Incidental Mutation 'R7078:Prg4'
| ID |
549311 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Prg4
|
| Ensembl Gene |
ENSMUSG00000006014 |
| Gene Name |
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) |
| Synonyms |
MSF, SZP, lubricin, DOL54 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.125)
|
| Stock # |
R7078 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
150325163-150341916 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 150334014 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 117
(T117A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125677
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006171]
[ENSMUST00000111901]
[ENSMUST00000111902]
[ENSMUST00000159035]
[ENSMUST00000161320]
[ENSMUST00000161611]
[ENSMUST00000162367]
[ENSMUST00000164600]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000006171
|
| SMART Domains |
Protein: ENSMUSP00000006171
Gene: ENSMUSG00000006014
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
26 |
68 |
9.21e-18 |
SMART |
|
SO
|
69 |
108 |
4.21e-12 |
SMART |
|
low complexity region
|
110 |
124 |
N/A |
INTRINSIC |
|
HX
|
169 |
211 |
1.67e-7 |
SMART |
|
HX
|
213 |
256 |
3.76e-10 |
SMART |
|
Blast:HX
|
369 |
422 |
2e-27 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111901
|
| SMART Domains |
Protein: ENSMUSP00000107532
Gene: ENSMUSG00000006014
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
26 |
68 |
9.21e-18 |
SMART |
|
SO
|
69 |
108 |
4.21e-12 |
SMART |
|
low complexity region
|
110 |
124 |
N/A |
INTRINSIC |
|
low complexity region
|
141 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
221 |
N/A |
INTRINSIC |
|
low complexity region
|
241 |
535 |
N/A |
INTRINSIC |
|
low complexity region
|
570 |
623 |
N/A |
INTRINSIC |
|
HX
|
711 |
753 |
1.67e-7 |
SMART |
|
HX
|
755 |
798 |
3.76e-10 |
SMART |
|
Blast:HX
|
911 |
964 |
5e-27 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000111902
AA Change: T76A
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000107533
Gene: ENSMUSG00000006014
AA Change: T76A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
25 |
67 |
2.71e-15 |
SMART |
|
low complexity region
|
69 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
86 |
143 |
N/A |
INTRINSIC |
|
low complexity region
|
150 |
171 |
N/A |
INTRINSIC |
|
low complexity region
|
188 |
198 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
268 |
N/A |
INTRINSIC |
|
low complexity region
|
288 |
582 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
588 |
614 |
2.72e-5 |
PROSPERO |
|
low complexity region
|
617 |
670 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
680 |
706 |
2.72e-5 |
PROSPERO |
|
HX
|
758 |
800 |
1.67e-7 |
SMART |
|
HX
|
802 |
845 |
3.76e-10 |
SMART |
|
Blast:HX
|
958 |
1011 |
4e-27 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159035
AA Change: T76A
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000124410
Gene: ENSMUSG00000006014
AA Change: T76A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
25 |
67 |
2.71e-15 |
SMART |
|
low complexity region
|
69 |
81 |
N/A |
INTRINSIC |
|
low complexity region
|
88 |
99 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161320
|
| SMART Domains |
