Incidental Mutation 'R8704:Or5p61'
ID 669193
Institutional Source Beutler Lab
Gene Symbol Or5p61
Ensembl Gene ENSMUSG00000108995
Gene Name olfactory receptor family 5 subfamily P member 61
Synonyms MOR204-30P, GA_x6K02T2PBJ9-10489044-10488091, Olfr485, MOR204-40_p
MMRRC Submission 068558-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R8704 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 107758125-107759078 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 107758711 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 123 (V123D)
Ref Sequence ENSEMBL: ENSMUSP00000147194 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000208296]
AlphaFold A0A140LJF5
Predicted Effect possibly damaging
Transcript: ENSMUST00000208296
AA Change: V123D

PolyPhen 2 Score 0.658 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.5%
Validation Efficiency 98% (39/40)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap1 T C 11: 69,773,489 (GRCm39) Q628R possibly damaging Het
Agbl1 G T 7: 76,239,302 (GRCm39) probably benign Het
Brf2 A G 8: 27,618,499 (GRCm39) V35A possibly damaging Het
Chtf8 A C 8: 107,612,672 (GRCm39) M89R probably benign Het
Copa A G 1: 171,931,693 (GRCm39) I315V probably benign Het
Csmd2 G A 4: 128,091,147 (GRCm39) E229K Het
Etf1 T C 18: 35,039,139 (GRCm39) E376G probably damaging Het
Fat2 T A 11: 55,172,137 (GRCm39) I2859F probably damaging Het
Foxp1 C G 6: 98,993,507 (GRCm39) Q132H unknown Het
Gal3st3 T C 19: 5,352,663 (GRCm39) V30A probably benign Het
Gars1 C T 6: 55,040,215 (GRCm39) R381C probably damaging Het
Gjd3 C T 11: 98,873,445 (GRCm39) R133H probably damaging Het
Haspin T C 11: 73,028,828 (GRCm39) N87S probably benign Het
Hcrt A T 11: 100,652,752 (GRCm39) probably benign Het
Heatr6 T A 11: 83,668,104 (GRCm39) M866K probably benign Het
Igf1r T C 7: 67,819,802 (GRCm39) probably benign Het
Lgr5 A G 10: 115,288,610 (GRCm39) L678P probably benign Het
Lypd5 A G 7: 24,050,982 (GRCm39) H31R possibly damaging Het
Mib2 A G 4: 155,743,620 (GRCm39) M275T possibly damaging Het
Mmp19 G A 10: 128,634,703 (GRCm39) V440I probably benign Het
Nefm T C 14: 68,358,510 (GRCm39) E508G unknown Het
Nlrp4a A T 7: 26,156,563 (GRCm39) I763L probably benign Het
Or9g4 T A 2: 85,504,562 (GRCm39) H311L Het
Pcdhb1 T A 18: 37,399,402 (GRCm39) V451D possibly damaging Het
Pfkfb2 T C 1: 130,625,780 (GRCm39) N467D probably benign Het
Ptprc G A 1: 138,043,362 (GRCm39) T63I probably benign Het
Rab9 C T X: 165,240,754 (GRCm39) D186N probably benign Het
Rhobtb2 G A 14: 70,031,373 (GRCm39) P584L probably damaging Het
Rhoc G C 3: 104,699,342 (GRCm39) A44P probably damaging Het
Sardh T C 2: 27,120,477 (GRCm39) E435G possibly damaging Het
Stfa1 A T 16: 36,105,536 (GRCm39) D89V probably damaging Het
Tec T C 5: 72,926,105 (GRCm39) K316E probably damaging Het
Tsen15 A T 1: 152,247,541 (GRCm39) Y150* probably null Het
Ugt1a5 T C 1: 88,094,087 (GRCm39) I105T probably benign Het
Usp25 A G 16: 76,856,178 (GRCm39) D257G probably benign Het
Vmn1r195 A G 13: 22,463,058 (GRCm39) Y176C possibly damaging Het
Wdr31 G A 4: 62,380,442 (GRCm39) A87V probably benign Het
Wwp2 A T 8: 108,212,228 (GRCm39) T177S probably benign Het
Zfp28 T C 7: 6,397,637 (GRCm39) C691R probably damaging Het
Other mutations in Or5p61
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3115:Or5p61 UTSW 7 107,759,029 (GRCm39) missense probably benign 0.00
R3116:Or5p61 UTSW 7 107,759,029 (GRCm39) missense probably benign 0.00
R3978:Or5p61 UTSW 7 107,758,819 (GRCm39) missense possibly damaging 0.52
R4722:Or5p61 UTSW 7 107,758,445 (GRCm39) missense probably benign 0.04
R5337:Or5p61 UTSW 7 107,758,480 (GRCm39) missense probably benign 0.01
R5553:Or5p61 UTSW 7 107,758,478 (GRCm39) missense probably benign 0.02
R6258:Or5p61 UTSW 7 107,758,181 (GRCm39) missense probably damaging 1.00
R6386:Or5p61 UTSW 7 107,758,409 (GRCm39) missense probably damaging 1.00
R6498:Or5p61 UTSW 7 107,758,639 (GRCm39) missense probably benign 0.20
R7096:Or5p61 UTSW 7 107,758,848 (GRCm39) missense probably benign
R7134:Or5p61 UTSW 7 107,758,883 (GRCm39) missense probably damaging 1.00
R7187:Or5p61 UTSW 7 107,758,585 (GRCm39) missense probably benign 0.00
R7226:Or5p61 UTSW 7 107,758,164 (GRCm39) missense probably benign 0.00
R7799:Or5p61 UTSW 7 107,758,637 (GRCm39) missense probably benign 0.00
R8371:Or5p61 UTSW 7 107,758,435 (GRCm39) missense probably benign
R8814:Or5p61 UTSW 7 107,758,272 (GRCm39) missense probably benign 0.03
R9451:Or5p61 UTSW 7 107,758,468 (GRCm39) missense probably benign 0.06
R9536:Or5p61 UTSW 7 107,759,075 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TTGACTCTATTTGGTCCACAGAAG -3'
(R):5'- GGAACCTCAGCACATTCCTTC -3'

Sequencing Primer
(F):5'- GAAGCATTAAGGAAACCCC -3'
(R):5'- AGCACATTCCTTCTCATCAGAG -3'
Posted On 2021-04-30