Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00821:Kmt2b'

14831

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Kmt2b

Ensembl Gene

ENSMUSG00000006307

Gene Name

lysine (K)-specific methyltransferase 2B

Synonyms

2610014H22Rik, Mll2, Wbp7

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00821

Quality Score

Status

Chromosome

Chromosomal Location

30268283-30288151 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 30270038 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 2436 (L2436Q)

Ref Sequence

ENSEMBL: ENSMUSP00000103789 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000006470] [ENSMUST00000043850] [ENSMUST00000108154] [ENSMUST00000108161] [ENSMUST00000172251] [ENSMUST00000167042] [ENSMUST00000171912]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000006470
AA Change: L2444Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000006470
Gene: ENSMUSG00000006307
AA Change: L2444Q

Domain	Start	End	E-Value	Type
AT_hook	18	30	2.82e2	SMART
low complexity region	66	106	N/A	INTRINSIC
low complexity region	110	122	N/A	INTRINSIC
AT_hook	149	159	2.4e2	SMART
AT_hook	218	230	1.95e2	SMART
low complexity region	249	263	N/A	INTRINSIC
low complexity region	272	302	N/A	INTRINSIC
coiled coil region	353	413	N/A	INTRINSIC
AT_hook	476	488	5.47e-1	SMART
low complexity region	501	517	N/A	INTRINSIC
low complexity region	578	606	N/A	INTRINSIC
low complexity region	621	657	N/A	INTRINSIC
low complexity region	673	700	N/A	INTRINSIC
low complexity region	715	728	N/A	INTRINSIC
low complexity region	738	777	N/A	INTRINSIC
low complexity region	910	922	N/A	INTRINSIC
Pfam:zf-CXXC	963	1010	7.2e-15	PFAM
low complexity region	1039	1061	N/A	INTRINSIC
low complexity region	1103	1115	N/A	INTRINSIC
PHD	1209	1256	1.25e-5	SMART
PHD	1257	1307	5.4e-10	SMART
PHD	1343	1400	1.27e-6	SMART
low complexity region	1415	1427	N/A	INTRINSIC
PHD	1646	1692	3.82e-1	SMART
FYRN	1745	1788	3.25e-19	SMART
low complexity region	1881	1899	N/A	INTRINSIC
low complexity region	1912	1942	N/A	INTRINSIC
low complexity region	1961	1978	N/A	INTRINSIC
low complexity region	1991	2003	N/A	INTRINSIC
low complexity region	2013	2026	N/A	INTRINSIC
low complexity region	2048	2061	N/A	INTRINSIC
low complexity region	2087	2105	N/A	INTRINSIC
low complexity region	2127	2138	N/A	INTRINSIC
low complexity region	2215	2235	N/A	INTRINSIC
low complexity region	2239	2270	N/A	INTRINSIC
low complexity region	2396	2406	N/A	INTRINSIC
FYRC	2419	2504	4.83e-36	SMART
SET	2581	2703	1.67e-42	SMART
PostSET	2705	2721	4.65e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000043850

SMART Domains

Protein: ENSMUSP00000042312
Gene: ENSMUSG00000036826

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
transmembrane domain	166	188	N/A	INTRINSIC
low complexity region	247	264	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000108154
AA Change: L2436Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000103789
Gene: ENSMUSG00000006307
AA Change: L2436Q

