Incidental Mutation 'R1274:Or5d36'
ID 150833
Institutional Source Beutler Lab
Gene Symbol Or5d36
Ensembl Gene ENSMUSG00000075137
Gene Name olfactory receptor family 5 subfamily D member 36
Synonyms Olfr1163, MOR174-8, GA_x6K02T2Q125-49563265-49562315
MMRRC Submission 039340-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R1274 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87900709-87901751 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 87900939 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tryptophan at position 262 (C262W)
Ref Sequence ENSEMBL: ENSMUSP00000149399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099835] [ENSMUST00000215268]
AlphaFold Q8VFR4
Predicted Effect probably damaging
Transcript: ENSMUST00000099835
AA Change: C262W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097423
Gene: ENSMUSG00000075137
AA Change: C262W

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 1.2e-44 PFAM
Pfam:7tm_1 43 292 2.3e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215268
AA Change: C262W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1l2 T C 19: 56,902,995 (GRCm39) D728G probably benign Het
Anpep C T 7: 79,488,004 (GRCm39) E518K probably benign Het
Ceacam3 A G 7: 16,897,064 (GRCm39) R677G probably damaging Het
Col16a1 T A 4: 129,991,594 (GRCm39) M1431K probably damaging Het
Dync1h1 G A 12: 110,602,943 (GRCm39) E2195K probably benign Het
Gm6563 A T 19: 23,653,701 (GRCm39) I164F probably benign Het
Msantd5f6 T C 4: 73,321,313 (GRCm39) Y148C probably damaging Het
Nav2 C A 7: 49,254,178 (GRCm39) Y2325* probably null Het
Or10ak12 T C 4: 118,666,593 (GRCm39) N156S probably benign Het
P2ry12 T C 3: 59,124,641 (GRCm39) T345A possibly damaging Het
Ptpn13 C T 5: 103,698,126 (GRCm39) P1078S probably damaging Het
Rgs20 G A 1: 4,982,670 (GRCm39) T166I probably damaging Het
Sik1 A T 17: 32,065,549 (GRCm39) L683Q possibly damaging Het
Slc7a5 C T 8: 122,610,453 (GRCm39) V454M probably benign Het
Snx30 A G 4: 59,885,133 (GRCm39) T258A probably benign Het
Vmn1r234 CTT CTTT 17: 21,449,513 (GRCm39) probably null Het
Zfp335 GTCCTCCTCCTCCTCCTC GTCCTCCTCCTCCTC 2: 164,749,388 (GRCm39) probably benign Het
Other mutations in Or5d36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Or5d36 APN 2 87,901,468 (GRCm39) missense possibly damaging 0.56
IGL01472:Or5d36 APN 2 87,901,322 (GRCm39) missense possibly damaging 0.56
IGL02111:Or5d36 APN 2 87,901,571 (GRCm39) missense probably benign 0.22
R1938:Or5d36 UTSW 2 87,901,300 (GRCm39) missense probably damaging 1.00
R2012:Or5d36 UTSW 2 87,901,063 (GRCm39) missense probably benign 0.03
R3056:Or5d36 UTSW 2 87,901,583 (GRCm39) missense probably benign
R4127:Or5d36 UTSW 2 87,901,579 (GRCm39) missense probably benign 0.00
R4748:Or5d36 UTSW 2 87,900,956 (GRCm39) missense probably benign 0.44
R4749:Or5d36 UTSW 2 87,900,956 (GRCm39) missense probably benign 0.44
R4769:Or5d36 UTSW 2 87,901,073 (GRCm39) missense probably benign 0.25
R6647:Or5d36 UTSW 2 87,901,053 (GRCm39) missense probably benign 0.03
R7111:Or5d36 UTSW 2 87,901,000 (GRCm39) missense probably damaging 1.00
R7168:Or5d36 UTSW 2 87,900,921 (GRCm39) missense probably benign 0.37
R8222:Or5d36 UTSW 2 87,901,381 (GRCm39) missense probably benign 0.00
R8869:Or5d36 UTSW 2 87,901,753 (GRCm39) critical splice acceptor site probably null
R9043:Or5d36 UTSW 2 87,900,983 (GRCm39) missense possibly damaging 0.94
R9205:Or5d36 UTSW 2 87,900,778 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- CATGGTAGAGAGAAACAGCCAGTGTTC -3'
(R):5'- CAAGCTGCTTGAAAACTTGGTCCTG -3'

Sequencing Primer
(F):5'- GATGGCTCAGTGAAGTTGGA -3'
(R):5'- ACTGGGTCATATATCTGGAGTACC -3'
Posted On 2014-01-29