Incidental Mutation 'R4664:Plxna4'
| ID |
353089 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxna4
|
| Ensembl Gene |
ENSMUSG00000029765 |
| Gene Name |
plexin A4 |
| Synonyms |
Plxa4 |
| MMRRC Submission |
041922-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.600)
|
| Stock # |
R4664 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
32121478-32565127 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 32493885 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Phenylalanine
at position 244
(V244F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000110748
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000115096]
|
| AlphaFold |
Q80UG2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000115096
AA Change: V244F
PolyPhen 2
Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000110748
Gene: ENSMUSG00000029765
AA Change: V244F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Sema
|
50 |
490 |
2.3e-131 |
SMART |
|
PSI
|
508 |
558 |
2.21e-14 |
SMART |
|
PSI
|
654 |
701 |
2.44e-7 |
SMART |
|
PSI
|
802 |
855 |
1.2e-6 |
SMART |
|
IPT
|
856 |
950 |
7.25e-16 |
SMART |
|
IPT
|
952 |
1036 |
4.1e-15 |
SMART |
|
IPT
|
1038 |
1138 |
2.86e-14 |
SMART |
|
IPT
|
1140 |
1229 |
6.88e-1 |
SMART |
|
transmembrane domain
|
1237 |
1259 |
N/A |
INTRINSIC |
|
Pfam:Plexin_cytopl
|
1310 |
1863 |
1.8e-264 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150314
|
| Meta Mutation Damage Score |
0.2292 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.2%
|
| Validation Efficiency |
96% (110/115) |
| MGI Phenotype |
PHENOTYPE: Homozygous null mice exhibit defective trajecotory and projection of peripheral sensory axons and sympathetic ganglion axons and the formation of the anterior commissure and the barrels. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(2) : Targeted, knock-out(2) |
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ano2 |
A |
G |
6: 125,840,501 (GRCm39) |
I391V |
probably benign |
Het |
| Apc |
T |
A |
18: 34,431,647 (GRCm39) |
L349M |
probably damaging |
Het |
| Atmin |
A |
G |
8: 117,684,698 (GRCm39) |
D786G |
probably damaging |
Het |
| Atp8a1 |
T |
A |
5: 67,919,929 (GRCm39) |
D379V |
possibly damaging |
Het |
| Aurkb |
A |
G |
11: 68,939,435 (GRCm39) |
K173E |
probably damaging |
Het |
| Bak1 |
T |
C |
17: 27,241,510 (GRCm39) |
I83V |
possibly damaging |
Het |
| Btbd17 |
A |
C |
11: 114,684,832 (GRCm39) |
V69G |
probably damaging |
Het |
| Cacna1a |
T |
A |
8: 85,328,396 (GRCm39) |
Y1597* |
probably null |
Het |
| Camk2a |
C |
A |
18: 61,088,696 (GRCm39) |
Q167K |
possibly damaging |
Het |
| Capn1 |
A |
T |
19: 6,061,045 (GRCm39) |
N253K |
probably benign |
Het |
| Ccer2 |
A |
G |
7: 28,455,928 (GRCm39) |
E40G |
probably benign |
Het |
| Cdc42bpa |
A |
G |
1: 179,972,130 (GRCm39) |
T527A |
probably damaging |
Het |
| Cdkl2 |
T |
C |
5: 92,185,124 (GRCm39) |
D89G |
probably damaging |
Het |
| Cep128 |
G |
T |
12: 91,263,027 (GRCm39) |
R291S |
probably damaging |
Het |
| Cert1 |
T |
C |
13: 96,735,965 (GRCm39) |
V175A |
probably benign |
Het |
| Chd4 |
A |
G |
6: 125,078,465 (GRCm39) |
M203V |
possibly damaging |
Het |
| Chrna4 |
A |
G |
2: 180,679,286 (GRCm39) |
S54P |
probably damaging |
Het |
| Cic |
TGTTGCCCTC |
T |
7: 24,990,099 (GRCm39) |
|
probably benign |
Het |
| Cntn5 |
T |
A |
9: 10,144,214 (GRCm39) |
I152L |
possibly damaging |
Het |
| Cntn6 |
A |
G |
6: 104,705,245 (GRCm39) |
E154G |
