Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02608:Or14j3'

300333

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or14j3

Ensembl Gene

ENSMUSG00000062629

Gene Name

olfactory receptor family 14 subfamily J member 3

Synonyms

MOR218-10, GA_x6K02T2PSCP-2049802-2048870, Olfr114

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL02608

Quality Score

Status

Chromosome

Chromosomal Location

37900304-37901242 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 37901110 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 45 (I45F)

Ref Sequence

ENSEMBL: ENSMUSP00000149735 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076914] [ENSMUST00000214871] [ENSMUST00000216249]

AlphaFold

Q923Q8

Predicted Effect

probably damaging
Transcript: ENSMUST00000076914
AA Change: I45F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000076181
Gene: ENSMUSG00000062629
AA Change: I45F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2e-43	PFAM
Pfam:7TM_GPCR_Srsx	35	305	3.7e-6	PFAM
Pfam:7tm_1	41	290	3e-19	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214871
AA Change: I45F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000216249
AA Change: I45F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aaas	T	A	15: 102,247,627 (GRCm39)	M415L	probably benign	Het
Akap6	T	C	12: 53,057,389 (GRCm39)	S952P	probably benign	Het
Aldh3a1	A	G	11: 61,107,147 (GRCm39)	R284G	probably damaging	Het
Aldh3b1	G	T	19: 3,964,061 (GRCm39)	H414N	probably damaging	Het
Chd5	G	A	4: 152,440,564 (GRCm39)	M141I	possibly damaging	Het
Cntn2	C	T	1: 132,453,654 (GRCm39)	A340T	possibly damaging	Het
Daw1	T	A	1: 83,187,055 (GRCm39)	C288*	probably null	Het
Dcn	A	G	10: 97,319,319 (GRCm39)	E32G	probably damaging	Het
Dock5	C	T	14: 68,065,888 (GRCm39)	V372M	probably benign	Het
Etf1	T	C	18: 35,064,670 (GRCm39)	E13G	probably damaging	Het
Filip1l	A	G	16: 57,392,469 (GRCm39)	E781G	probably benign	Het
Gucy1a2	A	G	9: 3,635,113 (GRCm39)	I386V	probably damaging	Het
Gvin-ps5	T	A	7: 105,928,876 (GRCm39)		noncoding transcript	Het
Hoxb5	T	A	11: 96,195,969 (GRCm39)		probably benign	Het
Iqch	T	A	9: 63,329,110 (GRCm39)		probably benign	Het
Itgal	C	T	7: 126,909,416 (GRCm39)	P423S	probably damaging	Het
Kti12	T	G	4: 108,705,359 (GRCm39)	L91R	probably damaging	Het
Lgals3	T	C	14: 47,623,058 (GRCm39)	M239T	probably benign	Het
Lrrc8a	T	C	2: 30,146,311 (GRCm39)	M375T	possibly damaging	Het
Ly75	T	C	2: 60,152,244 (GRCm39)	E1103G	probably benign	Het
Lyst	A	T	13: 13,887,339 (GRCm39)	E3056V	probably damaging	Het
Map3k7	T	C	4: 31,981,452 (GRCm39)		probably benign	Het
Ncor1	G	A	11: 62,264,040 (GRCm39)	T180I	probably benign	Het
Nectin4	T	C	1: 171,212,341 (GRCm39)	V313A	probably benign	Het
Nol4l	A	G	2: 153,278,213 (GRCm39)	S8P	possibly damaging	Het
Npas2	T	A	1: 39,384,527 (GRCm39)	S607T	probably benign	Het
Nup155	T	A	15: 8,138,955 (GRCm39)	M9K	probably benign	Het
Nwd1	T	C	8: 73,394,003 (GRCm39)	L422P	probably damaging	Het
Papola	G	T	12: 105,775,818 (GRCm39)	G245C	probably damaging	Het
Pcdhb6	T	C	18: 37,467,747 (GRCm39)	S223P	probably damaging	Het
Pdcd4	T	C	19: 53,915,638 (GRCm39)		probably null	Het
Pigg	T	C	5: 108,460,869 (GRCm39)	F27L	probably damaging	Het
Prpf40a	A	T	2: 53,036,165 (GRCm39)	M588K	probably damaging	Het
Psme4	A	G	11: 30,770,944 (GRCm39)	N764S	probably benign	Het
Ptar1	A	C	19: 23,683,076 (GRCm39)	E110A	possibly damaging	Het
Rbm12	A	T	2: 155,937,818 (GRCm39)		probably benign	Het
Rfx7	A	G	9: 72,524,576 (GRCm39)	T589A	probably benign	Het
Rpl21-ps4	G	T	14: 11,227,831 (GRCm38)		noncoding transcript	Het
Rpp38	T	C	2: 3,330,198 (GRCm39)	T235A	probably benign	Het
Sbno2	A	T	10: 79,903,236 (GRCm39)		probably null	Het
Scn3a	A	T	2: 65,354,510 (GRCm39)	C337*	probably null	Het
Sec61a2	T	C	2: 5,879,073 (GRCm39)	T312A	probably benign	Het
Snrpg	C	A	6: 86,353,550 (GRCm39)	D43E	probably damaging	Het
Stag1	A	T	9: 100,639,822 (GRCm39)	Q126L	probably null	Het
Taar6	A	G	10: 23,861,081 (GRCm39)	V155A	probably benign	Het
Tet1	G	A	10: 62,715,388 (GRCm39)	H136Y	possibly damaging	Het
Tet1	C	A	10: 62,674,866 (GRCm39)	S1070I	probably damaging	Het
Tfcp2	T	C	15: 100,411,991 (GRCm39)	T327A	possibly damaging	Het
Tnfrsf13c	C	T	15: 82,107,364 (GRCm39)	V144M	probably damaging	Het
Tnfrsf22	T	A	7: 143,198,533 (GRCm39)	K61*	probably null	Het
Trhr	T	C	15: 44,061,074 (GRCm39)	V198A	probably benign	Het
Trp53inp2	A	G	2: 155,228,569 (GRCm39)	R175G	probably damaging	Het
Try10	G	A	6: 41,332,421 (GRCm39)	G26R	probably damaging	Het
Vmn1r205	A	G	13: 22,776,370 (GRCm39)	V244A	probably damaging	Het
Wrnip1	T	A	13: 32,990,857 (GRCm39)	L372H	probably damaging	Het
Zfp280d	T	A	9: 72,215,261 (GRCm39)	L149Q	probably damaging	Het
Zfp445	A	G	9: 122,690,940 (GRCm39)	V85A	probably damaging	Het