Protein: ENSMUSP00000124801
Gene: ENSMUSG00000006014
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
25 |
67 |
3.83e-15 |
SMART |
|
low complexity region
|
69 |
83 |
N/A |
INTRINSIC |
|
low complexity region
|
100 |
110 |
N/A |
INTRINSIC |
|
low complexity region
|
148 |
179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000161611
AA Change: T117A
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000125677
Gene: ENSMUSG00000006014
AA Change: T117A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
26 |
68 |
9.21e-18 |
SMART |
|
SO
|
69 |
108 |
2.77e-12 |
SMART |
|
low complexity region
|
110 |
122 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
184 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
212 |
N/A |
INTRINSIC |
|
low complexity region
|
229 |
239 |
N/A |
INTRINSIC |
|
internal_repeat_3
|
244 |
271 |
7.42e-5 |
PROSPERO |
|
low complexity region
|
277 |
309 |
N/A |
INTRINSIC |
|
Pfam:Cornifin
|
578 |
691 |
2.2e-9 |
PFAM |
|
internal_repeat_3
|
796 |
825 |
7.42e-5 |
PROSPERO |
|
internal_repeat_2
|
797 |
823 |
1.24e-5 |
PROSPERO |
|
low complexity region
|
826 |
879 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
889 |
915 |
1.24e-5 |
PROSPERO |
|
HX
|
967 |
1009 |
1.67e-7 |
SMART |
|
HX
|
1011 |
1054 |
3.76e-10 |
SMART |
|
Blast:HX
|
1167 |
1220 |
6e-27 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162367
|
| SMART Domains |
Protein: ENSMUSP00000125551
Gene: ENSMUSG00000006014
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
26 |
68 |
9.21e-18 |
SMART |
|
SO
|
69 |
108 |
4.21e-12 |
SMART |
|
low complexity region
|
110 |
124 |
N/A |
INTRINSIC |
|
HX
|
169 |
211 |
1.67e-7 |
SMART |
|
HX
|
213 |
256 |
3.76e-10 |
SMART |
|
Blast:HX
|
369 |
422 |
2e-27 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000164600
AA Change: T117A
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000128943
Gene: ENSMUSG00000006014
AA Change: T117A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SO
|
26 |
68 |
9.21e-18 |
SMART |
|
SO
|
69 |
108 |
2.77e-12 |
SMART |
|
low complexity region
|
110 |
122 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
184 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
212 |
N/A |
INTRINSIC |
|
low complexity region
|
229 |
239 |
N/A |
INTRINSIC |
|
internal_repeat_3
|
244 |
271 |
7.42e-5 |
PROSPERO |
|
low complexity region
|
277 |
309 |
N/A |
INTRINSIC |
|
Pfam:Cornifin
|
404 |
497 |
2.4e-14 |
PFAM |
|
Pfam:Cornifin
|
468 |
584 |
3.2e-15 |
PFAM |
|
Pfam:Cornifin
|
550 |
648 |
3.3e-16 |
PFAM |
|
Pfam:Cornifin
|
625 |
722 |
2.1e-15 |
PFAM |
|
Pfam:Cornifin
|
647 |
743 |
7.8e-16 |
PFAM |
|
Pfam:Cornifin
|
706 |
822 |
1.4e-12 |
PFAM |
|
low complexity region
|
826 |
879 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
889 |
915 |
1.24e-5 |
PROSPERO |
|
HX
|
967 |
1009 |
1.67e-7 |
SMART |
|
HX
|
1011 |
1054 |
3.76e-10 |
SMART |
|
Blast:HX
|
1167 |
1220 |
6e-27 |
BLAST |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Aging homozygous null mice develop a hopping gait, irregular endochondral growth plates, altered cartilage surface, camptodactyly, progressive synovial hyperplasia and, ultimately, joint failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaca |
G |
A |
11: 84,154,138 (GRCm39) |
R953Q |
possibly damaging |
Het |
| Aldh1a1 |
A |
T |
19: 20,579,434 (GRCm39) |
H20L |
probably benign |
Het |
| Ankrd52 |
T |
A |
10: 128,219,526 (GRCm39) |
C487S |
probably benign |
Het |
| Ap1s3 |
T |
C |
1: 79,602,845 (GRCm39) |
E54G |
probably benign |
Het |
| Arglu1 |
A |
C |
8: 8,717,361 (GRCm39) |
M236R |
probably benign |
Het |
| Baz1b |
T |
A |
5: 135,246,293 (GRCm39) |
F581I |
probably benign |
Het |
| Bbox1 |
T |
G |
2: 110,122,884 (GRCm39) |
D135A |
probably benign |
Het |
| Bcl2l14 |
T |
A |
6: 134,400,786 (GRCm39) |
V69E |
probably damaging |
Het |
| Brinp3 |
C |
T |
1: 146,390,627 (GRCm39) |
Q58* |
probably null |
Het |
| Ccnb1ip1 |
T |
A |
14: 51,029,724 (GRCm39) |
K113* |
probably null |
Het |
| Cep128 |
T |
C |
12: 91,200,878 (GRCm39) |
I830M |
probably damaging |
Het |
| Ces2f |
C |
T |
8: 105,681,284 (GRCm39) |
T541I |
probably damaging |
Het |
| Chsy3 |
C |
A |
18: 59,309,149 (GRCm39) |
P134Q |
possibly damaging |
Het |
| Cobl |
T |
G |
11: 12,328,271 (GRCm39) |
T112P |
probably damaging |
Het |
| Cplane2 |
A |
T |
4: 140,947,159 (GRCm39) |
Y180F |
probably benign |
Het |
| Dcc |
T |
A |
18: 71,680,469 (GRCm39) |
K589I |
probably benign |
Het |
| Depdc1b |
T |
A |
13: 108,523,505 (GRCm39) |
I460K |
possibly damaging |
Het |
| Dlst |
T |
C |
12: 85,157,705 (GRCm39) |
F12S |
probably benign |
Het |
| Dnah1 |
G |
C |
14: 31,019,067 (GRCm39) |
F1342L |
probably damaging |
Het |
| Dtnb |
A |
G |
12: 3,798,480 (GRCm39) |
Q438R |
possibly damaging |
Het |
| Dusp4 |
C |
A |
8: 35,275,065 (GRCm39) |
S61R |
probably damaging |
Het |
| E130308A19Rik |
A |
G |
4: 59,737,688 (GRCm39) |
Y433C |
probably damaging |
Het |
| Ebf2 |
T |
C |
14: 67,661,407 (GRCm39) |
S512P |
probably benign |
Het |
| Elapor2 |
A |
G |
5: 9,460,709 (GRCm39) |
N210S |
probably benign |
Het |
| Eya1 |
C |
T |
1: 14,301,636 (GRCm39) |
|
probably null |
Het |
| Fsd1 |
G |
A |
17: 56,300,876 (GRCm39) |
R245H |
probably damaging |
Het |
| Fzr1 |
T |
A |
10: 81,204,463 (GRCm39) |
D379V |
probably damaging |
Het |
| Gk2 |
T |
A |
5: 97,604,195 (GRCm39) |
E214D |
probably benign |
Het |
| Gm10837 |
C |
G |
14: 122,728,142 (GRCm39) |
A6G |
unknown |
Het |
| Gmnc |
A |
T |
16: 26,779,272 (GRCm39) |
V251E |
probably benign |
Het |
| Golga3 |
A |
G |
5: 110,340,953 (GRCm39) |
Q549R |
probably damaging |
Het |
| Gsdmd |
T |
G |
15: 75,736,204 (GRCm39) |
V111G |
probably damaging |
Het |
| Gtf3c1 |
T |
C |
7: 125,244,914 (GRCm39) |
T1707A |
possibly damaging |
Het |
| Gucy2c |
C |
T |
6: 136,674,937 (GRCm39) |
V1049M |
probably benign |
Het |
| Gucy2g |
A |
G |
19: 55,229,583 (GRCm39) |
V29A |
probably damaging |
Het |
| Hecw1 |
A |
T |
13: 14,609,044 (GRCm39) |
M1K |
probably null |
Het |
| Hmcn1 |
T |
C |
1: 150,736,118 (GRCm39) |
D117G |
probably damaging |
Het |
| Ifnab |
T |
A |
4: 88,609,350 (GRCm39) |
T39S |
possibly damaging |
Het |
| Lcorl |
A |
G |
5: 45,904,566 (GRCm39) |
Y171H |
probably damaging |
Het |
| Ly6g6c |
C |
T |
17: 35,288,437 (GRCm39) |
P103L |
probably damaging |
Het |
| Macf1 |
T |
G |
4: 123,325,936 (GRCm39) |
E5189A |
probably damaging |
Het |
| Mapkap1 |
A |
G |
