Mutagenetix > Incidental Mutation

Incidental Mutation 'R9562:Pcdha12'

721160

Institutional Source

Beutler Lab

Gene Symbol

Pcdha12

Ensembl Gene

ENSMUSG00000103310

Gene Name

protocadherin alpha 12

Synonyms

Cnr5, Pcdha13, Crnr5

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.198) question?

Stock #

R9562 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

37153283-37320710 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 37155284 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 668 (S668P)

Ref Sequence

ENSEMBL: ENSMUSP00000047609 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047614] [ENSMUST00000070797] [ENSMUST00000115657] [ENSMUST00000115658] [ENSMUST00000115659] [ENSMUST00000115661] [ENSMUST00000115662] [ENSMUST00000192168] [ENSMUST00000192295] [ENSMUST00000192447] [ENSMUST00000192503] [ENSMUST00000192512] [ENSMUST00000192631] [ENSMUST00000193389] [ENSMUST00000193777] [ENSMUST00000193839] [ENSMUST00000194038] [ENSMUST00000194544] [ENSMUST00000194751] [ENSMUST00000195590]

AlphaFold

Q91Y18

Predicted Effect

probably damaging
Transcript: ENSMUST00000047614
AA Change: S668P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000047609
Gene: ENSMUSG00000103310
AA Change: S668P

Domain	Start	End	E-Value	Type
CA	19	131	3.78e-2	SMART
CA	155	240	3.26e-24	SMART
CA	264	348	6.37e-27	SMART
CA	372	453	3.31e-25	SMART
CA	477	563	6.18e-25	SMART
CA	594	676	5.6e-14	SMART
low complexity region	679	696	N/A	INTRINSIC
transmembrane domain	699	721	N/A	INTRINSIC
Pfam:Cadherin_tail	799	933	5.3e-58	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000070797

SMART Domains

Protein: ENSMUSP00000068828
Gene: ENSMUSG00000103442

Domain	Start	End	E-Value	Type
CA	22	132	3.09e-2	SMART
CA	156	241	6.14e-20	SMART
CA	265	349	3.92e-27	SMART
CA	373	454	4.94e-24	SMART
CA	478	564	1e-24	SMART
CA	592	672	4.55e-14	SMART
transmembrane domain	694	716	N/A	INTRINSIC
Pfam:Cadherin_tail	797	931	5.3e-58	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000115657

SMART Domains

Protein: ENSMUSP00000111321
Gene: ENSMUSG00000102206

Domain	Start	End	E-Value	Type
CA	21	131	2.95e-2	SMART
CA	155	240	7.44e-19	SMART
CA	264	347	5.63e-28	SMART
CA	371	452	3.14e-26	SMART
CA	476	562	1.42e-24	SMART
CA	593	675	1.03e-12	SMART
transmembrane domain	697	719	N/A	INTRINSIC
low complexity region	783	794	N/A	INTRINSIC
low complexity region	918	942	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000115658

SMART Domains

Protein: ENSMUSP00000111322
Gene: ENSMUSG00000007440

Domain	Start	End	E-Value	Type
low complexity region	15	21	N/A	INTRINSIC
CA	46	132	6.34e-2	SMART
CA	156	241	4.65e-20	SMART
CA	265	349	1.25e-25	SMART
CA	373	454	9.22e-24	SMART
CA	478	564	4.3e-24	SMART
CA	595	678	5.07e-12	SMART
low complexity region	706	721	N/A	INTRINSIC
Pfam:Cadherin_tail	795	929	5.3e-58	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000115659

SMART Domains

Protein: ENSMUSP00000111323
Gene: ENSMUSG00000103770

Domain	Start	End	E-Value	Type
low complexity region	44	51	N/A	INTRINSIC
CA	75	161	2.46e-2	SMART
CA	185	270	8.1e-20	SMART
CA	294	378	1.69e-22	SMART
CA	402	483	1.52e-24	SMART
CA	507	593	5.68e-24	SMART
CA	624	705	6.69e-12	SMART
transmembrane domain	727	749	N/A	INTRINSIC
Pfam:Cadherin_tail	828	962	5.6e-58	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000115661

SMART Domains

Protein: ENSMUSP00000111325
Gene: ENSMUSG00000103458

Domain	Start	End	E-Value	Type
CA	20	131	5.3e-2	SMART
CA	155	240	1.51e-19	SMART
CA	264	348	7.6e-25	SMART
CA	372	453	1.42e-24	SMART
CA	477	563	1.42e-24	SMART
CA	594	674	4.12e-12	SMART
low complexity region	706	721	N/A	INTRINSIC
Pfam:Cadherin_tail	796	930	3.9e-58	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000115662

SMART Domains

Protein: ENSMUSP00000111326
Gene: ENSMUSG00000104148

Domain	Start	End	E-Value	Type
CA	45	131	6.34e-2	SMART
CA	155	240	2.98e-18	SMART
CA	264	348	2.17e-29	SMART
CA	372	453	2.84e-24	SMART
CA	477	563	5.02e-25	SMART
CA	594	675	8.16e-16	SMART
transmembrane domain	695	717	N/A	INTRINSIC
low complexity region	916	940	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192168

SMART Domains

Protein: ENSMUSP00000142293
Gene: ENSMUSG00000103092

Domain	Start	End	E-Value	Type
CA	21	131	2.2e-2	SMART
CA	155	240	2.05e-21	SMART
CA	264	348	8.81e-21	SMART
CA	372	453	2.01e-24	SMART
CA	477	563	1.42e-24	SMART
CA	591	673	1.63e-15	SMART
transmembrane domain	693	715	N/A	INTRINSIC
low complexity region	902	926	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192295

SMART Domains

Protein: ENSMUSP00000142103
Gene: ENSMUSG00000104252

Domain	Start	End	E-Value	Type
CA	20	131	5.3e-2	SMART
CA	155	240	1.51e-19	SMART
CA	264	348	7.6e-25	SMART
CA	372	453	1.42e-24	SMART
CA	477	568	5.38e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000192447

SMART Domains

Protein: ENSMUSP00000142270
Gene: ENSMUSG00000102206

Domain	Start	End	E-Value	Type
CA	21	131	1.5e-4	SMART
CA	155	240	3.6e-21	SMART
CA	264	347	2.8e-30	SMART
CA	371	452	1.5e-28	SMART
CA	476	562	6.8e-27	SMART
CA	593	675	4.9e-15	SMART
transmembrane domain	697	719	N/A	INTRINSIC
low complexity region	783	794	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192503

SMART Domains

Protein: ENSMUSP00000141989
Gene: ENSMUSG00000102312

Domain	Start	End	E-Value	Type
low complexity region	11	17	N/A	INTRINSIC
CA	42	128	3.78e-2	SMART
CA	152	237	8.94e-22	SMART
CA	261	345	3.74e-24	SMART
CA	369	450	1.09e-25	SMART
CA	474	560	1.42e-24	SMART
CA	588	670	2.96e-13	SMART
transmembrane domain	692	714	N/A	INTRINSIC
low complexity region	910	934	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192512

SMART Domains

Protein: ENSMUSP00000141408
Gene: ENSMUSG00000104252

Domain	Start	End	E-Value	Type
CA	20	131	5.3e-2	SMART
CA	155	240	1.51e-19	SMART
CA	264	348	7.6e-25	SMART
CA	372	453	1.42e-24	SMART
CA	477	563	1.42e-24	SMART
CA	594	674	4.12e-12	SMART
low complexity region	706	721	N/A	INTRINSIC
low complexity region	915	939	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192631

SMART Domains

Protein: ENSMUSP00000142156
Gene: ENSMUSG00000104318

Domain	Start	End	E-Value	Type
CA	21	131	2.58e-2	SMART
CA	155	240	4.27e-19	SMART
CA	264	348	1.42e-24	SMART
CA	372	453	9.36e-25	SMART
CA	477	563	1.42e-24	SMART
CA	594	671	4.03e-6	SMART
transmembrane domain	696	718	N/A	INTRINSIC
low complexity region	905	929	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000193389

SMART Domains

Protein: ENSMUSP00000141459
Gene: ENSMUSG00000103707

Domain	Start	End	E-Value	Type
CA	21	131	5.67e-2	SMART
CA	155	240	4.72e-21	SMART
CA	264	348	1.9e-25	SMART
CA	372	453	3.31e-25	SMART
CA	477	563	1.42e-24	SMART
CA	594	676	5.91e-13	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000193777

SMART Domains

Protein: ENSMUSP00000141587
Gene: ENSMUSG00000103707

Domain	Start	End	E-Value	Type
CA	21	131	5.67e-2	SMART
CA	155	240	4.72e-21	SMART
CA	264	348	1.9e-25	SMART
CA	372	453	3.31e-25	SMART
CA	477	563	1.42e-24	SMART
CA	594	676	5.91e-13	SMART
low complexity region	914	938	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000193839

SMART Domains

Protein: ENSMUSP00000142308
Gene: ENSMUSG00000103442

Domain	Start	End	E-Value	Type
CA	22	132	3.09e-2	SMART
CA	156	241	6.14e-20	SMART
CA	265	349	3.92e-27	SMART
CA	373	454	4.94e-24	SMART
CA	478	564	1e-24	SMART
CA	592	672	4.55e-14	SMART
transmembrane domain	694	716	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000193856

Predicted Effect

probably benign
Transcript: ENSMUST00000193984

Predicted Effect

probably benign
Transcript: ENSMUST00000194038

SMART Domains

Protein: ENSMUSP00000142159
Gene: ENSMUSG00000103800

Domain	Start	End	E-Value	Type
CA	20	131	6.34e-2	SMART
CA	155	240	4.27e-19	SMART
CA	264	348	2.04e-25	SMART
CA	372	453	2.84e-24	SMART
CA	477	563	9.88e-24	SMART
CA	594	676	8.62e-15	SMART
transmembrane domain	699	721	N/A	INTRINSIC
low complexity region	914	938	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000194544

SMART Domains

Protein: ENSMUSP00000141847
Gene: ENSMUSG00000102836

Domain	Start	End	E-Value	Type
Blast:CA	18	66	5e-20	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000194751

SMART Domains

Protein: ENSMUSP00000142285
Gene: ENSMUSG00000103707

Domain	Start	End	E-Value	Type
low complexity region	15	21	N/A	INTRINSIC
Pfam:Cadherin_2	29	112	4.5e-32	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000195590

