Incidental Mutation 'R1826:Fasn'
| ID |
206822 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fasn
|
| Ensembl Gene |
ENSMUSG00000025153 |
| Gene Name |
fatty acid synthase |
| Synonyms |
A630082H08Rik, FAS |
| MMRRC Submission |
039853-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1826 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
120696672-120715373 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
C to T
at 120699325 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145585
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055655]
[ENSMUST00000206589]
|
| AlphaFold |
P19096 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055655
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146541
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155276
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206589
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.8%
- 10x: 95.1%
- 20x: 92.0%
|
| Validation Efficiency |
95% (116/122) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
T |
C |
19: 43,810,453 (GRCm39) |
S917P |
probably benign |
Het |
| Acsbg1 |
C |
T |
9: 54,529,840 (GRCm39) |
V256M |
possibly damaging |
Het |
| Adam34 |
T |
A |
8: 44,104,379 (GRCm39) |
D422V |
probably damaging |
Het |
| Adam6a |
T |
A |
12: 113,509,742 (GRCm39) |
V705E |
possibly damaging |
Het |
| Adamts12 |
C |
A |
15: 11,071,606 (GRCm39) |
P50Q |
probably benign |
Het |
| Arfgap3 |
C |
T |
15: 83,187,303 (GRCm39) |
|
probably null |
Het |
| Aspg |
T |
A |
12: 112,089,852 (GRCm39) |
D463E |
probably damaging |
Het |
| Atad2b |
G |
A |
12: 5,024,094 (GRCm39) |
S73N |
probably benign |
Het |
| Atp11a |
T |
C |
8: 12,896,154 (GRCm39) |
L788P |
probably damaging |
Het |
| B3gnt8 |
T |
C |
7: 25,328,188 (GRCm39) |
F206S |
probably damaging |
Het |
| Baz2b |
T |
C |
2: 59,799,077 (GRCm39) |
E349G |
probably benign |
Het |
| Bmp2k |
A |
T |
5: 97,209,261 (GRCm39) |
|
probably benign |
Het |
| Camta2 |
A |
G |
11: 70,574,134 (GRCm39) |
F128L |
probably damaging |
Het |
| Ccdc88a |
A |
T |
11: 29,439,637 (GRCm39) |
Q30L |
possibly damaging |
Het |
| Cdh1 |
T |
C |
8: 107,392,898 (GRCm39) |
M794T |
probably benign |
Het |
| Cdh5 |
A |
G |
8: 104,857,723 (GRCm39) |
N383S |
possibly damaging |
Het |
| Cep85l |
T |
C |
10: 53,224,908 (GRCm39) |
D227G |
possibly damaging |
Het |
| Clec4e |
A |
G |
6: 123,260,591 (GRCm39) |
S156P |
probably damaging |
Het |
| Col10a1 |
G |
T |
10: 34,270,645 (GRCm39) |
G206C |
probably damaging |
Het |
| Col4a2 |
T |
C |
8: 11,363,509 (GRCm39) |
|
probably null |
Het |
| Copg2 |
A |
G |
6: 30,789,777 (GRCm39) |
M517T |
probably benign |
Het |
| Cyp2f2 |
T |
A |
7: 26,831,987 (GRCm39) |
L414Q |
probably damaging |
Het |
| Dact1 |
G |
A |
12: 71,365,118 (GRCm39) |
G596D |
probably damaging |
Het |
| Dcaf13 |
T |
C |
15: 38,982,294 (GRCm39) |
C87R |
probably damaging |
Het |
| Dchs1 |
T |
G |
7: 105,406,834 (GRCm39) |
T2224P |
probably damaging |
Het |
| Dnah12 |
A |
G |
14: 26,432,174 (GRCm39) |
M429V |
probably benign |
Het |
| Dppa2 |
G |
A |
16: 48,137,711 (GRCm39) |
R231H |
probably damaging |
Het |
| Elavl4 |
T |
C |
4: 110,108,489 (GRCm39) |
D78G |
probably damaging |
Het |
| Enthd1 |
T |
C |
15: 80,358,482 (GRCm39) |
E346G |
probably damaging |
Het |
| Exoc3l |
A |
T |
8: 106,020,250 (GRCm39) |
I225N |
probably damaging |
Het |
| Fbxl7 |
G |
A |
15: 26,552,851 (GRCm39) |
R139C |
possibly damaging |
Het |
| Fbxw15 |
C |
A |
9: 109,388,782 (GRCm39) |
|
probably null |
Het |
| Flnc |
A |
G |
6: 29,455,184 (GRCm39) |
T1971A |
probably damaging |
