Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01347:Gbp11'

75127

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gbp11

Ensembl Gene

ENSMUSG00000092021

Gene Name

guanylate binding protein 11

Synonyms

Gm7141

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL01347

Quality Score

Status

Chromosome

Chromosomal Location

105323042-105346472 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 105331328 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000132552 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100960] [ENSMUST00000171587]

AlphaFold

A9YVJ5

Predicted Effect

probably benign
Transcript: ENSMUST00000100960

SMART Domains

Protein: ENSMUSP00000098520
Gene: ENSMUSG00000092021

Domain	Start	End	E-Value	Type
Pfam:GBP	16	279	1.5e-122	PFAM
Pfam:GBP_C	281	574	3.4e-114	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000171587

SMART Domains

Protein: ENSMUSP00000132552
Gene: ENSMUSG00000092021

Domain	Start	End	E-Value	Type
Pfam:GBP	16	279	4.9e-117	PFAM
Pfam:GBP_C	281	442	2.7e-75	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600015I10Rik	A	T	6: 48,932,543	Y574F	probably benign	Het
Apc	C	T	18: 34,317,670	P2506S	probably damaging	Het
Bdp1	T	A	13: 100,070,203	K610N	possibly damaging	Het
Bri3bp	T	G	5: 125,454,517	C176G	probably damaging	Het
Carnmt1	A	G	19: 18,691,454	I248V	probably benign	Het
Ccdc88b	A	G	19: 6,845,086	L1475P	probably damaging	Het
Cfap100	C	T	6: 90,406,121	V511M	possibly damaging	Het
Chchd3	T	C	6: 32,803,903	N78S	probably benign	Het
Cnnm4	G	A	1: 36,498,034	E480K	possibly damaging	Het
Cyp2d34	T	A	15: 82,616,777	I385F	possibly damaging	Het
D930048N14Rik	T	A	11: 51,654,788		probably benign	Het
Dgkg	A	T	16: 22,600,590	D53E	probably benign	Het
Dlx3	T	A	11: 95,120,533	L71H	probably damaging	Het
Egln2	A	C	7: 27,160,292	V332G	probably null	Het
Entpd2	A	G	2: 25,398,734	Q250R	probably benign	Het
Epyc	A	G	10: 97,674,731	D132G	probably damaging	Het
Fxr2	A	G	11: 69,652,288	D637G	probably benign	Het
Gapvd1	A	G	2: 34,706,696		probably null	Het
Gm17175	A	T	14: 51,570,850	C162S	probably damaging	Het
Gm5499	C	T	17: 87,078,911		noncoding transcript	Het
Gm5724	A	T	6: 141,754,466	Y113*	probably null	Het
Gps1	T	C	11: 120,788,260	V378A	probably benign	Het
Grik1	C	T	16: 87,957,593	R368Q	probably benign	Het
Gsap	A	G	5: 21,226,320	E214G	probably benign	Het
Hist1h2bl	A	G	13: 21,715,894	Y84H	probably damaging	Het
Jdp2	T	C	12: 85,608,246	S28P	probably benign	Het
Kif26b	T	C	1: 178,870,675	F577S	probably damaging	Het
Kl	G	A	5: 150,980,665	G294D	probably damaging	Het
Lgsn	T	A	1: 31,203,960	D374E	probably damaging	Het
Lman1	T	C	18: 65,991,610	I353V	probably damaging	Het
Lmna	T	C	3: 88,484,963	H374R	probably benign	Het
Lrrc57	A	G	2: 120,608,805	S31P	probably benign	Het
Lum	T	A	10: 97,568,685	N147K	probably damaging	Het
Olfr430	T	C	1: 174,070,066	I256T	probably benign	Het
Olfr57	A	G	10: 79,035,611	T272A	probably benign	Het
P4ha3	C	A	7: 100,305,933	L332I	probably damaging	Het
Pelp1	A	G	11: 70,395,679	I541T	probably damaging	Het
Pja2	A	C	17: 64,313,028	S2A	probably benign	Het
Rhbdl3	T	C	11: 80,353,442	L325P	probably damaging	Het
Robo2	T	C	16: 74,352,856	D28G	probably damaging	Het
Rpa1	A	G	11: 75,307,285	Y470H	probably damaging	Het
Rtn3	T	C	19: 7,457,280	N430S	probably benign	Het
Scg2	T	A	1: 79,436,821	I62L	probably benign	Het
Scn5a	T	A	9: 119,562,441	K62*	probably null	Het
Sec23ip	T	C	7: 128,762,405	V469A	probably benign	Het
Shank1	A	G	7: 44,342,120	T663A	unknown	Het
Stab2	G	T	10: 86,901,703		probably null	Het
Tmcc3	T	C	10: 94,582,285	L305P	probably damaging	Het
Tmem145	A	G	7: 25,314,835	N458S	probably damaging	Het
Tpr	G	A	1: 150,426,987	R1412Q	probably damaging	Het
Wdr1	A	T	5: 38,545,715	F173I	possibly damaging	Het
Wdr17	C	T	8: 54,651,345	V898I	probably benign	Het
Wdr64	A	T	1: 175,720,333	L145F	probably benign	Het
Wnt10b	A	G	15: 98,776,945		probably benign	Het
Zfyve26	A	T	12: 79,252,183		probably null	Het

Other mutations in Gbp11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01329:Gbp11	APN	5	105327616	critical splice acceptor site	probably null
IGL01762:Gbp11	APN	5	105327607	missense	probably benign
IGL02157:Gbp11	APN	5	105327508	missense	possibly damaging	0.95
Quilt	UTSW	5	105325508	missense	probably damaging	1.00
Tilted	UTSW	5	105331053	missense	probably damaging	1.00
R0550:Gbp11	UTSW	5	105343750	missense	probably benign	0.28
R0647:Gbp11	UTSW	5	105330964	missense	possibly damaging	0.93
R1530:Gbp11	UTSW	5	105327489	missense	probably damaging	0.99
R1612:Gbp11	UTSW	5	105326596	missense	possibly damaging	0.72
R1677:Gbp11	UTSW	5	105327411	missense	probably damaging	1.00
R1738:Gbp11	UTSW	5	105326644	missense	probably benign	0.02
R2063:Gbp11	UTSW	5	105328584	nonsense	probably null
R2869:Gbp11	UTSW	5	105331000	missense	probably benign	0.00
R2869:Gbp11	UTSW	5	105331000	missense	probably benign	0.00
R2870:Gbp11	UTSW	5	105331000	missense	probably benign	0.00
R2870:Gbp11	UTSW	5	105331000	missense	probably benign	0.00
R2873:Gbp11	UTSW	5	105331000	missense	probably benign	0.00
R3915:Gbp11	UTSW	5	105331112	missense	probably damaging	1.00
R4854:Gbp11	UTSW	5	105325508	missense	probably damaging	1.00
R5140:Gbp11	UTSW	5	105331053	missense	probably damaging	1.00
R5534:Gbp11	UTSW	5	105331038	missense	probably damaging	1.00
R6091:Gbp11	UTSW	5	105331388	missense	possibly damaging	0.95
R6336:Gbp11	UTSW	5	105325489
R6351:Gbp11	UTSW	5	105327598	missense	probably benign	0.07
R6956:Gbp11	UTSW	5	105328375	critical splice donor site	probably null
R7371:Gbp11	UTSW	5	105342105	missense	probably benign	0.06
R7393:Gbp11	UTSW	5	105327577	missense	possibly damaging	0.60
R7410:Gbp11	UTSW	5	105343908	missense	probably damaging	1.00
R7443:Gbp11	UTSW	5	105330950	critical splice donor site	probably null
R7898:Gbp11	UTSW	5	105324932	missense	probably benign	0.00
R8465:Gbp11	UTSW	5	105325062	missense	probably benign	0.00
R8467:Gbp11	UTSW	5	105327591	missense	probably damaging	1.00
R8672:Gbp11	UTSW	5	105343809	missense	probably damaging	1.00
R8858:Gbp11	UTSW	5	105325526	nonsense	probably null
R8960:Gbp11	UTSW	5	105331385	missense	probably damaging	0.98
R9097:Gbp11	UTSW	5	105326481	makesense	probably null
R9232:Gbp11	UTSW	5	105328424	missense	possibly damaging	0.76
R9380:Gbp11	UTSW	5	105327336	missense	probably benign	0.00
R9400:Gbp11	UTSW	5	105330975	missense	probably damaging	1.00
R9438:Gbp11	UTSW	5	105326605	nonsense	probably null

Posted On

2013-10-07