Incidental Mutation 'R7058:Rims2'
| ID |
548091 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rims2
|
| Ensembl Gene |
ENSMUSG00000037386 |
| Gene Name |
regulating synaptic membrane exocytosis 2 |
| Synonyms |
RIM2, 2810036I15Rik, Syt3-rs |
| MMRRC Submission |
045155-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.661)
|
| Stock # |
R7058 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
39061681-39547768 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 39449044 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 1194
(D1194G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154153
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042917]
[ENSMUST00000082054]
[ENSMUST00000227243]
|
| AlphaFold |
Q9EQZ7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000042917
AA Change: D1216G
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000048719
Gene: ENSMUSG00000037386
AA Change: D1216G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
30 |
154 |
9.5e-18 |
PFAM |
|
low complexity region
|
315 |
335 |
N/A |
INTRINSIC |
|
low complexity region
|
492 |
498 |
N/A |
INTRINSIC |
|
low complexity region
|
511 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
527 |
540 |
N/A |
INTRINSIC |
|
PDZ
|
646 |
725 |
8.27e-16 |
SMART |
|
low complexity region
|
740 |
748 |
N/A |
INTRINSIC |
|
C2
|
790 |
897 |
4.08e-21 |
SMART |
|
low complexity region
|
905 |
919 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1101 |
N/A |
INTRINSIC |
|
low complexity region
|
1116 |
1130 |
N/A |
INTRINSIC |
|
low complexity region
|
1208 |
1238 |
N/A |
INTRINSIC |
|
C2
|
1432 |
1535 |
3.78e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000082054
AA Change: D1174G
PolyPhen 2
Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000080711
Gene: ENSMUSG00000037386
AA Change: D1174G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
24 |
N/A |
INTRINSIC |
|
Pfam:FYVE_2
|
76 |
194 |
2.2e-11 |
PFAM |
|
low complexity region
|
355 |
375 |
N/A |
INTRINSIC |
|
low complexity region
|
532 |
538 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
561 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
580 |
N/A |
INTRINSIC |
|
PDZ
|
686 |
765 |
8.27e-16 |
SMART |
|
low complexity region
|
780 |
788 |
N/A |
INTRINSIC |
|
C2
|
830 |
937 |
4.08e-21 |
SMART |
|
low complexity region
|
945 |
959 |
N/A |
INTRINSIC |
|
low complexity region
|
1075 |
1086 |
N/A |
INTRINSIC |
|
low complexity region
|
1166 |
1196 |
N/A |
INTRINSIC |
|
C2
|
1390 |
1493 |
3.78e-16 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000227243
AA Change: D1194G
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
|
| Meta Mutation Damage Score |
0.1148 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (87/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017]
PHENOTYPE: Mice homozygous for a knock-out allele show reduced body size, aberrant insulin granule exocytosis, and impaired secretion of hormones associated with glucose homeostasis. Mice homozygous for another knock-out allele show a slightly reduced body size, abnormal maternal behavior and premature death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2610021A01Rik |
T |
C |
7: 41,275,554 (GRCm39) |
I419T |
possibly damaging |
Het |
| Afap1 |
T |
C |
5: 36,119,604 (GRCm39) |
V294A |
probably benign |
Het |
| Amotl1 |
T |
A |
9: 14,486,532 (GRCm39) |
Q454L |
possibly damaging |
Het |
| Ap2a1 |
T |
C |
7: 44,550,215 (GRCm39) |
S961G |
probably damaging |
Het |
| Asxl3 |
A |
G |
18: 22,650,731 (GRCm39) |
K907E |
probably damaging |
Het |
| BC028528 |
A |
T |
3: 95,792,323 (GRCm39) |
L137I |
possibly damaging |
Het |
| Cand1 |
A |
T |
10: 119,047,659 (GRCm39) |
N610K |
probably benign |
Het |
| Cat |
A |
G |
2: 103,304,698 (GRCm39) |
I109T |
probably benign |
Het |
| Ccdc18 |
T |
C |
5: 108,341,664 (GRCm39) |
V853A |
probably benign |
Het |
| Chd4 |
C |
A |
6: 125,085,405 (GRCm39) |
D805E |
possibly damaging |
Het |
| Cnih1 |
A |
C |
14: 47,017,652 (GRCm39) |
F77V |
probably damaging |
Het |
| Cntd1 |
A |
T |
11: 101,178,252 (GRCm39) |
I284F |
probably damaging |
Het |
| Col6a3 |
C |
A |
1: 90,755,759 (GRCm39) |
E177* |
probably null |
Het |
| Cpxm2 |
T |
A |
7: 131,745,408 (GRCm39) |
D139V |
probably benign |
Het |
| Cyp1a2 |
G |
T |
9: 57,584,525 (GRCm39) |
R510S |
probably damaging |
Het |
| D2hgdh |
T |
C |
1: 93,763,096 (GRCm39) |
S294P |
probably damaging |
Het |
| Dchs1 |
A |
G |
7: 105,406,228 (GRCm39) |
C2335R |
probably benign |
Het |
| Disc1 |
G |
T |
8: 125,977,724 (GRCm39) |
C719F |
probably damaging |
Het |
| Dnah14 |
A |
C |
1: 181,525,614 (GRCm39) |
D2180A |
probably benign |
Het |
| Dop1b |
G |
A |
16: 93,573,878 (GRCm39) |
R1582Q |
probably benign |
Het |
| Dsg2 |
A |
T |
18: 20,725,332 (GRCm39) |
H481L |
probably benign |
Het |
| Epha6 |
A |
G |
16: 59,503,013 (GRCm39) |
S965P |
probably damaging |
Het |
| Esrrg |
G |
T |
1: 187,882,503 (GRCm39) |
L253F |
probably damaging |
Het |
| Exoc6b |
T |
C |
6: 84,831,704 (GRCm39) |
K438R |
probably damaging |
Het |
| Fam98a |
C |
A |
17: 75,845,384 (GRCm39) |
R454L |
unknown |
Het |
| Fam98c |
A |
T |
7: 28,855,308 (GRCm39) |
|
probably null |
Het |
| Fhad1 |
CGG |
CG |
4: 141,645,602 (GRCm39) |
|
probably null |
Het |
| Galnt13 |
A |
G |
2: 54,988,587 (GRCm39) |
T470A |
probably damaging |
Het |
| Ggt7 |
A |
T |
2: 155,345,015 (GRCm39) |
|
probably null |
Het |
| Golim4 |
T |
C |
3: 75,785,957 (GRCm39) |
E606G |
probably damaging |
Het |
| Gpd2 |
G |
A |
2: 57,197,112 (GRCm39) |
|
probably null |
Het |
| Grin2b |
T |
C |
6: 135,757,304 (GRCm39) |
M386V |
probably damaging |
Het |
| Hfm1 |
A |
T |
5: 107,059,306 (GRCm39) |
S239T |
probably benign |
Het |
| Hmcn1 |
G |
A |
1: 150,649,641 (GRCm39) |
T615I |
probably benign |
Het |
| Hook2 |
G |
A |
8: 85,724,040 (GRCm39) |
E446K |
possibly damaging |
Het |
| Hsd3b1 |
C |
T |
3: 98,765,131 (GRCm39) |
|
probably null |
Het |
| Igsf9b |
A |
G |
9: 27,234,150 (GRCm39) |
Y421C |
probably damaging |
Het |
| Il21 |
A |
G |
3: 37,286,629 (GRCm39) |
L29P |
probably damaging |
Het |
| Ildr1 |
A |
G |
16: 36,542,730 (GRCm39) |
S421G |
probably benign |
Het |
| Kat2b |
C |
A |
17: 53,972,894 (GRCm39) |
T736K |
probably benign |
Het |
| Kcng1 |
A |
G |
2: 168,104,529 (GRCm39) |
V439A |
probably damaging |
Het |
| Kif21a |
A |
T |
15: 90,833,106 (GRCm39) |
|
probably null |
Het |
| Lat |
A |
G |
7: 125,968,318 (GRCm39) |
|
probably null |
Het |
| Mastl |
T |
A |
2: 23,023,425 (GRCm39) |
K433* |
probably null |
Het |
| Mettl2 |
A |
G |
11: 105,019,719 (GRCm39) |
R119G |
probably benign |
Het |
| Mia2 |
C |
T |
12: 59,231,021 (GRCm39) |
P1223L |
possibly damaging |
Het |
| Mkrn2os |
G |
T |
6: 115,563,635 (GRCm39) |
D133E |
probably benign |
Het |
| Mslnl |
A |
G |
17: 25,962,186 (GRCm39) |
T195A |
probably benign |
Het |
| Muc16 |
T |
G |
9: 18,551,051 (GRCm39) |
T5081P |
probably benign |
Het |
| Mylpf |
G |
C |
7: 126,813,139 (GRCm39) |
R110P |
probably damaging |
Het |
| Myo19 |
G |
T |
11: 84,798,194 (GRCm39) |
C738F |
possibly damaging |
Het |
| Nat8f4 |
T |
A |
6: 85,878,271 (GRCm39) |
N84I |
possibly damaging |
Het |
| Nol8 |
C |
T |
13: 49,829,862 (GRCm39) |
R1104C |
probably damaging |
Het |
| Notch1 |
A |
T |
2: 26,353,830 (GRCm39) |
D1932E |
probably benign |
Het |
| Nsun3 |
A |
T |
16: 62,596,663 (GRCm39) |
C152S |
possibly damaging |
Het |
| Opcml |
G |
A |
9: 28,586,507 (GRCm39) |
W75* |
probably null |
Het |
| Or14j10 |
A |
G |
17: 37,934,597 (GRCm39) |
F310L |
probably benign |
Het |
| Pcdh7 |
G |
A |
5: 57,879,582 (GRCm39) |
E1046K |
probably damaging |
Het |
| Pcdhb9 |
T |
A |
18: 37,536,334 (GRCm39) |
V776D |
probably benign |
Het |
| Pla2g4a |
A |
G |
1: 149,727,103 (GRCm39) |
L551S |
probably damaging |
Het |
| Plaa |
G |
A |
4: 94,458,060 (GRCm39) |
Q637* |
probably null |
Het |
| Plekhh1 |
A |
T |
12: 79,122,204 (GRCm39) |
E1099V |
probably damaging |
Het |
| Ppp4r1 |
A |
T |
17: 66,136,495 (GRCm39) |
N551Y |
probably benign |
Het |
| R3hdm2 |
T |
C |
10: 127,320,382 (GRCm39) |
V554A |
probably damaging |
Het |
| Rab44 |
A |
G |
17: 29,357,150 (GRCm39) |
|
probably null |
Het |
| Rab5c |
G |
A |
11: 100,610,789 (GRCm39) |
R40C |
probably damaging |
Het |
| Rasgrf2 |
T |
C |
13: 92,034,521 (GRCm39) |
T1119A |
probably damaging |
Het |
| Scarb1 |
A |
T |
5: 125,374,294 (GRCm39) |
C280S |
probably damaging |
Het |
| Sde2 |
T |
C |
1: 180,693,827 (GRCm39) |
F439S |
probably damaging |
Het |
| Setd5 |
T |
C |
6: 113,092,532 (GRCm39) |
I304T |
probably benign |
Het |
| Sipa1l1 |
A |
G |
12: 82,449,896 (GRCm39) |
E1106G |
probably benign |
Het |
| Sis |
T |
G |
3: 72,810,940 (GRCm39) |
S1694R |
probably damaging |
Het |
| Smad9 |
T |
A |
3: 54,693,614 (GRCm39) |
F181Y |
probably benign |
Het |
| Smg1 |
A |
G |
7: 117,797,502 (GRCm39) |
|
probably benign |
Het |
| Sspo |
T |
C |
6: 48,425,516 (GRCm39) |
Y46H |
probably damaging |
Het |
| Tdrd12 |
A |
G |
7: 35,177,534 (GRCm39) |
M940T |
unknown |
Het |
| Tmem44 |
G |
T |
16: 30,366,213 (GRCm39) |
T71K |
possibly damaging |
Het |
| Tmf1 |
T |
A |
6: 97,133,911 (GRCm39) |
E1009V |
probably damaging |
Het |
| Ttc39a |
C |
T |
4: 109,288,763 (GRCm39) |
R288W |
probably damaging |
Het |
| Ttc9c |
G |
A |
19: 8,796,191 (GRCm39) |
|
probably benign |
Het |
| Usp28 |
T |
A |
9: 48,950,456 (GRCm39) |
Y634N |
probably damaging |
Het |
| Vmn1r211 |
C |
T |
13: 23,036,063 (GRCm39) |
M201I |
probably benign |
Het |
| Vmn2r54 |
T |
A |
7: 12,349,722 (GRCm39) |
Q620L |
possibly damaging |
Het |
| Vps13c |
T |
C |
9: 67,831,110 (GRCm39) |
L1580P |
probably benign |
Het |
| Vrk3 |
C |
A |
7: 44,417,890 (GRCm39) |
F308L |
probably damaging |
Het |
| Zdbf2 |
T |
A |
1: 63,346,563 (GRCm39) |
H1647Q |
possibly damaging |
Het |
| Zfp984 |
A |
T |
4: 147,840,002 (GRCm39) |
M283K |
probably benign |
Het |
|
| Other mutations in Rims2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00339:Rims2
|
APN |
15 |
39,323,011 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL00502:Rims2
|
APN |
15 |
39,370,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00556:Rims2
|
APN |
15 |
39,320,070 (GRCm39) |
splice site |
probably null |
|
|
IGL00811:Rims2
|
APN |
15 |
39,155,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00827:Rims2
|
APN |
15 |
39,335,755 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Rims2
|
APN |
15 |
39,321,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02951:Rims2
|
APN |
15 |
39,398,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03009:Rims2
|
APN |
15 |
39,430,393 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03080:Rims2
|
APN |
15 |
39,399,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Rims2
|
APN |
15 |
39,322,989 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03252:Rims2
|
APN |
15 |
39,315,748 (GRCm39) |
missense |
probably benign |
|
|
IGL03365:Rims2
|
APN |
15 |
39,339,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03393:Rims2
|
APN |
15 |
39,326,009 (GRCm39) |
splice site |
probably null |
|
|
IGL03409:Rims2
|
APN |
15 |
39,320,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
rhyme
|
UTSW |
15 |
39,315,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4486001:Rims2
|
UTSW |
15 |
39,339,916 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0009:Rims2
|
UTSW |
15 |
39,398,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0009:Rims2
|
UTSW |
15 |
39,398,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0078:Rims2
|
UTSW |
15 |
39,398,251 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0367:Rims2
|
UTSW |
15 |
39,326,011 (GRCm39) |
splice site |
probably null |
|
|
R0401:Rims2
|
UTSW |
15 |
39,373,028 (GRCm39) |
splice site |
probably benign |
|
|
R0531:Rims2
|
UTSW |
15 |
39,430,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0791:Rims2
|
UTSW |
15 |
39,543,021 (GRCm39) |
splice site |
probably benign |
|
|
R0838:Rims2
|
UTSW |
15 |
39,544,421 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1201:Rims2
|
UTSW |
15 |
39,479,720 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1318:Rims2
|
UTSW |
15 |
39,381,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1457:Rims2
|
UTSW |
15 |
39,374,710 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1619:Rims2
|
UTSW |
15 |
39,370,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1672:Rims2
|
UTSW |
15 |
39,155,584 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1743:Rims2
|
UTSW |
15 |
39,543,046 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1766:Rims2
|
UTSW |
15 |
39,325,976 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1779:Rims2
|
UTSW |
15 |
39,545,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1804:Rims2
|
UTSW |
15 |
39,300,439 (GRCm39) |
nonsense |
probably null |
|
|
R1985:Rims2
|
UTSW |
15 |
39,208,710 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1986:Rims2
|
UTSW |
15 |
39,208,710 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2113:Rims2
|
UTSW |
15 |
39,374,722 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2260:Rims2
|
UTSW |
15 |
39,341,962 (GRCm39) |
nonsense |
probably null |
|
|
R2510:Rims2
|
UTSW |
15 |
39,449,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3693:Rims2
|
UTSW |
15 |
39,341,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3937:Rims2
|
UTSW |
15 |
39,301,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4425:Rims2
|
UTSW |
15 |
39,301,320 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4453:Rims2
|
UTSW |
15 |
39,155,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4474:Rims2
|
UTSW |
15 |
39,325,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4518:Rims2
|
UTSW |
15 |
39,300,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4526:Rims2
|
UTSW |
15 |
39,301,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4833:Rims2
|
UTSW |
15 |
39,399,310 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4936:Rims2
|
UTSW |
15 |
39,301,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Rims2
|
UTSW |
15 |
39,317,841 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5001:Rims2
|
UTSW |
15 |
39,315,824 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5054:Rims2
|
UTSW |
15 |
39,381,265 (GRCm39) |
splice site |
probably null |
|
|
R5072:Rims2
|
UTSW |
15 |
39,325,986 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5171:Rims2
|
UTSW |
15 |
39,300,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5429:Rims2
|
UTSW |
15 |
39,208,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5623:Rims2
|
UTSW |
15 |
39,342,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5624:Rims2
|
UTSW |
15 |
39,208,809 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5685:Rims2
|
UTSW |
15 |
39,300,602 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5784:Rims2
|
UTSW |
15 |
39,399,383 (GRCm39) |
splice site |
probably null |
|
|
R5790:Rims2
|
UTSW |
15 |
39,544,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5822:Rims2
|
UTSW |
15 |
39,339,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5963:Rims2
|
UTSW |
15 |
39,300,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5988:Rims2
|
UTSW |
15 |
39,155,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Rims2
|
UTSW |
15 |
39,538,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6239:Rims2
|
UTSW |
15 |
39,061,758 (GRCm39) |
start codon destroyed |
unknown |
|
|
R6407:Rims2
|
UTSW |
15 |
39,315,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6418:Rims2
|
UTSW |
15 |
39,373,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6495:Rims2
|
UTSW |
15 |
39,381,208 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6502:Rims2
|
UTSW |
15 |
39,398,251 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6753:Rims2
|
UTSW |
15 |
39,430,369 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6855:Rims2
|
UTSW |
15 |
39,208,911 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6948:Rims2
|
UTSW |
15 |
39,374,737 (GRCm39) |
missense |
probably benign |
|
|
R7167:Rims2
|
UTSW |
15 |
39,300,473 (GRCm39) |
missense |
probably benign |
|
|
R7217:Rims2
|
UTSW |
15 |
39,339,885 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7223:Rims2
|
UTSW |
15 |
39,300,428 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7289:Rims2
|
UTSW |
15 |
39,301,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7459:Rims2
|
UTSW |
15 |
39,381,235 (GRCm39) |
missense |
probably benign |
|
|
R7663:Rims2
|
UTSW |
15 |
39,370,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7792:Rims2
|
UTSW |
15 |
39,061,923 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7836:Rims2
|
UTSW |
15 |
39,544,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8082:Rims2
|
UTSW |
15 |
39,339,919 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8489:Rims2
|
UTSW |
15 |
39,479,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8730:Rims2
|
UTSW |
15 |
39,381,239 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8830:Rims2
|
UTSW |
15 |
39,300,758 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8857:Rims2
|
UTSW |
15 |
39,543,044 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8893:Rims2
|
UTSW |
15 |
39,398,350 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9010:Rims2
|
UTSW |
15 |
39,315,786 (GRCm39) |
nonsense |
probably null |
|
|
R9030:Rims2
|
UTSW |
15 |
39,339,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9287:Rims2
|
UTSW |
15 |
39,543,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9395:Rims2
|
UTSW |
15 |
39,155,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9451:Rims2
|
UTSW |
15 |
39,300,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9506:Rims2
|
UTSW |
15 |
39,335,832 (GRCm39) |
missense |
probably damaging |
0.97 |
|
X0034:Rims2
|
UTSW |
15 |
39,300,930 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,544,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Rims2
|
UTSW |
15 |
39,342,086 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Rims2
|
UTSW |
15 |
39,301,165 (GRCm39) |
missense |
probably benign |
0.24 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCTGAGTAGAGTATTGCAGTACCC -3'
(R):5'- GTCATCAGTTCTACAAAACTTGACC -3'
Sequencing Primer
(F):5'- GTAGAGTATTGCAGTACCCACCATG -3'
(R):5'- TCATGTTTATTCACAGCAATAAAACC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation