Mutagenetix > Incidental Mutation

Incidental Mutation 'R3792:Vmn1r210'

272603

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r210

Ensembl Gene

ENSMUSG00000061296

Gene Name

vomeronasal 1 receptor 210

Synonyms

V1rh10

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R3792 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23011364-23012284 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 23011573 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 238 (M238L)

Ref Sequence

ENSEMBL: ENSMUSP00000153776 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072044] [ENSMUST00000226180] [ENSMUST00000226294]

AlphaFold

Q8R274

Predicted Effect

probably damaging
Transcript: ENSMUST00000072044
AA Change: M238L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000071925
Gene: ENSMUSG00000061296
AA Change: M238L

Domain	Start	End	E-Value	Type
Pfam:V1R	34	297	8.6e-38	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000226180
AA Change: M238L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

Predicted Effect

probably damaging
Transcript: ENSMUST00000226294
AA Change: M238L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.4%
20x: 95.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930595M18Rik	A	G	X: 80,464,423 (GRCm39)	V428A	probably benign	Het
Aanat	T	C	11: 116,487,057 (GRCm39)	L88P	probably damaging	Het
Arhgap5	A	T	12: 52,566,671 (GRCm39)	N1214I	probably benign	Het
BC034090	A	T	1: 155,117,543 (GRCm39)	S192T	probably damaging	Het
Bco1	G	A	8: 117,857,415 (GRCm39)	V461I	possibly damaging	Het
Cass4	C	T	2: 172,274,478 (GRCm39)	P753L	probably damaging	Het
Cripto	C	T	9: 110,772,258 (GRCm39)	R46Q	probably benign	Het
Cubn	G	A	2: 13,432,725 (GRCm39)	R1199C	probably damaging	Het
Dcaf12l1	T	C	X: 43,877,313 (GRCm39)	N495S	possibly damaging	Het
Dop1b	C	A	16: 93,568,734 (GRCm39)	Q1599K	possibly damaging	Het
Dyrk1a	C	A	16: 94,485,933 (GRCm39)	L427I	probably benign	Het
Esp16	T	C	17: 39,848,739 (GRCm39)	I11T	possibly damaging	Het
Esyt3	A	T	9: 99,197,334 (GRCm39)	F832Y	possibly damaging	Het
F8	A	T	X: 74,328,971 (GRCm39)		probably null	Het
Fam135a	T	C	1: 24,067,392 (GRCm39)	Y259C	probably benign	Het
Fbxo38	T	C	18: 62,666,533 (GRCm39)		probably null	Het
Fbxo43	T	C	15: 36,163,005 (GRCm39)	I67M	probably benign	Het
Gcfc2	G	T	6: 81,907,748 (GRCm39)	C154F	probably benign	Het
Hipk2	C	T	6: 38,675,491 (GRCm39)	R1029H	probably damaging	Het
Ilk	G	A	7: 105,391,294 (GRCm39)	W73*	probably null	Het
Ism1	T	C	2: 139,582,173 (GRCm39)	S162P	probably damaging	Het
Itpkb	T	A	1: 180,160,738 (GRCm39)	L288Q	possibly damaging	Het
Itpr2	C	A	6: 146,316,852 (GRCm39)	K306N	probably damaging	Het
Kdm2a	C	T	19: 4,374,540 (GRCm39)	E864K	possibly damaging	Het
Kdm4b	G	A	17: 56,662,944 (GRCm39)	V172M	probably damaging	Het
Kyat3	A	T	3: 142,443,605 (GRCm39)	K406M	probably null	Het
Lipe	T	A	7: 25,097,045 (GRCm39)	K299N	possibly damaging	Het
Lrrc2	T	A	9: 110,795,585 (GRCm39)	C123*	probably null	Het
Mptx2	T	A	1: 173,102,240 (GRCm39)	I150F	probably damaging	Het
Mroh2b	G	T	15: 4,953,102 (GRCm39)	W612L	probably damaging	Het
Mucl2	T	C	15: 103,928,692 (GRCm39)	T27A	possibly damaging	Het
Nfx1	T	A	4: 41,004,357 (GRCm39)	C709*	probably null	Het
Oprm1	T	C	10: 6,789,544 (GRCm39)	S390P	probably benign	Het
Or2m12	A	G	16: 19,104,696 (GRCm39)	S266P	possibly damaging	Het
Or51v8	A	T	7: 103,319,353 (GRCm39)	I295N	probably damaging	Het
Pcdhb14	T	C	18: 37,582,715 (GRCm39)	L607P	probably damaging	Het
Rap1gds1	A	T	3: 138,671,721 (GRCm39)	I133N	probably damaging	Het
Rasl10a	T	C	11: 5,009,461 (GRCm39)	L83S	probably damaging	Het
Satb2	C	T	1: 56,884,779 (GRCm39)	V382M	probably damaging	Het
Sh3gl1	T	C	17: 56,325,949 (GRCm39)	K160R	probably damaging	Het
Sirt4	T	C	5: 115,618,351 (GRCm39)	D241G	probably benign	Het
Sla2	G	A	2: 156,717,862 (GRCm39)	R137C	probably damaging	Het
Spef2	A	G	15: 9,704,622 (GRCm39)	I454T	probably damaging	Het
Stag3	A	G	5: 138,296,611 (GRCm39)	K490E	probably benign	Het
Tcstv7b	G	T	13: 120,702,467 (GRCm39)	V88F	probably damaging	Het
Tctn3	T	C	19: 40,600,155 (GRCm39)	K95R	probably benign	Het
Trp53bp1	T	C	2: 121,030,810 (GRCm39)	I1784V	probably damaging	Het
Ttc21a	A	T	9: 119,783,231 (GRCm39)	E511V	probably damaging	Het
Ttn	A	G	2: 76,542,232 (GRCm39)	F25258L	probably damaging	Het
Ttn	A	C	2: 76,639,290 (GRCm39)	C13828G	probably damaging	Het
Vmn1r38	A	G	6: 66,753,891 (GRCm39)	I75T	probably benign	Het
Vmn2r84	T	A	10: 130,221,669 (GRCm39)	*850C	probably null	Het
Vwa7	T	C	17: 35,244,135 (GRCm39)		probably null	Het
Zfp128	T	A	7: 12,618,659 (GRCm39)	D52E	probably damaging	Het
Zfp618	T	C	4: 63,033,728 (GRCm39)		probably benign	Het
Zkscan2	T	A	7: 123,084,225 (GRCm39)	E633V	possibly damaging	Het