probably benign |
Het |
| Col16a1 |
A |
C |
4: 129,955,883 (GRCm39) |
|
probably benign |
Het |
| Cpvl |
C |
T |
6: 53,908,918 (GRCm39) |
E282K |
probably benign |
Het |
| Cyth2 |
T |
C |
7: 45,460,143 (GRCm39) |
D183G |
probably damaging |
Het |
| Ddx47 |
A |
T |
6: 134,989,319 (GRCm39) |
T48S |
possibly damaging |
Het |
| Dgkk |
A |
G |
X: 6,794,751 (GRCm39) |
D685G |
probably benign |
Het |
| Dis3l |
C |
T |
9: 64,238,080 (GRCm39) |
S29N |
unknown |
Het |
| Dlg5 |
T |
C |
14: 24,187,249 (GRCm39) |
H1834R |
possibly damaging |
Het |
| Dnah10 |
T |
C |
5: 124,905,536 (GRCm39) |
M4060T |
possibly damaging |
Het |
| Dock3 |
T |
A |
9: 106,870,743 (GRCm39) |
N557I |
possibly damaging |
Het |
| Dync2i1 |
T |
C |
12: 116,219,831 (GRCm39) |
E37G |
probably damaging |
Het |
| Eprs1 |
A |
T |
1: 185,105,273 (GRCm39) |
|
probably benign |
Het |
| Faim2 |
C |
A |
15: 99,422,581 (GRCm39) |
|
probably null |
Het |
| Faim2 |
T |
G |
15: 99,422,582 (GRCm39) |
S72R |
probably benign |
Het |
| Fanca |
T |
C |
8: 123,995,711 (GRCm39) |
T1364A |
probably damaging |
Het |
| Fance |
T |
C |
17: 28,534,636 (GRCm39) |
|
probably benign |
Het |
| Farsb |
A |
T |
1: 78,420,402 (GRCm39) |
H496Q |
possibly damaging |
Het |
| Fryl |
C |
T |
5: 73,248,022 (GRCm39) |
E1032K |
possibly damaging |
Het |
| Galnt14 |
A |
T |
17: 73,814,808 (GRCm39) |
|
probably benign |
Het |
| Gba2 |
A |
T |
4: 43,568,619 (GRCm39) |
|
probably benign |
Het |
| Gjb4 |
C |
A |
4: 127,245,571 (GRCm39) |
K123N |
probably damaging |
Het |
| Gmcl1 |
G |
A |
6: 86,709,980 (GRCm39) |
T56I |
probably benign |
Het |
| Gtf2ird1 |
T |
A |
5: 134,412,756 (GRCm39) |
E55V |
probably damaging |
Het |
| Gtpbp2 |
T |
C |
17: 46,472,080 (GRCm39) |
V5A |
probably benign |
Het |
| Hnrnpr |
A |
G |
4: 136,044,486 (GRCm39) |
|
probably benign |
Het |
| Homer3 |
G |
A |
8: 70,742,793 (GRCm39) |
|
probably null |
Het |
| Hsd3b3 |
T |
C |
3: 98,649,532 (GRCm39) |
S264G |
probably damaging |
Het |
| Ints8 |
T |
C |
4: 11,227,152 (GRCm39) |
M574V |
probably benign |
Het |
| Kif4-ps |
G |
A |
12: 101,115,477 (GRCm39) |
|
noncoding transcript |
Het |
| Klhl14 |
A |
T |
18: 21,687,765 (GRCm39) |
N552K |
probably benign |
Het |
| Klhl40 |
A |
G |
9: 121,609,799 (GRCm39) |
E528G |
probably damaging |
Het |
| Lactb2 |
T |
C |
1: 13,717,624 (GRCm39) |
E133G |
probably damaging |
Het |
| Lratd2 |
A |
T |
15: 60,695,478 (GRCm39) |
D89E |
probably benign |
Het |
| Lrrtm2 |
T |
C |
18: 35,347,310 (GRCm39) |
|
probably null |
Het |
| Mab21l2 |
T |
A |
3: 86,454,811 (GRCm39) |
Y63F |
probably benign |
Het |
| Mbd1 |
T |
A |
18: 74,402,597 (GRCm39) |
I33N |
possibly damaging |
Het |
| Mertk |
G |
A |
2: 128,643,132 (GRCm39) |
V844M |
probably benign |
Het |
| Myh11 |
T |
C |
16: 14,044,448 (GRCm39) |
T652A |
possibly damaging |
Het |
| Nlrp4a |
C |
A |
7: 26,148,943 (GRCm39) |
Y183* |
probably null |
Het |
| Noa1 |
T |
A |
5: 77,447,600 (GRCm39) |
T558S |
probably benign |
Het |
| Nol11 |
A |
T |
11: 107,071,826 (GRCm39) |
S256T |
possibly damaging |
Het |
| Nr1d1 |
G |
T |
11: 98,662,086 (GRCm39) |
R183S |
possibly damaging |
Het |
| Nrg2 |
G |
T |
18: 36,185,948 (GRCm39) |
Q264K |
possibly damaging |
Het |
| Nsd3 |
T |
A |
8: 26,188,894 (GRCm39) |
F1027I |
probably damaging |
Het |
| Ntrk3 |
T |
A |
7: 78,110,847 (GRCm39) |
I285F |
probably damaging |
Het |
| Obox8 |
T |
C |
7: 14,066,771 (GRCm39) |
N91S |
possibly damaging |
Het |
| Oga |
