Incidental Mutation 'R3842:Naa40'
ID 277226
Institutional Source Beutler Lab
Gene Symbol Naa40
Ensembl Gene ENSMUSG00000024764
Gene Name N(alpha)-acetyltransferase 40, NatD catalytic subunit
Synonyms 4931433E08Rik, Nat11
MMRRC Submission 040782-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.322) question?
Stock # R3842 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 7203033-7218548 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 7207174 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000025675 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025675]
AlphaFold Q8VE10
Predicted Effect probably benign
Transcript: ENSMUST00000025675
SMART Domains Protein: ENSMUSP00000025675
Gene: ENSMUSG00000024764

DomainStartEndE-ValueType
low complexity region 3 21 N/A INTRINSIC
Pfam:Acetyltransf_1 112 193 1.4e-8 PFAM
low complexity region 225 237 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency 100% (37/37)
MGI Phenotype PHENOTYPE: Mice homozygous for a conditional allele activated in hepatocytes exhibit protection from age-induced but not high fat diet-induced steatosis with altered lipid homeostasis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox2 C T 14: 8,251,543 (GRCm38) R318H probably damaging Het
Adamts16 T C 13: 70,887,010 (GRCm39) Y958C possibly damaging Het
Apol7e A G 15: 77,601,789 (GRCm39) E129G probably damaging Het
Bmp2k A G 5: 97,235,010 (GRCm39) probably benign Het
Camk2g T C 14: 20,814,966 (GRCm39) H26R probably damaging Het
Cpn2 A G 16: 30,079,336 (GRCm39) S122P probably damaging Het
Dhcr24 G T 4: 106,443,002 (GRCm39) G346C probably damaging Het
Egf G A 3: 129,491,442 (GRCm39) R351* probably null Het
Exosc10 T A 4: 148,648,322 (GRCm39) Y260* probably null Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fam83h C T 15: 75,874,499 (GRCm39) R946K probably benign Het
Fbxo30 A G 10: 11,165,856 (GRCm39) S193G probably damaging Het
Grik3 T C 4: 125,587,747 (GRCm39) probably benign Het
Gtf3c6 A T 10: 40,130,317 (GRCm39) probably null Het
Hivep1 T C 13: 42,311,203 (GRCm39) S1148P probably benign Het
Hmgb2 T A 8: 57,966,388 (GRCm39) S121T probably benign Het
Hyal2 T C 9: 107,449,320 (GRCm39) S359P probably damaging Het
Itgbl1 A G 14: 124,077,977 (GRCm39) T156A possibly damaging Het
Lrrk2 C A 15: 91,640,119 (GRCm39) Q1555K probably benign Het
Myom1 T C 17: 71,352,619 (GRCm39) V349A probably damaging Het
Ncam2 A G 16: 81,231,698 (GRCm39) Y54C probably damaging Het
Nemf C T 12: 69,378,723 (GRCm39) S533N probably damaging Het
Nkain1 T A 4: 130,537,296 (GRCm38) I80F probably damaging Het
Or10ak12 A G 4: 118,666,452 (GRCm39) V203A probably damaging Het
Or2ag13 G A 7: 106,473,302 (GRCm39) T50I probably benign Het
Or9k2 G A 10: 129,998,770 (GRCm39) R142C probably benign Het
Pde3b T C 7: 114,126,102 (GRCm39) S779P probably damaging Het
Prkar2a A G 9: 108,605,467 (GRCm39) Y175C probably damaging Het
Slc44a5 T C 3: 153,967,031 (GRCm39) probably benign Het
Smgc T A 15: 91,744,460 (GRCm39) probably benign Het
Tasp1 T A 2: 139,793,421 (GRCm39) S252C probably damaging Het
Tgfbrap1 A T 1: 43,098,314 (GRCm39) Y489N probably damaging Het
Topors C T 4: 40,262,123 (GRCm39) R387H probably benign Het
Ttn A G 2: 76,619,963 (GRCm39) S15902P probably damaging Het
Ttn T C 2: 76,680,647 (GRCm39) probably null Het
Other mutations in Naa40
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4929:Naa40 UTSW 19 7,207,347 (GRCm39) missense probably damaging 1.00
R5840:Naa40 UTSW 19 7,207,373 (GRCm39) missense probably benign
R7114:Naa40 UTSW 19 7,207,322 (GRCm39) missense probably damaging 1.00
R9289:Naa40 UTSW 19 7,211,485 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- AGGGTCTAGGTGCCTTTCTC -3'
(R):5'- CCTGGTACCTCATTGCTTGG -3'

Sequencing Primer
(F):5'- TCTCCTTGAGGAAGTCCAGGAG -3'
(R):5'- CTGGTACCTCATTGCTTGGGAAAAC -3'
Posted On 2015-04-06