Incidental Mutation 'IGL02183:Tmem161b'
ID 284314
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem161b
Ensembl Gene ENSMUSG00000035762
Gene Name transmembrane protein 161B
Synonyms 2810446P07Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02183
Quality Score
Status
Chromosome 13
Chromosomal Location 84370415-84444085 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 84420373 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 125 (Y125H)
Ref Sequence ENSEMBL: ENSMUSP00000055208 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057495] [ENSMUST00000223827] [ENSMUST00000223862] [ENSMUST00000225069]
AlphaFold Q8C2L6
Predicted Effect probably damaging
Transcript: ENSMUST00000057495
AA Change: Y125H

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000055208
Gene: ENSMUSG00000035762
AA Change: Y125H

DomainStartEndE-ValueType
Pfam:Tmemb_161AB 2 485 1.3e-213 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000223827
AA Change: Y125H

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
Predicted Effect probably damaging
Transcript: ENSMUST00000223862
AA Change: Y125H

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224501
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224744
Predicted Effect probably benign
Transcript: ENSMUST00000225069
Predicted Effect probably damaging
Transcript: ENSMUST00000225708
AA Change: Y110H

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225126
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mice exhibit lethality before genotyping age. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace2 T A X: 162,960,465 (GRCm39) probably benign Het
Acsm4 A T 7: 119,293,075 (GRCm39) probably null Het
Apcdd1 T C 18: 63,084,925 (GRCm39) M374T probably damaging Het
Arid4b A G 13: 14,344,575 (GRCm39) E551G possibly damaging Het
Bag4 A T 8: 26,258,058 (GRCm39) L423Q probably damaging Het
Celf1 C T 2: 90,831,831 (GRCm39) P96S probably damaging Het
Cracdl G A 1: 37,664,459 (GRCm39) P480S possibly damaging Het
Cry2 G A 2: 92,243,384 (GRCm39) R486W probably damaging Het
Csn1s1 G A 5: 87,825,477 (GRCm39) S228N possibly damaging Het
Ctnnd2 A G 15: 31,020,886 (GRCm39) Y1124C probably damaging Het
Cyp2j7 T C 4: 96,118,384 (GRCm39) probably benign Het
Dock7 A T 4: 98,847,228 (GRCm39) C1695S possibly damaging Het
Elmo3 T C 8: 106,034,955 (GRCm39) L415P probably benign Het
Entpd5 A G 12: 84,427,154 (GRCm39) probably benign Het
Gpatch11 T C 17: 79,149,660 (GRCm39) probably null Het
Gprin3 C A 6: 59,330,147 (GRCm39) R720I possibly damaging Het
Gria4 T G 9: 4,502,460 (GRCm39) T358P probably damaging Het
Hcn2 T C 10: 79,560,647 (GRCm39) probably null Het
Hivep3 A G 4: 119,989,221 (GRCm39) T1891A probably benign Het
Hmgcr A G 13: 96,799,635 (GRCm39) V153A probably damaging Het
Ifnar1 T C 16: 91,302,034 (GRCm39) V503A possibly damaging Het
Igf2r G A 17: 12,917,403 (GRCm39) probably benign Het
Ighg2b A G 12: 113,271,449 (GRCm39) S35P unknown Het
Jmy T C 13: 93,635,750 (GRCm39) D22G possibly damaging Het
Kdm5b T C 1: 134,552,669 (GRCm39) I1215T probably benign Het
Krt84 T C 15: 101,440,791 (GRCm39) I134V unknown Het
Magi3 T A 3: 103,992,663 (GRCm39) M270L probably benign Het
Maneal G A 4: 124,754,209 (GRCm39) T198I probably benign Het
Map7d3 A G X: 55,867,591 (GRCm39) probably benign Het
Myh7 T A 14: 55,212,188 (GRCm39) T1519S probably benign Het
Myo5a T C 9: 75,074,518 (GRCm39) probably benign Het
Naip5 T C 13: 100,358,150 (GRCm39) S1029G probably benign Het
Or14j1 G T 17: 38,146,304 (GRCm39) C138F probably damaging Het
Or4c11c A T 2: 88,662,372 (GRCm39) I304F probably benign Het
Or4g16 T A 2: 111,136,763 (GRCm39) V71E probably damaging Het
Or5d14 T C 2: 87,880,333 (GRCm39) T212A possibly damaging Het
Or5k15 T A 16: 58,710,184 (GRCm39) Q133L probably benign Het
Pald1 A T 10: 61,182,920 (GRCm39) probably benign Het
Pan2 T A 10: 128,144,944 (GRCm39) H230Q possibly damaging Het
Pcdh9 T C 14: 94,123,720 (GRCm39) I817V probably benign Het
Piezo2 A G 18: 63,153,705 (GRCm39) S2547P probably benign Het
Ppargc1b T A 18: 61,442,167 (GRCm39) probably null Het
Prdm6 T C 18: 53,597,749 (GRCm39) probably benign Het
Prr5l A T 2: 101,602,465 (GRCm39) probably benign Het
Rab3gap2 T A 1: 185,003,665 (GRCm39) L1020* probably null Het
Rhbdf1 T C 11: 32,160,543 (GRCm39) H669R probably damaging Het
Rnf150 A T 8: 83,730,234 (GRCm39) I255F probably damaging Het
Rnf17 T A 14: 56,745,325 (GRCm39) D1360E probably null Het
Sag T C 1: 87,756,197 (GRCm39) probably null Het
Scn2a C T 2: 65,501,947 (GRCm39) T90I probably benign Het
Scn9a T A 2: 66,314,955 (GRCm39) probably benign Het