SMART Domains

Protein: ENSMUSP00000141355
Gene: ENSMUSG00000104148

Domain	Start	End	E-Value	Type
CA	45	131	6.34e-2	SMART
CA	155	240	2.98e-18	SMART
CA	264	348	2.17e-29	SMART
CA	372	453	2.84e-24	SMART
CA	477	563	5.02e-25	SMART
CA	594	675	8.16e-16	SMART
transmembrane domain	695	717	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 129 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acacb	C	A	5: 114,371,397 (GRCm39)	P1842Q	probably damaging	Het
Aco2	G	A	15: 81,773,635 (GRCm39)	R58Q	probably null	Het
Acvr1	T	C	2: 58,338,385 (GRCm39)	K446E	probably damaging	Het
Adam39	T	C	8: 41,277,755 (GRCm39)	Y49H	probably benign	Het
Afg3l2	C	T	18: 67,554,365 (GRCm39)	V446M	probably damaging	Het
Aire	A	G	10: 77,871,579 (GRCm39)	V397A	probably benign	Het
Ankdd1a	C	T	9: 65,411,452 (GRCm39)	A352T	possibly damaging	Het
Aoc1l2	T	C	6: 48,907,909 (GRCm39)	M303T	probably benign	Het
Arfip2	T	C	7: 105,286,079 (GRCm39)	D270G	possibly damaging	Het
Arl4c	A	G	1: 88,629,134 (GRCm39)	C85R	probably damaging	Het
Arpp21	A	C	9: 111,956,354 (GRCm39)	V541G	possibly damaging	Het
Atp2a3	T	A	11: 72,873,578 (GRCm39)	M817K	probably damaging	Het
Bahcc1	C	T	11: 120,150,035 (GRCm39)	H106Y	possibly damaging	Het
Bcl9l	A	G	9: 44,412,076 (GRCm39)	S21G	possibly damaging	Het
C7	T	A	15: 5,086,579 (GRCm39)		probably null	Het
Cabcoco1	T	C	10: 68,272,725 (GRCm39)	D220G	possibly damaging	Het
Cacna1e	T	A	1: 154,283,486 (GRCm39)	D1960V	probably benign	Het
Casp4	A	T	9: 5,324,832 (GRCm39)	T215S	probably damaging	Het
Ccdc187	T	C	2: 26,183,698 (GRCm39)	S101G	possibly damaging	Het
Cdk12	A	G	11: 98,140,628 (GRCm39)	N1290D	unknown	Het
Cdo1	C	A	18: 46,861,104 (GRCm39)	V36L	probably benign	Het
Col5a3	G	A	9: 20,714,429 (GRCm39)	A381V	unknown	Het
Cspg4b	T	C	13: 113,504,574 (GRCm39)	I1901T		Het
Dcpp2	A	G	17: 24,119,453 (GRCm39)	E89G	probably damaging	Het
Dhx57	G	T	17: 80,561,817 (GRCm39)	A899E	probably damaging	Het
Dnaaf1	T	C	8: 120,309,392 (GRCm39)	I160T	probably damaging	Het
Dnah1	C	A	14: 30,986,394 (GRCm39)	A3698S	probably damaging	Het
Dnah12	C	A	14: 26,597,281 (GRCm39)	R3547S	possibly damaging	Het
Dnah3	A	G	7: 119,610,114 (GRCm39)	V1774A	probably benign	Het
Dop1a	G	A	9: 86,424,811 (GRCm39)	R2085Q	probably damaging	Het
Duox1	T	C	2: 122,151,203 (GRCm39)	Y293H	probably damaging	Het
Efcab5	G	A	11: 77,022,934 (GRCm39)	T593I	probably damaging	Het
Elp1	G	T	4: 56,772,521 (GRCm39)	P867T	probably benign	Het
Epas1	T	A	17: 87,112,667 (GRCm39)	D88E	probably damaging	Het
Epdr1	A	G	13: 19,778,821 (GRCm39)	F92L	possibly damaging	Het
Ercc6	T	C	14: 32,296,924 (GRCm39)	W1305R	probably damaging	Het
Etv6	A	G	6: 134,225,672 (GRCm39)	N212S	probably benign	Het
Fam20b	A	T	1: 156,530,010 (GRCm39)	Y141*	probably null	Het
Fancm	A	G	12: 65,168,494 (GRCm39)	N1619S	probably damaging	Het