Domain	Start	End	E-Value	Type
AT_hook	18	30	2.82e2	SMART
low complexity region	66	106	N/A	INTRINSIC
low complexity region	110	122	N/A	INTRINSIC
AT_hook	149	159	2.4e2	SMART
AT_hook	218	230	1.95e2	SMART
low complexity region	249	263	N/A	INTRINSIC
low complexity region	272	302	N/A	INTRINSIC
coiled coil region	353	413	N/A	INTRINSIC
AT_hook	476	488	5.47e-1	SMART
low complexity region	501	517	N/A	INTRINSIC
low complexity region	578	606	N/A	INTRINSIC
low complexity region	621	657	N/A	INTRINSIC
low complexity region	673	700	N/A	INTRINSIC
low complexity region	715	728	N/A	INTRINSIC
low complexity region	738	777	N/A	INTRINSIC
low complexity region	910	922	N/A	INTRINSIC
Pfam:zf-CXXC	963	1010	1e-14	PFAM
low complexity region	1039	1061	N/A	INTRINSIC
low complexity region	1103	1115	N/A	INTRINSIC
PHD	1209	1256	1.25e-5	SMART
PHD	1257	1307	5.4e-10	SMART
PHD	1343	1400	1.27e-6	SMART
low complexity region	1415	1427	N/A	INTRINSIC
PHD	1646	1692	3.82e-1	SMART
FYRN	1745	1788	3.25e-19	SMART
low complexity region	1872	1890	N/A	INTRINSIC
low complexity region	1903	1933	N/A	INTRINSIC
low complexity region	1952	1969	N/A	INTRINSIC
low complexity region	1982	1994	N/A	INTRINSIC
low complexity region	2004	2017	N/A	INTRINSIC
low complexity region	2039	2052	N/A	INTRINSIC
low complexity region	2078	2096	N/A	INTRINSIC
low complexity region	2118	2129	N/A	INTRINSIC
low complexity region	2206	2226	N/A	INTRINSIC
low complexity region	2230	2261	N/A	INTRINSIC
low complexity region	2383	2398	N/A	INTRINSIC
FYRC	2411	2496	4.83e-36	SMART
SET	2573	2695	1.67e-42	SMART
PostSET	2697	2713	4.65e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108161

SMART Domains

Protein: ENSMUSP00000103796
Gene: ENSMUSG00000109378

Domain	Start	End	E-Value	Type
Pfam:zf-CCCH	13	39	8.8e-10	PFAM
SCOP:d1jmta_	43	115	2e-17	SMART
PDB:1JMT\|A	43	116	3e-40	PDB
Blast:RRM	45	116	2e-36	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128456

Predicted Effect

unknown
Transcript: ENSMUST00000131002
AA Change: L1736Q

SMART Domains

Protein: ENSMUSP00000118486
Gene: ENSMUSG00000006307
AA Change: L1736Q

Domain	Start	End	E-Value	Type
low complexity region	7	20	N/A	INTRINSIC
low complexity region	30	69	N/A	INTRINSIC
low complexity region	202	214	N/A	INTRINSIC
Pfam:zf-CXXC	255	302	5.2e-15	PFAM
low complexity region	331	353	N/A	INTRINSIC
low complexity region	395	407	N/A	INTRINSIC
PHD	501	548	1.25e-5	SMART
PHD	549	599	5.4e-10	SMART
PHD	635	692	1.27e-6	SMART
low complexity region	707	719	N/A	INTRINSIC
PHD	938	984	3.82e-1	SMART
FYRN	1037	1080	3.25e-19	SMART
low complexity region	1173	1191	N/A	INTRINSIC
low complexity region	1204	1234	N/A	INTRINSIC
low complexity region	1253	1270	N/A	INTRINSIC
low complexity region	1283	1295	N/A	INTRINSIC
low complexity region	1305	1318	N/A	INTRINSIC
low complexity region	1340	1353	N/A	INTRINSIC
low complexity region	1379	1397	N/A	INTRINSIC
low complexity region	1419	1430	N/A	INTRINSIC
low complexity region	1507	1527	N/A	INTRINSIC
low complexity region	1531	1562	N/A	INTRINSIC
low complexity region	1684	1699	N/A	INTRINSIC
FYRC	1712	1797	4.83e-36	SMART
SET	1874	1996	1.67e-42	SMART
PostSET	1998	2014	4.65e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136959

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000163994

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152931

Predicted Effect

probably benign
Transcript: ENSMUST00000172251

SMART Domains

Protein: ENSMUSP00000132400
Gene: ENSMUSG00000036826

Domain	Start	End	E-Value	Type
signal peptide	1	41	N/A	INTRINSIC
transmembrane domain	186	208	N/A	INTRINSIC
low complexity region	267	284	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000167042