Other mutations in Or14j3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01534:Or14j3	APN	17	37,900,963 (GRCm39)	missense	possibly damaging	0.93
IGL01624:Or14j3	APN	17	37,900,816 (GRCm39)	missense	probably benign	0.00
IGL02026:Or14j3	APN	17	37,900,298 (GRCm39)	utr 3 prime	probably benign
IGL02632:Or14j3	APN	17	37,901,232 (GRCm39)	missense	probably benign	0.00
IGL02990:Or14j3	APN	17	37,900,559 (GRCm39)	missense	probably benign	0.00
R0114:Or14j3	UTSW	17	37,900,306 (GRCm39)	makesense	probably null
R1156:Or14j3	UTSW	17	37,900,408 (GRCm39)	missense	possibly damaging	0.93
R1366:Or14j3	UTSW	17	37,900,655 (GRCm39)	missense	probably benign	0.03
R3413:Or14j3	UTSW	17	37,900,587 (GRCm39)	missense	probably benign	0.00
R3701:Or14j3	UTSW	17	37,900,717 (GRCm39)	nonsense	probably null
R6122:Or14j3	UTSW	17	37,900,817 (GRCm39)	missense	probably benign	0.12
R6639:Or14j3	UTSW	17	37,900,822 (GRCm39)	missense	probably damaging	1.00
R7066:Or14j3	UTSW	17	37,901,034 (GRCm39)	missense	probably damaging	1.00
R7316:Or14j3	UTSW	17	37,901,026 (GRCm39)	missense	probably damaging	0.99
R8340:Or14j3	UTSW	17	37,901,034 (GRCm39)	missense	probably damaging	1.00
R8483:Or14j3	UTSW	17	37,900,866 (GRCm39)	missense	possibly damaging	0.52
R8555:Or14j3	UTSW	17	37,900,540 (GRCm39)	missense	possibly damaging	0.95
R9442:Or14j3	UTSW	17	37,900,633 (GRCm39)	missense	possibly damaging	0.95
R9617:Or14j3	UTSW	17	37,901,053 (GRCm39)	nonsense	probably null
R9718:Or14j3	UTSW	17	37,900,914 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16