Fbln5	A	T	12: 101,734,722 (GRCm39)	N183K	probably damaging	Het
Fer1l6	A	G	15: 58,490,370 (GRCm39)	D976G	possibly damaging	Het
Fgb	T	C	3: 82,952,409 (GRCm39)		probably null	Het
Fhod1	A	T	8: 106,074,422 (GRCm39)	Y22N	unknown	Het
Foxl3	C	A	5: 138,807,213 (GRCm39)	Q164K	probably benign	Het
Galm	C	T	17: 80,490,859 (GRCm39)	Q166*	probably null	Het
Gbe1	A	T	16: 70,198,664 (GRCm39)	Y119F	probably benign	Het
Gcnt7	T	A	2: 172,293,180 (GRCm39)	Y369F	probably damaging	Het
Gdap2	T	C	3: 100,099,006 (GRCm39)	I366T	possibly damaging	Het
Gm14295	T	C	2: 176,499,162 (GRCm39)	V4A	probably benign	Het
Gm32742	T	A	9: 51,068,327 (GRCm39)	Y249F	probably benign	Het
Gm40460	A	T	7: 141,794,701 (GRCm39)	C39S	unknown	Het
Gm6370	T	A	5: 146,429,281 (GRCm39)	C120*	probably null	Het
Harbi1	T	A	2: 91,542,698 (GRCm39)	L53*	probably null	Het
Herc3	A	G	6: 58,835,999 (GRCm39)	N280S	probably null	Het
Hipk2	T	A	6: 38,724,390 (GRCm39)	R447W	probably damaging	Het
Hydin	A	G	8: 111,312,786 (GRCm39)	I4176V	probably benign	Het
Ifi211	A	T	1: 173,733,052 (GRCm39)	I203N	probably benign	Het
Kcnc1	G	A	7: 46,077,010 (GRCm39)	V271M	probably benign	Het
Kcng1	T	A	2: 168,104,797 (GRCm39)	I350F	probably damaging	Het
Kif21b	A	T	1: 136,077,090 (GRCm39)	I371F	probably damaging	Het
Klrc1	A	G	6: 129,655,746 (GRCm39)	F43S	probably damaging	Het
Krtap6-2	A	G	16: 89,216,722 (GRCm39)	S82P	unknown	Het
Lamb1	T	A	12: 31,322,492 (GRCm39)	M186K	probably damaging	Het
Lrig2	T	C	3: 104,375,924 (GRCm39)	K451E	possibly damaging	Het
Lrrc15	G	A	16: 30,093,016 (GRCm39)	L108F	probably damaging	Het
Mark3	A	G	12: 111,570,960 (GRCm39)	I87V	probably damaging	Het
Mlh1	T	C	9: 111,060,013 (GRCm39)	K622E		Het
Mrgprb2	G	A	7: 48,202,674 (GRCm39)	T17M	possibly damaging	Het
Msantd5f4	G	T	4: 73,557,190 (GRCm39)	V8F	probably damaging	Het
Mtmr4	C	T	11: 87,493,241 (GRCm39)	R225C	probably damaging	Het
Nfatc1	A	G	18: 80,678,916 (GRCm39)	L824P	probably damaging	Het
Nlrp4f	A	T	13: 65,347,053 (GRCm39)	D46E	probably damaging	Het
Oga	CTCGGGTC	CTC	19: 45,743,096 (GRCm39)		probably null	Het
Or10h5	G	T	17: 33,434,415 (GRCm39)	T301N	probably benign	Het
Or13n4	A	C	7: 106,423,020 (GRCm39)	F238V	probably damaging	Het
Or1l4	G	T	2: 37,091,575 (GRCm39)	M107I	probably benign	Het
Or2w25	T	A	11: 59,504,580 (GRCm39)	N263K	probably damaging	Het
Or6z7	G	C	7: 6,483,243 (GRCm39)	A304G	probably null	Het
Or7e173	T	A	9: 19,939,045 (GRCm39)	Y63F	probably damaging	Het
Or8b1	G	T	9: 38,400,092 (GRCm39)	A256S	possibly damaging	Het
Otulin	A	G	15: 27,608,812 (GRCm39)	Y244H	probably damaging	Het
Pabpc4	T	C	4: 123,180,653 (GRCm39)	I125T	probably damaging	Het
Parp14	A	G	16: 35,677,775 (GRCm39)	I731T	probably benign	Het
Parp8	T	C	13: 117,029,631 (GRCm39)	T531A	probably benign	Het
