Incidental Mutation 'R8864:Tas2r104'
| ID |
675810 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tas2r104
|
| Ensembl Gene |
ENSMUSG00000061977 |
| Gene Name |
taste receptor, type 2, member 104 |
| Synonyms |
mt2r45, Tas2r4, mGR04, T2R04 |
| MMRRC Submission |
068680-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.052)
|
| Stock # |
R8864 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
131661799-131662707 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 131662632 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 26
(F26L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000072237
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053652]
[ENSMUST00000072404]
[ENSMUST00000080619]
|
| AlphaFold |
Q7M723 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053652
|
| SMART Domains |
Protein: ENSMUSP00000058006
Gene: ENSMUSG00000051153
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
9.4e-109 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072404
AA Change: F26L
PolyPhen 2
Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000072237
Gene: ENSMUSG00000061977
AA Change: F26L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
8.3e-102 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080619
|
| SMART Domains |
Protein: ENSMUSP00000079453
Gene: ENSMUSG00000063478
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
298 |
8.1e-104 |
PFAM |
|
| Meta Mutation Damage Score |
0.7273 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
100% (41/41) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts19 |
T |
A |
18: 59,023,497 (GRCm39) |
C297* |
probably null |
Het |
| Adamts3 |
T |
C |
5: 89,854,981 (GRCm39) |
|
probably benign |
Het |
| Best2 |
T |
A |
8: 85,735,942 (GRCm39) |
M331L |
probably benign |
Het |
| Cachd1 |
T |
A |
4: 100,852,026 (GRCm39) |
S1207R |
probably damaging |
Het |
| Cacna2d3 |
G |
T |
14: 29,055,735 (GRCm39) |
N298K |
probably damaging |
Het |
| Cyp2j12 |
T |
C |
4: 96,009,750 (GRCm39) |
Y203C |
probably damaging |
Het |
| Dnah8 |
T |
C |
17: 30,981,616 (GRCm39) |
I3046T |
possibly damaging |
Het |
| Eif3b |
T |
C |
5: 140,412,287 (GRCm39) |
V252A |
probably benign |
Het |
| Ergic2 |
A |
G |
6: 148,083,393 (GRCm39) |
V355A |
probably benign |
Het |
| F13a1 |
C |
T |
13: 37,061,753 (GRCm39) |
G670D |
probably damaging |
Het |
| Gfpt1 |
T |
A |
6: 87,031,605 (GRCm39) |
D82E |
probably benign |
Het |
| Ggnbp2 |
G |
A |
11: 84,730,902 (GRCm39) |
R376C |
probably damaging |
Het |
| Grn |
T |
C |
11: 102,327,211 (GRCm39) |
F191L |
unknown |
Het |
| Ighv1-16 |
C |
T |
12: 114,629,619 (GRCm39) |
G56D |
probably benign |
Het |
| Jrkl |
T |
C |
9: 13,244,326 (GRCm39) |
D445G |
probably benign |
Het |
| Loxl3 |
A |
G |
6: 83,012,739 (GRCm39) |
T93A |
probably damaging |
Het |
| Lrp1b |
C |
T |
2: 41,002,718 (GRCm39) |
A2094T |
|
Het |
| Lrriq3 |
T |
A |
3: 154,893,575 (GRCm39) |
D425E |
probably damaging |
Het |
| Majin |
T |
C |
19: 6,261,650 (GRCm39) |
V55A |
possibly damaging |
Het |
| Mapk8ip3 |
A |
T |
17: 25,118,492 (GRCm39) |
V1192E |
probably damaging |
Het |
| Mdga1 |
T |
C |
17: 30,150,295 (GRCm39) |
S106G |
unknown |
Het |
| Mtch2 |
C |
T |
2: 90,685,274 (GRCm39) |
R135* |
probably null |
Het |
| Naip1 |
T |
C |
13: 100,562,828 (GRCm39) |
N779S |
possibly damaging |
Het |
| Nfia |
T |
C |
4: 97,951,382 (GRCm39) |
V403A |
possibly damaging |
Het |
| Npas4 |
C |
A |
19: 5,038,556 (GRCm39) |
D121Y |
probably damaging |
Het |
| Rab3gap1 |
C |
T |
1: 127,837,630 (GRCm39) |
R231W |
probably damaging |
Het |
| Rangap1 |
C |
G |
15: 81,610,270 (GRCm39) |
|
probably benign |
Het |
| Rgs5 |
T |
A |
1: 169,517,990 (GRCm39) |
F75I |
probably benign |
Het |
| Rnf19a |
T |
C |
15: 36,265,452 (GRCm39) |
D215G |
possibly damaging |
Het |
| Rwdd4a |
A |
T |
8: 48,000,876 (GRCm39) |
|
probably benign |
Het |
| Setd5 |
G |
A |
6: 113,088,469 (GRCm39) |
R199H |
probably damaging |
Het |
| Spata31e1 |
T |
C |
13: 49,940,988 (GRCm39) |
N241D |
probably benign |
Het |
| Spef2 |
T |
C |
15: 9,599,833 (GRCm39) |
Q2004R |
unknown |
Het |
| Syne1 |
T |
C |
10: 5,370,473 (GRCm39) |
K236E |
probably benign |
Het |
| Tbc1d32 |
T |
A |
10: 55,963,655 (GRCm39) |
E954D |
probably benign |
Het |
| Tenm2 |
A |
C |
11: 35,918,022 (GRCm39) |
S1914A |
possibly damaging |
Het |
| Tln2 |
G |
T |
9: 67,237,834 (GRCm39) |
Y32* |
probably null |
Het |
| Tnc |
C |
T |
4: 63,911,296 (GRCm39) |
R1425H |
probably damaging |
Het |
| Unc13b |
T |
C |
4: 43,174,724 (GRCm39) |
C1851R |
unknown |
Het |
| Wapl |
T |
A |
14: 34,414,159 (GRCm39) |
D340E |
probably benign |
Het |
| Zfp74 |
T |
C |
7: 29,634,235 (GRCm39) |
E491G |
probably damaging |
Het |
|
| Other mutations in Tas2r104 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00590:Tas2r104
|
APN |
6 |
131,662,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01390:Tas2r104
|
APN |
6 |
131,662,448 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02751:Tas2r104
|
APN |
6 |
131,662,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4585001:Tas2r104
|
UTSW |
6 |
131,662,521 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0218:Tas2r104
|
UTSW |
6 |
131,662,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0453:Tas2r104
|
UTSW |
6 |
131,662,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0472:Tas2r104
|
UTSW |
6 |
131,662,434 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0614:Tas2r104
|
UTSW |
6 |
131,662,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1290:Tas2r104
|
UTSW |
6 |
131,661,808 (GRCm39) |
nonsense |
probably null |
|
|
R1480:Tas2r104
|
UTSW |
6 |
131,662,257 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1698:Tas2r104
|
UTSW |
6 |
131,662,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Tas2r104
|
UTSW |
6 |
131,662,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2229:Tas2r104
|
UTSW |
6 |
131,662,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3824:Tas2r104
|
UTSW |
6 |
131,662,002 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R3852:Tas2r104
|
UTSW |
6 |
131,661,888 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4283:Tas2r104
|
UTSW |
6 |
131,662,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4583:Tas2r104
|
UTSW |
6 |
131,662,398 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4710:Tas2r104
|
UTSW |
6 |
131,662,407 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4954:Tas2r104
|
UTSW |
6 |
131,661,968 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5559:Tas2r104
|
UTSW |
6 |
131,662,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5765:Tas2r104
|
UTSW |
6 |
131,662,236 (GRCm39) |
missense |
probably benign |
|
|
R5843:Tas2r104
|
UTSW |
6 |
131,661,938 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7304:Tas2r104
|
UTSW |
6 |
131,662,005 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8559:Tas2r104
|
UTSW |
6 |
131,662,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8951:Tas2r104
|
UTSW |
6 |
131,662,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTAAACCAAACGCTCAGATGG -3'
(R):5'- CCTCTGGAGTCATTATTTAAGGGG -3'
Sequencing Primer
(F):5'- CGCTCAGATGGTTAATAATTACCC -3'
(R):5'- CTGGAGTCATTATTTAAGGGGAGAAG -3'
|
| Posted On |
2021-07-15 |
Incidental Mutation