2: 34,453,151 (GRCm39) |
E348G |
probably damaging |
Het |
| Med25 |
G |
T |
7: 44,534,325 (GRCm39) |
A280D |
probably damaging |
Het |
| Mep1b |
C |
A |
18: 21,233,108 (GRCm39) |
A703E |
probably benign |
Het |
| Morn5 |
T |
A |
2: 35,944,990 (GRCm39) |
N71K |
probably benign |
Het |
| Mtmr10 |
T |
A |
7: 63,970,375 (GRCm39) |
Y373N |
possibly damaging |
Het |
| Myo1d |
C |
T |
11: 80,565,460 (GRCm39) |
E426K |
probably damaging |
Het |
| Ncbp1 |
G |
C |
4: 46,155,756 (GRCm39) |
V302L |
probably benign |
Het |
| Notch4 |
A |
G |
17: 34,801,520 (GRCm39) |
T1123A |
possibly damaging |
Het |
| Nudt18 |
T |
A |
14: 70,816,452 (GRCm39) |
M88K |
possibly damaging |
Het |
| Or12k8 |
A |
G |
2: 36,975,608 (GRCm39) |
S51P |
possibly damaging |
Het |
| Or5b100-ps1 |
A |
T |
19: 12,994,097 (GRCm39) |
D170V |
possibly damaging |
Het |
| Or6d12 |
T |
A |
6: 116,493,632 (GRCm39) |
L298Q |
probably damaging |
Het |
| Or8g4 |
A |
T |
9: 39,661,787 (GRCm39) |
Y35F |
possibly damaging |
Het |
| Pdcd6ip |
T |
C |
9: 113,488,953 (GRCm39) |
N694S |
probably benign |
Het |
| Pecam1 |
T |
A |
11: 106,579,773 (GRCm39) |
T430S |
probably benign |
Het |
| Plaa |
T |
G |
4: 94,462,288 (GRCm39) |
T530P |
probably benign |
Het |
| Ppfia3 |
G |
T |
7: 45,010,019 (GRCm39) |
Q95K |
probably damaging |
Het |
| Ppp4r2 |
T |
C |
6: 100,843,274 (GRCm39) |
S331P |
probably benign |
Het |
| Prrc2b |
A |
T |
2: 32,103,531 (GRCm39) |
D1003V |
probably benign |
Het |
| Ptk2 |
G |
A |
15: 73,093,658 (GRCm39) |
P854S |
possibly damaging |
Het |
| Rasef |
T |
C |
4: 73,698,626 (GRCm39) |
I12V |
probably benign |
Het |
| Robo2 |
T |
G |
16: 74,149,504 (GRCm39) |
Y108S |
probably damaging |
Het |
| Rp1 |
T |
A |
1: 4,277,014 (GRCm39) |
E762V |
unknown |
Het |
| Rsrc1 |
T |
C |
3: 66,901,987 (GRCm39) |
S46P |
unknown |
Het |
| Rttn |
A |
T |
18: 89,027,546 (GRCm39) |
T554S |
probably benign |
Het |
| Sall3 |
C |
T |
18: 81,017,314 (GRCm39) |
V205M |
probably damaging |
Het |
| Scn3a |
C |
A |
2: 65,327,944 (GRCm39) |
V849L |
probably damaging |
Het |
| Sec23a |
A |
G |
12: 59,039,069 (GRCm39) |
C277R |
probably benign |
Het |
| Sf3b3 |
C |
T |
8: 111,539,639 (GRCm39) |
A1075T |
possibly damaging |
Het |
| Sfxn5 |
T |
C |
6: 85,309,366 (GRCm39) |
D113G |
unknown |
Het |
| Slc22a22 |
C |
T |
15: 57,126,876 (GRCm39) |
M64I |
probably benign |
Het |
| Slc5a11 |
C |
T |
7: 122,857,669 (GRCm39) |
P253S |
probably damaging |
Het |
| Smarcd3 |
A |
G |
5: 24,798,067 (GRCm39) |
F449S |
probably damaging |
Het |
| Sspo |
C |
T |
6: 48,437,313 (GRCm39) |
T1357M |
probably damaging |
Het |
| Styx |
C |
T |
14: 45,609,873 (GRCm39) |
T179I |
probably benign |
Het |
| Syt7 |
A |
T |
19: 10,412,963 (GRCm39) |
T297S |
probably benign |
Het |
| Tbx19 |
T |
A |
1: 164,988,135 (GRCm39) |
|
probably benign |
Het |
| Tg |
T |
A |
15: 66,545,392 (GRCm39) |
V149E |
probably damaging |
Het |
| Tgfbr3l |
T |
A |
8: 4,299,238 (GRCm39) |
L35Q |
probably damaging |
Het |
| Tmem161b |
C |
A |
13: 84,370,537 (GRCm39) |
|
probably benign |
Het |
| Tmem219 |
T |
A |
7: 126,490,975 (GRCm39) |
T161S |
probably damaging |
Het |
| Tox2 |
T |
A |
2: 163,162,501 (GRCm39) |
L68H |
|
Het |
| Trim5 |
T |
A |