Het |
| Fnip1 |
T |
G |
11: 54,356,990 (GRCm39) |
V33G |
probably damaging |
Het |
| Foxn2 |
A |
G |
17: 88,794,233 (GRCm39) |
E390G |
possibly damaging |
Het |
| Fry |
C |
T |
5: 150,360,174 (GRCm39) |
S1940L |
possibly damaging |
Het |
| Fzd3 |
A |
T |
14: 65,490,555 (GRCm39) |
D9E |
probably benign |
Het |
| Gabrd |
T |
C |
4: 155,470,943 (GRCm39) |
Y255C |
probably damaging |
Het |
| Garem1 |
A |
T |
18: 21,262,509 (GRCm39) |
F768L |
probably benign |
Het |
| Gas2 |
T |
A |
7: 51,593,421 (GRCm39) |
L167Q |
probably damaging |
Het |
| Gm16391 |
A |
G |
17: 76,591,418 (GRCm39) |
|
noncoding transcript |
Het |
| Gm1979 |
A |
T |
5: 26,206,240 (GRCm39) |
N113K |
probably damaging |
Het |
| Gpr83 |
G |
T |
9: 14,779,629 (GRCm39) |
C269F |
possibly damaging |
Het |
| Hdac4 |
T |
A |
1: 91,912,421 (GRCm39) |
N352Y |
probably damaging |
Het |
| Hdac9 |
A |
G |
12: 34,479,491 (GRCm39) |
|
probably benign |
Het |
| Hhipl2 |
G |
A |
1: 183,217,253 (GRCm39) |
S673N |
probably benign |
Het |
| Iffo2 |
T |
A |
4: 139,341,376 (GRCm39) |
S417T |
probably benign |
Het |
| Itgb5 |
G |
T |
16: 33,685,930 (GRCm39) |
R90L |
possibly damaging |
Het |
| Jade1 |
T |
G |
3: 41,567,648 (GRCm39) |
L572W |
probably damaging |
Het |
| Kcnh1 |
T |
A |
1: 192,095,376 (GRCm39) |
M478K |
possibly damaging |
Het |
| Kcnma1 |
C |
A |
14: 23,380,997 (GRCm39) |
D903Y |
probably damaging |
Het |
| Kcnq4 |
T |
A |
4: 120,561,701 (GRCm39) |
H456L |
probably benign |
Het |
| Kif9 |
C |
A |
9: 110,346,701 (GRCm39) |
T613K |
probably benign |
Het |
| Krt36 |
T |
G |
11: 99,993,856 (GRCm39) |
|
probably benign |
Het |
| Kyat3 |
A |
T |
3: 142,428,940 (GRCm39) |
D89V |
possibly damaging |
Het |
| Lnpep |
A |
T |
17: 17,783,098 (GRCm39) |
F568I |
probably damaging |
Het |
| Lpl |
T |
C |
8: 69,354,943 (GRCm39) |
F444L |
possibly damaging |
Het |
| Lrp1 |
A |
T |
10: 127,389,576 (GRCm39) |
V3153E |
probably damaging |
Het |
| Lrrn1 |
A |
T |
6: 107,544,529 (GRCm39) |
N109I |
probably benign |
Het |
| Ltn1 |
A |
G |
16: 87,212,504 (GRCm39) |
Y686H |
probably damaging |
Het |
| Mcoln2 |
A |
C |
3: 145,881,227 (GRCm39) |
D166A |
possibly damaging |
Het |
| Ms4a6b |
A |
T |
19: 11,501,298 (GRCm39) |
I103F |
probably damaging |
Het |
| Mtmr10 |
T |
G |
7: 63,987,214 (GRCm39) |
S585A |
probably benign |
Het |
| Mx1 |
T |
C |
16: 97,256,837 (GRCm39) |
N114S |
possibly damaging |
Het |
| Mysm1 |
A |
T |
4: 94,858,923 (GRCm39) |
N75K |
probably benign |
Het |
| Nkx1-1 |
A |
G |
5: 33,591,277 (GRCm39) |
V15A |
unknown |
Het |
| Nlrp1a |
G |
A |
11: 71,013,573 (GRCm39) |
T559I |
possibly damaging |
Het |
| Nlrp1a |
T |
A |
11: 70,998,806 (GRCm39) |
|
probably benign |
Het |
| Oas1f |
A |
G |
5: 120,993,652 (GRCm39) |
K288R |
probably benign |
Het |
| Or10q1 |
T |
A |
19: 13,726,711 (GRCm39) |
D80E |
probably benign |
Het |
| Or55b3 |
A |
G |
7: 102,126,720 (GRCm39) |
L119P |
probably damaging |
Het |
| Or9e1 |
T |
A |
11: 58,732,257 (GRCm39) |
C106S |
probably benign |
Het |
| Pcdhb2 |
T |
A |
18: 37,429,038 (GRCm39) |
V337D |
probably damaging |
Het |
| Pcdhb5 |
C |
T |
18: 37,454,522 (GRCm39) |
R301* |
probably null |
Het |
| Phf12 |
T |
C |
11: 77,915,780 (GRCm39) |
|
probably benign |
Het |
| Pik3c2a |
C |
T |
7: 115,967,352 (GRCm39) |
D862N |
probably benign |
Het |
| Pkhd1l1 |
T |
A |
15: 44,366,741 (GRCm39) |
L740I |
possibly damaging |
Het |
| Ppp1r9a |
A |
T |
6: 5,111,060 (GRCm39) |
|
probably benign |
Het |
| Prg4 |
T |
C |
1: 150,327,760 (GRCm39) |
D820G |
probably benign |
Het |
| Prmt9 |
C |
T |
