Incidental Mutation 'R0734:Nin'
| ID |
68168 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nin
|
| Ensembl Gene |
ENSMUSG00000021068 |
| Gene Name |
ninein |
| Synonyms |
3110068G20Rik |
| MMRRC Submission |
038915-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0734 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
70058209-70160491 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 70076887 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1056
(V1056A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152530
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021468]
[ENSMUST00000085314]
[ENSMUST00000095666]
[ENSMUST00000169074]
[ENSMUST00000220689]
[ENSMUST00000222237]
[ENSMUST00000223257]
[ENSMUST00000222835]
|
| AlphaFold |
Q61043 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000021468
AA Change: V1763A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000021468
Gene: ENSMUSG00000021068
AA Change: V1763A
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000085314
AA Change: V1763A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000082422
Gene: ENSMUSG00000021068
AA Change: V1763A
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1971 |
2045 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095666
AA Change: V1763A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000093327
Gene: ENSMUSG00000021068
AA Change: V1763A
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169074
AA Change: V1763A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000129648
Gene: ENSMUSG00000021068
AA Change: V1763A
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220689
AA Change: V1056A
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221486
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000221579
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222237
AA Change: V1763A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000223257
AA Change: V1763A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000222137
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223048
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222835
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223469
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.5%
- 3x: 98.8%
- 10x: 97.0%
- 20x: 93.3%
|
| Validation Efficiency |
99% (80/81) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930562C15Rik |
T |
A |
16: 4,668,198 (GRCm39) |
S530T |
probably benign |
Het |
| Acer2 |
G |
T |
4: 86,835,796 (GRCm39) |
K223N |
probably benign |
Het |
| Adam19 |
T |
G |
11: 46,018,230 (GRCm39) |
C431G |
probably damaging |
Het |
| Adamts16 |
T |
G |
13: 70,886,600 (GRCm39) |
|
probably benign |
Het |
| Aox1 |
A |
T |
1: 58,344,500 (GRCm39) |
E531V |
probably benign |
Het |
| Apaf1 |
A |
T |
10: 90,872,883 (GRCm39) |
N720K |
probably benign |
Het |
| Atrnl1 |
T |
A |
19: 57,643,293 (GRCm39) |
W394R |
probably damaging |
Het |
| Bcl6 |
T |
C |
16: 23,786,889 (GRCm39) |
E634G |
probably damaging |
Het |
| Cfap65 |
T |
A |
1: 74,958,046 (GRCm39) |
Y954F |
probably damaging |
Het |
| Cobl |
A |
G |
11: 12,325,971 (GRCm39) |
V168A |
probably damaging |
Het |
| Cped1 |
C |
T |
6: 22,085,040 (GRCm39) |
P210S |
probably damaging |
Het |
| Crb1 |
C |
T |
1: 139,264,822 (GRCm39) |
V199M |
probably benign |
Het |
| Cyp2j6 |
A |
T |
4: 96,412,081 (GRCm39) |
|
probably benign |
Het |
| Dhrs3 |
C |
G |
4: 144,653,746 (GRCm39) |
S289W |
probably damaging |
Het |
| Dido1 |
T |
G |
2: 180,301,835 (GRCm39) |
Q2023P |
probably benign |
Het |
| Dlg4 |
G |
A |
11: 69,933,531 (GRCm39) |
G550R |
probably damaging |
Het |
| Dnah12 |
C |
A |
14: 26,521,970 (GRCm39) |
H1928N |
probably benign |
Het |
| Dthd1 |
A |
C |
5: 62,996,753 (GRCm39) |
|
probably benign |
Het |
| Erg |
C |
A |
16: 95,170,884 (GRCm39) |
G269C |
possibly damaging |
Het |
| Erich6 |
G |
A |
3: 58,536,809 (GRCm39) |
|
probably benign |
Het |
| F5 |
G |
C |
1: 164,026,486 (GRCm39) |
R1686P |
probably damaging |
Het |
| Fancc |
T |
C |
13: 63,479,656 (GRCm39) |
R300G |
probably damaging |