T |
C |
19: 45,760,384 (GRCm39) |
E258G |
probably benign |
Het |
| Orc5 |
C |
T |
5: 22,751,520 (GRCm39) |
S63N |
probably benign |
Het |
| Osbpl6 |
C |
T |
2: 76,398,552 (GRCm39) |
T412I |
probably benign |
Het |
| P2ry14 |
C |
T |
3: 59,022,563 (GRCm39) |
C308Y |
probably damaging |
Het |
| Pacsin1 |
T |
C |
17: 27,926,038 (GRCm39) |
F127L |
probably damaging |
Het |
| Pex11b |
T |
C |
3: 96,551,151 (GRCm39) |
L198P |
possibly damaging |
Het |
| Pla2g4e |
A |
T |
2: 120,001,669 (GRCm39) |
V660E |
probably damaging |
Het |
| Polr3b |
A |
G |
10: 84,550,233 (GRCm39) |
Y981C |
probably damaging |
Het |
| Popdc2 |
T |
A |
16: 38,194,649 (GRCm39) |
S357T |
probably damaging |
Het |
| Prr29 |
A |
G |
11: 106,267,159 (GRCm39) |
H58R |
probably damaging |
Het |
| Pyy |
T |
A |
11: 101,998,178 (GRCm39) |
M1L |
possibly damaging |
Het |
| Rasd2 |
T |
C |
8: 75,948,556 (GRCm39) |
S161P |
possibly damaging |
Het |
| Ryr3 |
C |
T |
2: 112,826,900 (GRCm39) |
|
probably benign |
Het |
| Sectm1a |
G |
A |
11: 120,960,552 (GRCm39) |
R88C |
possibly damaging |
Het |
| Serpinb13 |
C |
T |
1: 106,910,574 (GRCm39) |
S66L |
probably damaging |
Het |
| Siglecf |
A |
T |
7: 43,005,837 (GRCm39) |
I465F |
possibly damaging |
Het |
| Sorl1 |
A |
T |
9: 41,915,347 (GRCm39) |
M1294K |
probably damaging |
Het |
| Spam1 |
A |
T |
6: 24,796,661 (GRCm39) |
H204L |
probably benign |
Het |
| Sspo |
A |
T |
6: 48,450,468 (GRCm39) |
N2586Y |
possibly damaging |
Het |
| Tbc1d4 |
A |
G |
14: 101,700,263 (GRCm39) |
|
probably benign |
Het |
| Tceanc2 |
A |
T |
4: 107,022,757 (GRCm39) |
S77T |
probably damaging |
Het |
| Tedc2 |
A |
G |
17: 24,439,114 (GRCm39) |
|
probably benign |
Het |
| Tgm6 |
A |
G |
2: 129,979,314 (GRCm39) |
D148G |
probably benign |
Het |
| Tgm6 |
A |
T |
2: 129,983,128 (GRCm39) |
Q239L |
probably benign |
Het |
| Thsd7a |
T |
A |
6: 12,337,313 (GRCm39) |
T1235S |
possibly damaging |
Het |
| Thsd7a |
T |
A |
6: 12,504,012 (GRCm39) |
I381F |
possibly damaging |
Het |
| Tmc4 |
T |
C |
7: 3,674,270 (GRCm39) |
|
probably null |
Het |
| Tmem54 |
A |
T |
4: 129,004,704 (GRCm39) |
E186D |
possibly damaging |
Het |
| Tpk1 |
A |
T |
6: 43,588,269 (GRCm39) |
F32I |
probably benign |
Het |
| Trpc4ap |
A |
G |
2: 155,514,917 (GRCm39) |
I97T |
probably benign |
Het |
| Tut7 |
G |
A |
13: 59,948,413 (GRCm39) |
T636I |
possibly damaging |
Het |
| Txlnb |
A |
G |
10: 17,718,942 (GRCm39) |
E591G |
probably damaging |
Het |
| Tyk2 |
C |
T |
9: 21,025,503 (GRCm39) |
A741T |
probably damaging |
Het |
| Ubr4 |
G |
A |
4: 139,133,829 (GRCm39) |
E742K |
possibly damaging |
Het |
| Uckl1 |
A |
T |
2: 181,216,661 (GRCm39) |
S95T |
possibly damaging |
Het |
| Uevld |
T |
A |
7: 46,587,734 (GRCm39) |
D322V |
probably damaging |
Het |
| Ugt1a1 |
CAGAGAGAGAGAGA |
CAGAGAGAGAGA |
1: 88,139,706 (GRCm39) |
|
probably benign |
Het |
| Vmn1r238 |
G |
T |
18: 3,123,300 (GRCm39) |
T38K |
probably damaging |
Het |
| Vps8 |
T |
A |
16: 21,262,938 (GRCm39) |
|
probably null |
Het |
| Wdr83 |
T |
C |
8: 85,806,680 (GRCm39) |
|
probably benign |
Het |
| Zfp619 |
A |
G |
7: 39,183,559 (GRCm39) |
T51A |
probably benign |
Het |
|
| Other mutations in Plxna4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00429:Plxna4
|
APN |
6 |
32,139,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01395:Plxna4
|
APN |
6 |
32,216,368 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01506:Plxna4
|
APN |
6 |