Other mutations in Vmn1r210

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00938:Vmn1r210	APN	13	23,011,538 (GRCm39)	nonsense	probably null
IGL01541:Vmn1r210	APN	13	23,011,778 (GRCm39)	missense	probably benign
IGL01610:Vmn1r210	APN	13	23,011,977 (GRCm39)	missense	probably damaging	1.00
IGL01632:Vmn1r210	APN	13	23,011,366 (GRCm39)	makesense	probably null
IGL03268:Vmn1r210	APN	13	23,011,405 (GRCm39)	missense	probably benign	0.40
IGL03340:Vmn1r210	APN	13	23,011,644 (GRCm39)	missense	probably benign	0.23
R0227:Vmn1r210	UTSW	13	23,011,561 (GRCm39)	missense	probably benign	0.02
R0629:Vmn1r210	UTSW	13	23,012,044 (GRCm39)	missense	probably damaging	1.00
R4125:Vmn1r210	UTSW	13	23,011,779 (GRCm39)	missense	probably benign	0.00
R4132:Vmn1r210	UTSW	13	23,011,819 (GRCm39)	missense	probably benign	0.00
R4773:Vmn1r210	UTSW	13	23,011,374 (GRCm39)	missense	probably benign	0.00
R5653:Vmn1r210	UTSW	13	23,011,378 (GRCm39)	nonsense	probably null
R6128:Vmn1r210	UTSW	13	23,012,277 (GRCm39)	nonsense	probably null
R6452:Vmn1r210	UTSW	13	23,011,840 (GRCm39)	missense	probably damaging	1.00
R6501:Vmn1r210	UTSW	13	23,011,705 (GRCm39)	missense	possibly damaging	0.90
R6864:Vmn1r210	UTSW	13	23,011,713 (GRCm39)	missense	probably benign	0.06
R7623:Vmn1r210	UTSW	13	23,011,405 (GRCm39)	missense	probably benign	0.40
R7991:Vmn1r210	UTSW	13	23,011,684 (GRCm39)	missense	probably benign	0.01
R9244:Vmn1r210	UTSW	13	23,012,089 (GRCm39)	missense	probably benign	0.02
R9439:Vmn1r210	UTSW	13	23,011,397 (GRCm39)	missense	possibly damaging	0.66
R9538:Vmn1r210	UTSW	13	23,011,837 (GRCm39)	nonsense	probably null
R9732:Vmn1r210	UTSW	13	23,011,379 (GRCm39)	missense	possibly damaging	0.75
R9794:Vmn1r210	UTSW	13	23,011,432 (GRCm39)	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- GTGGGGTTTGTCTTACACACAG -3'
(R):5'- TCATGGTCCTGAGAGATGCAG -3'

Sequencing Primer
(F):5'- TGAGCATGCCAAAATTTAACCAG -3'
(R):5'- CCTGAGAGATGCAGTTTTTCAG -3'

Posted On

2015-03-25