Het |
| Fcer1g |
T |
A |
1: 171,058,748 (GRCm39) |
K47* |
probably null |
Het |
| Flt4 |
A |
G |
11: 49,517,544 (GRCm39) |
T289A |
possibly damaging |
Het |
| Gcnt2 |
T |
A |
13: 41,013,997 (GRCm39) |
F56Y |
probably benign |
Het |
| Gpatch8 |
G |
T |
11: 102,372,226 (GRCm39) |
S437R |
unknown |
Het |
| Grin2a |
T |
A |
16: 9,397,475 (GRCm39) |
I871F |
possibly damaging |
Het |
| Hsd17b4 |
T |
C |
18: 50,303,844 (GRCm39) |
V439A |
possibly damaging |
Het |
| Hykk |
A |
T |
9: 54,853,716 (GRCm39) |
K346M |
possibly damaging |
Het |
| Ifi208 |
T |
C |
1: 173,510,901 (GRCm39) |
L352S |
probably damaging |
Het |
| Ikzf1 |
T |
C |
11: 11,708,195 (GRCm39) |
V110A |
probably damaging |
Het |
| Irak3 |
A |
T |
10: 119,981,542 (GRCm39) |
|
probably benign |
Het |
| Lamp5 |
T |
A |
2: 135,900,950 (GRCm39) |
V50E |
probably damaging |
Het |
| Lgr6 |
C |
T |
1: 134,921,748 (GRCm39) |
A199T |
probably damaging |
Het |
| Lrch3 |
C |
T |
16: 32,817,853 (GRCm39) |
R570* |
probably null |
Het |
| Map1lc3a |
T |
C |
2: 155,118,896 (GRCm39) |
V20A |
possibly damaging |
Het |
| Map3k14 |
C |
A |
11: 103,117,826 (GRCm39) |
K655N |
probably benign |
Het |
| Mark2 |
A |
G |
19: 7,263,346 (GRCm39) |
|
probably benign |
Het |
| Mbtd1 |
G |
A |
11: 93,813,972 (GRCm39) |
G205D |
probably damaging |
Het |
| Med13 |
T |
C |
11: 86,192,063 (GRCm39) |
T861A |
probably benign |
Het |
| Meltf |
T |
A |
16: 31,700,776 (GRCm39) |
Y99N |
probably damaging |
Het |
| Mex3d |
G |
A |
10: 80,217,366 (GRCm39) |
T617I |
possibly damaging |
Het |
| Muc13 |
G |
A |
16: 33,623,452 (GRCm39) |
V249I |
probably damaging |
Het |
| Myo18a |
C |
A |
11: 77,738,230 (GRCm39) |
P1688Q |
probably damaging |
Het |
| Naaladl1 |
A |
T |
19: 6,162,904 (GRCm39) |
|
probably null |
Het |
| Ncoa3 |
T |
A |
2: 165,911,111 (GRCm39) |
|
probably benign |
Het |
| Nf2 |
T |
C |
11: 4,770,409 (GRCm39) |
T67A |
probably benign |
Het |
| Or1p1 |
A |
T |
11: 74,179,772 (GRCm39) |
Q100L |
probably damaging |
Het |
| Or4d10c |
T |
A |
19: 12,065,483 (GRCm39) |
R224S |
probably benign |
Het |
| Or5b105 |
G |
A |
19: 13,080,642 (GRCm39) |
R3C |
possibly damaging |
Het |
| P3h1 |
T |
C |
4: 119,095,885 (GRCm39) |
L331P |
probably damaging |
Het |
| Pabpc4l |
T |
C |
3: 46,401,408 (GRCm39) |
K79E |
possibly damaging |
Het |
| Pam |
T |
A |
1: 97,792,087 (GRCm39) |
R445* |
probably null |
Het |
| Pcdhb6 |
T |
C |
18: 37,468,387 (GRCm39) |
I436T |
probably damaging |
Het |
| Piezo2 |
A |
G |
18: 63,174,794 (GRCm39) |
Y1987H |
probably damaging |
Het |
| Plch2 |
G |
A |
4: 155,080,740 (GRCm39) |
T477I |
probably damaging |
Het |
| Postn |
G |
A |
3: 54,270,136 (GRCm39) |
G72R |
probably damaging |
Het |
| Proca1 |
G |
A |
11: 78,092,628 (GRCm39) |
|
probably benign |
Het |
| Psip1 |
T |
A |
4: 83,381,825 (GRCm39) |
|
probably benign |
Het |
| Ptprd |
G |
A |
4: 76,058,834 (GRCm39) |
P153L |
probably damaging |
Het |
| Rgl1 |
T |
C |
1: 152,430,051 (GRCm39) |
D242G |
probably damaging |
Het |
| Ric1 |
T |
A |
19: 29,572,218 (GRCm39) |
I671K |
possibly damaging |
Het |
| Rxrg |
T |
A |
1: 167,455,013 (GRCm39) |
C199S |
probably damaging |
Het |
| Sec24c |
A |
C |
14: 20,743,813 (GRCm39) |
D1006A |
probably damaging |
Het |
| Sec63 |
A |
G |
10: 42,672,204 (GRCm39) |
T173A |
probably benign |
Het |
| Sfxn5 |
T |
C |
6: 85,244,847 (GRCm39) |
|
probably benign |
Het |
| Spam1 |
A |
G |
6: 24,796,948 (GRCm39) |
I300V |
probably benign |
Het |
| Spem1 |
A |
G |
11: 69,712,097 (GRCm39) |
L189P |
probably damaging |
Het |
| Sptbn2 |
A |
T |
19: 4,798,151 (GRCm39) |
R1959* |
probably null |
Het |
| Timeless |
C |
T |
10: 128,085,929 (GRCm39) |
R935W |
probably damaging |
Het |
| Tnfrsf21 |
C |
T |
17: 43,349,104 (GRCm39) |
H239Y |
probably benign |
Het |
| Trim24 |
T |
C |
6: 37,896,400 (GRCm39) |
Y286H |
possibly damaging |
Het |
| Ttyh2 |
A |
G |
11: 114,601,019 (GRCm39) |
|
probably benign |
Het |
| Zbtb21 |
C |
T |
16: 97,753,827 (GRCm39) |
C180Y |
probably damaging |
Het |
| Zfp746 |
T |
C |
6: 48,041,833 (GRCm39) |
T298A |
probably damaging |
