Incidental Mutation 'R9508:Rassf7'
ID 717935
Institutional Source Beutler Lab
Gene Symbol Rassf7
Ensembl Gene ENSMUSG00000038618
Gene Name Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
Synonyms 2400009B11Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.137) question?
Stock # R9508 (G1)
Quality Score 169.009
Status Not validated
Chromosome 7
Chromosomal Location 140795773-140798571 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 140796924 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 46 (R46*)
Ref Sequence ENSEMBL: ENSMUSP00000038444 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026573] [ENSMUST00000046890] [ENSMUST00000127613] [ENSMUST00000133763] [ENSMUST00000141804] [ENSMUST00000148975] [ENSMUST00000153081] [ENSMUST00000170841] [ENSMUST00000209500] [ENSMUST00000210993]
AlphaFold Q9DD19
Predicted Effect probably benign
Transcript: ENSMUST00000026573
SMART Domains Protein: ENSMUSP00000026573
Gene: ENSMUSG00000025500

DomainStartEndE-ValueType
coiled coil region 114 170 N/A INTRINSIC
low complexity region 286 298 N/A INTRINSIC
Pfam:LTD 375 482 1.3e-13 PFAM
low complexity region 567 578 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000046890
AA Change: R46*
SMART Domains Protein: ENSMUSP00000038444
Gene: ENSMUSG00000038618
AA Change: R46*

DomainStartEndE-ValueType
RA 6 89 1.67e-19 SMART
low complexity region 181 215 N/A INTRINSIC
low complexity region 217 244 N/A INTRINSIC
coiled coil region 259 300 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127613
Predicted Effect probably null
Transcript: ENSMUST00000133763
AA Change: R46*
SMART Domains Protein: ENSMUSP00000118313
Gene: ENSMUSG00000038618
AA Change: R46*

DomainStartEndE-ValueType
RA 6 89 1.67e-19 SMART
low complexity region 181 200 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000141804
AA Change: R46*
SMART Domains Protein: ENSMUSP00000115948
Gene: ENSMUSG00000038618
AA Change: R46*

DomainStartEndE-ValueType
RA 6 89 1.67e-19 SMART
low complexity region 181 215 N/A INTRINSIC
low complexity region 217 243 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000148975
SMART Domains Protein: ENSMUSP00000118078
Gene: ENSMUSG00000038618

DomainStartEndE-ValueType
Blast:RA 6 35 5e-13 BLAST
PDB:2CS4|A 7 35 2e-11 PDB
low complexity region 36 47 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000153081
AA Change: R46*
SMART Domains Protein: ENSMUSP00000123128
Gene: ENSMUSG00000038618
AA Change: R46*

DomainStartEndE-ValueType
RA 6 89 1.67e-19 SMART
low complexity region 181 199 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000170841
SMART Domains Protein: ENSMUSP00000130905
Gene: ENSMUSG00000025500