8: 78,282,303 (GRCm39) |
Q67* |
probably null |
Het |
| Prob1 |
T |
C |
18: 35,786,628 (GRCm39) |
E542G |
possibly damaging |
Het |
| Pttg1 |
A |
G |
11: 43,311,193 (GRCm39) |
V188A |
probably damaging |
Het |
| Rassf1 |
T |
A |
9: 107,435,392 (GRCm39) |
L260H |
probably damaging |
Het |
| Rbm5 |
T |
A |
9: 107,619,613 (GRCm39) |
Q766L |
probably damaging |
Het |
| Rbms3 |
T |
A |
9: 116,651,936 (GRCm39) |
Y137F |
probably damaging |
Het |
| Rccd1 |
T |
C |
7: 79,969,966 (GRCm39) |
|
probably benign |
Het |
| Rnf182 |
G |
A |
13: 43,822,010 (GRCm39) |
W187* |
probably null |
Het |
| S100a11 |
A |
T |
3: 93,433,428 (GRCm39) |
I91F |
probably benign |
Het |
| Setd4 |
T |
A |
16: 93,388,187 (GRCm39) |
K100* |
probably null |
Het |
| Simc1 |
T |
A |
13: 54,672,452 (GRCm39) |
C267S |
probably benign |
Het |
| Slc16a1 |
G |
T |
3: 104,558,255 (GRCm39) |
A91S |
probably benign |
Het |
| Slc36a1 |
A |
G |
11: 55,111,279 (GRCm39) |
N133S |
probably benign |
Het |
| Ssxb16 |
T |
A |
X: 8,746,944 (GRCm39) |
Y133* |
probably null |
Het |
| Svil |
C |
T |
18: 5,063,383 (GRCm39) |
P885S |
probably benign |
Het |
| Svop |
A |
T |
5: 114,198,117 (GRCm39) |
|
probably null |
Het |
| Taar7d |
T |
C |
10: 23,903,474 (GRCm39) |
Y119H |
probably damaging |
Het |
| Tasor2 |
T |
A |
13: 3,631,759 (GRCm39) |
N914I |
probably damaging |
Het |
| Tgfb3 |
T |
C |
12: 86,108,818 (GRCm39) |
T304A |
probably benign |
Het |
| Tmem94 |
C |
A |
11: 115,684,039 (GRCm39) |
C786* |
probably null |
Het |
| Tnfrsf4 |
T |
A |
4: 156,100,736 (GRCm39) |
|
probably null |
Het |
| Tns1 |
C |
A |
1: 73,992,793 (GRCm39) |
M1I |
probably null |
Het |
| Trappc13 |
C |
T |
13: 104,306,327 (GRCm39) |
|
probably null |
Het |
| Trim72 |
T |
C |
7: 127,607,016 (GRCm39) |
F182L |
possibly damaging |
Het |
| Ttc6 |
T |
C |
12: 57,707,033 (GRCm39) |
S647P |
probably benign |
Het |
| Tulp1 |
A |
G |
17: 28,575,341 (GRCm39) |
L400P |
possibly damaging |
Het |
| Vegfc |
C |
T |
8: 54,634,347 (GRCm39) |
T342M |
possibly damaging |
Het |
| Vit |
T |
A |
17: 78,842,105 (GRCm39) |
V15E |
probably benign |
Het |
| Vps13d |
A |
T |
4: 144,881,573 (GRCm39) |
M1334K |
probably damaging |
Het |
| Zfp280d |
T |
C |
9: 72,206,062 (GRCm39) |
V23A |
probably damaging |
Het |
| Zfp608 |
A |
G |
18: 55,031,648 (GRCm39) |
I764T |
probably benign |
Het |
| Zfp94 |
T |
C |
7: 24,008,540 (GRCm39) |
Y33C |
probably damaging |
Het |
| Zfyve26 |
T |
A |
12: 79,315,823 (GRCm39) |
I1218F |
probably damaging |
Het |
|
| Other mutations in Fasn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Fasn
|
APN |
11 |
120,711,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Fasn
|
APN |
11 |
120,708,055 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01131:Fasn
|
APN |
11 |
120,705,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01603:Fasn
|
APN |
11 |
120,706,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01606:Fasn
|
APN |
11 |
120,699,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01897:Fasn
|
APN |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Fasn
|
APN |
11 |
120,710,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL01987:Fasn
|
APN |
11 |
120,708,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02103:Fasn
|
APN |
11 |
120,702,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Fasn
|
APN |
11 |
120,698,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Fasn
|
APN |
11 |
120,701,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02336:Fasn
|
APN |
11 |
120,704,562 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02417:Fasn
