Incidental Mutation 'R5933:Slit3'
| ID |
462032 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Slit3
|
| Ensembl Gene |
ENSMUSG00000056427 |
| Gene Name |
slit guidance ligand 3 |
| Synonyms |
Slit1, b2b2362.1Clo |
| MMRRC Submission |
044127-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.871)
|
| Stock # |
R5933 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
35012283-35599334 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 35520578 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 572
(V572M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000066857
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069837]
|
| AlphaFold |
Q9WVB4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000069837
AA Change: V572M
PolyPhen 2
Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000066857
Gene: ENSMUSG00000056427
AA Change: V572M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
23 |
N/A |
INTRINSIC |
|
LRRNT
|
33 |
65 |
2.12e-8 |
SMART |
|
LRR
|
59 |
83 |
1.37e2 |
SMART |
|
LRR_TYP
|
84 |
107 |
1.12e-3 |
SMART |
|
LRR_TYP
|
108 |
131 |
7.78e-3 |
SMART |
|
LRR_TYP
|
132 |
155 |
5.42e-2 |
SMART |
|
LRR
|
156 |
179 |
5.88e0 |
SMART |
|
LRR
|
180 |
203 |
7.55e-1 |
SMART |
|
LRRCT
|
215 |
264 |
1.33e-6 |
SMART |
|
LRRNT
|
279 |
311 |
6.79e-7 |
SMART |
|
LRR
|
305 |
329 |
1.16e2 |
SMART |
|
LRR
|
330 |
353 |
1.26e1 |
SMART |
|
LRR_TYP
|
354 |
377 |
2.79e-4 |
SMART |
|
LRR
|
378 |
401 |
4.05e-1 |
SMART |
|
LRR
|
402 |
425 |
4.05e-1 |
SMART |
|
LRRCT
|
437 |
486 |
7.75e-8 |
SMART |
|
LRRNT
|
504 |
536 |
1.95e-7 |
SMART |
|
LRR_TYP
|
556 |
579 |
7.49e-5 |
SMART |
|
LRR
|
581 |
603 |
6.41e1 |
SMART |
|
LRR_TYP
|
604 |
627 |
2.53e-2 |
SMART |
|
LRR
|
628 |
651 |
1.76e-1 |
SMART |
|
LRRCT
|
663 |
712 |
2.52e-7 |
SMART |
|
LRRNT
|
724 |
756 |
3e-8 |
SMART |
|
LRR
|
774 |
797 |
2.14e0 |
SMART |
|
LRR_TYP
|
798 |
821 |
2.95e-3 |
SMART |
|
LRR_TYP
|
822 |
845 |
2.43e-4 |
SMART |
|
LRRCT
|
857 |
906 |
1.12e-13 |
SMART |
|
EGF
|
919 |
953 |
6.86e-4 |
SMART |
|
EGF
|
958 |
994 |
8.84e-7 |
SMART |
|
EGF
|
999 |
1032 |
1.13e-4 |
SMART |
|
EGF
|
1037 |
1072 |
2.3e-5 |
SMART |
|
EGF_CA
|
1074 |
1110 |
5.92e-8 |
SMART |
|
EGF
|
1122 |
1155 |
3.79e-6 |
SMART |
|
LamG
|
1178 |
1314 |
3.16e-34 |
SMART |
|
EGF
|
1331 |
1365 |
2.19e-2 |
SMART |
|
EGF
|
1371 |
1403 |
1.13e-4 |
SMART |
|
EGF
|
1411 |
1444 |
5.57e-4 |
SMART |
|
CT
|
1455 |
1523 |
4.56e-5 |
SMART |
|
| Meta Mutation Damage Score |
0.0905 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 95.1%
|
| Validation Efficiency |
94% (99/105) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
C |
T |
3: 137,776,109 (GRCm39) |
P1766L |
probably damaging |
Het |
| Abca13 |
A |
G |
11: 9,199,658 (GRCm39) |
Q119R |
possibly damaging |
Het |
| Acot11 |
C |
T |
4: 106,617,327 (GRCm39) |
G240R |
probably damaging |
Het |
| Aipl1 |
A |
C |
11: 71,921,108 (GRCm39) |
C237G |
probably benign |
Het |
| Ankdd1a |
C |
T |
9: 65,416,978 (GRCm39) |
A154T |
probably benign |
Het |
| Arglu1 |
T |
C |
8: 8,740,047 (GRCm39) |
S91G |
probably benign |
Het |
| Arhgef33 |
C |
A |
17: 80,644,709 (GRCm39) |
H13N |
probably benign |
Het |
| Atp1a4 |
A |
G |
1: 172,059,841 (GRCm39) |
I796T |
possibly damaging |
Het |
| Birc6 |
C |
G |
17: 74,906,232 (GRCm39) |
S1374R |
probably damaging |
Het |
| Birc6 |
T |
A |
17: 74,906,233 (GRCm39) |
S72T |
probably damaging |
Het |
| Bmpr1b |
T |
C |
3: 141,577,128 (GRCm39) |
*59W |
probably null |
Het |
| Btbd16 |
A |
T |
