Mutagenetix > Incidental Mutation

Incidental Mutation 'R5539:Gm5422'

435831

Institutional Source

Beutler Lab

Gene Symbol

Gm5422

Ensembl Gene

ENSMUSG00000039684

Gene Name

predicted pseudogene 5422

Synonyms

MMRRC Submission

043097-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.915) question?

Stock #

R5539 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

31124133-31127039 bp(+) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

A to G at 31124646 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000050717

SMART Domains

Protein: ENSMUSP00000135967
Gene: ENSMUSG00000039684

Domain	Start	End	E-Value	Type
low complexity region	44	61	N/A	INTRINSIC
Pfam:PC_rep	438	474	6.8e-9	PFAM
Pfam:PC_rep	475	509	1.1e-8	PFAM
SCOP:d1gw5a_	603	760	4e-4	SMART
PDB:4CR4\|Z	648	901	1e-50	PDB

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216161

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 96.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310034C09Rik	A	T	16: 88,555,917 (GRCm39)	S44C	probably damaging	Het
Abca4	A	G	3: 121,963,557 (GRCm39)	I846V	probably damaging	Het
Aldh4a1	T	C	4: 139,365,833 (GRCm39)	S275P	probably benign	Het
Arhgap12	A	T	18: 6,111,932 (GRCm39)	L144H	probably benign	Het
Ccdc141	A	T	2: 76,845,437 (GRCm39)	I1210N	probably damaging	Het
Ccdc175	T	C	12: 72,191,587 (GRCm39)	T330A	probably benign	Het
Cybb	C	G	X: 9,316,989 (GRCm39)	D246H	probably benign	Het
Dnah17	T	C	11: 117,964,486 (GRCm39)	K2444E	probably benign	Het
Dnajc3	G	A	14: 119,208,159 (GRCm39)	V265M	probably damaging	Het
Flg2	T	A	3: 93,127,753 (GRCm39)	Y2222N	unknown	Het
Flnc	G	T	6: 29,446,229 (GRCm39)	G882V	probably damaging	Het
Fndc5	T	A	4: 129,032,514 (GRCm39)	V39D	probably damaging	Het
Gabrr3	A	T	16: 59,281,758 (GRCm39)	H371L	probably benign	Het
Gm10717	A	T	9: 3,030,438 (GRCm39)	H33L	probably damaging	Het
Kri1	G	A	9: 21,190,668 (GRCm39)	Q280*	probably null	Het
Lcp1	T	C	14: 75,466,738 (GRCm39)	V615A	probably benign	Het
Ltbp4	T	C	7: 27,027,149 (GRCm39)	Y407C	probably damaging	Het
Med30	G	T	15: 52,584,462 (GRCm39)	D127Y	probably damaging	Het
Mybpc2	A	G	7: 44,164,317 (GRCm39)	V416A	probably benign	Het
Notch2	C	T	3: 98,044,898 (GRCm39)	R1607C	probably damaging	Het
Nr4a3	T	A	4: 48,056,525 (GRCm39)		probably null	Het
Ntf5	G	T	7: 45,065,354 (GRCm39)	R162L	probably benign	Het
Nxpe3	A	G	16: 55,711,034 (GRCm39)	W2R	possibly damaging	Het
Or10d1c	T	C	9: 38,893,573 (GRCm39)	I256V	possibly damaging	Het
Or14j4	T	A	17: 37,921,646 (GRCm39)	M1L	probably benign	Het
Or1m1	G	A	9: 18,666,134 (GRCm39)	R266C	probably damaging	Het
Or5p58	A	T	7: 107,694,433 (GRCm39)	C115S	probably benign	Het
Pan2	C	A	10: 128,144,002 (GRCm39)	D99E	probably benign	Het
Pcdh12	T	C	18: 38,414,797 (GRCm39)	H776R	possibly damaging	Het
Prdm2	T	C	4: 142,859,264 (GRCm39)	H1342R	possibly damaging	Het
Prpf8	A	G	11: 75,394,464 (GRCm39)	T1800A	probably benign	Het
Prss40	T	C	1: 34,591,760 (GRCm39)	*148W	probably null	Het
Pygo1	C	T	9: 72,852,061 (GRCm39)	P83S	probably damaging	Het
Raf1	G	T	6: 115,596,317 (GRCm39)	S619R	probably damaging	Het
Rtf1	A	G	2: 119,560,405 (GRCm39)	M596V	possibly damaging	Het
Slc12a5	T	A	2: 164,829,126 (GRCm39)	D578E	possibly damaging	Het
Slc35b4	A	G	6: 34,153,737 (GRCm39)	V18A	probably damaging	Het
Spata31	T	A	13: 65,070,783 (GRCm39)	I977K	probably benign	Het
Tor2a	T	C	2: 32,650,672 (GRCm39)	I222T	probably damaging	Het
Trim23	T	C	13: 104,334,541 (GRCm39)	V347A	probably damaging	Het
Trip11	A	G	12: 101,851,386 (GRCm39)	S893P	probably damaging	Het
Trmt10c	G	A	16: 55,855,324 (GRCm39)	P104S	probably damaging	Het
Ubr3	A	T	2: 69,850,877 (GRCm39)	Y1765F	probably damaging	Het
Zfp951	C	T	5: 104,962,712 (GRCm39)	E285K	probably damaging	Het

