Incidental Mutation 'IGL03205:Olfr61'
ID413101
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr61
Ensembl Gene ENSMUSG00000096069
Gene Nameolfactory receptor 61
SynonymsMOR253-1, IH7, GA_x6K02T2PBJ9-42783826-42784758
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.155) question?
Stock #IGL03205
Quality Score
Status
Chromosome7
Chromosomal Location140628970-140638798 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 140638160 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Tyrosine at position 153 (C153Y)
Ref Sequence ENSEMBL: ENSMUSP00000147924 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084455] [ENSMUST00000210241] [ENSMUST00000210373] [ENSMUST00000211685]
Predicted Effect possibly damaging
Transcript: ENSMUST00000084455
AA Change: C153Y

PolyPhen 2 Score 0.905 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000081493
Gene: ENSMUSG00000096069
AA Change: C153Y

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 3.3e-49 PFAM
Pfam:7TM_GPCR_Srsx 36 175 1.3e-8 PFAM
Pfam:7tm_1 42 291 3.6e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000210241
AA Change: C153Y

PolyPhen 2 Score 0.905 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000210373
Predicted Effect possibly damaging
Transcript: ENSMUST00000211685
AA Change: C153Y

PolyPhen 2 Score 0.905 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bsph2 A T 7: 13,556,376 D120E probably damaging Het
Casp14 A G 10: 78,713,339 *258Q probably null Het
Ccdc54 A C 16: 50,590,891 F4C possibly damaging Het
Clcn4 C T 7: 7,290,420 V475M probably damaging Het
D630045J12Rik C T 6: 38,147,259 R1586H probably damaging Het
Eml4 T A 17: 83,454,444 S453R probably damaging Het
Flt1 T C 5: 147,699,821 K118E probably benign Het
Kif20b A T 19: 34,959,463 E154D probably damaging Het
Meis2 C T 2: 115,864,250 V471I probably benign Het
Naa16 G A 14: 79,356,512 T371I possibly damaging Het
Naa20 A G 2: 145,903,331 T8A possibly damaging Het
Pla2g6 G A 15: 79,317,785 P62L probably damaging Het
Pmel A G 10: 128,716,448 T384A probably benign Het
Ryr3 T C 2: 112,632,142 Y4863C probably damaging Het
Slc4a4 G A 5: 89,149,330 V510I probably benign Het
Smad3 T A 9: 63,667,866 Y23F probably benign Het
Sugt1 G A 14: 79,596,801 A81T probably damaging Het
Svs3b A T 2: 164,256,261 F47I probably damaging Het
Thbs4 T C 13: 92,762,774 D571G probably damaging Het
Trav15-1-dv6-1 T C 14: 53,560,028 Y45H probably damaging Het
Zbtb5 A T 4: 44,994,949 M145K probably damaging Het
Other mutations in Olfr61
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Olfr61 APN 7 140638256 missense probably damaging 1.00
IGL01837:Olfr61 APN 7 140638211 missense probably damaging 1.00
IGL02349:Olfr61 APN 7 140638471 missense probably benign 0.00
IGL02713:Olfr61 APN 7 140637916 missense probably damaging 0.98
IGL02982:Olfr61 APN 7 140637952 missense probably benign 0.06
R1477:Olfr61 UTSW 7 140638442 missense possibly damaging 0.94
R1564:Olfr61 UTSW 7 140638054 missense probably benign 0.21
R1900:Olfr61 UTSW 7 140638592 missense probably damaging 0.99
R2149:Olfr61 UTSW 7 140638052 missense probably damaging 0.99
R2504:Olfr61 UTSW 7 140638484 missense probably benign 0.01
R2887:Olfr61 UTSW 7 140638225 missense probably damaging 1.00
R3787:Olfr61 UTSW 7 140637835 missense probably benign 0.01
R4628:Olfr61 UTSW 7 140638384 missense probably benign 0.04
R4775:Olfr61 UTSW 7 140637916 missense probably damaging 0.98
R5805:Olfr61 UTSW 7 140638471 missense probably benign 0.00
R6019:Olfr61 UTSW 7 140638012 missense probably benign 0.03
R6244:Olfr61 UTSW 7 140638433 missense probably damaging 1.00
R7303:Olfr61 UTSW 7 140638354 missense probably damaging 1.00
R7505:Olfr61 UTSW 7 140638052 missense probably damaging 1.00
R7783:Olfr61 UTSW 7 140637724 missense possibly damaging 0.86
Z1088:Olfr61 UTSW 7 140638220 missense probably benign
Posted On2016-08-02