Incidental Mutation 'R6217:Lrrc3'
ID503792
Institutional Source Beutler Lab
Gene Symbol Lrrc3
Ensembl Gene ENSMUSG00000051652
Gene Nameleucine rich repeat containing 3
Synonyms
MMRRC Submission 044350-MU
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R6217 (G1)
Quality Score225.009
Status Validated
Chromosome10
Chromosomal Location77897575-77902536 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 77901009 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 198 (T198S)
Ref Sequence ENSEMBL: ENSMUSP00000059570 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057608]
Predicted Effect probably benign
Transcript: ENSMUST00000057608
AA Change: T198S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000059570
Gene: ENSMUSG00000051652
AA Change: T198S

DomainStartEndE-ValueType
LRRNT 32 68 6.53e-9 SMART
LRR 67 86 7.17e1 SMART
LRR_TYP 87 110 1.87e-5 SMART
LRR 113 135 2.14e0 SMART
Blast:LRRCT 145 197 7e-10 BLAST
transmembrane domain 204 226 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000178996
SMART Domains Protein: ENSMUSP00000136431
Gene: ENSMUSG00000096573

DomainStartEndE-ValueType
internal_repeat_1 4 32 6.69e-6 PROSPERO
internal_repeat_1 52 80 6.69e-6 PROSPERO
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185309
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 97% (59/61)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700074P13Rik G A 6: 40,926,085 P118S possibly damaging Het
Abraxas2 G A 7: 132,874,965 A145T probably damaging Het
Adamts20 T C 15: 94,338,715 D808G probably benign Het
Ankdd1a C T 9: 65,508,061 A227T possibly damaging Het
Arsk T A 13: 76,091,816 Q46L unknown Het
Asnsd1 A G 1: 53,348,028 F147L probably benign Het
Atp5a1 T A 18: 77,781,356 S427T probably benign Het
Atp6v1b2 A C 8: 69,109,878 probably null Het
AU021092 T A 16: 5,212,186 T322S possibly damaging Het
Bcl7c A T 7: 127,708,526 M1K probably null Het
Cacna1i T C 15: 80,389,132 V1673A probably damaging Het
Ccdc146 A T 5: 21,317,902 probably null Het
Cdc7 A G 5: 106,972,794 D122G probably damaging Het
Cfap46 CCTTCTTCT CCTTCT 7: 139,638,900 probably benign Het
Chd3 T A 11: 69,345,535 Q1950L probably damaging Het
Cutc T C 19: 43,759,997 L111S probably damaging Het
Cyp2j6 A G 4: 96,518,161 F458L probably damaging Het
Ddhd1 T C 14: 45,619,514 probably null Het
Dstyk T C 1: 132,459,939 S804P probably damaging Het
Ech1 A G 7: 28,831,836 D283G possibly damaging Het
Exosc10 A G 4: 148,582,311 probably null Het
Fam160b2 T C 14: 70,591,758 probably null Het
Fancg A C 4: 43,010,084 V5G probably benign Het
Fbxo11 A G 17: 88,008,904 V394A probably benign Het
Fcmr C T 1: 130,878,323 R339W probably damaging Het
Fsip2 T A 2: 82,988,418 L4832M possibly damaging Het
Gab1 A G 8: 80,791,608 V125A possibly damaging Het
Gabrr1 A T 4: 33,149,026 probably null Het
Gon4l T C 3: 88,892,661 V871A possibly damaging Het
Hspg2 A G 4: 137,540,248 T2056A probably damaging Het
Lsamp A T 16: 42,134,312 E174V possibly damaging Het
Ltbr C T 6: 125,307,454 V342M probably damaging Het
Muc16 A T 9: 18,655,446 S1926T unknown Het
Ntn1 C A 11: 68,213,332 V497F possibly damaging Het
Olfr181 T C 16: 58,926,514 D19G probably benign Het
Olfr700 A T 7: 106,806,072 L130Q probably damaging Het
Olfr936 A T 9: 39,046,743 *270R probably null Het
Osmr T C 15: 6,823,566 Y615C probably damaging Het
Pcdhgb2 T C 18: 37,690,001 V15A possibly damaging Het
Pkd2l2 A G 18: 34,414,680 N162S probably benign Het
Ppp1r12a G A 10: 108,240,184 probably null Het
Prtg C T 9: 72,904,794 P899S probably damaging Het
Ptprn A T 1: 75,248,166 S912R probably damaging Het
Rex2 A G 4: 147,057,474 T140A possibly damaging Het
Ryr2 T G 13: 11,834,078 D339A probably damaging Het
Sf3b1 C T 1: 55,007,518 R289H probably damaging Het
Slc17a9 A G 2: 180,737,662 D309G probably benign Het
Slc4a10 A G 2: 62,303,951 R1004G probably benign Het
Sprr2f A T 3: 92,366,059 Q55L unknown Het
Syne1 C T 10: 5,293,761 G2801D probably benign Het
Tenm3 A T 8: 48,293,665 V1026D probably damaging Het
Ticam1 A T 17: 56,270,730 I455N probably damaging Het
Tmem161b A G 13: 84,251,244 I6M possibly damaging Het
Ubn1 A G 16: 5,077,232 E714G probably damaging Het
Ush2a T G 1: 188,743,454 probably null Het
Usp19 G A 9: 108,500,144 V874M probably damaging Het
Vmn2r106 T C 17: 20,268,239 T633A probably benign Het
Vmn2r75 A T 7: 86,166,167 probably benign Het
Zfyve27 T C 19: 42,189,577 V386A probably damaging Het
Zscan20 A T 4: 128,604,534 W24R probably damaging Het
Other mutations in Lrrc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0568:Lrrc3 UTSW 10 77901585 missense probably damaging 0.96
R1169:Lrrc3 UTSW 10 77900930 missense probably damaging 1.00
R4660:Lrrc3 UTSW 10 77894032 unclassified probably benign
R4915:Lrrc3 UTSW 10 77901419 missense probably benign 0.37
R4917:Lrrc3 UTSW 10 77901419 missense probably benign 0.37
R5439:Lrrc3 UTSW 10 77901465 missense probably benign 0.00
R6921:Lrrc3 UTSW 10 77901032 missense probably damaging 0.99
R7024:Lrrc3 UTSW 10 77900991 missense probably damaging 1.00
R8387:Lrrc3 UTSW 10 77901512 missense possibly damaging 0.64
R8498:Lrrc3 UTSW 10 77900990 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTAAGAGGCTCCTTGGAGACTG -3'
(R):5'- GGACTTATCCCACAATCGCATC -3'

Sequencing Primer
(F):5'- TCCTTGGAGACTGGAGCACTAG -3'
(R):5'- CAAGTTGAGTGCCAAGATCCGC -3'
Posted On2018-02-27