Incidental Mutation 'R1915:Apc2'
| ID |
214786 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Apc2
|
| Ensembl Gene |
ENSMUSG00000020135 |
| Gene Name |
APC regulator of WNT signaling pathway 2 |
| Synonyms |
APCL |
| MMRRC Submission |
039933-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R1915 (G1)
|
| Quality Score |
168 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
80131811-80154097 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 80151701 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 2252
(I2252L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000100996
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020341]
[ENSMUST00000020349]
[ENSMUST00000105359]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020341
|
| SMART Domains |
Protein: ENSMUSP00000020341
Gene: ENSMUSG00000020133
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:UPF0449
|
6 |
103 |
7.5e-40 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020349
AA Change: I2223L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000020349
Gene: ENSMUSG00000020135
AA Change: I2223L
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:1DEB|B
|
4 |
57 |
9e-17 |
PDB |
|
Pfam:Suppressor_APC
|
123 |
205 |
1.3e-28 |
PFAM |
|
coiled coil region
|
214 |
236 |
N/A |
INTRINSIC |
|
low complexity region
|
242 |
261 |
N/A |
INTRINSIC |
|
ARM
|
300 |
355 |
2.95e0 |
SMART |
|
ARM
|
417 |
468 |
2.22e-2 |
SMART |
|
ARM
|
470 |
511 |
3.22e0 |
SMART |
|
ARM
|
513 |
555 |
3.56e-1 |
SMART |
|
ARM
|
557 |
602 |
2.1e1 |
SMART |
|
ARM
|
607 |
647 |
1.82e-7 |
SMART |
|
Blast:ARM
|
649 |
689 |
6e-18 |
BLAST |
|
low complexity region
|
772 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
817 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
859 |
870 |
N/A |
INTRINSIC |
|
low complexity region
|
971 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1103 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1134 |
1159 |
4.4e-9 |
PFAM |
|
low complexity region
|
1197 |
1208 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1244 |
1269 |
4.1e-8 |
PFAM |
|
Pfam:SAMP
|
1323 |
1343 |
2.1e-10 |
PFAM |
|
Pfam:APC_crr
|
1369 |
1394 |
5.8e-8 |
PFAM |
|
low complexity region
|
1500 |
1516 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1540 |
1565 |
5.7e-8 |
PFAM |
|
Pfam:SAMP
|
1594 |
1613 |
8.8e-11 |
PFAM |
|
low complexity region
|
1673 |
1699 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1757 |
2093 |
1.1e-142 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105359
AA Change: I2252L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000100996
Gene: ENSMUSG00000020135
AA Change: I2252L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:APC_N_CC
|
30 |
81 |
2.7e-34 |
PFAM |
|
Pfam:Suppressor_APC
|
148 |
228 |
1.4e-27 |
PFAM |
|
coiled coil region
|
238 |
260 |
N/A |
INTRINSIC |
|
low complexity region
|
266 |
285 |
N/A |
INTRINSIC |
|
ARM
|
324 |
379 |
2.95e0 |
SMART |
|
ARM
|
446 |
497 |
2.22e-2 |
SMART |
|
ARM
|
499 |
540 |
3.22e0 |
SMART |
|
ARM
|
542 |
584 |
3.56e-1 |
SMART |
|
ARM
|
586 |
631 |
2.1e1 |
SMART |
|
ARM
|
636 |
676 |
1.82e-7 |
SMART |
|
Blast:ARM
|
678 |
718 |
6e-18 |
BLAST |
|
Pfam:Arm_APC_u3
|
719 |
977 |
1.1e-26 |
PFAM |
|
low complexity region
|
1000 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1086 |
1098 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1132 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1164 |
1187 |
9.3e-8 |
PFAM |
|
low complexity region
|
1226 |
1237 |
N/A |
INTRINSIC |
|
Pfam:APC_crr
|
1274 |
1297 |
7.9e-10 |
PFAM |
|
Pfam:APC_crr
|
1399 |
1423 |
1.3e-9 |
PFAM |
