Mutagenetix > Incidental Mutation

Incidental Mutation 'R8976:Or5p73'

683440

Institutional Source

Beutler Lab

Gene Symbol

Or5p73

Ensembl Gene

ENSMUSG00000096679

Gene Name

olfactory receptor family 5 subfamily P member 73

Synonyms

MOR204-36, Olfr498, GA_x6K02T2PBJ9-10795522-10796514

MMRRC Submission

068810-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R8976 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

108064533-108065525 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 108064630 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 33 (I33N)

Ref Sequence

ENSEMBL: ENSMUSP00000150971 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000217616]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000217616
AA Change: I33N

PolyPhen 2 Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.4%

Validation Efficiency

98% (60/61)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgef11	A	G	3: 87,635,321 (GRCm39)	I906V	probably benign	Het
Atad2b	T	A	12: 4,967,923 (GRCm39)		probably null	Het
Atr	T	A	9: 95,772,819 (GRCm39)	D1243E	probably benign	Het
Baiap2l1	A	T	5: 144,223,117 (GRCm39)	H73Q	probably benign	Het
Bdp1	C	A	13: 100,197,407 (GRCm39)	G993*	probably null	Het
Cacna2d4	A	T	6: 119,315,118 (GRCm39)	I883F	possibly damaging	Het
Cep250	C	T	2: 155,812,042 (GRCm39)	A446V	unknown	Het
Crem	A	G	18: 3,268,088 (GRCm39)	V80A	possibly damaging	Het
Cyp2j9	T	C	4: 96,479,399 (GRCm39)	K62E	probably benign	Het
Dnah17	T	A	11: 117,917,666 (GRCm39)	I4132F	probably damaging	Het
Dnm3	G	A	1: 162,135,505 (GRCm39)	P423S	probably damaging	Het
Dop1b	G	T	16: 93,558,969 (GRCm39)	V572L	probably benign	Het
F12	T	A	13: 55,569,777 (GRCm39)		probably benign	Het
F2	A	G	2: 91,466,738 (GRCm39)	S2P	probably benign	Het
Fam171a2	T	C	11: 102,329,451 (GRCm39)	E436G	possibly damaging	Het
Fat1	T	C	8: 45,484,332 (GRCm39)	V3190A	probably benign	Het
Flnb	A	T	14: 7,901,882 (GRCm38)		probably null	Het
Frs3	A	T	17: 48,009,546 (GRCm39)	D9V	probably benign	Het
Galnt17	T	G	5: 130,935,543 (GRCm39)	E380A	probably benign	Het
Glrb	A	C	3: 80,758,363 (GRCm39)	V350G	probably damaging	Het
Helz2	T	A	2: 180,876,486 (GRCm39)	K1336M	possibly damaging	Het
Ifnlr1	T	A	4: 135,428,650 (GRCm39)	V159E	probably damaging	Het
Igf2r	T	C	17: 12,945,659 (GRCm39)	E310G	probably damaging	Het
Il2rb	C	T	15: 78,370,681 (GRCm39)	D145N	probably benign	Het
Iqcb1	A	G	16: 36,692,005 (GRCm39)	I535V	probably benign	Het
Keap1	A	C	9: 21,142,663 (GRCm39)	L531V	probably damaging	Het
Lrrc8d	T	A	5: 105,960,957 (GRCm39)	W456R	probably damaging	Het
Med12l	T	A	3: 59,183,329 (GRCm39)	H1910Q	probably damaging	Het
Mybphl	G	A	3: 108,272,334 (GRCm39)	E8K	probably damaging	Het
Odad3	T	A	9: 21,903,334 (GRCm39)		probably benign	Het
Olig2	A	G	16: 91,023,363 (GRCm39)	S26G	probably benign	Het
Or10a4	T	C	7: 106,697,466 (GRCm39)	S265P	possibly damaging	Het
Or6f2	T	C	7: 139,756,885 (GRCm39)	V284A	probably damaging	Het
Or7a38	T	C	10: 78,753,418 (GRCm39)	I248T	possibly damaging	Het
Or7g22	T	A	9: 19,049,141 (GRCm39)	M284K	probably damaging	Het
Pcdhb22	G	A	18: 37,651,396 (GRCm39)		probably benign	Het
Plekha8	A	T	6: 54,607,521 (GRCm39)	E376V	probably damaging	Het
Polr2a	A	G	11: 69,638,037 (GRCm39)	V144A	possibly damaging	Het
Pramel34	T	A	5: 93,785,977 (GRCm39)	N101I	probably damaging	Het
Prr18	T	C	17: 8,560,047 (GRCm39)	S68P	probably damaging	Het
Ptprk	G	A	10: 28,461,669 (GRCm39)	R1153H	probably damaging	Het
Pus1	A	G	5: 110,922,789 (GRCm39)	F293L	possibly damaging	Het
Shank3	A	G	15: 89,442,381 (GRCm39)	E1758G	probably damaging	Het
Ska3	A	T	14: 58,057,851 (GRCm39)	I167N	probably damaging	Het
Ski	A	G	4: 155,242,411 (GRCm39)	S663P	probably damaging	Het
Slc49a3	A	C	5: 108,589,897 (GRCm39)	S502A	probably benign	Het
Spa17	C	T	9: 37,523,254 (GRCm39)	R11Q	possibly damaging	Het
Spag5	T	C	11: 78,195,413 (GRCm39)	V240A	probably benign	Het
Srl	A	T	16: 4,300,894 (GRCm39)	Y726N	probably damaging	Het
Ssbp4	A	T	8: 71,052,336 (GRCm39)		probably null	Het
Surf1	A	T	2: 26,805,767 (GRCm39)	C48S	probably benign	Het
Tigd3	G	A	19: 5,941,853 (GRCm39)	P426S	probably benign	Het
Tmem176b	A	G	6: 48,812,600 (GRCm39)	S122P	probably damaging	Het
Trim23	G	T	13: 104,328,545 (GRCm39)	L355F	probably damaging	Het
Ttn	G	A	2: 76,545,110 (GRCm39)	T32664M	probably damaging	Het
Ulk3	T	A	9: 57,502,220 (GRCm39)		probably benign	Het
Unc80	A	G	1: 66,511,169 (GRCm39)	H59R	possibly damaging	Het
Vmn1r19	A	G	6: 57,381,719 (GRCm39)	I91V	probably benign	Het
Vmn2r10	T	A	5: 109,145,479 (GRCm39)	N543Y	probably damaging	Het
Zbtb14	G	A	17: 69,694,752 (GRCm39)	R150H	possibly damaging	Het
Zfp831	T	C	2: 174,487,079 (GRCm39)	Y585H	possibly damaging	Het

Other mutations in Or5p73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03232:Or5p73	APN	7	108,064,812 (GRCm39)	missense	probably benign	0.06
IGL03348:Or5p73	APN	7	108,064,615 (GRCm39)	missense	probably benign
IGL03408:Or5p73	APN	7	108,064,554 (GRCm39)	missense	probably damaging	1.00
IGL03047:Or5p73	UTSW	7	108,064,983 (GRCm39)	missense	probably damaging	0.97
R0208:Or5p73	UTSW	7	108,064,750 (GRCm39)	missense	probably damaging	1.00
R0363:Or5p73	UTSW	7	108,064,941 (GRCm39)	missense	possibly damaging	0.81
R1481:Or5p73	UTSW	7	108,065,167 (GRCm39)	missense	probably benign	0.00
R1886:Or5p73	UTSW	7	108,064,947 (GRCm39)	missense	probably benign	0.39
R2065:Or5p73	UTSW	7	108,064,875 (GRCm39)	missense	possibly damaging	0.69
R2103:Or5p73	UTSW	7	108,064,810 (GRCm39)	missense	probably benign	0.03
R3731:Or5p73	UTSW	7	108,064,633 (GRCm39)	missense	possibly damaging	0.88
R4763:Or5p73	UTSW	7	108,065,393 (GRCm39)	missense	probably benign	0.34
R4839:Or5p73	UTSW	7	108,064,938 (GRCm39)	missense	probably benign	0.03
R4997:Or5p73	UTSW	7	108,064,701 (GRCm39)	missense	probably benign	0.01
R5533:Or5p73	UTSW	7	108,065,469 (GRCm39)	missense	probably benign	0.00
R7286:Or5p73	UTSW	7	108,064,642 (GRCm39)	missense	possibly damaging	0.52
R7910:Or5p73	UTSW	7	108,064,978 (GRCm39)	missense	probably benign	0.01
R8005:Or5p73	UTSW	7	108,064,693 (GRCm39)	missense	probably benign	0.01
R8487:Or5p73	UTSW	7	108,064,784 (GRCm39)	missense	possibly damaging	0.69
R9097:Or5p73	UTSW	7	108,064,815 (GRCm39)	missense	probably damaging	1.00
Z1088:Or5p73	UTSW	7	108,064,578 (GRCm39)	missense	probably benign
Z1176:Or5p73	UTSW	7	108,064,578 (GRCm39)	missense	probably benign
Z1177:Or5p73	UTSW	7	108,065,228 (GRCm39)	missense	probably benign	0.08
Z1177:Or5p73	UTSW	7	108,064,578 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- GTAATGTTCTCCATGCCCCG -3'
(R):5'- CCGAGGTAAACTGAATAGAACATCC -3'

Sequencing Primer
(F):5'- TGCCCCGGTTAACTGAAATG -3'
(R):5'- CATCCAATGTAGGAGATGGTATTTTG -3'

Posted On

2021-10-11