Incidental Mutation 'IGL00900:Angptl2'
ID 26826
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Angptl2
Ensembl Gene ENSMUSG00000004105
Gene Name angiopoietin-like 2
Synonyms Arp2
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.257) question?
Stock # IGL00900
Quality Score
Status
Chromosome 2
Chromosomal Location 33106081-33137729 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 33133784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 369 (M369L)
Ref Sequence ENSEMBL: ENSMUSP00000004208 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004208] [ENSMUST00000042615] [ENSMUST00000091039] [ENSMUST00000113165] [ENSMUST00000131298] [ENSMUST00000193373]
AlphaFold Q9R045
Predicted Effect probably benign
Transcript: ENSMUST00000004208
AA Change: M369L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000004208
Gene: ENSMUSG00000004105
AA Change: M369L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
coiled coil region 77 113 N/A INTRINSIC
coiled coil region 152 180 N/A INTRINSIC
low complexity region 205 228 N/A INTRINSIC
FBG 273 488 3.62e-107 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000042615
SMART Domains Protein: ENSMUSP00000048451
Gene: ENSMUSG00000038831

DomainStartEndE-ValueType
low complexity region 21 26 N/A INTRINSIC
RasGEF 46 273 4.59e-86 SMART
low complexity region 286 301 N/A INTRINSIC
PH 372 485 1.87e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000091039
SMART Domains Protein: ENSMUSP00000088563
Gene: ENSMUSG00000038831

DomainStartEndE-ValueType
low complexity region 21 26 N/A INTRINSIC
RasGEF 46 290 7.54e-105 SMART
low complexity region 303 318 N/A INTRINSIC
low complexity region 397 411 N/A INTRINSIC
PH 460 573 1.87e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000113165
SMART Domains Protein: ENSMUSP00000108790
Gene: ENSMUSG00000038831

DomainStartEndE-ValueType
low complexity region 21 26 N/A INTRINSIC
RasGEF 46 290 7.54e-105 SMART
low complexity region 303 318 N/A INTRINSIC
low complexity region 397 411 N/A INTRINSIC
PH 459 572 1.87e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131298
SMART Domains Protein: ENSMUSP00000118363
Gene: ENSMUSG00000038831

DomainStartEndE-ValueType
low complexity region 21 26 N/A INTRINSIC
RasGEF 46 290 7.54e-105 SMART
low complexity region 303 318 N/A INTRINSIC
PH 390 503 1.87e-13 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143252
Predicted Effect probably benign
Transcript: ENSMUST00000193373
SMART Domains Protein: ENSMUSP00000142084
Gene: ENSMUSG00000004105