SMART Domains

Protein: ENSMUSP00000128886
Gene: ENSMUSG00000109378

Domain	Start	End	E-Value	Type
ZnF_C3H1	13	39	4.79e-3	SMART
RRM	66	143	5.99e-4	SMART
ZnF_C3H1	149	175	2.49e-1	SMART
low complexity region	187	219	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000171912

SMART Domains

Protein: ENSMUSP00000130983
Gene: ENSMUSG00000109378

Domain	Start	End	E-Value	Type
ZnF_C3H1	13	39	4.79e-3	SMART
RRM	66	143	5.99e-4	SMART
ZnF_C3H1	149	175	2.49e-1	SMART
low complexity region	187	219	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous disruption of this gene leads to embryonic growth retardation, abnormal somite development, neural tube defects, increased apoptosis, and complete embryonic lethality. Homozygotes for a hypomorphic allele show embryonic growth arrest, altered DNA methylation, and reduced female fertility. [provided by MGI curators]

Allele List at MGI

All alleles(8) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(4)

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cad	T	C	5: 31,218,828 (GRCm39)	Y550H	probably damaging	Het
Cep350	A	G	1: 155,737,950 (GRCm39)	V2631A	probably benign	Het
Cpa2	A	G	6: 30,564,411 (GRCm39)	D414G	probably benign	Het
Dhx38	T	C	8: 110,282,286 (GRCm39)	I714V	probably benign	Het
Dis3	T	C	14: 99,328,922 (GRCm39)	I277V	probably benign	Het
Espl1	T	C	15: 102,208,248 (GRCm39)	L418P	probably damaging	Het
F7	A	G	8: 13,078,802 (GRCm39)	T78A	probably benign	Het
Faim	G	A	9: 98,874,218 (GRCm39)	G15R	probably damaging	Het
Golga3	C	A	5: 110,352,799 (GRCm39)	H897N	possibly damaging	Het
Itgae	T	A	11: 73,013,974 (GRCm39)	D724E	probably damaging	Het
Klb	A	T	5: 65,529,492 (GRCm39)	Y340F	probably damaging	Het
Krt17	A	G	11: 100,151,457 (GRCm39)	L112P	probably damaging	Het
Lrp2	T	A	2: 69,289,860 (GRCm39)	N3660Y	probably damaging	Het
Mia2	T	C	12: 59,217,106 (GRCm39)		probably null	Het
Myh2	C	T	11: 67,088,223 (GRCm39)		probably benign	Het
Nr2f1	A	G	13: 78,346,233 (GRCm39)		probably benign	Het
Odf2l	T	A	3: 144,856,748 (GRCm39)	S568T	probably damaging	Het
Parl	G	A	16: 20,116,958 (GRCm39)	P80S	probably damaging	Het
Ppfibp2	T	G	7: 107,329,083 (GRCm39)	F531V	probably damaging	Het
Prpf40b	A	G	15: 99,214,382 (GRCm39)	E854G	probably benign	Het
Rere	A	G	4: 150,703,920 (GRCm39)	K1551E	probably damaging	Het
Sacm1l	A	T	9: 123,399,614 (GRCm39)	Q302L	possibly damaging	Het
Slc41a2	A	G	10: 83,149,394 (GRCm39)		probably benign	Het
Smchd1	T	C	17: 71,705,618 (GRCm39)	T994A	possibly damaging	Het
Ubxn7	G	A	16: 32,188,216 (GRCm39)	D125N	probably damaging	Het
Zfp667	A	G	7: 6,308,396 (GRCm39)	N355D	possibly damaging	Het
Zfp839	T	C	12: 110,831,441 (GRCm39)		probably null	Het
Zfpm2	T	A	15: 40,966,783 (GRCm39)	N957K	probably damaging	Het

