Incidental Mutation 'R8877:Trbv14'
ID 676633
Institutional Source Beutler Lab
Gene Symbol Trbv14
Ensembl Gene ENSMUSG00000076471
Gene Name T cell receptor beta, variable 14
Synonyms Gm16910, BV13S1, Tcrb-V13
MMRRC Submission 068745-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R8877 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 41112101-41112550 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 41112292 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 30 (A30T)
Ref Sequence ENSEMBL: ENSMUSP00000100088 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103271] [ENSMUST00000103272]
AlphaFold A0A140T8L9
Predicted Effect probably benign
Transcript: ENSMUST00000103271
SMART Domains Protein: ENSMUSP00000100087
Gene: ENSMUSG00000076470

DomainStartEndE-ValueType
IGv 36 111 1.14e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103272
AA Change: A30T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000100088
Gene: ENSMUSG00000076471
AA Change: A30T

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IG_like 37 113 1.4e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (58/58)
MGI Phenotype PHENOTYPE: Mice homozygous for either of two knock-out alleles exhibit decreased T cell number with virtually no production of Vbeta13-expressing T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900092C05Rik T A 7: 12,288,704 (GRCm39) probably null Het
Acp2 G A 2: 91,036,129 (GRCm39) R109H probably damaging Het
Adamts8 T C 9: 30,862,688 (GRCm39) S298P probably damaging Het
Anxa7 A G 14: 20,517,548 (GRCm39) V157A probably benign Het
Arid3b T C 9: 57,740,904 (GRCm39) K181E probably damaging Het
Armt1 A G 10: 4,400,864 (GRCm39) T204A possibly damaging Het
Brip1 A C 11: 86,043,532 (GRCm39) V344G possibly damaging Het
Ccdc40 C T 11: 119,153,992 (GRCm39) S1088L probably damaging Het
Ccdc93 A T 1: 121,403,867 (GRCm39) H332L probably benign Het
Celsr3 A G 9: 108,706,877 (GRCm39) D1120G probably damaging Het
Cep104 T A 4: 154,077,985 (GRCm39) I631N probably damaging Het
Col17a1 C T 19: 47,637,197 (GRCm39) A1354T unknown Het
Cpa2 T C 6: 30,541,692 (GRCm39) L10P probably damaging Het
Creg2 G T 1: 39,689,861 (GRCm39) T83K probably benign Het
Ddit3 T C 10: 127,131,884 (GRCm39) I144T probably damaging Het
Dmxl1 A G 18: 50,011,292 (GRCm39) I1150V possibly damaging Het
Eprs1 C T 1: 185,148,071 (GRCm39) R1278* probably null Het
Esco1 A G 18: 10,575,017 (GRCm39) V685A probably damaging Het
Gid8 C T 2: 180,358,710 (GRCm39) A125V probably damaging Het
Gin1 A G 1: 97,710,941 (GRCm39) D208G possibly damaging Het
Gja10 G A 4: 32,602,441 (GRCm39) probably benign Het
Grin2d T C 7: 45,503,699 (GRCm39) I679V probably damaging Het
Gsto2 C A 19: 47,873,176 (GRCm39) R184S probably damaging Het
Hira T A 16: 18,770,854 (GRCm39) H830Q probably benign Het
Hmcn1 G A 1: 150,514,659 (GRCm39) T3571I probably benign Het
Khnyn T C 14: 56,131,782 (GRCm39) V568A possibly damaging Het
Kif13a T A 13: 46,954,921 (GRCm39) probably null Het
Larp4b T C 13: 9,193,835 (GRCm39) V161A probably benign Het
Larp6 T A 9: 60,644,850 (GRCm39) M330K probably benign Het
Lhfpl6 A G 3: 52,950,974 (GRCm39) R83G possibly damaging Het
Mavs A G 2: 131,087,489 (GRCm39) N329S possibly damaging Het
Mep1b T A 18: 21,221,630 (GRCm39) N193K possibly damaging Het
Msantd5f6 T A 4: 73,322,468 (GRCm39) R12* probably null Het
Mttp A T 3: 137,818,317 (GRCm39) D380E probably damaging Het
Nbeal2 G A 9: 110,459,311 (GRCm39) T1939I probably damaging Het
Nsun7 A T 5: 66,453,294 (GRCm39) R670* probably null Het
Obsl1 G A 1: 75,473,167 (GRCm39) R1019* probably null Het
Or10ak12 A G 4: 118,666,482 (GRCm39) V193A probably damaging Het
Or5w11 T C 2: 87,459,212 (GRCm39) M19T probably damaging Het
Phc3 C T 3: 30,968,271 (GRCm39) V922I probably damaging Het
Pip5kl1 T C 2: 32,468,951 (GRCm39) V190A possibly damaging Het
Plekhg2 G T 7: 28,060,278 (GRCm39) T993N possibly damaging Het
Psg26 C T 7: 18,217,865 (GRCm39) V18I probably benign Het
Slc11a1 A G 1: 74,419,424 (GRCm39) Y187C probably damaging Het
Smarcd3 A G 5: 24,798,990 (GRCm39) S323P possibly damaging Het
Spen G T 4: 141,199,137 (GRCm39) Y3163* probably null Het
Stx4a T A 7: 127,447,633 (GRCm39) V259D probably damaging Het
Synj2 T C 17: 6,087,941 (GRCm39) S1331P probably damaging Het
Tmprss11c G A 5: 86,385,540 (GRCm39) Q311* probably null Het
Tpo T A 12: 30,142,738 (GRCm39) N662I probably damaging Het
Trav13d-4 C A 14: 53,995,350 (GRCm39) D101E probably damaging Het
Unc80 T C 1: 66,567,144 (GRCm39) S917P possibly damaging Het
Zc3h6 T A 2: 128,856,319 (GRCm39) C466* probably null Het
Zfp462 T C 4: 55,011,097 (GRCm39) V1021A probably damaging Het
Zfp51 T C 17: 21,682,017 (GRCm39) M72T probably damaging Het
Zfp704 C T 3: 9,674,416 (GRCm39) E122K unknown Het
Zfyve26 T C 12: 79,334,152 (GRCm39) K289E probably benign Het
Other mutations in Trbv14
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2508:Trbv14 UTSW 6 41,112,424 (GRCm39) missense probably benign
R4725:Trbv14 UTSW 6 41,112,332 (GRCm39) missense probably benign 0.03
R4872:Trbv14 UTSW 6 41,112,259 (GRCm39) missense probably benign 0.03
R7352:Trbv14 UTSW 6 41,112,429 (GRCm39) missense possibly damaging 0.55
R8439:Trbv14 UTSW 6 41,112,299 (GRCm39) missense probably benign 0.00
R8931:Trbv14 UTSW 6 41,112,364 (GRCm39) missense probably damaging 1.00
R9351:Trbv14 UTSW 6 41,112,428 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CAAGACCTTGCTGTGGTAAGCC -3'
(R):5'- CAGAAAATCGATCCGAGGGC -3'

Sequencing Primer
(F):5'- TGCCCTCAATCTGCCATGGG -3'
(R):5'- TCCGAGGGCAACTGTGAATTATC -3'
Posted On 2021-07-15