Other mutations in Gm5422

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL01306:Gm5422	APN	10	31,125,432 (GRCm39)	exon	noncoding transcript
IGL01569:Gm5422	APN	10	31,125,897 (GRCm39)	exon	noncoding transcript
IGL01645:Gm5422	APN	10	31,126,069 (GRCm39)	exon	noncoding transcript
IGL02273:Gm5422	APN	10	31,126,003 (GRCm39)	exon	noncoding transcript
IGL02603:Gm5422	APN	10	31,125,436 (GRCm39)	exon	noncoding transcript
IGL02928:Gm5422	APN	10	31,126,250 (GRCm39)	exon	noncoding transcript
IGL03003:Gm5422	APN	10	31,126,840 (GRCm39)	exon	noncoding transcript
IGL03274:Gm5422	APN	10	31,126,348 (GRCm39)	exon	noncoding transcript
IGL03297:Gm5422	APN	10	31,125,727 (GRCm39)	exon	noncoding transcript
ANU23:Gm5422	UTSW	10	31,125,432 (GRCm39)	exon	noncoding transcript
R0010:Gm5422	UTSW	10	31,125,750 (GRCm39)	exon	noncoding transcript
R0506:Gm5422	UTSW	10	31,126,318 (GRCm39)	exon	noncoding transcript
R0560:Gm5422	UTSW	10	31,125,240 (GRCm39)	exon	noncoding transcript
R0573:Gm5422	UTSW	10	31,126,156 (GRCm39)	exon	noncoding transcript
R0652:Gm5422	UTSW	10	31,125,277 (GRCm39)	exon	noncoding transcript
R1210:Gm5422	UTSW	10	31,126,719 (GRCm39)	intron	noncoding transcript
R1259:Gm5422	UTSW	10	31,125,111 (GRCm39)	exon	noncoding transcript
R1352:Gm5422	UTSW	10	31,126,731 (GRCm39)	intron	noncoding transcript
R1631:Gm5422	UTSW	10	31,125,802 (GRCm39)	exon	noncoding transcript
R1707:Gm5422	UTSW	10	31,124,458 (GRCm39)	exon	noncoding transcript
R1893:Gm5422	UTSW	10	31,125,609 (GRCm39)	exon	noncoding transcript
R2011:Gm5422	UTSW	10	31,124,764 (GRCm39)	exon	noncoding transcript
R2132:Gm5422	UTSW	10	31,124,929 (GRCm39)	exon	noncoding transcript
R3427:Gm5422	UTSW	10	31,124,842 (GRCm39)	exon	noncoding transcript
R3772:Gm5422	UTSW	10	31,124,510 (GRCm39)	exon	noncoding transcript
R4703:Gm5422	UTSW	10	31,125,608 (GRCm39)	exon	noncoding transcript
R5603:Gm5422	UTSW	10	31,126,840 (GRCm39)	exon	noncoding transcript
R5660:Gm5422	UTSW	10	31,126,048 (GRCm39)	exon	noncoding transcript
R6124:Gm5422	UTSW	10	31,125,396 (GRCm39)	exon	noncoding transcript
R6178:Gm5422	UTSW	10	31,125,688 (GRCm39)	exon	noncoding transcript
R8263:Gm5422	UTSW	10	31,125,099 (GRCm39)	missense	noncoding transcript

Predicted Primers

Posted On

2016-10-24