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Fibrinogen_C 49 112 4.2e-21 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]
PHENOTYPE: When fed a high-fat diet, mice homozygous for a knock-out allele show decreased weight gain, reduced adipocity, a lower respiratory quotient, reduced inflammation in adipose tissues, enhanced glucose tolerance, and increased insulin sensitivity in both skeletal muscle and liver relative to controls. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatf T C 11: 84,361,383 (GRCm39) probably benign Het
Agap3 G A 5: 24,681,366 (GRCm39) probably benign Het
Arhgef11 A G 3: 87,590,867 (GRCm39) D36G possibly damaging Het
Ccnt1 A G 15: 98,452,514 (GRCm39) V134A probably damaging Het
Ces1e T C 8: 93,944,245 (GRCm39) H191R probably damaging Het
Dhh A G 15: 98,796,101 (GRCm39) probably benign Het
Edil3 C A 13: 89,437,652 (GRCm39) H418N probably benign Het
Fam161b T C 12: 84,402,743 (GRCm39) I296V probably benign Het
Focad T A 4: 88,047,260 (GRCm39) N86K probably damaging Het
Foxn1 C T 11: 78,262,109 (GRCm39) G87S probably benign Het
Glipr1l2 T C 10: 111,933,887 (GRCm39) Y220H probably benign Het
Hnrnpa1 A G 15: 103,152,166 (GRCm39) probably benign Het
Hnrnpm C A 17: 33,868,876 (GRCm39) R517L probably damaging Het
Ipo11 T C 13: 106,983,952 (GRCm39) M797V possibly damaging Het
Itprid2 G A 2: 79,490,822 (GRCm39) R980Q probably damaging Het
Klhdc2 T A 12: 69,350,308 (GRCm39) F118I probably benign Het
Mtap T A 4: 89,090,594 (GRCm39) Y221* probably null Het
Myh2 T C 11: 67,070,210 (GRCm39) V414A probably damaging Het
Ncor2 A T 5: 125,102,848 (GRCm39) Y1999N probably damaging Het
Or5d39 A G 2: 87,979,604 (GRCm39) F253S possibly damaging Het
Oxsm A G 14: 16,242,023 (GRCm38) S249P probably damaging Het
Pabpc4l T A 3: 46,401,507 (GRCm39) I46F possibly damaging Het
Pcnx2 A G 8: 126,589,975 (GRCm39) probably benign Het
Rasal2 A G 1: 157,239,499 (GRCm39) S4P possibly damaging Het
Reln A G 5: 22,185,115 (GRCm39) V1534A probably damaging Het
Rnf138 T A 18: 21,154,017 (GRCm39) D174E possibly damaging Het
Sh3pxd2a T A 19: 47,302,594 (GRCm39) N162Y probably benign Het
Slc6a4 A T 11: 76,914,006 (GRCm39) T519S probably benign Het
Slfn9 A T 11: 82,872,197 (GRCm39) C846* probably null Het
Trip12 A G 1: 84,702,485 (GRCm39) S1945P possibly damaging Het
Vmn1r232 A G 17: 21,134,394 (GRCm39) F69L probably benign Het
Zeb2 T C 2: 44,887,287 (GRCm39) D545G probably damaging Het
Other mutations in Angptl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00502:Angptl2 APN 2 33,118,406 (GRCm39) missense probably damaging 1.00
IGL00585:Angptl2 APN 2 33,136,239 (GRCm39) missense probably damaging 0.98
IGL01521:Angptl2 APN 2 33,136,215 (GRCm39) missense probably damaging 1.00
IGL02711:Angptl2 APN 2 33,118,255 (GRCm39) missense probably benign 0.00
IGL02826:Angptl2 APN 2 33,118,327 (GRCm39) missense probably benign 0.19
Bloodhound UTSW 2 33,118,342 (GRCm39) missense probably benign
Grazie UTSW 2 33,133,922 (GRCm39) nonsense probably null
Huntress UTSW 2 33,118,814 (GRCm39) missense probably benign 0.02
R1309:Angptl2 UTSW 2 33,136,140 (GRCm39) missense probably benign 0.38
R1541:Angptl2 UTSW 2 33,136,177 (GRCm39) missense probably benign 0.26
R1542:Angptl2 UTSW 2 33,118,897 (GRCm39) missense probably benign 0.24
R1604:Angptl2 UTSW 2 33,133,785 (GRCm39) missense possibly damaging 0.89
R3432:Angptl2 UTSW 2 33,118,814 (GRCm39) missense probably benign 0.02
R4331:Angptl2 UTSW 2 33,118,760 (GRCm39) missense probably damaging 0.99
R4652:Angptl2 UTSW 2 33,133,895 (GRCm39) missense probably damaging 1.00
R4741:Angptl2 UTSW 2 33,136,200 (GRCm39) missense probably benign 0.12
R5107:Angptl2 UTSW 2 33,118,615 (GRCm39) missense probably damaging 0.98
R5504:Angptl2 UTSW 2 33,119,050 (GRCm39) intron probably benign
R5694:Angptl2 UTSW 2 33,118,628 (GRCm39) missense probably damaging 1.00
R5967:Angptl2 UTSW 2 33,118,718 (GRCm39) missense probably damaging 1.00
R6185:Angptl2 UTSW 2 33,119,026 (GRCm39) missense probably benign 0.00
R6797:Angptl2 UTSW 2 33,118,277 (GRCm39) missense probably benign 0.00
R7151:Angptl2 UTSW 2 33,133,922 (GRCm39) nonsense probably null
R7471:Angptl2 UTSW 2 33,133,751 (GRCm39) missense possibly damaging 0.89
R7742:Angptl2 UTSW 2 33,133,928 (GRCm39) missense probably damaging 1.00
R7763:Angptl2 UTSW 2 33,132,394 (GRCm39) nonsense probably null
R8719:Angptl2 UTSW 2 33,133,914 (GRCm39) missense possibly damaging 0.74
R8927:Angptl2 UTSW 2 33,132,316 (GRCm39) missense probably benign 0.35
R8928:Angptl2 UTSW 2 33,132,316 (GRCm39) missense probably benign 0.35
R9204:Angptl2 UTSW 2 33,118,342 (GRCm39) missense probably benign
R9663:Angptl2 UTSW 2 33,118,231 (GRCm39) missense probably benign 0.02
R9775:Angptl2 UTSW 2 33,118,230 (GRCm39) start codon destroyed probably null 0.00
Posted On 2013-04-17