|
low complexity region
|
1529 |
1545 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1603 |
N/A |
INTRINSIC |
|
Pfam:SAMP
|
1624 |
1642 |
1.3e-11 |
PFAM |
|
low complexity region
|
1702 |
1728 |
N/A |
INTRINSIC |
|
Pfam:APC_basic
|
1786 |
2122 |
1.3e-122 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.4%
|
| Validation Efficiency |
100% (85/85) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele display gradual postnatal growth retardation, abnormal lamination of the cerebral cortex, hippocampus, olfactory bulb and cerebellum, impaired neuronal migration and impaired coordination. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca6 |
T |
C |
11: 110,103,036 (GRCm39) |
R852G |
probably benign |
Het |
| Adam2 |
C |
A |
14: 66,275,006 (GRCm39) |
V576F |
possibly damaging |
Het |
| Afmid |
T |
C |
11: 117,726,625 (GRCm39) |
F250L |
possibly damaging |
Het |
| Bcar1 |
A |
G |
8: 112,442,030 (GRCm39) |
V270A |
probably damaging |
Het |
| Btnl7-ps |
T |
A |
17: 34,760,619 (GRCm39) |
|
noncoding transcript |
Het |
| Cdkn2aip |
T |
C |
8: 48,164,961 (GRCm39) |
T251A |
probably benign |
Het |
| Cdx1 |
A |
G |
18: 61,152,970 (GRCm39) |
V212A |
probably benign |
Het |
| Cep95 |
C |
T |
11: 106,705,464 (GRCm39) |
T483I |
probably damaging |
Het |
| Cfap100 |
T |
C |
6: 90,389,329 (GRCm39) |
|
probably benign |
Het |
| Cfap54 |
A |
G |
10: 92,720,564 (GRCm39) |
V2630A |
unknown |
Het |
| Chia1 |
T |
A |
3: 106,035,875 (GRCm39) |
N238K |
probably benign |
Het |
| Cldn23 |
T |
A |
8: 36,293,099 (GRCm39) |
I130F |
possibly damaging |
Het |
| Cntrl |
T |
C |
2: 35,052,873 (GRCm39) |
M1126T |
probably benign |
Het |
| Col28a1 |
A |
G |
6: 8,176,333 (GRCm39) |
F8S |
probably benign |
Het |
| Cpeb3 |
C |
T |
19: 37,031,665 (GRCm39) |
R579Q |
probably damaging |
Het |
| Creld2 |
G |
A |
15: 88,704,834 (GRCm39) |
W103* |
probably null |
Het |
| Dbh |
A |
G |
2: 27,058,234 (GRCm39) |
D134G |
probably damaging |
Het |
| Dcbld1 |
G |
T |
10: 52,193,131 (GRCm39) |
C292F |
probably damaging |
Het |
| Dlgap5 |
T |
C |
14: 47,645,230 (GRCm39) |
K304E |
probably benign |
Het |
| Dnajc2 |
A |
G |
5: 21,986,317 (GRCm39) |
|
probably null |
Het |
| Eps8l2 |
G |
A |
7: 140,941,765 (GRCm39) |
V650M |
probably damaging |
Het |
| Erlin1 |
T |
C |
19: 44,047,504 (GRCm39) |
Y139C |
probably damaging |
Het |
| Exoc3 |
A |
G |
13: 74,321,413 (GRCm39) |
|
probably null |
Het |
| F5 |
C |
A |
1: 164,010,486 (GRCm39) |
R406S |
probably damaging |
Het |
| Fahd1 |
A |
T |
17: 25,068,622 (GRCm39) |
W152R |
possibly damaging |
Het |
| Farp2 |
T |
A |
1: 93,456,424 (GRCm39) |
S36T |
probably benign |
Het |
| Foxs1 |
A |
G |
2: 152,774,760 (GRCm39) |
C98R |
probably damaging |
Het |
| Gal3st4 |
T |
A |
5: 138,263,672 (GRCm39) |
K442N |
probably benign |
Het |
| Gm10644 |
G |
A |
8: 84,660,479 (GRCm39) |
|
probably benign |
Het |
| Gm8674 |
A |
T |
13: 50,054,889 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr88 |
G |
T |
3: 116,046,073 (GRCm39) |
S79R |
possibly damaging |
Het |
| Heatr9 |
T |
G |
11: 83,409,035 (GRCm39) |
I171L |
possibly damaging |
Het |
| Hectd4 |
A |
G |
5: 121,460,357 (GRCm39) |
T2209A |
probably benign |
Het |
| Hsh2d |
A |
G |
8: 72,947,365 (GRCm39) |
T21A |
probably damaging |
Het |
| Irf4 |
A |
T |
13: 30,945,445 (GRCm39) |
Q397L |
probably benign |
Het |
| Itgae |
T |
A |
11: 73,009,469 (GRCm39) |
|
probably benign |
Het |
| Jrkl |
A |
T |
9: 13,245,609 (GRCm39) |
D17E |
possibly damaging |
Het |
| Kcna4 |
T |
C |
2: 107,127,123 (GRCm39) |
V619A |
probably benign |
Het |
| Kcnh6 |
T |
A |
11: 105,908,270 (GRCm39) |
Y295* |