7: 130,386,011 (GRCm39) |
Q63L |
probably damaging |
Het |
| Cacna1c |
C |
T |
6: 118,589,541 (GRCm39) |
R1592H |
probably damaging |
Het |
| Caps2 |
G |
A |
10: 112,051,351 (GRCm39) |
E541K |
probably benign |
Het |
| Card9 |
T |
C |
2: 26,242,509 (GRCm39) |
E500G |
probably damaging |
Het |
| Carnmt1 |
T |
C |
19: 18,681,469 (GRCm39) |
V396A |
probably benign |
Het |
| Ccnl1 |
T |
A |
3: 65,855,763 (GRCm39) |
K320M |
probably damaging |
Het |
| Cdh20 |
A |
C |
1: 104,912,396 (GRCm39) |
D550A |
probably damaging |
Het |
| Cdhr1 |
T |
A |
14: 36,811,419 (GRCm39) |
T231S |
probably benign |
Het |
| Cenpe |
T |
C |
3: 134,967,389 (GRCm39) |
V2177A |
probably benign |
Het |
| Cfap69 |
A |
G |
5: 5,690,183 (GRCm39) |
C161R |
probably damaging |
Het |
| Ctsd |
C |
T |
7: 141,930,316 (GRCm39) |
V403I |
probably benign |
Het |
| Cyth1 |
C |
T |
11: 118,076,585 (GRCm39) |
|
probably null |
Het |
| Dazl |
A |
T |
17: 50,594,781 (GRCm39) |
|
probably null |
Het |
| Disp3 |
A |
T |
4: 148,325,770 (GRCm39) |
C1329* |
probably null |
Het |
| Dld |
C |
T |
12: 31,383,982 (GRCm39) |
V374I |
probably benign |
Het |
| Dnah7c |
T |
C |
1: 46,558,375 (GRCm39) |
Y494H |
probably damaging |
Het |
| Dnttip2 |
T |
A |
3: 122,069,217 (GRCm39) |
M144K |
probably benign |
Het |
| Drc1 |
A |
T |
5: 30,502,873 (GRCm39) |
D132V |
probably damaging |
Het |
| Enpp6 |
A |
G |
8: 47,519,039 (GRCm39) |
D269G |
probably benign |
Het |
| Ephx4 |
T |
A |
5: 107,551,631 (GRCm39) |
|
probably null |
Het |
| Evl |
T |
C |
12: 108,649,516 (GRCm39) |
S345P |
possibly damaging |
Het |
| Fam193a |
A |
T |
5: 34,623,024 (GRCm39) |
D1204V |
probably damaging |
Het |
| Fat2 |
A |
T |
11: 55,174,877 (GRCm39) |
D1945E |
probably damaging |
Het |
| Fat4 |
T |
C |
3: 39,005,524 (GRCm39) |
|
probably null |
Het |
| Fbln7 |
A |
T |
2: 128,719,418 (GRCm39) |
M72L |
probably benign |
Het |
| Flnc |
T |
C |
6: 29,441,105 (GRCm39) |
V353A |
probably damaging |
Het |
| Fry |
T |
C |
5: 150,314,265 (GRCm39) |
|
probably benign |
Het |
| Galnt14 |
A |
T |
17: 73,833,300 (GRCm39) |
C225S |
probably benign |
Het |
| Gapvd1 |
T |
C |
2: 34,574,303 (GRCm39) |
S1265G |
probably benign |
Het |
| Gm13030 |
A |
G |
4: 138,598,515 (GRCm39) |
F136S |
unknown |
Het |
| Gucy1a1 |
T |
C |
3: 82,002,114 (GRCm39) |
H655R |
probably damaging |
Het |
| Hk1 |
A |
G |
10: 62,105,773 (GRCm39) |
L890P |
probably damaging |
Het |
| Igfn1 |
T |
A |
1: 135,898,341 (GRCm39) |
R742* |
probably null |
Het |
| Igkv12-49 |
T |
C |
6: 69,693,553 (GRCm39) |
|
noncoding transcript |
Het |
| Igkv2-109 |
T |
A |
6: 68,279,965 (GRCm39) |
L62Q |
possibly damaging |
Het |
| Itgb3 |
A |
G |
11: 104,528,805 (GRCm39) |
T311A |
possibly damaging |
Het |
| Kl |
A |
G |
5: 150,912,948 (GRCm39) |
E899G |
probably damaging |
Het |
| Kyat3 |
A |
T |
3: 142,429,021 (GRCm39) |
D151V |
probably damaging |
Het |
| Morc2b |
A |
T |
17: 33,357,583 (GRCm39) |
M63K |
possibly damaging |
Het |
| Mtbp |
T |
A |
15: 55,434,723 (GRCm39) |
F298L |
possibly damaging |
Het |
| Mtmr3 |
C |
T |
11: 4,448,951 (GRCm39) |
V272I |
probably benign |
Het |
| Muc4 |
A |
G |
16: 32,574,480 (GRCm39) |
T977A |
probably benign |
Het |
| Nebl |
G |
A |
2: 17,408,998 (GRCm39) |
H367Y |
probably benign |
Het |
| Nop58 |
T |
A |
1: 59,743,824 (GRCm39) |
Y274* |
probably null |
Het |
| Nuak1 |
T |
A |
10: 84,210,666 (GRCm39) |
Q474L |
probably damaging |
Het |
| Obscn |
A |
G |
11: 58,889,331 (GRCm39) |
S7523P |
unknown |
Het |
| Oosp3 |
T |
A |