Het |
|
| Other mutations in Nin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Nin
|
APN |
12 |
70,076,862 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00677:Nin
|
APN |
12 |
70,073,634 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00823:Nin
|
APN |
12 |
70,061,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01103:Nin
|
APN |
12 |
70,103,532 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01113:Nin
|
APN |
12 |
70,078,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01420:Nin
|
APN |
12 |
70,092,188 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01556:Nin
|
APN |
12 |
70,089,962 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01663:Nin
|
APN |
12 |
70,090,439 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL02002:Nin
|
APN |
12 |
70,109,473 (GRCm39) |
nonsense |
probably null |
|
|
IGL02030:Nin
|
APN |
12 |
70,092,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02202:Nin
|
APN |
12 |
70,102,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02207:Nin
|
APN |
12 |
70,103,431 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02257:Nin
|
APN |
12 |
70,149,465 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02394:Nin
|
APN |
12 |
70,090,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02531:Nin
|
APN |
12 |
70,067,706 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03028:Nin
|
APN |
12 |
70,082,044 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03155:Nin
|
APN |
12 |
70,078,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03197:Nin
|
APN |
12 |
70,073,584 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02835:Nin
|
UTSW |
12 |
70,103,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0132:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,061,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,061,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0947:Nin
|
UTSW |
12 |
70,107,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1085:Nin
|
UTSW |
12 |
70,067,736 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1367:Nin
|
UTSW |
12 |
70,090,703 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1452:Nin
|
UTSW |
12 |
70,064,424 (GRCm39) |
nonsense |
probably null |
|
|
R1477:Nin
|
UTSW |
12 |
70,090,958 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1518:Nin
|
UTSW |
12 |
70,061,547 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1566:Nin
|
UTSW |
12 |
70,101,253 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1572:Nin
|
UTSW |
12 |
70,085,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1583:Nin
|
UTSW |
12 |
70,078,512 (GRCm39) |
missense |
probably benign |
|
|
R1584:Nin
|
UTSW |
12 |
70,089,443 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1699:Nin
|
UTSW |
12 |
70,092,337 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1699:Nin
|
UTSW |
12 |
70,077,712 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1765:Nin
|
UTSW |
12 |
70,089,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1794:Nin
|
UTSW |
12 |
70,090,569 (GRCm39) |
nonsense |
probably null |
|
|
R1952:Nin
|
UTSW |
12 |
70,077,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2004:Nin
|
UTSW |
12 |
70,072,251 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2025:Nin
|
UTSW |
12 |
70,076,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2060:Nin
|
UTSW |
12 |
70,089,192 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2213:Nin
|
UTSW |
12 |
70,092,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Nin
|
UTSW |
12 |
70,108,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2247:Nin
|
UTSW |
12 |
70,101,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2972:Nin
|
UTSW |
12 |
70,109,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3776:Nin
|
UTSW |
12 |
70,085,456 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3881:Nin
|
UTSW |
12 |
70,089,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3930:Nin
|
UTSW |
12 |
70,125,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3959:Nin
|
UTSW |
12 |