DomainStartEndE-ValueType
coiled coil region 124 180 N/A INTRINSIC
low complexity region 296 308 N/A INTRINSIC
SCOP:d1ifra_ 385 487 1e-22 SMART
low complexity region 577 588 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000209500
AA Change: R46*
Predicted Effect probably null
Transcript: ENSMUST00000210993
AA Change: R46*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik G A 13: 119,617,484 (GRCm39) V536I Het
Adam18 A G 8: 25,143,778 (GRCm39) I187T possibly damaging Het
Adam24 A G 8: 41,132,941 (GRCm39) I136M probably benign Het
B3galt2 A T 1: 143,522,280 (GRCm39) I139F possibly damaging Het
Cacna1i C T 15: 80,279,372 (GRCm39) P2038S probably benign Het
Cbll1 A T 12: 31,544,685 (GRCm39) I26N probably damaging Het
Cldn1 A T 16: 26,179,619 (GRCm39) Y149* probably null Het
Cnot11 T C 1: 39,581,575 (GRCm39) V372A probably damaging Het
Cnot2 A G 10: 116,329,616 (GRCm39) L458P probably damaging Het
Cnot4 T C 6: 35,045,554 (GRCm39) E219G Het
Col8a1 T G 16: 57,448,947 (GRCm39) I188L unknown Het
Daam2 T C 17: 49,765,618 (GRCm39) K1095R probably damaging Het
Dnah9 T C 11: 65,725,089 (GRCm39) T4355A probably damaging Het
Dsg4 A G 18: 20,604,070 (GRCm39) I846V probably damaging Het
Ehd4 C T 2: 119,921,966 (GRCm39) G430E probably damaging Het
Fanci T C 7: 79,083,033 (GRCm39) Y670H possibly damaging Het
Galnt10 T A 11: 57,673,040 (GRCm39) N465K possibly damaging Het
Glipr1l1 A G 10: 111,912,015 (GRCm39) N183S probably damaging Het
Gnl1 T C 17: 36,299,625 (GRCm39) Y599H possibly damaging Het
Gpr26 T C 7: 131,585,830 (GRCm39) S267P probably benign Het
Grk2 A T 19: 4,341,636 (GRCm39) N179K probably damaging Het
Igf2bp2 T A 16: 21,898,845 (GRCm39) M255L probably benign Het
Ighv2-6 T C 12: 113,680,430 (GRCm39) I70M probably benign Het
Igkv4-74 T A 6: 69,161,942 (GRCm39) N76Y probably damaging Het
Il11ra1 T C 4: 41,767,527 (GRCm39) V293A probably damaging Het
Itpr3 G A 17: 27,337,651 (GRCm39) probably benign Het
Kank2 A T 9: 21,687,076 (GRCm39) L582Q probably damaging Het
Kmt2b T C 7: 30,269,259 (GRCm39) T2554A probably damaging Het
Mecom T A 3: 30,010,621 (GRCm39) Y619F probably benign Het
Mknk1 A G 4: 115,732,579 (GRCm39) N269S probably benign Het
Mpp2 T A 11: 101,951,692 (GRCm39) E435D probably damaging Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Or2f2 A G 6: 42,767,928 (GRCm39) *318W probably null Het
Or5g9 A G 2: 85,552,165 (GRCm39) R139G possibly damaging Het
Or7a41 A T 10: 78,870,933 (GRCm39) Q101L probably damaging Het
P3h3 A G 6: 124,830,012 (GRCm39) probably null Het
Paqr5 C T 9: 61,880,079 (GRCm39) V72M probably benign Het
Pilrb2 G A 5: 137,869,261 (GRCm39) T113I probably damaging Het
Pitpnm3 T C 11: 72,003,121 (GRCm39) E63G probably damaging Het
Ppp4r4 G A 12: 103,542,561 (GRCm39) V108M possibly damaging Het
Ptprf G T 4: 118,126,776 (GRCm39) S46* probably null Het
Rab2a T C 4: 8,582,447 (GRCm39) L143P Het
Sec23a T C 12: 59,036,185 (GRCm39) D393G probably benign Het
Semp2l2b A G 10: 21,942,816 (GRCm39) V388A probably damaging Het
Serpinb9f T A 13: 33,518,515 (GRCm39) F338L probably benign Het
Spg7 T C 8: 123,800,623 (GRCm39) V66A probably damaging Het
Sult2a4 C T 7: 13,723,437 (GRCm39) R27H probably benign Het
Sumo2 A C 11: 115,414,538 (GRCm39) Y95D possibly damaging Het
Tbx18 G A 9: 87,587,926 (GRCm39) S397F probably damaging Het
Ticam2 G C 18: 46,693,748 (GRCm39) P113R probably damaging Het
Timeless A G 10: 128,076,096 (GRCm39) S63G probably benign Het
Tinag C T 9: 76,912,981 (GRCm39) C276Y probably damaging Het
Tmem143 A T 7: 45,565,630 (GRCm39) K364* probably null Het
Tmem160 A G 7: 16,186,840 (GRCm39) probably benign Het
Tmod4 G C 3: 95,034,713 (GRCm39) E154Q probably benign Het
Trpv1 G T 11: 73,145,090 (GRCm39) K725N Het
Ttn G T 2: 76,715,978 (GRCm39) A7767D unknown Het
Tubd1 T A 11: 86,448,640 (GRCm39) Y318N probably damaging Het
Ufd1 T A 16: 18,643,802 (GRCm39) M187K possibly damaging Het
Unc5c A G 3: 141,494,736 (GRCm39) N424D possibly damaging Het
Usp19 C T 9: 108,371,608 (GRCm39) S329L probably damaging Het
Vps16 T A 2: 130,284,361 (GRCm39) I704N possibly damaging Het
Vwf A T 6: 125,532,471 (GRCm39) I72F Het
Ypel4 T C 2: 84,567,304 (GRCm39) S46P probably damaging Het
Zcchc8 A C 5: 123,842,584 (GRCm39) probably null Het
Other mutations in Rassf7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02098:Rassf7 APN 7 140,798,203 (GRCm39) missense possibly damaging 0.95
R0883:Rassf7 UTSW 7 140,796,903 (GRCm39) splice site probably benign
R1275:Rassf7 UTSW 7 140,797,060 (GRCm39) missense probably damaging 1.00
R1616:Rassf7 UTSW 7 140,796,645 (GRCm39) missense probably damaging 1.00
R5546:Rassf7 UTSW 7 140,796,973 (GRCm39) splice site probably null
R5597:Rassf7 UTSW 7 140,797,024 (GRCm39) missense probably damaging 1.00
R5663:Rassf7 UTSW 7 140,797,003 (GRCm39) missense probably damaging 1.00
R6250:Rassf7 UTSW 7 140,797,156 (GRCm39) missense probably damaging 0.98
R6806:Rassf7 UTSW 7 140,796,722 (GRCm39) missense probably damaging 1.00
R6817:Rassf7 UTSW 7 140,797,360 (GRCm39) missense probably damaging 1.00
R6962:Rassf7 UTSW 7 140,797,503 (GRCm39) missense possibly damaging 0.86
R7054:Rassf7 UTSW 7 140,797,556 (GRCm39) missense probably benign 0.01
R7562:Rassf7 UTSW 7 140,797,101 (GRCm39) nonsense probably null
R7682:Rassf7 UTSW 7 140,797,847 (GRCm39) missense probably damaging 1.00
R9308:Rassf7 UTSW 7 140,798,063 (GRCm39) missense probably benign
X0026:Rassf7 UTSW 7 140,798,045 (GRCm39) nonsense probably null
Z1088:Rassf7 UTSW 7 140,797,058 (GRCm39) missense probably damaging 1.00
Z1177:Rassf7 UTSW 7 140,798,198 (GRCm39) missense probably benign 0.34
Predicted Primers PCR Primer
(F):5'- TGGCCCAAGCTATAGGTGAG -3'
(R):5'- ATCTAAGGTTGAAGGTCAGTGC -3'

Sequencing Primer
(F):5'- CCCAAGCTATAGGTGAGTTTCTTG -3'
(R):5'- ACGAACTGGGCATCGTTCTG -3'
Posted On 2022-07-18