32,493,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01606:Plxna4
|
APN |
6 |
32,134,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Plxna4
|
APN |
6 |
32,287,413 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01767:Plxna4
|
APN |
6 |
32,214,613 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL01968:Plxna4
|
APN |
6 |
32,192,139 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02109:Plxna4
|
APN |
6 |
32,192,576 (GRCm39) |
missense |
probably benign |
|
|
IGL02299:Plxna4
|
APN |
6 |
32,142,091 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02306:Plxna4
|
APN |
6 |
32,183,059 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02312:Plxna4
|
APN |
6 |
32,142,052 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02326:Plxna4
|
APN |
6 |
32,129,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02658:Plxna4
|
APN |
6 |
32,162,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02683:Plxna4
|
APN |
6 |
32,494,541 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02701:Plxna4
|
APN |
6 |
32,494,494 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02995:Plxna4
|
APN |
6 |
32,493,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03030:Plxna4
|
APN |
6 |
32,179,160 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03264:Plxna4
|
APN |
6 |
32,155,337 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL03304:Plxna4
|
APN |
6 |
32,141,986 (GRCm39) |
splice site |
probably benign |
|
|
IGL03382:Plxna4
|
APN |
6 |
32,179,129 (GRCm39) |
missense |
probably benign |
0.23 |
|
corona
|
UTSW |
6 |
32,494,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Disposed
|
UTSW |
6 |
32,493,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
inclined
|
UTSW |
6 |
32,214,658 (GRCm39) |
nonsense |
probably null |
|
|
Slope
|
UTSW |
6 |
32,211,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
G4846:Plxna4
|
UTSW |
6 |
32,169,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0133:Plxna4
|
UTSW |
6 |
32,174,009 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0200:Plxna4
|
UTSW |
6 |
32,174,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0308:Plxna4
|
UTSW |
6 |
32,214,703 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0468:Plxna4
|
UTSW |
6 |
32,192,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Plxna4
|
UTSW |
6 |
32,179,054 (GRCm39) |
missense |
probably benign |
|
|
R0542:Plxna4
|
UTSW |
6 |
32,169,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0548:Plxna4
|
UTSW |
6 |
32,134,950 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Plxna4
|
UTSW |
6 |
32,162,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1144:Plxna4
|
UTSW |
6 |
32,174,091 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1190:Plxna4
|
UTSW |
6 |
32,228,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1228:Plxna4
|
UTSW |
6 |
32,201,087 (GRCm39) |
splice site |
probably null |
|
|
R1569:Plxna4
|
UTSW |
6 |
32,162,410 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1803:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1832:Plxna4
|
UTSW |
6 |
32,174,761 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2068:Plxna4
|
UTSW |
6 |
32,494,551 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2157:Plxna4
|
UTSW |
6 |
32,493,909 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2842:Plxna4
|
UTSW |
6 |
32,192,566 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2849:Plxna4
|
UTSW |
6 |