Parvg	G	T	15: 84,213,065 (GRCm39)	V49L	probably benign	Het
Pcdhb9	A	C	18: 37,534,665 (GRCm39)	N220H	probably benign	Het
Pcdhga4	T	G	18: 37,819,527 (GRCm39)	S359A	probably benign	Het
Pi4k2b	T	A	5: 52,908,799 (GRCm39)	S208R	probably damaging	Het
Plxnb2	T	C	15: 89,050,136 (GRCm39)	Y487C	probably damaging	Het
Pm20d1	G	A	1: 131,730,501 (GRCm39)	V252I	probably damaging	Het
Pxdc1	T	A	13: 34,836,258 (GRCm39)	H54L	probably damaging	Het
Rag1	A	T	2: 101,473,327 (GRCm39)	V605E	probably damaging	Het
Rasgrf2	A	T	13: 92,034,469 (GRCm39)		probably null	Het
Relch	T	C	1: 105,591,876 (GRCm39)	V15A	probably damaging	Het
Rflnb	T	A	11: 75,912,951 (GRCm39)	T146S	probably damaging	Het
Rfx5	T	A	3: 94,866,639 (GRCm39)	L646Q	unknown	Het
Rnf43	A	G	11: 87,618,891 (GRCm39)	T81A	probably benign	Het
Ros1	T	C	10: 51,943,170 (GRCm39)	D2048G	probably damaging	Het
Rpl13a-ps1	T	A	19: 50,018,612 (GRCm39)	K188I	possibly damaging	Het
Rpl24	T	A	16: 55,790,509 (GRCm39)	S122T	probably benign	Het
Ryr2	G	A	13: 11,760,104 (GRCm39)	T1549M	probably damaging	Het
Sbf2	T	C	7: 110,040,702 (GRCm39)	Q375R	possibly damaging	Het
Sec23a	A	T	12: 59,048,817 (GRCm39)	F131I	possibly damaging	Het
Secisbp2	T	C	13: 51,837,320 (GRCm39)	I827T	probably damaging	Het
Serpinb6d	A	G	13: 33,854,756 (GRCm39)	R244G	probably benign	Het
Skor2	C	T	18: 76,946,376 (GRCm39)	H33Y	unknown	Het
Snx17	C	A	5: 31,355,088 (GRCm39)	Q368K	probably damaging	Het
Stac	T	A	9: 111,401,411 (GRCm39)	E345V	probably benign	Het
Stx4a	A	G	7: 127,445,375 (GRCm39)	N164S	possibly damaging	Het
Tasor	T	C	14: 27,201,766 (GRCm39)		probably null	Het
Tbcb	A	T	7: 29,930,549 (GRCm39)		probably null	Het
Tecpr2	T	C	12: 110,914,141 (GRCm39)	S1151P	possibly damaging	Het
Timm50	A	G	7: 28,007,069 (GRCm39)	F202S	possibly damaging	Het
Tle2	A	G	10: 81,417,567 (GRCm39)	D244G	probably benign	Het
Tlr4	G	A	4: 66,759,522 (GRCm39)	V772I	possibly damaging	Het
Tmem214	G	A	5: 31,027,043 (GRCm39)	W11*	probably null	Het
Tmem241	A	T	18: 12,176,356 (GRCm39)	L227*	probably null	Het
Top2b	A	C	14: 16,365,718 (GRCm38)	T14P	probably benign	Het
Trim44	T	C	2: 102,187,827 (GRCm39)	T309A	probably benign	Het
Trps1	A	C	15: 50,524,657 (GRCm39)	I1091S	probably damaging	Het
Tspan2	C	A	3: 102,672,583 (GRCm39)	T200K	probably damaging	Het
Tuba8	A	G	6: 121,200,063 (GRCm39)	N249S	probably benign	Het
Vmn1r189	A	G	13: 22,286,426 (GRCm39)	L137P	probably damaging	Het
Vmn2r29	A	T	7: 7,244,855 (GRCm39)	W340R	probably benign	Het
Vmn2r52	A	C	7: 9,893,476 (GRCm39)	D554E	probably benign	Het
Zc3h4	C	G	7: 16,168,891 (GRCm39)	P1075R	unknown	Het
Zfp599	A	G	9: 22,160,999 (GRCm39)	S389P	probably damaging	Het
Zfp777	A	T	6: 48,021,580 (GRCm39)	V14D	possibly damaging	Het
Zswim8	C	T	14: 20,762,150 (GRCm39)	Q262*	probably null	Het