19: 11,682,753 (GRCm39) |
D140E |
probably benign |
Het |
| Or52z15 |
T |
A |
7: 103,332,680 (GRCm39) |
C242S |
probably damaging |
Het |
| Padi2 |
G |
A |
4: 140,644,952 (GRCm39) |
R62H |
probably benign |
Het |
| Patl1 |
A |
G |
19: 11,917,136 (GRCm39) |
N661S |
probably benign |
Het |
| Pcyox1l |
G |
T |
18: 61,831,544 (GRCm39) |
N238K |
probably benign |
Het |
| Pmch |
A |
G |
10: 87,927,011 (GRCm39) |
T5A |
probably benign |
Het |
| Polr3h |
A |
G |
15: 81,800,835 (GRCm39) |
L169P |
probably damaging |
Het |
| Ptpn4 |
A |
G |
1: 119,615,453 (GRCm39) |
V567A |
probably damaging |
Het |
| Rasgrp2 |
T |
G |
19: 6,452,543 (GRCm39) |
F39V |
probably damaging |
Het |
| Setd1b |
G |
A |
5: 123,296,815 (GRCm39) |
|
probably benign |
Het |
| Sh3glb2 |
A |
T |
2: 30,240,401 (GRCm39) |
|
probably null |
Het |
| Slc46a3 |
A |
T |
5: 147,830,700 (GRCm39) |
N44K |
probably benign |
Het |
| Slc9b1 |
T |
A |
3: 135,099,756 (GRCm39) |
N425K |
probably benign |
Het |
| Slfn14 |
A |
T |
11: 83,170,288 (GRCm39) |
V452E |
probably damaging |
Het |
| Slfn8 |
A |
T |
11: 82,894,161 (GRCm39) |
M826K |
probably benign |
Het |
| Smr3a |
C |
A |
5: 88,155,873 (GRCm39) |
|
probably null |
Het |
| Snap29 |
T |
C |
16: 17,224,194 (GRCm39) |
S70P |
probably damaging |
Het |
| Svopl |
T |
A |
6: 37,993,949 (GRCm39) |
|
probably benign |
Het |
| Tbc1d17 |
A |
T |
7: 44,494,761 (GRCm39) |
F186I |
probably damaging |
Het |
| Tgm6 |
T |
C |
2: 129,983,176 (GRCm39) |
V255A |
probably damaging |
Het |
| Tjp1 |
G |
T |
7: 64,952,600 (GRCm39) |
T1498K |
probably benign |
Het |
| Tkfc |
C |
A |
19: 10,574,711 (GRCm39) |
E176D |
probably benign |
Het |
| Tmem102 |
C |
T |
11: 69,694,506 (GRCm39) |
V489I |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,551,781 (GRCm39) |
V22930A |
probably damaging |
Het |
| Tyms |
A |
T |
5: 30,278,357 (GRCm39) |
|
probably null |
Het |
| Uaca |
T |
A |
9: 60,748,238 (GRCm39) |
D67E |
probably damaging |
Het |
| Unc119b |
G |
A |
5: 115,265,508 (GRCm39) |
|
probably benign |
Het |
| Usp29 |
A |
T |
7: 6,964,744 (GRCm39) |
T196S |
probably benign |
Het |
| Usp37 |
A |
G |
1: 74,525,141 (GRCm39) |
S228P |
probably damaging |
Het |
| Usp42 |
C |
A |
5: 143,701,270 (GRCm39) |
A918S |
probably benign |
Het |
| Vmn2r72 |
T |
A |
7: 85,387,058 (GRCm39) |
L835F |
probably benign |
Het |
| Vps13a |
T |
C |
19: 16,637,894 (GRCm39) |
T2396A |
probably benign |
Het |
| Whrn |
A |
T |
4: 63,412,945 (GRCm39) |
S176T |
probably damaging |
Het |
| Zbtb42 |
T |
C |
12: 112,647,055 (GRCm39) |
F410S |
probably damaging |
Het |
| Zfp616 |
T |
C |
11: 73,973,952 (GRCm39) |
S74P |
probably damaging |
Het |
| Zswim6 |
A |
G |
13: 107,880,642 (GRCm39) |
|
noncoding transcript |
Het |
|
| Other mutations in Slit3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00731:Slit3
|
APN |
11 |
35,512,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01324:Slit3
|
APN |
11 |
35,501,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01612:Slit3
|
APN |
11 |
35,591,211 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02145:Slit3
|
APN |
11 |
35,520,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02146:Slit3
|
APN |
11 |
35,125,675 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02430:Slit3
|
APN |
11 |
35,068,601 (GRCm39) |
splice site |
probably null |
|
|
IGL02528:Slit3
|
APN |
11 |
35,469,801 (GRCm39) |
missense |
probably benign |
|
|
IGL02530:Slit3
|
APN |
11 |
35,598,969 (GRCm39) |
makesense |
probably null |
|
|
IGL02640:Slit3
|
APN |
11 |
35,591,172 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02819:Slit3
|
APN |
11 |
35,062,417 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02839:Slit3
|
APN |
11 |
35,539,874 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL03150:Slit3
|
APN |
11 |
35,399,084 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL03161:Slit3
|
APN |
11 |
35,591,241 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03336:Slit3
|
APN |
11 |
35,560,928 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Bloated
|
UTSW |
11 |
35,524,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
Quellung
|
UTSW |
11 |
35,542,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02988:Slit3
|
UTSW |
11 |
35,598,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4791001:Slit3
|
UTSW |
11 |
35,552,072 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0013:Slit3
|
UTSW |
11 |
35,598,745 (GRCm39) |
missense |
probably benign |
|
|
R0013:Slit3
|
UTSW |
11 |
35,598,745 (GRCm39) |
missense |
probably benign |
|
|
R0334:Slit3
|
UTSW |
11 |
35,469,928 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0385:Slit3
|
UTSW |
11 |
35,591,109 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0840:Slit3
|
UTSW |
11 |
35,514,263 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Slit3
|
UTSW |
11 |
35,012,462 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1364:Slit3
|
UTSW |
11 |
35,560,934 (GRCm39) |
missense |
probably benign |
|
|
R1476:Slit3
|
UTSW |
11 |
35,577,126 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1508:Slit3
|
UTSW |
11 |
35,461,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1665:Slit3
|
UTSW |
11 |
35,125,733 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1692:Slit3
|
UTSW |
11 |
35,550,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1696:Slit3
|
UTSW |
11 |
35,566,750 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1727:Slit3
|
UTSW |
11 |
35,520,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1752:Slit3
|
UTSW |
11 |
35,455,480 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1970:Slit3
|
UTSW |
11 |
35,521,668 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2077:Slit3
|
UTSW |
11 |
35,435,575 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2126:Slit3
|
UTSW |
11 |
35,579,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2143:Slit3
|
UTSW |
11 |
35,503,088 (GRCm39) |
splice site |
probably null |
|
|
R2162:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R2873:Slit3
|
UTSW |
11 |
35,435,620 (GRCm39) |
nonsense |
probably null |
|
|
R3813:Slit3
|
UTSW |
11 |
35,566,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3831:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3832:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3833:Slit3
|
UTSW |
11 |
35,579,509 (GRCm39) |
missense |
probably null |
1.00 |
|
R3839:Slit3
|
UTSW |
11 |
35,399,064 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4152:Slit3
|
UTSW |
11 |
35,589,147 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4387:Slit3
|
UTSW |
11 |
35,574,875 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4795:Slit3
|
UTSW |
11 |
35,542,647 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4910:Slit3
|
UTSW |
11 |
35,523,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4933:Slit3
|
UTSW |
11 |
35,579,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Slit3
|
UTSW |
11 |
35,479,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5106:Slit3
|
UTSW |
11 |
35,503,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5138:Slit3
|
UTSW |
11 |
35,479,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5218:Slit3
|
UTSW |
11 |
35,575,002 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5338:Slit3
|
UTSW |
11 |
35,512,975 (GRCm39) |
missense |
probably benign |
|
|
R5354:Slit3
|
UTSW |
11 |
35,566,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5436:Slit3
|
UTSW |
11 |
35,598,738 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5896:Slit3
|
UTSW |
11 |
35,598,932 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5963:Slit3
|
UTSW |
11 |
35,591,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5964:Slit3
|
UTSW |
11 |
35,591,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6125:Slit3
|
UTSW |
11 |
35,461,560 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6153:Slit3
|
UTSW |
11 |
35,591,310 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6484:Slit3
|
UTSW |
11 |
35,552,125 (GRCm39) |
missense |
probably benign |
|
|
R6526:Slit3
|
UTSW |
11 |
35,552,119 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6797:Slit3
|
UTSW |
11 |
35,524,779 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6887:Slit3
|
UTSW |
11 |
35,435,633 (GRCm39) |
splice site |
probably null |
|
|
R7067:Slit3
|
UTSW |
11 |
35,399,057 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7150:Slit3
|
UTSW |
11 |
35,461,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7228:Slit3
|
UTSW |
11 |
35,490,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7232:Slit3
|
UTSW |
11 |
35,501,516 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7418:Slit3
|
UTSW |
11 |
35,577,255 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7545:Slit3
|
UTSW |
11 |
35,591,139 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7727:Slit3
|
UTSW |
11 |
35,574,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Slit3
|
UTSW |
11 |
35,591,235 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8177:Slit3
|
UTSW |
11 |
35,469,919 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8179:Slit3
|
UTSW |
11 |
35,554,903 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8416:Slit3
|
UTSW |
11 |
35,399,062 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8417:Slit3
|
UTSW |
11 |
35,501,438 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8476:Slit3
|
UTSW |
11 |
35,520,596 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8785:Slit3
|
UTSW |
11 |
35,560,968 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8955:Slit3
|
UTSW |
11 |
35,589,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9040:Slit3
|
UTSW |
11 |
35,594,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9068:Slit3
|
UTSW |
11 |
35,574,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Slit3
|
UTSW |
11 |
35,012,463 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9266:Slit3
|
UTSW |
11 |
35,598,808 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9539:Slit3
|
UTSW |
11 |
35,589,155 (GRCm39) |
nonsense |
probably null |
|
|
R9636:Slit3
|
UTSW |
11 |
35,594,088 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0028:Slit3
|
UTSW |
11 |
35,455,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Slit3
|
UTSW |
11 |
35,598,751 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AAGTAAGAGTGACTCTTCCAGGC -3'
(R):5'- TGACTGTGATCCCTGTCCAC -3'
Sequencing Primer
(F):5'- ACTGAGACCCTTTAAGTCCTGGG -3'
(R):5'- GTGATCCCTGTCCACAGTTG -3'
|
| Posted On |
2017-02-28 |
Incidental Mutation