32,162,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2892:Plxna4
|
UTSW |
6 |
32,493,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2930:Plxna4
|
UTSW |
6 |
32,142,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3892:Plxna4
|
UTSW |
6 |
32,192,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4065:Plxna4
|
UTSW |
6 |
32,213,300 (GRCm39) |
nonsense |
probably null |
|
|
R4276:Plxna4
|
UTSW |
6 |
32,177,883 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4307:Plxna4
|
UTSW |
6 |
32,140,444 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4331:Plxna4
|
UTSW |
6 |
32,127,480 (GRCm39) |
nonsense |
probably null |
|
|
R4478:Plxna4
|
UTSW |
6 |
32,173,068 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4529:Plxna4
|
UTSW |
6 |
32,473,831 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4566:Plxna4
|
UTSW |
6 |
32,494,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4568:Plxna4
|
UTSW |
6 |
32,129,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4685:Plxna4
|
UTSW |
6 |
32,142,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Plxna4
|
UTSW |
6 |
32,493,623 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4939:Plxna4
|
UTSW |
6 |
32,142,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5153:Plxna4
|
UTSW |
6 |
32,201,094 (GRCm39) |
splice site |
probably null |
|
|
R5181:Plxna4
|
UTSW |
6 |
32,493,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Plxna4
|
UTSW |
6 |
32,228,007 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5259:Plxna4
|
UTSW |
6 |
32,493,956 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5306:Plxna4
|
UTSW |
6 |
32,183,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5487:Plxna4
|
UTSW |
6 |
32,494,218 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Plxna4
|
UTSW |
6 |
32,155,293 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5542:Plxna4
|
UTSW |
6 |
32,183,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5567:Plxna4
|
UTSW |
6 |
32,134,915 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5634:Plxna4
|
UTSW |
6 |
32,214,658 (GRCm39) |
nonsense |
probably null |
|
|
R5653:Plxna4
|
UTSW |
6 |
32,494,551 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5665:Plxna4
|
UTSW |
6 |
32,192,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5845:Plxna4
|
UTSW |
6 |
32,214,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Plxna4
|
UTSW |
6 |
32,494,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5938:Plxna4
|
UTSW |
6 |
32,211,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5973:Plxna4
|
UTSW |
6 |
32,228,000 (GRCm39) |
splice site |
probably null |
|
|
R6433:Plxna4
|
UTSW |
6 |
32,192,613 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6482:Plxna4
|
UTSW |
6 |
32,493,672 (GRCm39) |
missense |
probably benign |
|
|
R6560:Plxna4
|
UTSW |
6 |
32,192,613 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6721:Plxna4
|
UTSW |
6 |
32,177,794 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6810:Plxna4
|
UTSW |
6 |
32,287,457 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6985:Plxna4
|
UTSW |
6 |
32,214,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7024:Plxna4
|
UTSW |
6 |
32,169,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7046:Plxna4
|
UTSW |
6 |
32,493,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7137:Plxna4
|
UTSW |
6 |
32,494,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7163:Plxna4
|
UTSW |
6 |
