Incidental Mutation 'IGL03339:Ighg2c'
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ID417136
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ighg2c
Ensembl Gene ENSMUSG00000076612
Gene Nameimmunoglobulin heavy constant gamma 2C
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.105) question?
Stock #IGL03339
Quality Score
Status
Chromosome12
Chromosomal Location113287285-113288932 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 113287994 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glycine at position 171 (V171G)
Gene Model predicted gene model for transcript(s):
Predicted Effect unknown
Transcript: ENSMUST00000103416
AA Change: V171G
SMART Domains Protein: ENSMUSP00000100212
Gene: ENSMUSG00000076612
AA Change: V171G

DomainStartEndE-ValueType
IGc1 21 91 2.4e-15 SMART
IG_like 143 218 1.64e-2 SMART
IGc1 249 322 1.97e-34 SMART
transmembrane domain 350 372 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000195192
AA Change: V171G
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A G 2: 152,442,456 E323G probably damaging Het
A4gnt T C 9: 99,620,548 S254P probably damaging Het
Actn4 A G 7: 28,901,982 L447P probably damaging Het
Agbl2 C A 2: 90,797,563 S237R probably damaging Het
Apc G A 18: 34,298,474 D309N probably damaging Het
Arhgef3 A G 14: 27,401,857 M492V probably damaging Het
Atp10b T A 11: 43,230,615 M1035K probably null Het
Cfap69 T A 5: 5,586,436 probably benign Het
Ctf1 A G 7: 127,713,994 N24S probably benign Het
Cx3cr1 T A 9: 120,051,437 K300* probably null Het
Ddx25 A T 9: 35,542,003 Y484N probably damaging Het
Eif4g1 A G 16: 20,680,984 E506G possibly damaging Het
Ficd G T 5: 113,738,739 R325L probably benign Het
G6pc2 A G 2: 69,220,895 probably benign Het
Gm11168 C A 9: 3,004,767 P103T probably benign Het
Hbb-y A T 7: 103,852,769 H98Q probably damaging Het
Hmcn1 A G 1: 150,701,969 S2014P probably benign Het
Hoxc5 T C 15: 103,014,136 Y19H probably damaging Het
Igfbpl1 A G 4: 45,813,555 probably benign Het
Kctd13 A G 7: 126,945,018 D296G probably benign Het
Mfsd2b A C 12: 4,874,335 M1R probably null Het
Nipbl A G 15: 8,350,876 S811P probably benign Het
Olfr118 G A 17: 37,672,557 C178Y possibly damaging Het
Olfr119 G T 17: 37,700,791 M40I probably damaging Het
Olfr1484 T G 19: 13,586,075 M257R probably damaging Het
Olfr569 G A 7: 102,887,782 R124C probably benign Het
Pcolce2 T C 9: 95,678,340 probably benign Het
Pik3c2a G T 7: 116,418,021 T167K possibly damaging Het
Ppp1r18 A G 17: 35,868,046 D271G probably benign Het
Rnf213 T C 11: 119,443,004 I3013T probably damaging Het
Rock1 A T 18: 10,097,493 M765K probably benign Het
Sec16a T C 2: 26,435,933 Y1244C probably benign Het
Taar7d T C 10: 24,027,306 C29R possibly damaging Het
Tmem56 C T 3: 121,228,840 probably benign Het
Ttn A C 2: 76,741,920 F26210V probably damaging Het
Ube2b A T 11: 51,986,707 V145D probably damaging Het
Vmn1r219 T G 13: 23,163,410 S256R possibly damaging Het
Other mutations in Ighg2c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02087:Ighg2c APN 12 113285366 unclassified probably benign
IGL02560:Ighg2c APN 12 113287884 missense unknown
R0047:Ighg2c UTSW 12 113288168 splice site probably benign
R0047:Ighg2c UTSW 12 113288168 splice site probably benign
R0415:Ighg2c UTSW 12 113287910 missense unknown
R0571:Ighg2c UTSW 12 113288762 nonsense probably null
R0634:Ighg2c UTSW 12 113287964 missense unknown
R0893:Ighg2c UTSW 12 113287433 missense unknown
R1169:Ighg2c UTSW 12 113285952 unclassified probably benign
R3895:Ighg2c UTSW 12 113287658 missense unknown
R5065:Ighg2c UTSW 12 113288088 missense unknown
R6407:Ighg2c UTSW 12 113288651 missense unknown
R6846:Ighg2c UTSW 12 113288310 missense unknown
R7052:Ighg2c UTSW 12 113288723 missense
R7231:Ighg2c UTSW 12 113288016 missense
R7513:Ighg2c UTSW 12 113288851 missense
Z1177:Ighg2c UTSW 12 113287680 missense
Posted On2016-08-02