Incidental Mutation 'R8441:Trav9d-4'
ID 654222
Institutional Source Beutler Lab
Gene Symbol Trav9d-4
Ensembl Gene ENSMUSG00000090868
Gene Name T cell receptor alpha variable 9D-4
Synonyms
MMRRC Submission 067885-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R8441 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 53220913-53221227 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 53221284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 93 (S93G)
Ref Sequence ENSEMBL: ENSMUSP00000143411 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167409] [ENSMUST00000200548]
AlphaFold A0A075B685
Predicted Effect probably benign
Transcript: ENSMUST00000167409
AA Change: S92G

PolyPhen 2 Score 0.265 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000132136
Gene: ENSMUSG00000090868
AA Change: S92G

DomainStartEndE-ValueType
IG 26 102 4.74e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000200548
AA Change: S93G

PolyPhen 2 Score 0.232 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000143411
Gene: ENSMUSG00000090868
AA Change: S93G

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IG 27 103 2e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 A G 2: 69,087,574 (GRCm39) Y1064H possibly damaging Het
Ahrr T C 13: 74,362,182 (GRCm39) D567G probably benign Het
Aldh1b1 T A 4: 45,802,465 (GRCm39) M1K probably null Het
Ankrd12 A T 17: 66,349,546 (GRCm39) S96T probably benign Het
Arhgef10 A T 8: 15,041,237 (GRCm39) probably benign Het
Bsn G A 9: 107,988,651 (GRCm39) A2367V probably benign Het
Cmpk2 G A 12: 26,527,204 (GRCm39) A398T probably benign Het
Cpn2 A G 16: 30,078,849 (GRCm39) L284P probably damaging Het
Cubn T C 2: 13,432,658 (GRCm39) D1221G probably damaging Het
Dnah7c A G 1: 46,572,398 (GRCm39) K957R probably damaging Het
Eif1ad2 T G 12: 87,786,384 (GRCm39) D98E probably benign Het
Flnb T A 14: 7,896,488 (GRCm38) V893E probably benign Het
Flrt3 C A 2: 140,502,546 (GRCm39) V361L probably benign Het
Fnta G A 8: 26,501,209 (GRCm39) R104* probably null Het
Ggt1 C T 10: 75,415,185 (GRCm39) T233I possibly damaging Het
Gpr37l1 A T 1: 135,094,875 (GRCm39) V123E probably damaging Het
Grpel1 A G 5: 36,622,556 (GRCm39) R7G probably benign Het
H2-M10.5 A T 17: 37,084,199 (GRCm39) I54L probably benign Het
Mapk8ip3 A T 17: 25,139,474 (GRCm39) probably benign Het
Mcm3 T C 1: 20,884,690 (GRCm39) D271G probably benign Het
Naip6 A G 13: 100,422,265 (GRCm39) V1256A possibly damaging Het
Nipbl A G 15: 8,322,599 (GRCm39) V2604A probably benign Het
Nlrp1b T A 11: 71,073,204 (GRCm39) D213V probably damaging Het
Npbwr1 G A 1: 5,987,397 (GRCm39) A39V possibly damaging Het
Nr6a1 T C 2: 38,632,888 (GRCm39) D191G probably benign Het
Olfml1 T G 7: 107,166,977 (GRCm39) V2G probably benign Het
Or4k38 A T 2: 111,166,131 (GRCm39) Y97* probably null Het
Or5b105 T A 19: 13,080,020 (GRCm39) Y216F probably damaging Het
Otof T C 5: 30,538,200 (GRCm39) K1175E probably damaging Het
Pira13 C A 7: 3,826,301 (GRCm39) E231* probably null Het
Plekhg2 C T 7: 28,060,291 (GRCm39) V989I probably benign Het
Prkcq A G 2: 11,253,037 (GRCm39) D229G probably benign Het
Ptprf A T 4: 118,075,255 (GRCm39) probably benign Het
Rest G T 5: 77,429,766 (GRCm39) Q728H possibly damaging Het
Scube1 A T 15: 83,494,423 (GRCm39) I868N probably damaging Het
Spcs3 A G 8: 54,981,375 (GRCm39) probably null Het
Speg A G 1: 75,387,976 (GRCm39) S1445G possibly damaging Het
Spmap2 C A 10: 79,412,510 (GRCm39) R327L probably damaging Het
Tmem145 T C 7: 25,008,200 (GRCm39) F261S possibly damaging Het
Trbv5 T A 6: 41,039,517 (GRCm39) C41S probably damaging Het
Trpm5 A G 7: 142,626,171 (GRCm39) S1131P possibly damaging Het
Ttc28 C T 5: 111,325,507 (GRCm39) R313* probably null Het
Ubap2l T C 3: 89,920,007 (GRCm39) T853A unknown Het
Xirp2 T C 2: 67,343,159 (GRCm39) V1800A possibly damaging Het
Zfhx2 A G 14: 55,303,985 (GRCm39) L1333P possibly damaging Het
Other mutations in Trav9d-4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4760:Trav9d-4 UTSW 14 53,221,258 (GRCm39) missense probably damaging 0.98
R6553:Trav9d-4 UTSW 14 53,221,198 (GRCm39) missense probably benign 0.38
R7374:Trav9d-4 UTSW 14 53,221,300 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCTCTGAAGGAGCCTCTC -3'
(R):5'- AGTCAGATAGTGGATATTTCAGCTG -3'

Sequencing Primer
(F):5'- TCTGAAGGAGCCTCTCTGCAG -3'
(R):5'- GCTGGAAATGAGCTGCGC -3'
Posted On 2020-10-20