7: 103,927,681 (GRCm39) |
D153V |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,580,651 (GRCm39) |
Y23414C |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,582,153 (GRCm39) |
N22913K |
probably damaging |
Het |
| Ubr2 |
A |
C |
17: 47,266,779 (GRCm39) |
M1124R |
possibly damaging |
Het |
| Vmn2r75 |
A |
G |
7: 85,815,568 (GRCm39) |
S99P |
probably damaging |
Het |
| Wdr83 |
T |
C |
8: 85,802,680 (GRCm39) |
D219G |
probably damaging |
Het |
| Wdr90 |
C |
T |
17: 26,068,623 (GRCm39) |
V1285M |
probably damaging |
Het |
| Zmynd15 |
A |
T |
11: 70,351,581 (GRCm39) |
L62F |
probably damaging |
Het |
|
| Other mutations in Prg4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00493:Prg4
|
APN |
1 |
150,327,671 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02033:Prg4
|
APN |
1 |
150,331,619 (GRCm39) |
intron |
probably benign |
|
|
IGL02154:Prg4
|
APN |
1 |
150,330,613 (GRCm39) |
intron |
probably benign |
|
|
IGL03111:Prg4
|
APN |
1 |
150,327,653 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03177:Prg4
|
APN |
1 |
150,331,354 (GRCm39) |
intron |
probably benign |
|
|
IGL03260:Prg4
|
APN |
1 |
150,331,378 (GRCm39) |
intron |
probably benign |
|
|
IGL03281:Prg4
|
APN |
1 |
150,325,839 (GRCm39) |
splice site |
probably benign |
|
|
R0046:Prg4
|
UTSW |
1 |
150,331,837 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0046:Prg4
|
UTSW |
1 |
150,331,837 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0196:Prg4
|
UTSW |
1 |
150,330,243 (GRCm39) |
intron |
probably benign |
|
|
R0233:Prg4
|
UTSW |
1 |
150,329,298 (GRCm39) |
splice site |
probably benign |
|
|
R0255:Prg4
|
UTSW |
1 |
150,331,558 (GRCm39) |
intron |
probably benign |
|
|
R0616:Prg4
|
UTSW |
1 |
150,336,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1016:Prg4
|
UTSW |
1 |
150,330,442 (GRCm39) |
intron |
probably benign |
|
|
R1826:Prg4
|
UTSW |
1 |
150,327,760 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1862:Prg4
|
UTSW |
1 |
150,336,420 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1863:Prg4
|
UTSW |
1 |
150,336,420 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1922:Prg4
|
UTSW |
1 |
150,325,750 (GRCm39) |
nonsense |
probably null |
|
|
R1940:Prg4
|
UTSW |
1 |
150,331,774 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3765:Prg4
|
UTSW |
1 |
150,327,122 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3855:Prg4
|
UTSW |
1 |
150,327,751 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3894:Prg4
|
UTSW |
1 |
150,330,510 (GRCm39) |
intron |
probably benign |
|
|
R3895:Prg4
|
UTSW |
1 |
150,330,510 (GRCm39) |
intron |
probably benign |
|
|
R3912:Prg4
|
UTSW |
1 |
150,327,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3935:Prg4
|
UTSW |
1 |
150,333,908 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4050:Prg4
|
UTSW |
1 |
150,330,510 (GRCm39) |
intron |
probably benign |
|
|
R4475:Prg4
|
UTSW |
1 |
150,330,610 (GRCm39) |
intron |
probably benign |
|
|
R4794:Prg4
|
UTSW |
1 |
150,330,297 (GRCm39) |
intron |
probably benign |
|
|
R4910:Prg4
|
UTSW |
1 |
150,331,574 (GRCm39) |
intron |
probably benign |
|
|
R4911:Prg4
|
UTSW |
1 |
150,331,574 (GRCm39) |
intron |
probably benign |
|
|
R4993:Prg4
