Incidental Mutation 'IGL02989:Olfr1211'
ID406833
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1211
Ensembl Gene ENSMUSG00000075112
Gene Nameolfactory receptor 1211
SynonymsMOR233-21, MOR233-16P, GA_x6K02T2Q125-50409367-50408432
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.078) question?
Stock #IGL02989
Quality Score
Status
Chromosome2
Chromosomal Location88926876-88938111 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 88929704 bp
ZygosityHeterozygous
Amino Acid Change Serine to Threonine at position 204 (S204T)
Ref Sequence ENSEMBL: ENSMUSP00000150571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099808] [ENSMUST00000213412] [ENSMUST00000215205]
Predicted Effect possibly damaging
Transcript: ENSMUST00000099808
AA Change: S204T

PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000097396
Gene: ENSMUSG00000075112
AA Change: S204T

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 9.5e-49 PFAM
Pfam:7tm_1 39 286 2.5e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141958
Predicted Effect possibly damaging
Transcript: ENSMUST00000213412
AA Change: S204T

PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215205
AA Change: S204T

PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1a1 T A 19: 20,640,058 probably benign Het
Arhgap15 A G 2: 43,780,736 D44G probably damaging Het
Arhgap35 A T 7: 16,497,655 *1500R probably null Het
Arid1b A G 17: 5,335,047 Y1413C probably damaging Het
Atf6 A G 1: 170,788,683 probably benign Het
BC030867 A G 11: 102,255,299 I134V probably benign Het
Cant1 T C 11: 118,411,212 Y93C probably damaging Het
Cat A G 2: 103,472,973 F153S probably damaging Het
Ccdc187 G A 2: 26,276,431 R712W possibly damaging Het
Clpb T C 7: 101,779,220 S396P probably damaging Het
Cntnap5a A G 1: 116,412,083 probably benign Het
Dap3 G A 3: 88,930,571 probably benign Het
Dnah6 T A 6: 73,069,420 D3195V probably damaging Het
Eprs T G 1: 185,418,366 F1355C probably benign Het
Faim2 A G 15: 99,520,362 probably benign Het
Fam208b A T 13: 3,584,820 H662Q probably benign Het
Fancg A G 4: 43,007,121 probably benign Het
Fbxo42 T A 4: 141,199,534 I375N probably damaging Het
Gabrr3 A T 16: 59,448,008 D328V probably damaging Het
Gm5849 T A 3: 90,777,800 D26V probably damaging Het
Gm6563 T C 19: 23,675,870 L8P possibly damaging Het
Gpld1 A G 13: 24,990,036 N815D possibly damaging Het
Idh2 T A 7: 80,099,108 I142F probably damaging Het
Kcnh7 A C 2: 62,721,925 N907K probably benign Het
Mcm3ap A G 10: 76,471,060 T336A possibly damaging Het
Olfr1469 C A 19: 13,411,486 Q306K probably benign Het
Olfr556 T C 7: 102,670,444 S175P possibly damaging Het
Pilrb1 C A 5: 137,857,230 R133L possibly damaging Het
Pitpnm3 C A 11: 72,120,186 probably benign Het
Prkdc C T 16: 15,800,016 T3237I possibly damaging Het
Pspc1 A G 14: 56,771,696 probably benign Het
Rasgrp4 G A 7: 29,148,406 E414K probably damaging Het
Rgs12 T A 5: 34,965,119 L82Q probably damaging Het
Sh3gl3 T C 7: 82,273,879 V117A probably benign Het
Shisa5 G A 9: 109,055,994 A112T probably damaging Het
Tedc1 A G 12: 113,163,321 E401G probably benign Het
Tsc22d1 T C 14: 76,418,901 M940T probably benign Het
Vmn1r129 A T 7: 21,360,738 V185E probably damaging Het
Zfp982 C A 4: 147,512,595 D136E possibly damaging Het
Other mutations in Olfr1211
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02724:Olfr1211 APN 2 88929448 missense probably damaging 1.00
IGL02936:Olfr1211 APN 2 88929784 missense probably benign 0.01
IGL02960:Olfr1211 APN 2 88929784 missense possibly damaging 0.80
R0193:Olfr1211 UTSW 2 88930283 missense probably benign 0.01
R0413:Olfr1211 UTSW 2 88929562 missense probably benign 0.16
R1644:Olfr1211 UTSW 2 88929387 missense probably benign 0.01
R3715:Olfr1211 UTSW 2 88929413 missense probably benign 0.07
R4019:Olfr1211 UTSW 2 88929736 missense probably benign 0.02
R4722:Olfr1211 UTSW 2 88929980 missense possibly damaging 0.91
R4751:Olfr1211 UTSW 2 88929914 missense probably damaging 1.00
R4859:Olfr1211 UTSW 2 88930283 missense probably benign 0.01
R5053:Olfr1211 UTSW 2 88930253 missense probably benign 0.02
R6148:Olfr1211 UTSW 2 88930253 missense probably benign 0.00
R7064:Olfr1211 UTSW 2 88929509 missense probably benign 0.00
R7527:Olfr1211 UTSW 2 88930090 missense probably benign 0.00
R7584:Olfr1211 UTSW 2 88929805 missense probably damaging 1.00
R7989:Olfr1211 UTSW 2 88929514 missense probably damaging 0.99
Posted On2016-08-02