probably null |
Het |
| Kif1b |
G |
A |
4: 149,351,673 (GRCm39) |
T263I |
probably damaging |
Het |
| Large2 |
G |
T |
2: 92,196,170 (GRCm39) |
|
probably benign |
Het |
| Lcp1 |
T |
A |
14: 75,436,737 (GRCm39) |
Y28N |
possibly damaging |
Het |
| Man1c1 |
G |
C |
4: 134,430,749 (GRCm39) |
P11R |
probably damaging |
Het |
| Mccc2 |
T |
C |
13: 100,085,038 (GRCm39) |
|
probably null |
Het |
| Mlh3 |
T |
C |
12: 85,308,442 (GRCm39) |
Y1115C |
probably benign |
Het |
| Mlst8 |
C |
T |
17: 24,696,264 (GRCm39) |
W155* |
probably null |
Het |
| Myh10 |
T |
C |
11: 68,681,034 (GRCm39) |
L1025P |
probably damaging |
Het |
| Myof |
T |
A |
19: 37,966,141 (GRCm39) |
N393I |
probably damaging |
Het |
| Nalcn |
C |
T |
14: 123,540,181 (GRCm39) |
V1140I |
probably benign |
Het |
| Ncald |
C |
T |
15: 37,397,324 (GRCm39) |
A119T |
probably benign |
Het |
| Nipbl |
T |
C |
15: 8,373,114 (GRCm39) |
E1044G |
possibly damaging |
Het |
| Nup58 |
T |
C |
14: 60,475,980 (GRCm39) |
K279R |
probably benign |
Het |
| Oas1a |
A |
T |
5: 121,043,876 (GRCm39) |
N85K |
possibly damaging |
Het |
| Or11g1 |
C |
T |
14: 50,651,798 (GRCm39) |
P266S |
probably damaging |
Het |
| Or8b12i |
T |
C |
9: 20,082,324 (GRCm39) |
Y181C |
probably benign |
Het |
| Or8k30 |
A |
G |
2: 86,339,343 (GRCm39) |
D180G |
probably damaging |
Het |
| Pou2f2 |
C |
T |
7: 24,799,581 (GRCm39) |
A92T |
possibly damaging |
Het |
| Ppp1r16a |
T |
C |
15: 76,577,268 (GRCm39) |
L212P |
probably damaging |
Het |
| Pram1 |
A |
T |
17: 33,860,131 (GRCm39) |
I233F |
probably benign |
Het |
| Ptbp3 |
A |
T |
4: 59,517,635 (GRCm39) |
L84Q |
probably damaging |
Het |
| Ptgr2 |
A |
T |
12: 84,349,096 (GRCm39) |
Q145L |
probably benign |
Het |
| Ptpn23 |
A |
T |
9: 110,215,575 (GRCm39) |
D1396E |
probably damaging |
Het |
| Pudp |
T |
C |
18: 50,701,278 (GRCm39) |
N152D |
probably benign |
Het |
| Rbm20 |
T |
A |
19: 53,852,518 (GRCm39) |
L1166Q |
probably damaging |
Het |
| Rictor |
T |
G |
15: 6,789,053 (GRCm39) |
I223R |
probably damaging |
Het |
| Ripor1 |
A |
T |
8: 106,343,518 (GRCm39) |
E270D |
probably damaging |
Het |
| Rorc |
T |
C |
3: 94,298,480 (GRCm39) |
C322R |
probably damaging |
Het |
| Rpgrip1l |
T |
C |
8: 91,959,552 (GRCm39) |
D1116G |
probably benign |
Het |
| Rsf1 |
GCG |
GCGACGGCGACG |
7: 97,229,114 (GRCm39) |
|
probably benign |
Het |
| Sptan1 |
C |
G |
2: 29,901,048 (GRCm39) |
Q1425E |
probably benign |
Het |
| Srd5a3 |
G |
A |
5: 76,295,552 (GRCm39) |
V81I |
probably benign |
Het |
| Stk36 |
T |
A |
1: 74,673,346 (GRCm39) |
S1080T |
probably benign |
Het |
| Sugp2 |
T |
A |
8: 70,706,310 (GRCm39) |
I790K |
probably damaging |
Het |
| Syde2 |
T |
G |
3: 145,720,071 (GRCm39) |
Y764* |
probably null |
Het |
| Tmem130 |
A |
G |
5: 144,674,666 (GRCm39) |
F353S |
probably damaging |
Het |
| Tmem131 |
T |
A |
1: 36,835,347 (GRCm39) |
K1591N |
probably damaging |
Het |
| Urb2 |
C |
A |
8: 124,756,537 (GRCm39) |
T748K |
possibly damaging |
Het |
| Uri1 |
A |
T |
7: 37,661,103 (GRCm39) |
I480K |
probably damaging |
Het |
| Zcchc3 |
A |
C |
2: 152,255,601 (GRCm39) |
V366G |
probably benign |
Het |
| Zfp292 |
G |
A |
4: 34,805,100 (GRCm39) |
S2648F |
possibly damaging |
Het |
| Zfp54 |
T |
C |
17: 21,654,414 (GRCm39) |
Y303H |
probably benign |
Het |
| Zfp729b |
A |
G |
13: 67,741,339 (GRCm39) |
F319L |
probably damaging |
Het |
| Zfp934 |
G |
A |
13: 62,665,769 (GRCm39) |
H291Y |
probably damaging |
Het |
|
| Other mutations in Apc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01069:Apc2
|
APN |
10 |
80,147,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01154:Apc2
|