70,097,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4229:Nin
|
UTSW |
12 |
70,097,984 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4359:Nin
|
UTSW |
12 |
70,061,712 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4423:Nin
|
UTSW |
12 |
70,089,752 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4461:Nin
|
UTSW |
12 |
70,089,359 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4639:Nin
|
UTSW |
12 |
70,085,375 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4791:Nin
|
UTSW |
12 |
70,090,581 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4839:Nin
|
UTSW |
12 |
70,137,325 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4912:Nin
|
UTSW |
12 |
70,090,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5712:Nin
|
UTSW |
12 |
70,089,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Nin
|
UTSW |
12 |
70,124,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5804:Nin
|
UTSW |
12 |
70,092,375 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5874:Nin
|
UTSW |
12 |
70,077,692 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5992:Nin
|
UTSW |
12 |
70,092,298 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6077:Nin
|
UTSW |
12 |
70,066,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6184:Nin
|
UTSW |
12 |
70,090,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6307:Nin
|
UTSW |
12 |
70,061,631 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6315:Nin
|
UTSW |
12 |
70,092,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Nin
|
UTSW |
12 |
70,091,955 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6492:Nin
|
UTSW |
12 |
70,101,308 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6562:Nin
|
UTSW |
12 |
70,102,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6578:Nin
|
UTSW |
12 |
70,107,968 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6613:Nin
|
UTSW |
12 |
70,077,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7112:Nin
|
UTSW |
12 |
70,149,573 (GRCm39) |
missense |
|
|
|
R7170:Nin
|
UTSW |
12 |
70,091,013 (GRCm39) |
missense |
|
|
|
R7324:Nin
|
UTSW |
12 |
70,090,508 (GRCm39) |
missense |
|
|
|
R7338:Nin
|
UTSW |
12 |
70,090,838 (GRCm39) |
missense |
|
|
|
R7372:Nin
|
UTSW |
12 |
70,102,803 (GRCm39) |
missense |
|
|
|
R7431:Nin
|
UTSW |
12 |
70,124,997 (GRCm39) |
missense |
|
|
|
R7577:Nin
|
UTSW |
12 |
70,109,480 (GRCm39) |
missense |
|
|
|
R7655:Nin
|
UTSW |
12 |
70,089,542 (GRCm39) |
missense |
|
|
|
R7656:Nin
|
UTSW |
12 |
70,089,542 (GRCm39) |
missense |
|
|
|
R7683:Nin
|
UTSW |
12 |
70,124,956 (GRCm39) |
missense |
|
|
|
R7769:Nin
|
UTSW |
12 |
70,090,004 (GRCm39) |
missense |
|
|
|
R7981:Nin
|
UTSW |
12 |
70,089,591 (GRCm39) |
missense |
|
|
|
R8138:Nin
|
UTSW |
12 |
70,089,672 (GRCm39) |
missense |
|
|
|
R8141:Nin
|
UTSW |
12 |
70,076,795 (GRCm39) |
missense |
|
|
|
R8754:Nin
|
UTSW |
12 |
70,077,787 (GRCm39) |
intron |
probably benign |
|
|
R8790:Nin
|
UTSW |
12 |
70,067,793 (GRCm39) |
missense |
|
|
|
R8899:Nin
|
UTSW |
12 |
70,077,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8974:Nin
|
UTSW |
12 |
70,124,932 (GRCm39) |
missense |
|
|
|
R9085:Nin
|
UTSW |
12 |
70,076,786 (GRCm39) |
nonsense |
probably null |
|
|
R9143:Nin
|
UTSW |
12 |
70,137,349 (GRCm39) |
missense |
|
|
|
R9380:Nin
|
UTSW |
12 |
70,074,805 (GRCm39) |
missense |
|
|
|
R9496:Nin
|
UTSW |
12 |
70,102,762 (GRCm39) |
missense |
|
|
|
R9638:Nin
|
UTSW |
12 |
70,067,618 (GRCm39) |
missense |
|
|
|
R9709:Nin
|
UTSW |
12 |
70,149,468 (GRCm39) |
missense |
|
|
|
R9745:Nin
|
UTSW |
12 |
70,089,899 (GRCm39) |
missense |
|
|
|
R9792:Nin
|
UTSW |
12 |
70,094,009 (GRCm39) |
missense |
|
|
|
Z1176:Nin
|
UTSW |
12 |
70,095,938 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Nin
|
UTSW |
12 |
70,101,200 (GRCm39) |
missense |
|
|
|
Z1177:Nin
|
UTSW |
12 |
70,090,869 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTTCAGAAGCAAACATCCCTGAC -3'
(R):5'- GCATACGAAGCACCCTGAGTTTCC -3'
Sequencing Primer
(F):5'- atatagagagagagagagagagagG -3'
(R):5'- GTTTCCACTGAACTGCTGGAAAG -3'
|
| Posted On |
2013-09-03 |
Incidental Mutation