Other mutations in Kmt2b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00580:Kmt2b	APN	7	30,285,938 (GRCm39)	unclassified	probably benign
IGL00985:Kmt2b	APN	7	30,279,352 (GRCm39)	missense	probably damaging	1.00
IGL01092:Kmt2b	APN	7	30,279,932 (GRCm39)	missense	probably damaging	1.00
IGL01933:Kmt2b	APN	7	30,268,939 (GRCm39)	critical splice donor site	probably null
IGL01949:Kmt2b	APN	7	30,276,586 (GRCm39)	splice site	probably null
IGL02253:Kmt2b	APN	7	30,281,152 (GRCm39)	missense	probably damaging	1.00
IGL02455:Kmt2b	APN	7	30,278,303 (GRCm39)	critical splice donor site	probably null
IGL02493:Kmt2b	APN	7	30,268,936 (GRCm39)	unclassified	probably benign
IGL02504:Kmt2b	APN	7	30,285,968 (GRCm39)	unclassified	probably benign
IGL02532:Kmt2b	APN	7	30,286,314 (GRCm39)	unclassified	probably benign
IGL02698:Kmt2b	APN	7	30,278,118 (GRCm39)	splice site	probably benign
IGL02717:Kmt2b	APN	7	30,282,869 (GRCm39)	missense	probably damaging	1.00
IGL02826:Kmt2b	APN	7	30,276,569 (GRCm39)	missense	probably damaging	1.00
IGL02966:Kmt2b	APN	7	30,274,887 (GRCm39)	missense	probably benign	0.02
IGL03386:Kmt2b	APN	7	30,273,396 (GRCm39)	missense	possibly damaging	0.94
Dean	UTSW	7	30,268,835 (GRCm39)	missense	possibly damaging	0.83
provost	UTSW	7	30,281,633 (GRCm39)	missense	probably damaging	1.00
tenure	UTSW	7	30,268,600 (GRCm39)	missense	probably damaging	1.00
3-1:Kmt2b	UTSW	7	30,269,040 (GRCm39)	nonsense	probably null
FR4304:Kmt2b	UTSW	7	30,285,788 (GRCm39)	unclassified	probably benign
FR4340:Kmt2b	UTSW	7	30,285,800 (GRCm39)	unclassified	probably benign
FR4340:Kmt2b	UTSW	7	30,285,794 (GRCm39)	unclassified	probably benign
FR4340:Kmt2b	UTSW	7	30,285,788 (GRCm39)	unclassified	probably benign
FR4342:Kmt2b	UTSW	7	30,285,800 (GRCm39)	unclassified	probably benign
FR4449:Kmt2b	UTSW	7	30,285,794 (GRCm39)	unclassified	probably benign
FR4449:Kmt2b	UTSW	7	30,285,791 (GRCm39)	unclassified	probably benign
FR4449:Kmt2b	UTSW	7	30,285,786 (GRCm39)	unclassified	probably benign
FR4548:Kmt2b	UTSW	7	30,285,805 (GRCm39)	unclassified	probably benign
FR4589:Kmt2b	UTSW	7	30,285,806 (GRCm39)	unclassified	probably benign
FR4589:Kmt2b	UTSW	7	30,285,789 (GRCm39)	nonsense	probably null
FR4589:Kmt2b	UTSW	7	30,285,786 (GRCm39)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,285,795 (GRCm39)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,285,792 (GRCm39)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,285,791 (GRCm39)	unclassified	probably benign
FR4737:Kmt2b	UTSW	7	30,285,803 (GRCm39)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,285,787 (GRCm39)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,285,785 (GRCm39)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,285,798 (GRCm39)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,285,791 (GRCm39)	unclassified	probably benign
FR4976:Kmt2b	UTSW	7	30,285,789 (GRCm39)	nonsense	probably null
PIT4403001:Kmt2b	UTSW	7	30,285,114 (GRCm39)	missense	probably damaging	1.00
PIT4802001:Kmt2b	UTSW	7	30,278,996 (GRCm39)	missense	probably damaging	0.99
R0057:Kmt2b	UTSW	7	30,276,217 (GRCm39)	splice site	probably benign
R0131:Kmt2b	UTSW	7	30,283,346 (GRCm39)	missense	probably damaging	0.99
R0241:Kmt2b	UTSW	7	30,276,494 (GRCm39)	missense	probably damaging	1.00
R0241:Kmt2b	UTSW	7	30,276,494 (GRCm39)	missense	probably damaging	1.00
R0377:Kmt2b	UTSW	7	30,273,618 (GRCm39)	missense	probably damaging	1.00
R0396:Kmt2b	UTSW	7	30,276,180 (GRCm39)	missense	probably damaging	1.00
R1241:Kmt2b	UTSW	7	30,274,365 (GRCm39)	missense	probably damaging	0.98
R1252:Kmt2b	UTSW	7	30,279,912 (GRCm39)	missense	probably damaging	0.99
R1418:Kmt2b	UTSW	7	30,276,385 (GRCm39)	splice site	probably benign
R1599:Kmt2b	UTSW	7	30,270,000 (GRCm39)	missense	probably damaging	1.00
R1632:Kmt2b	UTSW	7	30,283,387 (GRCm39)	missense	probably damaging	1.00
R1745:Kmt2b	UTSW	7	30,285,275 (GRCm39)	missense	possibly damaging	0.90
R1867:Kmt2b	UTSW	7	30,274,083 (GRCm39)	missense	possibly damaging	0.71
R1955:Kmt2b	UTSW	7	30,274,776 (GRCm39)	missense	possibly damaging	0.90
R2040:Kmt2b	UTSW	7	30,268,845 (GRCm39)	missense	probably damaging	1.00
R2113:Kmt2b	UTSW	7	30,282,812 (GRCm39)	missense	probably damaging	1.00
R2216:Kmt2b	UTSW	7	30,273,490 (GRCm39)	missense	probably benign	0.25
R2401:Kmt2b	UTSW	7	30,276,133 (GRCm39)	missense	probably damaging	1.00
R2518:Kmt2b	UTSW	7	30,275,493 (GRCm39)	missense	probably benign	0.10
R3436:Kmt2b	UTSW	7	30,276,117 (GRCm39)	missense	probably damaging	1.00
R4248:Kmt2b	UTSW	7	30,273,489 (GRCm39)	missense	probably benign	0.25
R4259:Kmt2b	UTSW	7	30,280,506 (GRCm39)	missense	probably damaging	0.99
R4290:Kmt2b	UTSW	7	30,281,261 (GRCm39)	critical splice donor site	probably null
R4388:Kmt2b	UTSW	7	30,288,015 (GRCm39)	unclassified	probably benign
R4542:Kmt2b	UTSW	7	30,279,684 (GRCm39)	missense	probably damaging	0.99
R4649:Kmt2b	UTSW	7	30,285,783 (GRCm39)	unclassified	probably benign
R4722:Kmt2b	UTSW	7	30,282,627 (GRCm39)	missense	probably damaging	1.00
R4891:Kmt2b	UTSW	7	30,276,186 (GRCm39)	nonsense	probably null
R4916:Kmt2b	UTSW	7	30,277,942 (GRCm39)	missense	probably damaging	0.99
R5104:Kmt2b	UTSW	7	30,269,265 (GRCm39)	missense	probably damaging	1.00
R5254:Kmt2b	UTSW	7	30,268,600 (GRCm39)	missense	probably damaging	1.00
R5262:Kmt2b	UTSW	7	30,269,219 (GRCm39)	missense	probably damaging	1.00
R5307:Kmt2b	UTSW	7	30,281,098 (GRCm39)	missense	possibly damaging	0.91
R5526:Kmt2b	UTSW	7	30,279,869 (GRCm39)	missense	probably damaging	1.00
R5609:Kmt2b	UTSW	7	30,276,570 (GRCm39)	missense	probably damaging	0.99
R6150:Kmt2b	UTSW	7	30,287,902 (GRCm39)	unclassified	probably benign
R6727:Kmt2b	UTSW	7	30,283,984 (GRCm39)	missense	probably damaging	0.98
R6824:Kmt2b	UTSW	7	30,285,701 (GRCm39)	unclassified	probably benign
R7048:Kmt2b	UTSW	7	30,268,731 (GRCm39)	missense	probably damaging	0.99
R7155:Kmt2b	UTSW	7	30,279,388 (GRCm39)	missense	probably damaging	0.99
R7307:Kmt2b	UTSW	7	30,279,896 (GRCm39)	missense	probably damaging	0.99
R7388:Kmt2b	UTSW	7	30,281,385 (GRCm39)	missense	probably damaging	1.00
R7555:Kmt2b	UTSW	7	30,268,835 (GRCm39)	missense	possibly damaging	0.83
R7569:Kmt2b	UTSW	7	30,268,978 (GRCm39)	missense	possibly damaging	0.54
R7616:Kmt2b	UTSW	7	30,281,633 (GRCm39)	missense	probably damaging	1.00
R7669:Kmt2b	UTSW	7	30,282,656 (GRCm39)	missense	possibly damaging	0.84
R7881:Kmt2b	UTSW	7	30,279,208 (GRCm39)	missense	probably damaging	1.00
R7999:Kmt2b	UTSW	7	30,276,199 (GRCm39)	missense	probably damaging	1.00
R8003:Kmt2b	UTSW	7	30,268,802 (GRCm39)	missense	probably damaging	0.98
R8189:Kmt2b	UTSW	7	30,268,756 (GRCm39)	missense	probably damaging	0.98
R8291:Kmt2b	UTSW	7	30,284,894 (GRCm39)	missense	probably damaging	1.00
R8314:Kmt2b	UTSW	7	30,278,347 (GRCm39)	missense	probably damaging	0.99
R8802:Kmt2b	UTSW	7	30,283,496 (GRCm39)	missense	probably damaging	1.00
R8954:Kmt2b	UTSW	7	30,273,640 (GRCm39)	missense	probably damaging	1.00
R9046:Kmt2b	UTSW	7	30,285,479 (GRCm39)	missense	probably benign	0.00
R9225:Kmt2b	UTSW	7	30,286,172 (GRCm39)	missense	unknown
R9258:Kmt2b	UTSW	7	30,281,893 (GRCm39)	missense	probably null	0.99
R9414:Kmt2b	UTSW	7	30,282,307 (GRCm39)	missense	probably damaging	0.99
R9468:Kmt2b	UTSW	7	30,284,513 (GRCm39)	missense	probably damaging	0.98
R9508:Kmt2b	UTSW	7	30,269,259 (GRCm39)	missense	probably damaging	0.99
R9642:Kmt2b	UTSW	7	30,283,340 (GRCm39)	critical splice donor site	probably null
R9667:Kmt2b	UTSW	7	30,287,784 (GRCm39)	missense	unknown
R9709:Kmt2b	UTSW	7	30,279,228 (GRCm39)	missense	probably damaging	0.98
RF001:Kmt2b	UTSW	7	30,285,807 (GRCm39)	unclassified	probably benign
RF006:Kmt2b	UTSW	7	30,285,802 (GRCm39)	unclassified	probably benign
RF020:Kmt2b	UTSW	7	30,285,807 (GRCm39)	unclassified	probably benign
RF021:Kmt2b	UTSW	7	30,285,782 (GRCm39)	unclassified	probably benign
RF030:Kmt2b	UTSW	7	30,285,802 (GRCm39)	unclassified	probably benign
RF035:Kmt2b	UTSW	7	30,285,782 (GRCm39)	unclassified	probably benign
X0067:Kmt2b	UTSW	7	30,278,998 (GRCm39)	missense	probably damaging	0.99
Z1088:Kmt2b	UTSW	7	30,284,676 (GRCm39)	missense	probably benign	0.28
Z1176:Kmt2b	UTSW	7	30,276,795 (GRCm39)	missense	probably damaging	1.00
Z1177:Kmt2b	UTSW	7	30,285,841 (GRCm39)	missense	unknown
Z1177:Kmt2b	UTSW	7	30,283,588 (GRCm39)	missense	probably damaging	0.98
Z1177:Kmt2b	UTSW	7	30,274,449 (GRCm39)	missense	probably benign	0.08
Z1186:Kmt2b	UTSW	7	30,284,732 (GRCm39)	missense	probably benign
Z1186:Kmt2b	UTSW	7	30,274,404 (GRCm39)	missense	probably benign

Posted On

2012-12-06