Incidental Mutation 'R6721:Or10h5'
ID 529609
Institutional Source Beutler Lab
Gene Symbol Or10h5
Ensembl Gene ENSMUSG00000096169
Gene Name olfactory receptor family 10 subfamily H member 5
Synonyms Olfr1564, Gm4461
MMRRC Submission 044839-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.156) question?
Stock # R6721 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 33434235-33435325 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 33434508 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Glutamic Acid at position 270 (G270E)
Ref Sequence ENSEMBL: ENSMUSP00000150573 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112162] [ENSMUST00000208645] [ENSMUST00000213642] [ENSMUST00000213751] [ENSMUST00000215450]
AlphaFold K7N6V7
Predicted Effect probably benign
Transcript: ENSMUST00000112162
AA Change: G273E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000127247
Gene: ENSMUSG00000096169
AA Change: G273E

DomainStartEndE-ValueType
Pfam:7tm_4 34 312 3.3e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 263 1.5e-5 PFAM
Pfam:7tm_1 44 297 5e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208645
AA Change: G270E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000213642
AA Change: G270E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000213751
AA Change: G270E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000215450
AA Change: G270E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.0%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,629,634 (GRCm39) L3588S probably benign Het
Ankrd27 T C 7: 35,311,976 (GRCm39) F402S probably damaging Het
Aplp1 T C 7: 30,139,720 (GRCm39) Q359R probably null Het
Arhgef10l T C 4: 140,297,655 (GRCm39) Y546C probably damaging Het
Bltp2 T C 11: 78,170,625 (GRCm39) Y1615H probably damaging Het
Cd46 T C 1: 194,765,939 (GRCm39) Y142C probably damaging Het
Cfap418 A G 4: 10,874,744 (GRCm39) N44D probably benign Het
Chd3 T C 11: 69,260,045 (GRCm39) probably benign Het
Cmtm2b A G 8: 105,049,077 (GRCm39) S31G possibly damaging Het
CN725425 A G 15: 91,115,821 (GRCm39) K21R possibly damaging Het
Cngb1 T C 8: 95,997,516 (GRCm39) T560A probably benign Het
Creb3l3 T C 10: 80,926,977 (GRCm39) D151G probably damaging Het
Cts7 A T 13: 61,504,108 (GRCm39) V124E probably damaging Het
Ctsd G A 7: 141,930,590 (GRCm39) P349S possibly damaging Het
Ern1 A G 11: 106,302,478 (GRCm39) W459R probably damaging Het
Faxc A T 4: 21,982,672 (GRCm39) probably null Het
Gabbr1 T C 17: 37,365,084 (GRCm39) I239T probably damaging Het
Galnt12 T A 4: 47,122,529 (GRCm39) C269* probably null Het
Gmpr2 A T 14: 55,910,191 (GRCm39) D7V probably damaging Het
Hivep3 T A 4: 119,952,296 (GRCm39) I204N possibly damaging Het
Il16 A T 7: 83,312,270 (GRCm39) probably null Het
Jag1 T C 2: 136,936,394 (GRCm39) T367A probably benign Het
Lefty2 T C 1: 180,722,166 (GRCm39) V168A probably damaging Het
Mecom T C 3: 30,034,023 (GRCm39) E227G probably damaging Het
Muc5ac T A 7: 141,352,729 (GRCm39) C739S possibly damaging Het
Npy1r T A 8: 67,156,941 (GRCm39) C120* probably null Het
Nup153 A G 13: 46,854,502 (GRCm39) V530A probably damaging Het
Ogfr T A 2: 180,237,221 (GRCm39) L602Q possibly damaging Het
Or10g7 C T 9: 39,905,603 (GRCm39) P166S possibly damaging Het
Or7e178 A C 9: 20,225,576 (GRCm39) D213E probably benign Het
Perm1 G T 4: 156,302,776 (GRCm39) R440L probably benign Het
Plcb4 T C 2: 135,752,157 (GRCm39) V121A probably benign Het
Plxna4 C T 6: 32,177,794 (GRCm39) V1036M probably benign Het
Ppl A T 16: 4,925,333 (GRCm39) M102K probably damaging Het
Prop1 T C 11: 50,844,213 (GRCm39) S7G probably benign Het
Rabggta A G 14: 55,954,660 (GRCm39) L507P probably damaging Het
Sfmbt2 A G 2: 10,547,836 (GRCm39) T473A probably damaging Het
Spc25 A C 2: 69,027,517 (GRCm39) M125R possibly damaging Het
Taok3 T C 5: 117,393,928 (GRCm39) M567T probably benign Het
Tlr3 A G 8: 45,851,917 (GRCm39) Y327H probably benign Het
Tmem209 A G 6: 30,497,174 (GRCm39) F339L probably benign Het
U2surp T C 9: 95,373,157 (GRCm39) N279S probably damaging Het
Ythdf3 G A 3: 16,258,025 (GRCm39) M61I possibly damaging Het
Zfp647 T C 15: 76,796,076 (GRCm39) I195V probably benign Het
Other mutations in Or10h5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00965:Or10h5 APN 17 33,434,947 (GRCm39) missense probably benign 0.41
R0079:Or10h5 UTSW 17 33,435,079 (GRCm39) missense probably benign 0.14
R0939:Or10h5 UTSW 17 33,434,635 (GRCm39) missense possibly damaging 0.72
R1279:Or10h5 UTSW 17 33,435,300 (GRCm39) missense possibly damaging 0.59
R2167:Or10h5 UTSW 17 33,434,542 (GRCm39) missense probably damaging 0.97
R2866:Or10h5 UTSW 17 33,435,252 (GRCm39) missense probably benign 0.22
R4738:Or10h5 UTSW 17 33,434,784 (GRCm39) missense probably benign 0.03
R4976:Or10h5 UTSW 17 33,434,728 (GRCm39) missense probably benign 0.35
R6452:Or10h5 UTSW 17 33,434,919 (GRCm39) missense probably benign 0.03
R7322:Or10h5 UTSW 17 33,434,673 (GRCm39) missense probably damaging 1.00
R8032:Or10h5 UTSW 17 33,434,924 (GRCm39) missense possibly damaging 0.85
R8470:Or10h5 UTSW 17 33,434,868 (GRCm39) missense probably benign 0.00
R9560:Or10h5 UTSW 17 33,434,986 (GRCm39) missense probably damaging 1.00
R9562:Or10h5 UTSW 17 33,434,415 (GRCm39) missense probably benign 0.06
R9753:Or10h5 UTSW 17 33,434,688 (GRCm39) missense possibly damaging 0.60
Predicted Primers PCR Primer
(F):5'- TACACTCCCACTGGTAAGCC -3'
(R):5'- CCTCTATTGAAGTTGGCATGTG -3'

Sequencing Primer
(F):5'- CCACTGGTAAGCCATTGTCTTTAGG -3'
(R):5'- TAGGAATAGTGTGCATCACAGCCC -3'
Posted On 2018-08-01