Incidental Mutation 'IGL02224:Or5b106'
ID 285256
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5b106
Ensembl Gene ENSMUSG00000057503
Gene Name olfactory receptor family 5 subfamily B member 106
Synonyms MOR202-17, GA_x6K02T2RE5P-3473421-3472498, Olfr1459
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # IGL02224
Quality Score
Status
Chromosome 19
Chromosomal Location 13123098-13124021 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13123120 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Methionine at position 301 (K301M)
Ref Sequence ENSEMBL: ENSMUSP00000150886 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078299] [ENSMUST00000213493]
AlphaFold Q8VFV9
Predicted Effect probably damaging
Transcript: ENSMUST00000078299
AA Change: K301M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000077414
Gene: ENSMUSG00000057503
AA Change: K301M

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 8e-50 PFAM
Pfam:7tm_1 39 288 1.5e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213493
AA Change: K301M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215405
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c12 T A 13: 4,329,289 (GRCm39) T23S probably damaging Het
Alpk3 G A 7: 80,726,616 (GRCm39) probably benign Het
Atp8b3 A G 10: 80,361,810 (GRCm39) probably benign Het
Atr C T 9: 95,760,682 (GRCm39) R1051C probably damaging Het
B4galt2 T C 4: 117,734,110 (GRCm39) D309G probably benign Het
C130026L21Rik A G 5: 111,730,291 (GRCm39) noncoding transcript Het
Cadm3 A G 1: 173,165,628 (GRCm39) I344T possibly damaging Het
Cd101 T C 3: 100,924,318 (GRCm39) T370A probably benign Het
Col6a5 A T 9: 105,741,534 (GRCm39) S2462T probably damaging Het
Csf3r A T 4: 125,937,332 (GRCm39) N739Y probably benign Het
Ensa T C 3: 95,535,990 (GRCm39) S108P probably benign Het
Fancd2 T A 6: 113,545,281 (GRCm39) probably null Het
Fbp1 T A 13: 63,035,821 (GRCm39) T13S probably damaging Het
Flrt2 C A 12: 95,746,802 (GRCm39) T380K possibly damaging Het
Gpatch11 T C 17: 79,148,522 (GRCm39) probably benign Het
Hagh A G 17: 25,071,861 (GRCm39) D29G probably damaging Het
Hmmr T C 11: 40,600,831 (GRCm39) Q513R unknown Het
Hoxb8 T C 11: 96,173,981 (GRCm39) S65P probably benign Het
Il4ra T C 7: 125,169,271 (GRCm39) probably benign Het
Lbp A G 2: 158,148,669 (GRCm39) N27S probably damaging Het
Msh4 G A 3: 153,595,822 (GRCm39) T76I possibly damaging Het
Nfat5 T C 8: 108,071,447 (GRCm39) V281A probably benign Het
Or10ag53 C T 2: 87,082,821 (GRCm39) S180F probably benign Het
Or13c25 A T 4: 52,911,392 (GRCm39) V134D probably damaging Het
Or4p20 C T 2: 88,254,052 (GRCm39) probably null Het
Or5w16 T A 2: 87,576,757 (GRCm39) C72* probably null Het
Phf11b A T 14: 59,563,515 (GRCm39) probably benign Het
Pik3c2a A G 7: 115,962,575 (GRCm39) probably benign Het
Prdx1 T A 4: 116,549,064 (GRCm39) F66L probably damaging Het
Prss39 A G 1: 34,538,459 (GRCm39) H108R probably damaging Het
Spta1 C A 1: 174,045,255 (GRCm39) probably benign Het
Tmem87b A G 2: 128,676,127 (GRCm39) I297V possibly damaging Het
Vmn1r191 T C 13: 22,363,068 (GRCm39) R229G probably damaging Het
Vmn2r113 A T 17: 23,174,960 (GRCm39) R524* probably null Het
Washc2 T A 6: 116,197,530 (GRCm39) D254E possibly damaging Het
Zfp318 C T 17: 46,707,736 (GRCm39) R265* probably null Het
Zfp773 T C 7: 7,135,975 (GRCm39) H207R probably benign Het
Other mutations in Or5b106
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01371:Or5b106 APN 19 13,123,192 (GRCm39) missense possibly damaging 0.82
IGL01618:Or5b106 APN 19 13,123,614 (GRCm39) missense probably benign 0.00
IGL01800:Or5b106 APN 19 13,123,993 (GRCm39) missense probably damaging 1.00
BB009:Or5b106 UTSW 19 13,123,345 (GRCm39) missense probably benign 0.10
BB019:Or5b106 UTSW 19 13,123,345 (GRCm39) missense probably benign 0.10
PIT4651001:Or5b106 UTSW 19 13,123,991 (GRCm39) missense probably benign 0.02
R0617:Or5b106 UTSW 19 13,123,727 (GRCm39) missense probably benign 0.28
R2041:Or5b106 UTSW 19 13,124,041 (GRCm39) start gained probably benign
R2878:Or5b106 UTSW 19 13,123,771 (GRCm39) missense probably benign 0.38
R3742:Or5b106 UTSW 19 13,123,258 (GRCm39) missense probably damaging 0.98
R4905:Or5b106 UTSW 19 13,123,541 (GRCm39) missense probably benign 0.07
R4914:Or5b106 UTSW 19 13,123,355 (GRCm39) missense possibly damaging 0.64
R4915:Or5b106 UTSW 19 13,123,355 (GRCm39) missense possibly damaging 0.64
R4916:Or5b106 UTSW 19 13,123,355 (GRCm39) missense possibly damaging 0.64
R4917:Or5b106 UTSW 19 13,123,355 (GRCm39) missense possibly damaging 0.64
R4918:Or5b106 UTSW 19 13,123,355 (GRCm39) missense possibly damaging 0.64
R5367:Or5b106 UTSW 19 13,123,865 (GRCm39) missense probably damaging 0.98
R6242:Or5b106 UTSW 19 13,123,450 (GRCm39) missense probably benign 0.05
R6632:Or5b106 UTSW 19 13,123,552 (GRCm39) missense probably benign 0.02
R6893:Or5b106 UTSW 19 13,123,106 (GRCm39) missense probably benign 0.00
R7932:Or5b106 UTSW 19 13,123,345 (GRCm39) missense probably benign 0.10
R9572:Or5b106 UTSW 19 13,123,928 (GRCm39) missense possibly damaging 0.78
R9730:Or5b106 UTSW 19 13,123,747 (GRCm39) missense possibly damaging 0.80
Posted On 2015-04-16