Incidental Mutation 'IGL01390:Tas2r104'
| ID |
79173 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r104
|
| Ensembl Gene |
ENSMUSG00000061977 |
| Gene Name |
taste receptor, type 2, member 104 |
| Synonyms |
mt2r45, Tas2r4, mGR04, T2R04 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.052)
|
| Stock # |
IGL01390
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
131661799-131662707 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 131662448 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 87
(Y87F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000072237
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053652]
[ENSMUST00000072404]
[ENSMUST00000080619]
|
| AlphaFold |
Q7M723 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053652
|
| SMART Domains |
Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
9.4e-109 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072404
AA Change: Y87F
PolyPhen 2
Score 0.127 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977
AA Change: Y87F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
8.3e-102 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080619
|
| SMART Domains |
Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
8.1e-104 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atp6v0a1 |
A |
G |
11: 100,934,628 (GRCm39) |
K565R |
probably benign |
Het |
| Cacna2d3 |
T |
C |
14: 28,665,548 (GRCm39) |
T158A |
possibly damaging |
Het |
| Dnah5 |
A |
G |
15: 28,411,686 (GRCm39) |
D3685G |
probably benign |
Het |
| Dock1 |
T |
C |
7: 134,346,776 (GRCm39) |
I236T |
possibly damaging |
Het |
| Dock6 |
A |
G |
9: 21,714,341 (GRCm39) |
V1803A |
probably damaging |
Het |
| Epb41 |
T |
C |
4: 131,731,048 (GRCm39) |
I178V |
probably benign |
Het |
| Gm10110 |
C |
A |
14: 90,135,677 (GRCm39) |
|
noncoding transcript |
Het |
| H2ac6 |
T |
C |
13: 23,867,499 (GRCm39) |
|
probably benign |
Het |
| Hoxb7 |
A |
C |
11: 96,177,837 (GRCm39) |
N95T |
probably benign |
Het |
| Ikzf2 |
C |
A |
1: 69,609,801 (GRCm39) |
C116F |
probably damaging |
Het |
| Ints8 |
A |
T |
4: 11,218,679 (GRCm39) |
|
probably benign |
Het |
| Itprid1 |
C |
T |
6: 55,874,983 (GRCm39) |
P311L |
probably benign |
Het |
| Man2a1 |
T |
C |
17: 65,017,700 (GRCm39) |
Y649H |
probably benign |
Het |
| Mcm8 |
T |
C |
2: 132,679,998 (GRCm39) |
|
probably benign |
Het |
| Msi1 |
T |
A |
5: 115,576,780 (GRCm39) |
D137E |
possibly damaging |
Het |
| Or8u10 |
T |
C |
2: 85,915,984 (GRCm39) |
I46V |
probably benign |
Het |
| Pde6c |
A |
G |
19: 38,150,376 (GRCm39) |
Y507C |
probably benign |
Het |
| Prl7d1 |
A |
G |
13: 27,894,149 (GRCm39) |
V140A |
possibly damaging |
Het |
| Rb1 |
T |
A |
14: 73,532,439 (GRCm39) |
I132F |
probably benign |
Het |
| Rgl1 |
A |
G |
1: 152,447,339 (GRCm39) |
|
probably benign |
Het |
| Rpl18a |
G |
T |
8: 71,348,154 (GRCm39) |
|
probably benign |
Het |
| Sf3b1 |
T |
C |
1: 55,026,588 (GRCm39) |
I1274V |
probably benign |
Het |
| Slc9a3 |
A |
C |
13: 74,298,880 (GRCm39) |
I100L |
probably benign |
Het |
| Sorcs3 |
T |
A |
19: 48,778,570 (GRCm39) |
Y996N |
probably damaging |
Het |
| Sra1 |
A |
G |
18: 36,803,134 (GRCm39) |
L37P |
probably damaging |
Het |
| Stim1 |
A |
G |
7: 102,076,369 (GRCm39) |
Q440R |
possibly damaging |
Het |
| Tacc3 |
C |
T |
5: 33,825,405 (GRCm39) |
|
probably benign |
Het |
| Tbl2 |
T |
C |
5: 135,185,217 (GRCm39) |
|
probably benign |
Het |
| Vsig10l |
C |
T |
7: 43,115,889 (GRCm39) |
S410F |
probably damaging |
Het |
|
| Other mutations in Tas2r104 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00590:Tas2r104
|
APN |
6 |
131,662,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02751:Tas2r104
|
APN |
6 |
131,662,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4585001:Tas2r104
|
UTSW |
6 |
131,662,521 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0218:Tas2r104
|
UTSW |
6 |
131,662,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0453:Tas2r104
|
UTSW |
6 |
131,662,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0472:Tas2r104
|
UTSW |
6 |
131,662,434 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0614:Tas2r104
|
UTSW |
6 |
131,662,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1290:Tas2r104
|
UTSW |
6 |
131,661,808 (GRCm39) |
nonsense |
probably null |
|
|
R1480:Tas2r104
|
UTSW |
6 |
131,662,257 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1698:Tas2r104
|
UTSW |
6 |
131,662,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Tas2r104
|
UTSW |
6 |
131,662,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2229:Tas2r104
|
UTSW |
6 |
131,662,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3824:Tas2r104
|
UTSW |
6 |
131,662,002 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R3852:Tas2r104
|
UTSW |
6 |
131,661,888 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4283:Tas2r104
|
UTSW |
6 |
131,662,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4583:Tas2r104
|
UTSW |
6 |
131,662,398 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4710:Tas2r104
|
UTSW |
6 |
131,662,407 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4954:Tas2r104
|
UTSW |
6 |
131,661,968 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5559:Tas2r104
|
UTSW |
6 |
131,662,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5765:Tas2r104
|
UTSW |
6 |
131,662,236 (GRCm39) |
missense |
probably benign |
|
|
R5843:Tas2r104
|
UTSW |
6 |
131,661,938 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7304:Tas2r104
|
UTSW |
6 |
131,662,005 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8559:Tas2r104
|
UTSW |
6 |
131,662,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8864:Tas2r104
|
UTSW |
6 |
131,662,632 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8951:Tas2r104
|
UTSW |
6 |
131,662,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-11-05 |
Incidental Mutation