Prox2 A T 12: 85,141,115 (GRCm39) W363R probably damaging Het
Psmg1 T A 16: 95,785,171 (GRCm39) R139S probably benign Het
Rab11fip3 A G 17: 26,286,554 (GRCm39) probably null Het
Samd9l G A 6: 3,374,157 (GRCm39) R1035C probably benign Het
Shkbp1 G A 7: 27,051,521 (GRCm39) probably benign Het
Slc30a5 C A 13: 100,943,249 (GRCm39) L536F probably damaging Het
Slc6a17 A T 3: 107,378,753 (GRCm39) L643* probably null Het
Slit3 T C 11: 35,479,812 (GRCm39) Y330H probably damaging Het
St13 G C 15: 81,283,786 (GRCm39) R4G probably benign Het
Stoml3 A C 3: 53,408,213 (GRCm39) K86N possibly damaging Het
Tmtc1 A T 6: 148,139,344 (GRCm39) L926Q possibly damaging Het
Tns4 T G 11: 98,969,605 (GRCm39) R285S possibly damaging Het
Uncx C T 5: 139,532,874 (GRCm39) T313M probably benign Het
Vmn2r75 G A 7: 85,814,735 (GRCm39) R253C possibly damaging Het
Zbed6 T C 1: 133,586,462 (GRCm39) S292G probably damaging Het
Zfp143 A G 7: 109,673,325 (GRCm39) T142A probably damaging Het
Zfp287 T C 11: 62,605,777 (GRCm39) K366E probably damaging Het
Other mutations in Or5w16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01014:Or5w16 APN 2 87,577,469 (GRCm39) missense probably benign 0.03
IGL01538:Or5w16 APN 2 87,576,942 (GRCm39) missense probably benign 0.10
IGL01735:Or5w16 APN 2 87,576,650 (GRCm39) missense probably benign 0.00
IGL02224:Or5w16 APN 2 87,576,757 (GRCm39) nonsense probably null
IGL03047:Or5w16 UTSW 2 87,577,338 (GRCm39) missense possibly damaging 0.63
R0537:Or5w16 UTSW 2 87,577,017 (GRCm39) missense probably benign 0.06
R1701:Or5w16 UTSW 2 87,576,894 (GRCm39) missense probably damaging 0.99
R1998:Or5w16 UTSW 2 87,577,316 (GRCm39) missense probably damaging 1.00
R2430:Or5w16 UTSW 2 87,576,999 (GRCm39) missense possibly damaging 0.52
R4750:Or5w16 UTSW 2 87,576,852 (GRCm39) missense probably benign
R5494:Or5w16 UTSW 2 87,576,950 (GRCm39) missense probably damaging 1.00
R5521:Or5w16 UTSW 2 87,577,406 (GRCm39) missense probably benign 0.24
R7786:Or5w16 UTSW 2 87,576,645 (GRCm39) missense probably damaging 1.00
R8017:Or5w16 UTSW 2 87,577,392 (GRCm39) missense probably damaging 0.98
R8019:Or5w16 UTSW 2 87,577,392 (GRCm39) missense probably damaging 0.98
R8463:Or5w16 UTSW 2 87,577,437 (GRCm39) missense probably benign 0.01
R8827:Or5w16 UTSW 2 87,576,777 (GRCm39) missense possibly damaging 0.63
R9038:Or5w16 UTSW 2 87,577,125 (GRCm39) missense probably damaging 1.00
X0019:Or5w16 UTSW 2 87,576,764 (GRCm39) missense possibly damaging 0.96
Z1088:Or5w16 UTSW 2 87,576,833 (GRCm39) missense probably damaging 0.99
Z1177:Or5w16 UTSW 2 87,576,968 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- GCCTAGATAAATTAGAGCACAGTCTAC -3'
(R):5'- GATCAAAGGCCATCACTGCC -3'

Sequencing Primer
(F):5'- GAGCACAGTCTACTTTTAATGCTTTC -3'
(R):5'- CACAGGTAAAGAAAAACTGTAATGC -3'
Posted On 2016-06-15