Incidental Mutation 'R6543:Scrt2'
ID 520900
Institutional Source Beutler Lab
Gene Symbol Scrt2
Ensembl Gene ENSMUSG00000060257
Gene Name scratch family zinc finger 2
Synonyms
MMRRC Submission 044669-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # R6543 (G1)
Quality Score 156.008
Status Validated
Chromosome 2
Chromosomal Location 151923737-151937722 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 151935063 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 72 (A72V)
Ref Sequence ENSEMBL: ENSMUSP00000066280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064061]
AlphaFold Q8BTH6
Predicted Effect probably benign
Transcript: ENSMUST00000064061
AA Change: A72V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000066280
Gene: ENSMUSG00000060257
AA Change: A72V

DomainStartEndE-ValueType
low complexity region 64 82 N/A INTRINSIC
low complexity region 114 158 N/A INTRINSIC
ZnF_C2H2 161 183 1.26e-2 SMART
ZnF_C2H2 192 214 6.23e-2 SMART
ZnF_C2H2 218 240 6.42e-4 SMART
ZnF_C2H2 246 268 7.9e-4 SMART
ZnF_C2H2 274 294 5.26e1 SMART
low complexity region 300 311 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.6%
Validation Efficiency 100% (41/41)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap4e1 T C 2: 126,908,525 (GRCm39) V1091A probably benign Het
Arhgef11 A G 3: 87,640,715 (GRCm39) N1320D probably benign Het
Atl3 T A 19: 7,487,463 (GRCm39) F126Y probably damaging Het
Borcs5 C T 6: 134,687,143 (GRCm39) T167M probably damaging Het
Cplane2 T G 4: 140,944,599 (GRCm39) V50G probably benign Het
Creld2 A G 15: 88,709,481 (GRCm39) T331A probably benign Het
Cuzd1 A G 7: 130,911,497 (GRCm39) V494A probably damaging Het
Dclk1 C T 3: 55,407,552 (GRCm39) P244S probably damaging Het
Esyt3 T C 9: 99,220,825 (GRCm39) N126S possibly damaging Het
Focad T C 4: 88,197,493 (GRCm39) S629P unknown Het
Grip1 T C 10: 119,821,499 (GRCm39) L389P probably benign Het
Igkv4-91 A T 6: 68,745,582 (GRCm39) D105E probably damaging Het
Il20ra G A 10: 19,625,071 (GRCm39) A117T probably damaging Het
Il6ra A G 3: 89,784,170 (GRCm39) V367A probably damaging Het
Itga8 C T 2: 12,306,455 (GRCm39) V47M probably damaging Het
Limk2 T C 11: 3,300,682 (GRCm39) Y220C probably damaging Het
Lims1 T A 10: 58,248,273 (GRCm39) C243* probably null Het
Man1a C A 10: 53,811,077 (GRCm39) G435* probably null Het
Msantd5f4 A G 4: 73,557,215 (GRCm39) E16G probably damaging Het
Mtor T A 4: 148,630,053 (GRCm39) I2250N probably damaging Het
N4bp1 G A 8: 87,588,534 (GRCm39) Q135* probably null Het
Nbeal2 A T 9: 110,473,526 (GRCm39) D76E probably benign Het
Nbn T C 4: 15,986,605 (GRCm39) S669P probably benign Het
Nfrkb C T 9: 31,312,281 (GRCm39) Q456* probably null Het
Or6c3b C A 10: 129,527,859 (GRCm39) G17V probably benign Het
Pcnx3 C T 19: 5,715,275 (GRCm39) A1557T probably benign Het
Pgd C T 4: 149,245,209 (GRCm39) probably null Het
Prokr2 T A 2: 132,215,819 (GRCm39) Q53L probably benign Het
Pxmp4 C A 2: 154,429,979 (GRCm39) A137S possibly damaging Het
Rasef C T 4: 73,698,756 (GRCm39) probably benign Het
Scpppq1 T C 5: 104,222,741 (GRCm39) probably benign Het
Sipa1l2 T C 8: 126,177,101 (GRCm39) E1171G possibly damaging Het
Slc26a8 T C 17: 28,857,375 (GRCm39) T923A possibly damaging Het
Slco1a6 T C 6: 142,078,872 (GRCm39) K141R probably benign Het
Slfn5 T A 11: 82,849,492 (GRCm39) probably null Het
Sympk A T 7: 18,770,755 (GRCm39) H282L probably damaging Het
Tnr A G 1: 159,751,677 (GRCm39) Y1324C probably damaging Het
Topaz1 A G 9: 122,577,600 (GRCm39) N170S possibly damaging Het
Trav6-3 T C 14: 53,666,219 (GRCm39) M1T probably null Het
Trim66 A G 7: 109,075,086 (GRCm39) S392P probably benign Het
Ttn T C 2: 76,599,155 (GRCm39) T10958A probably damaging Het
Ubr7 A G 12: 102,734,494 (GRCm39) K256R probably benign Het
Other mutations in Scrt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01518:Scrt2 APN 2 151,935,560 (GRCm39) missense probably damaging 1.00
R1747:Scrt2 UTSW 2 151,935,638 (GRCm39) missense probably damaging 1.00
R1989:Scrt2 UTSW 2 151,924,007 (GRCm39) missense probably damaging 0.96
R5443:Scrt2 UTSW 2 151,924,043 (GRCm39) missense probably benign 0.22
R7126:Scrt2 UTSW 2 151,935,006 (GRCm39) missense probably damaging 1.00
R9680:Scrt2 UTSW 2 151,924,018 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TCCACCCAGGGAGATTCGAG -3'
(R):5'- GTACGTCTTGCCGCACTCTG -3'

Sequencing Primer
(F):5'- CAGGGAGATTCGAGACCCG -3'
(R):5'- GATGAAGAAGGCGTCCAT -3'
Posted On 2018-06-06