APN |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01411:Apc2
|
APN |
10 |
80,150,912 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01598:Apc2
|
APN |
10 |
80,148,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01621:Apc2
|
APN |
10 |
80,142,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01720:Apc2
|
APN |
10 |
80,150,333 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01837:Apc2
|
APN |
10 |
80,150,492 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01933:Apc2
|
APN |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02243:Apc2
|
APN |
10 |
80,138,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02292:Apc2
|
APN |
10 |
80,138,258 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02956:Apc2
|
APN |
10 |
80,142,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03081:Apc2
|
APN |
10 |
80,148,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03172:Apc2
|
APN |
10 |
80,149,220 (GRCm39) |
missense |
probably damaging |
0.98 |
|
LCD18:Apc2
|
UTSW |
10 |
80,135,808 (GRCm39) |
intron |
probably benign |
|
|
R0278:Apc2
|
UTSW |
10 |
80,148,647 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0501:Apc2
|
UTSW |
10 |
80,150,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0594:Apc2
|
UTSW |
10 |
80,142,090 (GRCm39) |
nonsense |
probably null |
|
|
R0607:Apc2
|
UTSW |
10 |
80,149,935 (GRCm39) |
missense |
probably benign |
|
|
R0624:Apc2
|
UTSW |
10 |
80,150,417 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0633:Apc2
|
UTSW |
10 |
80,143,289 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0638:Apc2
|
UTSW |
10 |
80,140,801 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0647:Apc2
|
UTSW |
10 |
80,140,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0830:Apc2
|
UTSW |
10 |
80,151,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1071:Apc2
|
UTSW |
10 |
80,147,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1221:Apc2
|
UTSW |
10 |
80,142,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1432:Apc2
|
UTSW |
10 |
80,148,183 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1579:Apc2
|
UTSW |
10 |
80,147,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Apc2
|
UTSW |
10 |
80,137,676 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1700:Apc2
|
UTSW |
10 |
80,148,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Apc2
|
UTSW |
10 |
80,144,964 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Apc2
|
UTSW |
10 |
80,149,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Apc2
|
UTSW |
10 |
80,150,678 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1999:Apc2
|
UTSW |
10 |
80,144,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Apc2
|
UTSW |
10 |
80,143,443 (GRCm39) |
splice site |
probably null |
|
|
R2219:Apc2
|
UTSW |
10 |
80,144,943 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2393:Apc2
|
UTSW |
10 |
80,148,903 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3862:Apc2
|
UTSW |
10 |
80,143,393 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3900:Apc2
|
UTSW |
10 |
80,131,806 (GRCm39) |
splice site |
probably null |
|
|
R3901:Apc2
|
UTSW |
10 |
80,150,922 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3952:Apc2
|
UTSW |
10 |
80,150,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4009:Apc2
|
UTSW |
10 |
80,149,426 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4090:Apc2
|
UTSW |
10 |
80,141,378 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4695:Apc2
|
UTSW |
10 |
80,146,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Apc2
|
UTSW |
10 |
80,150,192 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4807:Apc2
