Mutagenetix > Incidental Mutation

Incidental Mutation 'R9044:Or13a19'

687921

Institutional Source

Beutler Lab

Gene Symbol

Or13a19

Ensembl Gene

ENSMUSG00000061489

Gene Name

olfactory receptor family 13 subfamily A member 19

Synonyms

Olfr525, MOR251-2, GA_x6K02T2PBJ9-42472898-42473827

MMRRC Submission

068871-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R9044 (G1)

Quality Score

157.009

Status

Validated

Chromosome

Chromosomal Location

139902614-139903543 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 139902485 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149361 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078103] [ENSMUST00000214594]

AlphaFold

Q8VGL5

Predicted Effect

probably benign
Transcript: ENSMUST00000078103

SMART Domains

Protein: ENSMUSP00000077243
Gene: ENSMUSG00000061489

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	1.1e-53	PFAM
Pfam:7TM_GPCR_Srsx	35	260	1.5e-5	PFAM
Pfam:7tm_1	41	290	1.3e-26	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214594

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.1%

Validation Efficiency

95% (62/65)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610008E11Rik	A	T	10: 78,902,314 (GRCm39)	Y667*	probably null	Het
Acacb	A	G	5: 114,373,578 (GRCm39)	H1869R	probably benign	Het
Adgrb1	A	G	15: 74,441,748 (GRCm39)	T950A	possibly damaging	Het
Alms1	T	A	6: 85,673,735 (GRCm39)	L3110Q	probably damaging	Het
Ambra1	A	T	2: 91,740,434 (GRCm39)		probably benign	Het
Brpf3	A	T	17: 29,025,871 (GRCm39)	N315Y	possibly damaging	Het
Clxn	A	G	16: 14,738,261 (GRCm39)	D142G	probably damaging	Het
Cpne7	C	T	8: 123,856,951 (GRCm39)	P402L	probably damaging	Het
Cyba	T	A	8: 123,151,630 (GRCm39)	D189V	probably benign	Het
Dexi	A	G	16: 10,321,385 (GRCm39)		probably benign	Het
Dnah2	C	T	11: 69,420,247 (GRCm39)	V156I	probably benign	Het
Drc7	T	C	8: 95,797,077 (GRCm39)	V420A	probably damaging	Het
Eef2k	T	A	7: 120,479,584 (GRCm39)	V167E	probably damaging	Het
Eid2	T	C	7: 27,968,038 (GRCm39)	I220T	possibly damaging	Het
Fggy	A	C	4: 95,732,334 (GRCm39)	T442P	probably benign	Het
Foxi3	T	G	6: 70,933,683 (GRCm39)	S57A	probably benign	Het
Foxi3	T	A	6: 70,934,186 (GRCm39)		probably null	Het
Galntl5	C	T	5: 25,415,326 (GRCm39)	P286S	possibly damaging	Het
Gm5592	A	G	7: 40,938,274 (GRCm39)	K519E	probably benign	Het
Gse1	T	A	8: 120,957,269 (GRCm39)	S587T	unknown	Het
Kcns1	G	T	2: 164,009,996 (GRCm39)	F254L	probably damaging	Het
Kif15	A	G	9: 122,840,781 (GRCm39)	T23A	probably benign	Het
Kif16b	T	C	2: 142,541,577 (GRCm39)	Q1241R	possibly damaging	Het
Lck	A	T	4: 129,450,098 (GRCm39)	L205Q	probably damaging	Het
Map9	C	T	3: 82,287,525 (GRCm39)	A420V	possibly damaging	Het
Mdm2	A	T	10: 117,530,960 (GRCm39)	D170E		Het
Mllt6	T	A	11: 97,554,485 (GRCm39)	C30S	probably damaging	Het
Muc5b	T	G	7: 141,411,795 (GRCm39)	D1580E	unknown	Het
Oaf	C	T	9: 43,135,308 (GRCm39)	A157T	probably damaging	Het
Or2ab1	T	A	11: 58,489,126 (GRCm39)	N295K	possibly damaging	Het
Or2n1d	A	T	17: 38,646,320 (GRCm39)	T91S	possibly damaging	Het
Osbp2	T	C	11: 3,667,128 (GRCm39)	I8V	probably damaging	Het
Pcdh9	T	C	14: 94,124,247 (GRCm39)	Y641C	probably damaging	Het
Phf10	A	T	17: 15,166,584 (GRCm39)	C429S	probably damaging	Het
Plekha6	C	G	1: 133,201,687 (GRCm39)	P367A	probably benign	Het
Plekha6	C	A	1: 133,201,688 (GRCm39)	P367Q	possibly damaging	Het
Plod2	T	A	9: 92,489,273 (GRCm39)	I756K	probably damaging	Het
Plxnb2	C	A	15: 89,044,566 (GRCm39)		probably benign	Het
Pop1	T	A	15: 34,530,554 (GRCm39)	M1014K	possibly damaging	Het
Prrt4	T	C	6: 29,171,540 (GRCm39)	D304G	probably benign	Het
Rcan2	C	A	17: 44,147,245 (GRCm39)	L28I	probably benign	Het
Rffl	C	T	11: 82,701,020 (GRCm39)	V269I	probably benign	Het
Rhox3c	C	T	X: 36,651,303 (GRCm39)		probably benign	Het
Ric1	C	T	19: 29,577,294 (GRCm39)	A1066V	probably damaging	Het
Rsf1	ATGGCG	ATGGCGACGGTGGCG	7: 97,229,111 (GRCm39)		probably benign	Het
Ryr2	A	T	13: 11,752,989 (GRCm39)	Y1777*	probably null	Het
Scart2	G	T	7: 139,828,010 (GRCm39)	G73C	probably damaging	Het
Sh3tc1	T	G	5: 35,854,834 (GRCm39)	K1288Q	possibly damaging	Het
Slc10a5	A	C	3: 10,399,792 (GRCm39)	I289M	probably damaging	Het
Slc16a9	A	G	10: 70,110,797 (GRCm39)	T128A	probably benign	Het
Slc7a11	T	C	3: 50,333,632 (GRCm39)	H373R	probably benign	Het
Spesp1	A	G	9: 62,180,623 (GRCm39)	I95T	probably benign	Het
Sra1	C	T	18: 36,800,946 (GRCm39)	V131I	probably benign	Het
Stxbp5l	A	G	16: 37,024,930 (GRCm39)	V556A	possibly damaging	Het
Sycp2	T	C	2: 177,989,617 (GRCm39)	E1414G	probably damaging	Het
Trac	A	T	14: 54,458,148 (GRCm39)	K57*	probably null	Het
Trps1	T	C	15: 50,686,003 (GRCm39)	E724G	probably benign	Het
Tubgcp6	T	G	15: 88,987,397 (GRCm39)	D1192A	possibly damaging	Het
Usp48	G	A	4: 137,340,996 (GRCm39)	G332E	probably benign	Het
Vps18	T	G	2: 119,128,034 (GRCm39)	I952M	probably damaging	Het
Wdr36	T	C	18: 32,970,499 (GRCm39)	F20S	probably damaging	Het
Wdr62	C	A	7: 29,962,062 (GRCm39)	R450L	probably benign	Het
Xab2	T	C	8: 3,668,641 (GRCm39)	K76E	probably benign	Het
Zpr1	A	G	9: 46,190,995 (GRCm39)	D300G	probably damaging	Het