Other mutations in Pcdha12

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00817:Pcdha12	APN	18	37,154,986 (GRCm39)	missense	probably benign	0.00
R2884:Pcdha12	UTSW	18	37,153,757 (GRCm39)	missense	probably damaging	1.00
R3111:Pcdha12	UTSW	18	37,155,243 (GRCm39)	missense	probably damaging	0.98
R3619:Pcdha12	UTSW	18	37,153,757 (GRCm39)	missense	probably damaging	1.00
R4605:Pcdha12	UTSW	18	37,154,576 (GRCm39)	missense	probably damaging	1.00
R4629:Pcdha12	UTSW	18	37,154,926 (GRCm39)	missense	probably damaging	0.99
R4711:Pcdha12	UTSW	18	37,153,976 (GRCm39)	missense	probably benign	0.00
R4987:Pcdha12	UTSW	18	37,154,604 (GRCm39)	missense	probably damaging	1.00
R5489:Pcdha12	UTSW	18	37,155,260 (GRCm39)	missense	probably benign	0.01
R5568:Pcdha12	UTSW	18	37,153,443 (GRCm39)	missense	probably damaging	1.00
R5649:Pcdha12	UTSW	18	37,155,468 (GRCm39)	missense	probably benign	0.01
R6211:Pcdha12	UTSW	18	37,153,374 (GRCm39)	missense	probably damaging	0.99
R6268:Pcdha12	UTSW	18	37,155,477 (GRCm39)	missense	possibly damaging	0.94
R6793:Pcdha12	UTSW	18	37,155,234 (GRCm39)	missense	probably damaging	1.00
R6999:Pcdha12	UTSW	18	37,153,329 (GRCm39)	missense	probably benign	0.00
R7065:Pcdha12	UTSW	18	37,154,679 (GRCm39)	missense	probably damaging	1.00
R7192:Pcdha12	UTSW	18	37,153,316 (GRCm39)	missense	probably benign	0.00
R7411:Pcdha12	UTSW	18	37,154,661 (GRCm39)	missense	probably damaging	1.00
R7486:Pcdha12	UTSW	18	37,154,610 (GRCm39)	missense	probably damaging	1.00
R7768:Pcdha12	UTSW	18	37,155,404 (GRCm39)	missense	probably damaging	1.00
R7857:Pcdha12	UTSW	18	37,155,468 (GRCm39)	missense	probably benign	0.01
R7940:Pcdha12	UTSW	18	37,153,409 (GRCm39)	missense	probably damaging	0.99
R8271:Pcdha12	UTSW	18	37,154,953 (GRCm39)	missense	probably damaging	0.99
R8306:Pcdha12	UTSW	18	37,155,638 (GRCm39)	missense	probably benign	0.06
R8405:Pcdha12	UTSW	18	37,154,250 (GRCm39)	missense	possibly damaging	0.94
R8475:Pcdha12	UTSW	18	37,154,136 (GRCm39)	missense	possibly damaging	0.95
R8715:Pcdha12	UTSW	18	37,153,523 (GRCm39)	missense	probably damaging	1.00
R8725:Pcdha12	UTSW	18	37,154,736 (GRCm39)	missense	probably benign	0.01
R9307:Pcdha12	UTSW	18	37,153,874 (GRCm39)	missense	probably damaging	1.00
R9407:Pcdha12	UTSW	18	37,153,614 (GRCm39)	missense	probably damaging	0.99
R9450:Pcdha12	UTSW	18	37,153,992 (GRCm39)	missense	probably damaging	1.00
R9460:Pcdha12	UTSW	18	37,153,574 (GRCm39)	missense	probably damaging	1.00
R9495:Pcdha12	UTSW	18	37,155,526 (GRCm39)	missense	probably damaging	1.00
R9514:Pcdha12	UTSW	18	37,155,526 (GRCm39)	missense	probably damaging	1.00
R9577:Pcdha12	UTSW	18	37,155,126 (GRCm39)	missense	probably benign	0.17
R9596:Pcdha12	UTSW	18	37,154,302 (GRCm39)	missense	probably benign	0.32
R9673:Pcdha12	UTSW	18	37,155,234 (GRCm39)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- CAGTAGATGCGGACTCTGGTTAC -3'
(R):5'- ATCTGTGGACCTTGCTGAGC -3'

Sequencing Primer
(F):5'- ATGCGGACTCTGGTTACAATGC -3'
(R):5'- TACACGTTGACAGTCACC -3'

Posted On

2022-08-09