Serpinb13 T C 1: 106,926,640 (GRCm39) M212T probably damaging Het
Slc39a14 C T 14: 70,544,134 (GRCm39) G484E possibly damaging Het
Slco1a1 A T 6: 141,867,669 (GRCm39) probably benign Het
Slitrk3 A T 3: 72,957,312 (GRCm39) Y487N probably damaging Het
Stkld1 T C 2: 26,836,671 (GRCm39) M279T probably benign Het
Tmem71 A G 15: 66,426,874 (GRCm39) probably benign Het
Ubxn7 T C 16: 32,188,201 (GRCm39) F142L probably damaging Het
Vmn2r22 A G 6: 123,614,963 (GRCm39) L209P probably damaging Het
Wdr73 A T 7: 80,543,508 (GRCm39) W136R probably damaging Het
Wif1 C T 10: 120,911,181 (GRCm39) R107C probably damaging Het
Ythdf2 G T 4: 131,932,885 (GRCm39) L92M probably benign Het
Zfp53 T A 17: 21,720,512 (GRCm39) I34N possibly damaging Het
Zpld2 A G 4: 133,929,291 (GRCm39) L338S probably benign Het
Other mutations in Tmem161b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00666:Tmem161b APN 13 84,442,715 (GRCm39) splice site probably benign
IGL01086:Tmem161b APN 13 84,370,541 (GRCm39) utr 5 prime probably benign
IGL01150:Tmem161b APN 13 84,440,526 (GRCm39) nonsense probably null
IGL01566:Tmem161b APN 13 84,442,881 (GRCm39) missense probably benign 0.35
IGL02481:Tmem161b APN 13 84,432,112 (GRCm39) missense probably damaging 0.99
IGL02519:Tmem161b APN 13 84,442,863 (GRCm39) missense probably damaging 1.00
IGL03207:Tmem161b APN 13 84,442,714 (GRCm39) splice site probably benign
R6836_Tmem161b_587 UTSW 13 84,370,537 (GRCm39) start gained probably benign
R0015:Tmem161b UTSW 13 84,370,533 (GRCm39) splice site probably null
R0376:Tmem161b UTSW 13 84,440,502 (GRCm39) missense probably benign 0.43
R0613:Tmem161b UTSW 13 84,399,439 (GRCm39) missense probably damaging 1.00
R1925:Tmem161b UTSW 13 84,408,348 (GRCm39) missense probably benign 0.07
R1935:Tmem161b UTSW 13 84,441,585 (GRCm39) missense probably damaging 1.00
R1936:Tmem161b UTSW 13 84,441,585 (GRCm39) missense probably damaging 1.00
R2325:Tmem161b UTSW 13 84,442,887 (GRCm39) missense possibly damaging 0.94
R2988:Tmem161b UTSW 13 84,440,574 (GRCm39) nonsense probably null
R4327:Tmem161b UTSW 13 84,399,359 (GRCm39) missense probably damaging 1.00
R4525:Tmem161b UTSW 13 84,405,921 (GRCm39) missense probably benign 0.00
R4558:Tmem161b UTSW 13 84,399,363 (GRCm39) missense possibly damaging 0.50
R5133:Tmem161b UTSW 13 84,442,887 (GRCm39) missense possibly damaging 0.94
R5134:Tmem161b UTSW 13 84,442,887 (GRCm39) missense possibly damaging 0.94
R5727:Tmem161b UTSW 13 84,434,909 (GRCm39) missense possibly damaging 0.63
R5875:Tmem161b UTSW 13 84,442,977 (GRCm39) missense probably damaging 1.00
R6217:Tmem161b UTSW 13 84,399,363 (GRCm39) missense possibly damaging 0.50
R6527:Tmem161b UTSW 13 84,420,383 (GRCm39) missense probably benign 0.06
R6550:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6551:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6553:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6554:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6640:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6641:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6685:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6836:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6837:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6838:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7077:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7078:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7386:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7388:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7429:Tmem161b UTSW 13 84,430,866 (GRCm39) critical splice acceptor site probably null
R7430:Tmem161b UTSW 13 84,430,866 (GRCm39) critical splice acceptor site probably null
R7547:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7548:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7634:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7636:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8094:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8095:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8255:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8257:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8669:Tmem161b UTSW 13 84,420,288 (GRCm39) critical splice acceptor site probably null
R9049:Tmem161b UTSW 13 84,442,754 (GRCm39) missense probably benign
R9092:Tmem161b UTSW 13 84,440,503 (GRCm39) missense possibly damaging 0.69
R9316:Tmem161b UTSW 13 84,430,855 (GRCm39) missense possibly damaging 0.84
R9326:Tmem161b UTSW 13 84,440,602 (GRCm39) nonsense probably null
Posted On 2015-04-16