Mutagenetix > Incidental Mutation

Incidental Mutation 'R8704:Lypd5'

669191

Institutional Source

Beutler Lab

Gene Symbol

Lypd5

Ensembl Gene

ENSMUSG00000030484

Gene Name

Ly6/Plaur domain containing 5

Synonyms

2210003I03Rik, 2310011E23Rik

MMRRC Submission

068558-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8704 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

24048621-24053672 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 24050982 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 31 (H31R)

Ref Sequence

ENSEMBL: ENSMUSP00000032683 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032683]

AlphaFold

Q9D7Z7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000032683
AA Change: H31R

PolyPhen 2 Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000032683
Gene: ENSMUSG00000030484
AA Change: H31R

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Blast:LU	24	119	7e-38	BLAST
LU	132	225	1.19e-1	SMART
low complexity region	230	248	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.9%
20x: 99.5%

Validation Efficiency

98% (39/40)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acap1	T	C	11: 69,773,489 (GRCm39)	Q628R	possibly damaging	Het
Agbl1	G	T	7: 76,239,302 (GRCm39)		probably benign	Het
Brf2	A	G	8: 27,618,499 (GRCm39)	V35A	possibly damaging	Het
Chtf8	A	C	8: 107,612,672 (GRCm39)	M89R	probably benign	Het
Copa	A	G	1: 171,931,693 (GRCm39)	I315V	probably benign	Het
Csmd2	G	A	4: 128,091,147 (GRCm39)	E229K		Het
Etf1	T	C	18: 35,039,139 (GRCm39)	E376G	probably damaging	Het
Fat2	T	A	11: 55,172,137 (GRCm39)	I2859F	probably damaging	Het
Foxp1	C	G	6: 98,993,507 (GRCm39)	Q132H	unknown	Het
Gal3st3	T	C	19: 5,352,663 (GRCm39)	V30A	probably benign	Het
Gars1	C	T	6: 55,040,215 (GRCm39)	R381C	probably damaging	Het
Gjd3	C	T	11: 98,873,445 (GRCm39)	R133H	probably damaging	Het
Haspin	T	C	11: 73,028,828 (GRCm39)	N87S	probably benign	Het
Hcrt	A	T	11: 100,652,752 (GRCm39)		probably benign	Het
Heatr6	T	A	11: 83,668,104 (GRCm39)	M866K	probably benign	Het
Igf1r	T	C	7: 67,819,802 (GRCm39)		probably benign	Het
Lgr5	A	G	10: 115,288,610 (GRCm39)	L678P	probably benign	Het
Mib2	A	G	4: 155,743,620 (GRCm39)	M275T	possibly damaging	Het
Mmp19	G	A	10: 128,634,703 (GRCm39)	V440I	probably benign	Het
Nefm	T	C	14: 68,358,510 (GRCm39)	E508G	unknown	Het
Nlrp4a	A	T	7: 26,156,563 (GRCm39)	I763L	probably benign	Het
Or5p61	A	T	7: 107,758,711 (GRCm39)	V123D	possibly damaging	Het
Or9g4	T	A	2: 85,504,562 (GRCm39)	H311L		Het
Pcdhb1	T	A	18: 37,399,402 (GRCm39)	V451D	possibly damaging	Het
Pfkfb2	T	C	1: 130,625,780 (GRCm39)	N467D	probably benign	Het
Ptprc	G	A	1: 138,043,362 (GRCm39)	T63I	probably benign	Het
Rab9	C	T	X: 165,240,754 (GRCm39)	D186N	probably benign	Het
Rhobtb2	G	A	14: 70,031,373 (GRCm39)	P584L	probably damaging	Het
Rhoc	G	C	3: 104,699,342 (GRCm39)	A44P	probably damaging	Het
Sardh	T	C	2: 27,120,477 (GRCm39)	E435G	possibly damaging	Het
Stfa1	A	T	16: 36,105,536 (GRCm39)	D89V	probably damaging	Het
Tec	T	C	5: 72,926,105 (GRCm39)	K316E	probably damaging	Het
Tsen15	A	T	1: 152,247,541 (GRCm39)	Y150*	probably null	Het
Ugt1a5	T	C	1: 88,094,087 (GRCm39)	I105T	probably benign	Het
Usp25	A	G	16: 76,856,178 (GRCm39)	D257G	probably benign	Het
Vmn1r195	A	G	13: 22,463,058 (GRCm39)	Y176C	possibly damaging	Het
Wdr31	G	A	4: 62,380,442 (GRCm39)	A87V	probably benign	Het
Wwp2	A	T	8: 108,212,228 (GRCm39)	T177S	probably benign	Het
Zfp28	T	C	7: 6,397,637 (GRCm39)	C691R	probably damaging	Het

Other mutations in Lypd5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01066:Lypd5	APN	7	24,052,910 (GRCm39)	missense	probably benign	0.10
IGL01121:Lypd5	APN	7	24,050,976 (GRCm39)	missense	probably benign
IGL01689:Lypd5	APN	7	24,052,054 (GRCm39)	splice site	probably benign
IGL02584:Lypd5	APN	7	24,052,993 (GRCm39)	missense	possibly damaging	0.59
IGL02888:Lypd5	APN	7	24,052,044 (GRCm39)	missense	probably damaging	0.98
R5167:Lypd5	UTSW	7	24,051,889 (GRCm39)	missense	possibly damaging	0.79
R5982:Lypd5	UTSW	7	24,052,462 (GRCm39)	missense	probably damaging	1.00
R6746:Lypd5	UTSW	7	24,052,531 (GRCm39)	splice site	probably null
R7951:Lypd5	UTSW	7	24,051,060 (GRCm39)	missense	probably damaging	0.96
R8725:Lypd5	UTSW	7	24,053,101 (GRCm39)	missense	probably damaging	1.00
R8727:Lypd5	UTSW	7	24,053,101 (GRCm39)	missense	probably damaging	1.00
R8897:Lypd5	UTSW	7	24,051,015 (GRCm39)	missense	probably benign	0.13
X0057:Lypd5	UTSW	7	24,048,646 (GRCm39)	utr 5 prime	probably benign
Z1177:Lypd5	UTSW	7	24,052,038 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGACAGAGGTCTTCCAGGAC -3'
(R):5'- GTGTGAACCACCAAGTCCAC -3'

Sequencing Primer
(F):5'- TCTTCCAGGACCTTGGCAG -3'
(R):5'- GTGAACCACCAAGTCCACTCATTG -3'

Posted On

2021-04-30