32,473,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7199:Plxna4
|
UTSW |
6 |
32,192,113 (GRCm39) |
nonsense |
probably null |
|
|
R7248:Plxna4
|
UTSW |
6 |
32,139,095 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7260:Plxna4
|
UTSW |
6 |
32,216,455 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7361:Plxna4
|
UTSW |
6 |
32,173,057 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7383:Plxna4
|
UTSW |
6 |
32,129,734 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7405:Plxna4
|
UTSW |
6 |
32,173,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7516:Plxna4
|
UTSW |
6 |
32,214,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7635:Plxna4
|
UTSW |
6 |
32,473,676 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7754:Plxna4
|
UTSW |
6 |
32,129,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7763:Plxna4
|
UTSW |
6 |
32,200,915 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7789:Plxna4
|
UTSW |
6 |
32,183,168 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8167:Plxna4
|
UTSW |
6 |
32,493,981 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8191:Plxna4
|
UTSW |
6 |
32,493,885 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8225:Plxna4
|
UTSW |
6 |
32,139,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8284:Plxna4
|
UTSW |
6 |
32,129,789 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8305:Plxna4
|
UTSW |
6 |
32,188,000 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8438:Plxna4
|
UTSW |
6 |
32,179,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8493:Plxna4
|
UTSW |
6 |
32,192,647 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8714:Plxna4
|
UTSW |
6 |
32,140,379 (GRCm39) |
nonsense |
probably null |
|
|
R8759:Plxna4
|
UTSW |
6 |
32,169,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8822:Plxna4
|
UTSW |
6 |
32,127,431 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8844:Plxna4
|
UTSW |
6 |
32,174,026 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8974:Plxna4
|
UTSW |
6 |
32,216,447 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9020:Plxna4
|
UTSW |
6 |
32,211,497 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9144:Plxna4
|
UTSW |
6 |
32,162,496 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9206:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9208:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9257:Plxna4
|
UTSW |
6 |
32,139,018 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9269:Plxna4
|
UTSW |
6 |
32,155,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Plxna4
|
UTSW |
6 |
32,159,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9469:Plxna4
|
UTSW |
6 |
32,494,526 (GRCm39) |
missense |
probably benign |
|
|
R9583:Plxna4
|
UTSW |
6 |
32,192,169 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9647:Plxna4
|
UTSW |
6 |
32,228,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9695:Plxna4
|
UTSW |
6 |
32,183,056 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9801:Plxna4
|
UTSW |
6 |
32,140,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
V1024:Plxna4
|
UTSW |
6 |
32,211,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Plxna4
|
UTSW |
6 |
32,493,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACCAGCTTTAGACAAGTAGGC -3'
(R):5'- CACAGCAGTGGATGGCAAAC -3'
Sequencing Primer
(F):5'- CTTTAGACAAGTAGGCAGCCTGTAAC -3'
(R):5'- GTGGATGGCAAACCTGAATATTTTCC -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation