Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01566:Tmem161b'

90979

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem161b

Ensembl Gene

ENSMUSG00000035762

Gene Name

transmembrane protein 161B

Synonyms

2810446P07Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01566

Quality Score

Status

Chromosome

Chromosomal Location

84370415-84444085 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 84442881 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 267 (I267T)

Ref Sequence

ENSEMBL: ENSMUSP00000152891 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057495] [ENSMUST00000223827] [ENSMUST00000223862] [ENSMUST00000225069]

AlphaFold

Q8C2L6

Predicted Effect

probably benign
Transcript: ENSMUST00000057495
AA Change: I449T

PolyPhen 2 Score 0.157 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000055208
Gene: ENSMUSG00000035762
AA Change: I449T

Domain	Start	End	E-Value	Type
Pfam:Tmemb_161AB	2	485	1.3e-213	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000223827

Predicted Effect

probably benign
Transcript: ENSMUST00000223862

Predicted Effect

probably benign
Transcript: ENSMUST00000225069
AA Change: I267T

PolyPhen 2 Score 0.351 (Sensitivity: 0.90; Specificity: 0.89)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mice exhibit lethality before genotyping age. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AB124611	T	C	9: 21,447,285 (GRCm39)	V149A	possibly damaging	Het
Casc3	T	C	11: 98,714,227 (GRCm39)		probably null	Het
Dhdds	T	C	4: 133,718,648 (GRCm39)	I162V	probably damaging	Het
Dsg1a	T	C	18: 20,469,840 (GRCm39)		probably benign	Het
E030025P04Rik	T	A	11: 109,034,714 (GRCm39)	D58V	unknown	Het
Gcn1	A	G	5: 115,749,117 (GRCm39)	N1883S	probably damaging	Het
Gucy1a2	T	C	9: 3,634,661 (GRCm39)	L235P	probably damaging	Het
Jkampl	G	A	6: 73,445,673 (GRCm39)	T292I	probably damaging	Het
Kprp	T	C	3: 92,731,271 (GRCm39)	N593S	probably benign	Het
Mme	T	C	3: 63,269,350 (GRCm39)		probably benign	Het
Nr6a1	G	T	2: 38,617,901 (GRCm39)	Q419K	probably benign	Het
Pcolce	A	G	5: 137,603,422 (GRCm39)		probably benign	Het
Ppp2cb	C	A	8: 34,101,791 (GRCm39)	R110S	probably benign	Het
Slc35f1	A	G	10: 52,965,551 (GRCm39)	Y322C	probably damaging	Het
Slc5a3	T	C	16: 91,874,465 (GRCm39)	V174A	probably damaging	Het
St8sia4	G	T	1: 95,581,482 (GRCm39)	R87S	probably benign	Het
Tfdp2	A	G	9: 96,177,083 (GRCm39)	E5G	probably damaging	Het
Ttn	A	G	2: 76,782,365 (GRCm39)	L957P	probably damaging	Het
Ttn	A	G	2: 76,612,445 (GRCm39)		probably benign	Het
Ubqln1	A	T	13: 58,327,481 (GRCm39)		probably null	Het
Wdfy3	A	C	5: 102,044,454 (GRCm39)		probably benign	Het

Other mutations in Tmem161b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00666:Tmem161b	APN	13	84,442,715 (GRCm39)	splice site	probably benign
IGL01086:Tmem161b	APN	13	84,370,541 (GRCm39)	utr 5 prime	probably benign
IGL01150:Tmem161b	APN	13	84,440,526 (GRCm39)	nonsense	probably null
IGL02183:Tmem161b	APN	13	84,420,373 (GRCm39)	missense	probably damaging	1.00
IGL02481:Tmem161b	APN	13	84,432,112 (GRCm39)	missense	probably damaging	0.99
IGL02519:Tmem161b	APN	13	84,442,863 (GRCm39)	missense	probably damaging	1.00
IGL03207:Tmem161b	APN	13	84,442,714 (GRCm39)	splice site	probably benign
R6836_Tmem161b_587	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R0015:Tmem161b	UTSW	13	84,370,533 (GRCm39)	splice site	probably null
R0376:Tmem161b	UTSW	13	84,440,502 (GRCm39)	missense	probably benign	0.43
R0613:Tmem161b	UTSW	13	84,399,439 (GRCm39)	missense	probably damaging	1.00
R1925:Tmem161b	UTSW	13	84,408,348 (GRCm39)	missense	probably benign	0.07
R1935:Tmem161b	UTSW	13	84,441,585 (GRCm39)	missense	probably damaging	1.00
R1936:Tmem161b	UTSW	13	84,441,585 (GRCm39)	missense	probably damaging	1.00
R2325:Tmem161b	UTSW	13	84,442,887 (GRCm39)	missense	possibly damaging	0.94
R2988:Tmem161b	UTSW	13	84,440,574 (GRCm39)	nonsense	probably null
R4327:Tmem161b	UTSW	13	84,399,359 (GRCm39)	missense	probably damaging	1.00
R4525:Tmem161b	UTSW	13	84,405,921 (GRCm39)	missense	probably benign	0.00
R4558:Tmem161b	UTSW	13	84,399,363 (GRCm39)	missense	possibly damaging	0.50
R5133:Tmem161b	UTSW	13	84,442,887 (GRCm39)	missense	possibly damaging	0.94
R5134:Tmem161b	UTSW	13	84,442,887 (GRCm39)	missense	possibly damaging	0.94
R5727:Tmem161b	UTSW	13	84,434,909 (GRCm39)	missense	possibly damaging	0.63
R5875:Tmem161b	UTSW	13	84,442,977 (GRCm39)	missense	probably damaging	1.00
R6217:Tmem161b	UTSW	13	84,399,363 (GRCm39)	missense	possibly damaging	0.50
R6527:Tmem161b	UTSW	13	84,420,383 (GRCm39)	missense	probably benign	0.06
R6550:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6551:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6553:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6554:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6640:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6641:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6685:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6836:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6837:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R6838:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7077:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7078:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7386:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7388:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7429:Tmem161b	UTSW	13	84,430,866 (GRCm39)	critical splice acceptor site	probably null
R7430:Tmem161b	UTSW	13	84,430,866 (GRCm39)	critical splice acceptor site	probably null
R7547:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7548:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7634:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R7636:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R8094:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R8095:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R8255:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R8257:Tmem161b	UTSW	13	84,370,537 (GRCm39)	start gained	probably benign
R8669:Tmem161b	UTSW	13	84,420,288 (GRCm39)	critical splice acceptor site	probably null
R9049:Tmem161b	UTSW	13	84,442,754 (GRCm39)	missense	probably benign
R9092:Tmem161b	UTSW	13	84,440,503 (GRCm39)	missense	possibly damaging	0.69
R9316:Tmem161b	UTSW	13	84,430,855 (GRCm39)	missense	possibly damaging	0.84
R9326:Tmem161b	UTSW	13	84,440,602 (GRCm39)	nonsense	probably null

Posted On

2013-12-09