|
APN |
11 |
120,711,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Fasn
|
APN |
11 |
120,699,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Fasn
|
APN |
11 |
120,699,892 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02724:Fasn
|
APN |
11 |
120,700,659 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02862:Fasn
|
APN |
11 |
120,709,805 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02947:Fasn
|
APN |
11 |
120,706,502 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03025:Fasn
|
APN |
11 |
120,708,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03131:Fasn
|
APN |
11 |
120,701,550 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03157:Fasn
|
APN |
11 |
120,698,735 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03182:Fasn
|
APN |
11 |
120,703,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03370:Fasn
|
APN |
11 |
120,703,621 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB007:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
BB017:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0243:Fasn
|
UTSW |
11 |
120,706,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0304:Fasn
|
UTSW |
11 |
120,710,762 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0389:Fasn
|
UTSW |
11 |
120,707,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Fasn
|
UTSW |
11 |
120,701,894 (GRCm39) |
missense |
probably benign |
|
|
R0626:Fasn
|
UTSW |
11 |
120,702,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1037:Fasn
|
UTSW |
11 |
120,700,277 (GRCm39) |
missense |
probably benign |
|
|
R1061:Fasn
|
UTSW |
11 |
120,713,008 (GRCm39) |
splice site |
probably null |
|
|
R1109:Fasn
|
UTSW |
11 |
120,703,150 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1498:Fasn
|
UTSW |
11 |
120,706,245 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1552:Fasn
|
UTSW |
11 |
120,709,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Fasn
|
UTSW |
11 |
120,704,075 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1624:Fasn
|
UTSW |
11 |
120,703,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Fasn
|
UTSW |
11 |
120,707,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1846:Fasn
|
UTSW |
11 |
120,704,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2298:Fasn
|
UTSW |
11 |
120,704,642 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2513:Fasn
|
UTSW |
11 |
120,705,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3002:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3154:Fasn
|
UTSW |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3434:Fasn
|
UTSW |
11 |
120,713,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4794:Fasn
|
UTSW |
11 |
120,702,121 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4840:Fasn
|
UTSW |
11 |
120,703,885 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4863:Fasn
|
UTSW |
11 |
120,699,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Fasn
|
UTSW |
11 |
120,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4915:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4916:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4918:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4936:Fasn
|
UTSW |
11 |
120,706,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Fasn
|
UTSW |
11 |
120,702,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5092:Fasn
|
UTSW |
11 |
120,705,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Fasn
|
UTSW |
11 |
120,702,217 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5175:Fasn
|
UTSW |
11 |
