Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00226:Zfp623'

2131

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp623

Ensembl Gene

ENSMUSG00000050846

Gene Name

zinc finger protein 623

Synonyms

2610029D06Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.368) question?

Stock #

IGL00226

Quality Score

Status

Chromosome

Chromosomal Location

75812801-75821249 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 75820052 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 336 (I336T)

Ref Sequence

ENSEMBL: ENSMUSP00000036049 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037260]

AlphaFold

Q9CY99

Predicted Effect

probably damaging
Transcript: ENSMUST00000037260
AA Change: I336T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000036049
Gene: ENSMUSG00000050846
AA Change: I336T

Domain	Start	End	E-Value	Type
ZnF_C2H2	119	141	5.59e-4	SMART
ZnF_C2H2	147	169	9.96e-1	SMART
ZnF_C2H2	175	197	2.4e-3	SMART
ZnF_C2H2	203	225	6.42e-4	SMART
ZnF_C2H2	231	253	1.3e-4	SMART
ZnF_C2H2	259	281	1.3e-4	SMART
ZnF_C2H2	287	309	1.28e-3	SMART
ZnF_C2H2	315	337	3.21e-4	SMART
ZnF_C2H2	343	365	3.39e-3	SMART
ZnF_C2H2	371	393	4.87e-4	SMART
ZnF_C2H2	399	421	2.53e-2	SMART
ZnF_C2H2	427	449	3.95e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810062G17Rik	C	A	3: 36,533,690 (GRCm39)		probably benign	Het
Ankib1	G	A	5: 3,777,573 (GRCm39)	S439L	probably benign	Het
Cdcp3	T	A	7: 130,839,823 (GRCm39)		probably null	Het
Cpd	G	T	11: 76,688,615 (GRCm39)	H886N	probably benign	Het
Dhrs7	A	G	12: 72,706,124 (GRCm39)	C94R	probably damaging	Het
Dmxl2	T	A	9: 54,323,277 (GRCm39)	H1369L	probably damaging	Het
Dnah5	A	G	15: 28,272,488 (GRCm39)	N1068S	probably benign	Het
Dop1a	T	A	9: 86,433,732 (GRCm39)	D2329E	possibly damaging	Het
Eif1ad	A	G	19: 5,418,212 (GRCm39)		probably benign	Het
Fam149a	T	C	8: 45,792,380 (GRCm39)	R693G	probably damaging	Het
Fbxw18	T	A	9: 109,522,411 (GRCm39)	T153S	probably benign	Het
Glg1	A	T	8: 111,886,481 (GRCm39)	C1104S	probably damaging	Het
Jak3	T	C	8: 72,134,341 (GRCm39)		probably benign	Het
Kctd6	C	T	14: 8,222,856 (GRCm38)	R233C	possibly damaging	Het
Kpna3	A	G	14: 61,611,737 (GRCm39)	V300A	possibly damaging	Het
Msh5	A	T	17: 35,248,857 (GRCm39)	Y725*	probably null	Het
Myh2	T	C	11: 67,076,059 (GRCm39)	S749P	possibly damaging	Het
Or2ag15	T	A	7: 106,340,908 (GRCm39)	T78S	probably benign	Het
Or4c110	A	G	2: 88,831,683 (GRCm39)		probably benign	Het
Or5ac17	A	T	16: 59,036,859 (GRCm39)	M39K	probably damaging	Het
Or8g19	T	A	9: 39,056,053 (GRCm39)	I219N	possibly damaging	Het
Pdcd1	A	G	1: 93,967,860 (GRCm39)		probably benign	Het
Pde5a	T	A	3: 122,588,006 (GRCm39)	F391I	probably damaging	Het
Ptpn12	A	C	5: 21,203,666 (GRCm39)	S371A	probably damaging	Het
Sec16b	A	G	1: 157,365,900 (GRCm39)	Y254C	probably damaging	Het
Slc2a10	G	A	2: 165,356,700 (GRCm39)	C120Y	probably damaging	Het
Spink5	G	A	18: 44,120,938 (GRCm39)		probably benign	Het
Svil	A	G	18: 5,099,045 (GRCm39)	Q1250R	probably benign	Het
Tph1	G	T	7: 46,306,294 (GRCm39)	N222K	probably benign	Het
Vmn2r83	A	T	10: 79,314,805 (GRCm39)	D351V	probably damaging	Het
Zfp54	A	G	17: 21,653,821 (GRCm39)	D105G	possibly damaging	Het

Other mutations in Zfp623

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01524:Zfp623	APN	15	75,819,528 (GRCm39)	missense	probably benign
IGL01927:Zfp623	APN	15	75,819,354 (GRCm39)	missense	possibly damaging	0.57
IGL03199:Zfp623	APN	15	75,819,119 (GRCm39)	missense	probably benign	0.40
R0076:Zfp623	UTSW	15	75,819,058 (GRCm39)	missense	probably benign
R0352:Zfp623	UTSW	15	75,820,433 (GRCm39)	missense	probably benign	0.00
R0360:Zfp623	UTSW	15	75,820,510 (GRCm39)	missense	probably benign
R0364:Zfp623	UTSW	15	75,820,510 (GRCm39)	missense	probably benign
R1783:Zfp623	UTSW	15	75,819,760 (GRCm39)	missense	probably damaging	0.99
R2219:Zfp623	UTSW	15	75,819,379 (GRCm39)	missense	possibly damaging	0.90
R5975:Zfp623	UTSW	15	75,820,012 (GRCm39)	missense	probably benign	0.43
R6161:Zfp623	UTSW	15	75,820,470 (GRCm39)	missense	probably benign	0.22
R6342:Zfp623	UTSW	15	75,819,837 (GRCm39)	nonsense	probably null
R6490:Zfp623	UTSW	15	75,820,308 (GRCm39)	missense	probably damaging	1.00
R6513:Zfp623	UTSW	15	75,819,317 (GRCm39)	missense	probably benign
R7028:Zfp623	UTSW	15	75,820,154 (GRCm39)	missense	probably damaging	0.99
R7399:Zfp623	UTSW	15	75,819,247 (GRCm39)	missense	probably damaging	0.98
R7716:Zfp623	UTSW	15	75,820,271 (GRCm39)	missense	probably damaging	1.00
R8362:Zfp623	UTSW	15	75,819,488 (GRCm39)	missense	probably damaging	1.00
R8445:Zfp623	UTSW	15	75,819,402 (GRCm39)	nonsense	probably null
R9028:Zfp623	UTSW	15	75,819,349 (GRCm39)	missense	probably damaging	0.97
R9035:Zfp623	UTSW	15	75,820,162 (GRCm39)	missense	possibly damaging	0.93
R9310:Zfp623	UTSW	15	75,819,949 (GRCm39)	missense	probably damaging	1.00

Posted On

2011-12-09