Other mutations in Or13a19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02143:Or13a19	APN	7	139,903,505 (GRCm39)	nonsense	probably null
IGL02450:Or13a19	APN	7	139,903,140 (GRCm39)	missense	possibly damaging	0.95
IGL02927:Or13a19	APN	7	139,902,654 (GRCm39)	missense	probably damaging	1.00
IGL03008:Or13a19	APN	7	139,903,445 (GRCm39)	missense	probably damaging	1.00
IGL03202:Or13a19	APN	7	139,903,019 (GRCm39)	missense	possibly damaging	0.96
R0268:Or13a19	UTSW	7	139,903,068 (GRCm39)	missense	possibly damaging	0.63
R0612:Or13a19	UTSW	7	139,903,101 (GRCm39)	missense	possibly damaging	0.63
R0751:Or13a19	UTSW	7	139,903,238 (GRCm39)	missense	probably benign
R0801:Or13a19	UTSW	7	139,902,831 (GRCm39)	missense	probably damaging	1.00
R0940:Or13a19	UTSW	7	139,903,065 (GRCm39)	missense	probably benign	0.01
R2220:Or13a19	UTSW	7	139,903,484 (GRCm39)	missense	probably benign	0.03
R3748:Or13a19	UTSW	7	139,903,041 (GRCm39)	missense	possibly damaging	0.87
R4660:Or13a19	UTSW	7	139,903,325 (GRCm39)	missense	possibly damaging	0.67
R4683:Or13a19	UTSW	7	139,902,681 (GRCm39)	missense	probably benign	0.01
R4887:Or13a19	UTSW	7	139,903,014 (GRCm39)	missense	probably benign
R4919:Or13a19	UTSW	7	139,903,427 (GRCm39)	nonsense	probably null
R5097:Or13a19	UTSW	7	139,903,008 (GRCm39)	missense	probably damaging	1.00
R5836:Or13a19	UTSW	7	139,902,827 (GRCm39)	missense	probably benign
R7024:Or13a19	UTSW	7	139,902,759 (GRCm39)	missense	possibly damaging	0.75
R8242:Or13a19	UTSW	7	139,902,696 (GRCm39)	nonsense	probably null
R8390:Or13a19	UTSW	7	139,903,027 (GRCm39)	missense	possibly damaging	0.56
R8739:Or13a19	UTSW	7	139,902,647 (GRCm39)	missense	probably damaging	1.00
R8813:Or13a19	UTSW	7	139,902,793 (GRCm39)	nonsense	probably null
R8876:Or13a19	UTSW	7	139,902,716 (GRCm39)	missense	probably damaging	1.00
R8988:Or13a19	UTSW	7	139,902,938 (GRCm39)	missense	possibly damaging	0.87
R9176:Or13a19	UTSW	7	139,903,121 (GRCm39)	missense	probably damaging	1.00
R9626:Or13a19	UTSW	7	139,903,236 (GRCm39)	missense	probably benign	0.06

Predicted Primers

PCR Primer
(F):5'- CCAGTTCTCAGAGTATCATAGGGC -3'
(R):5'- TTCCTGCAAGAGCCAGGATG -3'

Sequencing Primer
(F):5'- AGGGCATGATCTATGTTAAATCAAAC -3'
(R):5'- TCCTCAGAGAGTCCCTGCAG -3'

Posted On

2021-11-19