120,707,195 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5183:Fasn
|
UTSW |
11 |
120,699,708 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5506:Fasn
|
UTSW |
11 |
120,700,336 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5557:Fasn
|
UTSW |
11 |
120,703,252 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5614:Fasn
|
UTSW |
11 |
120,704,154 (GRCm39) |
missense |
probably benign |
|
|
R5728:Fasn
|
UTSW |
11 |
120,704,339 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5838:Fasn
|
UTSW |
11 |
120,706,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5959:Fasn
|
UTSW |
11 |
120,699,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6029:Fasn
|
UTSW |
11 |
120,711,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6134:Fasn
|
UTSW |
11 |
120,713,012 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6335:Fasn
|
UTSW |
11 |
120,706,185 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6452:Fasn
|
UTSW |
11 |
120,706,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6627:Fasn
|
UTSW |
11 |
120,709,753 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6742:Fasn
|
UTSW |
11 |
120,701,279 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6767:Fasn
|
UTSW |
11 |
120,708,313 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6927:Fasn
|
UTSW |
11 |
120,699,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6976:Fasn
|
UTSW |
11 |
120,710,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Fasn
|
UTSW |
11 |
120,710,946 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7157:Fasn
|
UTSW |
11 |
120,701,291 (GRCm39) |
nonsense |
probably null |
|
|
R7373:Fasn
|
UTSW |
11 |
120,704,802 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7575:Fasn
|
UTSW |
11 |
120,703,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7652:Fasn
|
UTSW |
11 |
120,707,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Fasn
|
UTSW |
11 |
120,704,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Fasn
|
UTSW |
11 |
120,700,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7930:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R8007:Fasn
|
UTSW |
11 |
120,700,353 (GRCm39) |
missense |
probably benign |
|
|
R8012:Fasn
|
UTSW |
11 |
120,702,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Fasn
|
UTSW |
11 |
120,702,969 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8557:Fasn
|
UTSW |
11 |
120,706,610 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8711:Fasn
|
UTSW |
11 |
120,709,944 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8772:Fasn
|
UTSW |
11 |
120,711,362 (GRCm39) |
missense |
probably benign |
|
|
R8856:Fasn
|
UTSW |
11 |
120,708,979 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8875:Fasn
|
UTSW |
11 |
120,703,224 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9071:Fasn
|
UTSW |
11 |
120,708,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Fasn
|
UTSW |
11 |
120,706,496 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9238:Fasn
|
UTSW |
11 |
120,705,871 (GRCm39) |
missense |
probably benign |
|
|
R9249:Fasn
|
UTSW |
11 |
120,703,915 (GRCm39) |
missense |
probably benign |
|
|
R9345:Fasn
|
UTSW |
11 |
120,706,735 (GRCm39) |
missense |
probably benign |
0.22 |
|
X0067:Fasn
|
UTSW |
11 |
120,707,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Fasn
|
UTSW |
11 |
120,706,297 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTCCAGGCTCTTCAGTGG -3'
(R):5'- GTCCTAAGTGTTGCTACCTGTGTC -3'
Sequencing Primer
(F):5'- AGGCTCTTCAGTGGCAGCAG -3'
(R):5'- ACCTGTGTCTTGGCTTTGAATTCAC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation