Incidental Mutation 'IGL00821:Zfp667'
| ID |
14991 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp667
|
| Ensembl Gene |
ENSMUSG00000054893 |
| Gene Name |
zinc finger protein 667 |
| Synonyms |
A830025F02Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
IGL00821
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
6289578-6310882 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 6308396 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Aspartic acid
at position 355
(N355D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128658
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086327]
[ENSMUST00000108562]
[ENSMUST00000153840]
[ENSMUST00000170776]
|
| AlphaFold |
Q2TL60 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000086327
AA Change: N355D
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000083507
Gene: ENSMUSG00000054893
AA Change: N355D
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
4.77e-30 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
200 |
222 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
253 |
275 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
357 |
379 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
385 |
407 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
414 |
436 |
5.06e-2 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
470 |
492 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
498 |
520 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
526 |
548 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
554 |
576 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
582 |
604 |
1.38e-3 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000108562
AA Change: N355D
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000104202
Gene: ENSMUSG00000054893
AA Change: N355D
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
4.77e-30 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
200 |
222 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
253 |
275 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
357 |
379 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
385 |
407 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
414 |
436 |
5.06e-2 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
470 |
492 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
498 |
520 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
526 |
548 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
554 |
576 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
582 |
604 |
1.38e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153840
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170776
AA Change: N355D
PolyPhen 2
Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000128658
Gene: ENSMUSG00000054893
AA Change: N355D
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
4.77e-30 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
200 |
222 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
253 |
275 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
357 |
379 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
385 |
407 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
414 |
436 |
5.06e-2 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
470 |
492 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
498 |
520 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
526 |
548 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
554 |
576 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
582 |
604 |
1.38e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
All alleles(4) : Targeted, other(2) Gene trapped(2)
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cad |
T |
C |
5: 31,218,828 (GRCm39) |
Y550H |
probably damaging |
Het |
| Cep350 |
A |
G |
1: 155,737,950 (GRCm39) |
V2631A |
probably benign |
Het |
| Cpa2 |
A |
G |
6: 30,564,411 (GRCm39) |
D414G |
probably benign |
Het |
| Dhx38 |
T |
C |
8: 110,282,286 (GRCm39) |
I714V |
probably benign |
Het |
| Dis3 |
T |
C |
14: 99,328,922 (GRCm39) |
I277V |
probably benign |
Het |
| Espl1 |
T |
C |
15: 102,208,248 (GRCm39) |
L418P |
probably damaging |
Het |
| F7 |
A |
G |
8: 13,078,802 (GRCm39) |
T78A |
probably benign |
Het |
| Faim |
G |
A |
9: 98,874,218 (GRCm39) |
G15R |
probably damaging |
Het |
| Golga3 |
C |
A |
5: 110,352,799 (GRCm39) |
H897N |
possibly damaging |
Het |
| Itgae |
T |
A |
11: 73,013,974 (GRCm39) |
D724E |
probably damaging |
Het |
| Klb |
A |
T |
5: 65,529,492 (GRCm39) |
Y340F |
probably damaging |
Het |
| Kmt2b |
A |
T |
7: 30,270,038 (GRCm39) |
L2436Q |
probably damaging |
Het |
| Krt17 |
A |
G |
11: 100,151,457 (GRCm39) |
L112P |
probably damaging |
Het |
| Lrp2 |
T |
A |
2: 69,289,860 (GRCm39) |
N3660Y |
probably damaging |
Het |
| Mia2 |
T |
C |
12: 59,217,106 (GRCm39) |
|
probably null |
Het |
| Myh2 |
C |
T |
11: 67,088,223 (GRCm39) |
|
probably benign |
Het |
| Nr2f1 |
A |
G |
13: 78,346,233 (GRCm39) |
|
probably benign |
Het |
| Odf2l |
T |
A |
3: 144,856,748 (GRCm39) |
S568T |
probably damaging |
Het |
| Parl |
G |
A |
16: 20,116,958 (GRCm39) |
P80S |
probably damaging |
Het |
| Ppfibp2 |
T |
G |
7: 107,329,083 (GRCm39) |
F531V |
probably damaging |
Het |
| Prpf40b |
A |
G |
15: 99,214,382 (GRCm39) |
E854G |
probably benign |
Het |
| Rere |
A |
G |
4: 150,703,920 (GRCm39) |
K1551E |
probably damaging |
Het |
| Sacm1l |
A |
T |
9: 123,399,614 (GRCm39) |
Q302L |
possibly damaging |
Het |
| Slc41a2 |
A |
G |
10: 83,149,394 (GRCm39) |
|
probably benign |
Het |
| Smchd1 |
T |
C |
17: 71,705,618 (GRCm39) |
T994A |
possibly damaging |
Het |
| Ubxn7 |
G |
A |
16: 32,188,216 (GRCm39) |
D125N |
probably damaging |
Het |
| Zfp839 |
T |
C |
12: 110,831,441 (GRCm39) |
|
probably null |
Het |
| Zfpm2 |
T |
A |
15: 40,966,783 (GRCm39) |
N957K |
probably damaging |
Het |
|
| Other mutations in Zfp667 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01325:Zfp667
|
APN |
7 |
6,293,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01386:Zfp667
|
APN |
7 |
6,307,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01960:Zfp667
|
APN |
7 |
6,308,336 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03394:Zfp667
|
APN |
7 |
6,292,438 (GRCm39) |
critical splice donor site |
probably null |
|
|
B5639:Zfp667
|
UTSW |
7 |
6,293,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0458:Zfp667
|
UTSW |
7 |
6,307,844 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0845:Zfp667
|
UTSW |
7 |
6,309,091 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1768:Zfp667
|
UTSW |
7 |
6,308,066 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1953:Zfp667
|
UTSW |
7 |
6,308,087 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2023:Zfp667
|
UTSW |
7 |
6,308,416 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3159:Zfp667
|
UTSW |
7 |
6,308,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4080:Zfp667
|
UTSW |
7 |
6,308,105 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4476:Zfp667
|
UTSW |
7 |
6,307,598 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4584:Zfp667
|
UTSW |
7 |
6,293,624 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4783:Zfp667
|
UTSW |
7 |
6,308,684 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5037:Zfp667
|
UTSW |
7 |
6,308,949 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5300:Zfp667
|
UTSW |
7 |
6,307,635 (GRCm39) |
missense |
probably benign |
|
|
R5311:Zfp667
|
UTSW |
7 |
6,308,715 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5312:Zfp667
|
UTSW |
7 |
6,308,466 (GRCm39) |
missense |
probably benign |
|
|
R5340:Zfp667
|
UTSW |
7 |
6,308,252 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6262:Zfp667
|
UTSW |
7 |
6,307,973 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7386:Zfp667
|
UTSW |
7 |
6,308,949 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8383:Zfp667
|
UTSW |
7 |
6,308,370 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8919:Zfp667
|
UTSW |
7 |
6,308,256 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9099:Zfp667
|
UTSW |
7 |
6,308,322 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9422:Zfp667
|
UTSW |
7 |
6,308,321 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Zfp667
|
UTSW |
7 |
6,307,856 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Posted On |
2012-12-06 |
Incidental Mutation