|
UTSW |
1 |
150,336,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5378:Prg4
|
UTSW |
1 |
150,330,977 (GRCm39) |
intron |
probably benign |
|
|
R5381:Prg4
|
UTSW |
1 |
150,330,204 (GRCm39) |
intron |
probably benign |
|
|
R5452:Prg4
|
UTSW |
1 |
150,331,519 (GRCm39) |
intron |
probably benign |
|
|
R5870:Prg4
|
UTSW |
1 |
150,331,300 (GRCm39) |
nonsense |
probably null |
|
|
R5888:Prg4
|
UTSW |
1 |
150,328,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5929:Prg4
|
UTSW |
1 |
150,329,880 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6058:Prg4
|
UTSW |
1 |
150,327,197 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6059:Prg4
|
UTSW |
1 |
150,325,748 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R6232:Prg4
|
UTSW |
1 |
150,331,567 (GRCm39) |
intron |
probably benign |
|
|
R6272:Prg4
|
UTSW |
1 |
150,330,517 (GRCm39) |
intron |
probably benign |
|
|
R6459:Prg4
|
UTSW |
1 |
150,330,052 (GRCm39) |
intron |
probably benign |
|
|
R6659:Prg4
|
UTSW |
1 |
150,336,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6663:Prg4
|
UTSW |
1 |
150,330,852 (GRCm39) |
intron |
probably benign |
|
|
R6882:Prg4
|
UTSW |
1 |
150,329,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6970:Prg4
|
UTSW |
1 |
150,331,657 (GRCm39) |
intron |
probably benign |
|
|
R7102:Prg4
|
UTSW |
1 |
150,328,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7264:Prg4
|
UTSW |
1 |
150,329,818 (GRCm39) |
missense |
not run |
|
|
R7487:Prg4
|
UTSW |
1 |
150,331,656 (GRCm39) |
missense |
unknown |
|
|
R7531:Prg4
|
UTSW |
1 |
150,330,786 (GRCm39) |
missense |
unknown |
|
|
R7651:Prg4
|
UTSW |
1 |
150,330,696 (GRCm39) |
missense |
unknown |
|
|
R7701:Prg4
|
UTSW |
1 |
150,333,293 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8072:Prg4
|
UTSW |
1 |
150,331,774 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8168:Prg4
|
UTSW |
1 |
150,331,601 (GRCm39) |
missense |
unknown |
|
|
R8248:Prg4
|
UTSW |
1 |
150,330,877 (GRCm39) |
missense |
unknown |
|
|
R8436:Prg4
|
UTSW |
1 |
150,331,318 (GRCm39) |
missense |
unknown |
|
|
R8460:Prg4
|
UTSW |
1 |
150,331,692 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8514:Prg4
|
UTSW |
1 |
150,330,396 (GRCm39) |
missense |
unknown |
|
|
R8904:Prg4
|
UTSW |
1 |
150,331,810 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9072:Prg4
|
UTSW |
1 |
150,331,288 (GRCm39) |
missense |
unknown |
|
|
R9073:Prg4
|
UTSW |
1 |
150,331,288 (GRCm39) |
missense |
unknown |
|
|
R9274:Prg4
|
UTSW |
1 |
150,331,924 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9337:Prg4
|
UTSW |
1 |
150,327,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9488:Prg4
|
UTSW |
1 |
150,327,024 (GRCm39) |
missense |
probably benign |
|
|
R9613:Prg4
|
UTSW |
1 |
150,331,660 (GRCm39) |
missense |
unknown |
|
|
R9670:Prg4
|
UTSW |
1 |
150,326,618 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0024:Prg4
|
UTSW |
1 |
150,330,243 (GRCm39) |
intron |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGACCCTTTGAGGATATTCATGTG -3'
(R):5'- AGCAATGTGTTCTCCGAATTATTGG -3'
Sequencing Primer
(F):5'- TCATGTGAATAGTCCACCTACAGG -3'
(R):5'- GAGTTACTTGAGTTGGGCTACAAGC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation