Mutagenetix > Incidental Mutation

Incidental Mutation 'R8789:Gm10800'

670797

Institutional Source

Beutler Lab

Gene Symbol

Gm10800

Ensembl Gene

ENSMUSG00000075014

Gene Name

predicted gene 10800

Synonyms

MMRRC Submission

068608-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.285) question?

Stock #

R8789 (G1)

Quality Score

214.458

Status

Not validated

Chromosome

Chromosomal Location

98496892-98497646 bp(-) (GRCm39)

Type of Mutation

frame shift

DNA Base Change (assembly)

CAAGAAAACTGAAAATCAAAGAAAACTGAAAATCA to CAAGAAAACTGAAAATCA at 98497361 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000097275 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099683] [ENSMUST00000099684]

AlphaFold

D3Z496

Predicted Effect

probably null
Transcript: ENSMUST00000099683

SMART Domains

Protein: ENSMUSP00000097275
Gene: ENSMUSG00000075014

Domain	Start	End	E-Value	Type
internal_repeat_1	1	41	1.13e-5	PROSPERO
internal_repeat_2	26	49	4.11e-5	PROSPERO
transmembrane domain	78	96	N/A	INTRINSIC
internal_repeat_1	114	174	1.13e-5	PROSPERO
low complexity region	177	188	N/A	INTRINSIC
internal_repeat_2	197	219	4.11e-5	PROSPERO

Predicted Effect

probably benign
Transcript: ENSMUST00000099684

SMART Domains

Protein: ENSMUSP00000097276
Gene: ENSMUSG00000075015

Domain	Start	End	E-Value	Type
internal_repeat_1	2	73	1.19e-13	PROSPERO
internal_repeat_1	80	167	1.19e-13	PROSPERO

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.1%

Validation Efficiency

100% (45/45)

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr5	C	T	2: 158,478,604 (GRCm39)	Q485*	probably null	Het
Arsa	C	T	15: 89,358,260 (GRCm39)	V350I	probably benign	Het
Bean1	CT	C	8: 104,908,664 (GRCm39)		probably null	Het
Cav2	T	C	6: 17,281,996 (GRCm39)	Y85H	probably damaging	Het
Ccdc93	A	G	1: 121,424,784 (GRCm39)	Q570R	probably damaging	Het
Cd72	A	G	4: 43,452,628 (GRCm39)	S122P	probably damaging	Het
Cep72	A	G	13: 74,186,367 (GRCm39)	M619T	possibly damaging	Het
Cers5	C	A	15: 99,637,551 (GRCm39)	V233F	possibly damaging	Het
Cntn5	A	G	9: 9,673,292 (GRCm39)	Y803H	probably damaging	Het
Crybg2	T	C	4: 133,801,554 (GRCm39)	S596P	probably benign	Het
Crybg3	T	C	16: 59,375,359 (GRCm39)	E251G	probably benign	Het
Csmd1	T	A	8: 17,266,722 (GRCm39)	N68I	probably damaging	Het
Ctr9	A	G	7: 110,642,933 (GRCm39)	N466S	possibly damaging	Het
Cyp2a4	T	A	7: 26,007,106 (GRCm39)	I71N	probably damaging	Het
Cyp2j11	C	T	4: 96,227,405 (GRCm39)	E204K	probably damaging	Het
Cyp4f39	T	C	17: 32,710,848 (GRCm39)	F469S	probably damaging	Het
Dmac2	T	A	7: 25,320,495 (GRCm39)	S65T	probably benign	Het
Duxf1	T	C	10: 58,059,426 (GRCm39)	N443D	unknown	Het
Elp3	G	A	14: 65,802,870 (GRCm39)	P243S	probably damaging	Het
Foxg1	T	A	12: 49,432,143 (GRCm39)	M292K	probably benign	Het
Fsip2	T	C	2: 82,815,822 (GRCm39)	S3852P	possibly damaging	Het
Gm10912	A	C	2: 103,897,046 (GRCm39)	K62Q	possibly damaging	Het
Grk2	G	A	19: 4,338,511 (GRCm39)	R474C	probably damaging	Het
Hapstr1	T	C	16: 8,660,865 (GRCm39)	I114T	probably benign	Het
Hoxc12	T	C	15: 102,846,732 (GRCm39)	I208T	probably benign	Het
Htra3	G	A	5: 35,836,602 (GRCm39)	P30L	unknown	Het
Itgal	A	G	7: 126,904,421 (GRCm39)	H298R	probably benign	Het
Klrb1c	A	G	6: 128,761,148 (GRCm39)	S160P	probably benign	Het
Or13c7d	A	T	4: 43,770,793 (GRCm39)	C73S	probably damaging	Het
Or2z9	T	C	8: 72,854,135 (GRCm39)	F177S	probably damaging	Het
Phrf1	T	A	7: 140,836,581 (GRCm39)	D284E	unknown	Het
Pmp2	T	A	3: 10,247,564 (GRCm39)	I42F	probably damaging	Het
Psg26	T	C	7: 18,216,494 (GRCm39)	D115G	probably damaging	Het
Pym1	T	C	10: 128,601,073 (GRCm39)	V32A	probably benign	Het
R3hdm2	T	G	10: 127,293,521 (GRCm39)	S142A	probably damaging	Het
Recql4	T	C	15: 76,588,546 (GRCm39)	H1105R	probably benign	Het
Rimkla	T	C	4: 119,349,607 (GRCm39)	Y17C	probably damaging	Het
Rnf207	C	T	4: 152,391,924 (GRCm39)	R623K	probably benign	Het
Ros1	A	T	10: 51,999,328 (GRCm39)	N1207K	probably damaging	Het
Scg2	G	T	1: 79,413,500 (GRCm39)	Q368K	probably benign	Het
Serpinb6e	G	A	13: 34,017,213 (GRCm39)	T269I	probably damaging	Het
Tsc22d2	A	T	3: 58,367,438 (GRCm39)	K663*	probably null	Het
Ubr4	T	A	4: 139,137,494 (GRCm39)	N1026K	possibly damaging	Het
Ubtfl1	A	G	9: 18,321,609 (GRCm39)	D379G	unknown	Het
Vps13d	T	C	4: 144,795,743 (GRCm39)	M3700V		Het
Zscan4-ps3	T	C	7: 11,346,288 (GRCm39)	L136P	probably damaging	Het

Other mutations in Gm10800

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01022:Gm10800	APN	2	98,497,576 (GRCm39)	unclassified	probably benign
BB012:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
FR4976:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
PIT4131001:Gm10800	UTSW	2	98,497,250 (GRCm39)	missense	probably benign
PIT4131001:Gm10800	UTSW	2	98,497,163 (GRCm39)	missense	probably benign
PIT4131001:Gm10800	UTSW	2	98,496,893 (GRCm39)	missense	probably benign	0.11
PIT4142001:Gm10800	UTSW	2	98,497,250 (GRCm39)	missense	probably benign
PIT4142001:Gm10800	UTSW	2	98,497,163 (GRCm39)	missense	probably benign
PIT4142001:Gm10800	UTSW	2	98,496,893 (GRCm39)	missense	probably benign	0.11
PIT4142001:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
PIT4402001:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
PIT4498001:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R0025:Gm10800	UTSW	2	98,496,925 (GRCm39)	missense	probably benign	0.05
R5077:Gm10800	UTSW	2	98,497,379 (GRCm39)	missense	probably benign	0.01
R5687:Gm10800	UTSW	2	98,496,965 (GRCm39)	missense	probably benign
R7146:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R7206:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R7619:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R7930:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R7931:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R7998:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R8019:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R8110:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R8111:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R8488:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R8509:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R8692:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R8722:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R8902:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R8903:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R8935:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R9104:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R9571:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- ACTGTAGGACGTGGAATATTGC -3'
(R):5'- GTGTGTACCTACTTTGGAAACAG -3'

Sequencing Primer
(F):5'- GAGAAACATCTACTTGACGACTTG -3'
(R):5'- GCCATATTTCACGTCCTAAAGTGTG -3'

Posted On

2021-04-30