|
UTSW |
10 |
80,150,196 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4886:Apc2
|
UTSW |
10 |
80,150,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4964:Apc2
|
UTSW |
10 |
80,149,841 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5056:Apc2
|
UTSW |
10 |
80,137,148 (GRCm39) |
missense |
probably benign |
|
|
R5057:Apc2
|
UTSW |
10 |
80,144,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5165:Apc2
|
UTSW |
10 |
80,151,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5241:Apc2
|
UTSW |
10 |
80,148,068 (GRCm39) |
missense |
probably benign |
|
|
R5649:Apc2
|
UTSW |
10 |
80,149,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5924:Apc2
|
UTSW |
10 |
80,147,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6124:Apc2
|
UTSW |
10 |
80,142,185 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6218:Apc2
|
UTSW |
10 |
80,142,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6376:Apc2
|
UTSW |
10 |
80,148,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6490:Apc2
|
UTSW |
10 |
80,149,757 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6572:Apc2
|
UTSW |
10 |
80,147,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Apc2
|
UTSW |
10 |
80,149,401 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7171:Apc2
|
UTSW |
10 |
80,151,170 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7180:Apc2
|
UTSW |
10 |
80,146,990 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7326:Apc2
|
UTSW |
10 |
80,147,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Apc2
|
UTSW |
10 |
80,149,316 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7378:Apc2
|
UTSW |
10 |
80,147,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7384:Apc2
|
UTSW |
10 |
80,148,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Apc2
|
UTSW |
10 |
80,138,017 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7543:Apc2
|
UTSW |
10 |
80,150,720 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7743:Apc2
|
UTSW |
10 |
80,140,749 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7759:Apc2
|
UTSW |
10 |
80,147,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8244:Apc2
|
UTSW |
10 |
80,151,166 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8327:Apc2
|
UTSW |
10 |
80,137,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8489:Apc2
|
UTSW |
10 |
80,143,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8494:Apc2
|
UTSW |
10 |
80,150,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8669:Apc2
|
UTSW |
10 |
80,149,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8773:Apc2
|
UTSW |
10 |
80,142,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8920:Apc2
|
UTSW |
10 |
80,149,934 (GRCm39) |
missense |
probably benign |
|
|
R9178:Apc2
|
UTSW |
10 |
80,150,235 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9224:Apc2
|
UTSW |
10 |
80,150,111 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9357:Apc2
|
UTSW |
10 |
80,146,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9394:Apc2
|
UTSW |
10 |
80,145,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Apc2
|
UTSW |
10 |
80,147,183 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R9689:Apc2
|
UTSW |
10 |
80,150,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0018:Apc2
|
UTSW |
10 |
80,148,098 (GRCm39) |
missense |
probably benign |
0.02 |
|
Z1177:Apc2
|
UTSW |
10 |
80,147,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGCCACTTCTAAGACCAAC -3'
(R):5'- AGCATTTAGAGAGCAGGCCC -3'
Sequencing Primer
(F):5'- TGGCCACTTCTAAGACCAACTCTAG -3'
(R):5'- AGTTCCAGATTCAGGCCTATAC -3'
|
| Posted On |
2014-07-14 |
Incidental Mutation