Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02615:Dpp4'

300628

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dpp4

Ensembl Gene

ENSMUSG00000035000

Gene Name

dipeptidylpeptidase 4

Synonyms

Cd26, THAM, Dpp-4

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02615

Quality Score

Status

Chromosome

Chromosomal Location

62160417-62242575 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 62189672 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 410 (Y410C)

Ref Sequence

ENSEMBL: ENSMUSP00000044050 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047812]

AlphaFold

P28843

Predicted Effect

probably damaging
Transcript: ENSMUST00000047812
AA Change: Y410C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000044050
Gene: ENSMUSG00000035000
AA Change: Y410C

Domain	Start	End	E-Value	Type
transmembrane domain	7	29	N/A	INTRINSIC
Pfam:DPPIV_N	102	473	5.7e-110	PFAM
Pfam:Abhydrolase_5	545	752	1e-11	PFAM
Pfam:DLH	546	754	4e-7	PFAM
Pfam:Peptidase_S9	551	760	3.4e-61	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129738

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136879

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutants show hypoglycemia, hyperinsulinemia, and increased plasma glucagon-like peptide 1 in glucose tolerance tests. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A430033K04Rik	G	T	5: 138,644,402 (GRCm39)	E96*	probably null	Het
Adck5	C	T	15: 76,473,367 (GRCm39)	S72L	possibly damaging	Het
Afdn	A	G	17: 14,046,238 (GRCm39)	H404R	probably benign	Het
Aph1c	A	T	9: 66,726,688 (GRCm39)	V222E	possibly damaging	Het
Armc8	T	C	9: 99,409,122 (GRCm39)		probably benign	Het
Bcl2l13	A	T	6: 120,839,828 (GRCm39)	D42V	probably damaging	Het
Bhlhe22	C	T	3: 18,109,064 (GRCm39)	T38I	possibly damaging	Het
Ccdc51	A	T	9: 108,918,503 (GRCm39)	T31S	probably benign	Het
Ctbp2	A	G	7: 132,597,076 (GRCm39)	I669T	probably benign	Het
Dennd4c	A	G	4: 86,739,704 (GRCm39)	T998A	probably benign	Het
Gli2	T	A	1: 118,772,128 (GRCm39)	N526Y	probably damaging	Het
Ighv1-64	A	G	12: 115,471,307 (GRCm39)	I70T	possibly damaging	Het
Mphosph10	A	T	7: 64,030,793 (GRCm39)		probably benign	Het
Mrps34	A	G	17: 25,114,767 (GRCm39)		probably null	Het
Myo1f	A	T	17: 33,823,630 (GRCm39)	I1053L	probably benign	Het
Nckap5l	G	A	15: 99,327,263 (GRCm39)	P142L	possibly damaging	Het
Platr26	T	A	2: 71,560,770 (GRCm39)		noncoding transcript	Het
Rag2	T	A	2: 101,459,913 (GRCm39)	Y74*	probably null	Het
Rnf213	A	T	11: 119,331,615 (GRCm39)	M2275L	probably damaging	Het
Rsbn1	T	A	3: 103,861,068 (GRCm39)	L498Q	probably damaging	Het
Scp2	A	G	4: 107,964,828 (GRCm39)	V62A	probably benign	Het
Spag17	A	G	3: 99,979,401 (GRCm39)	I1421V	probably benign	Het
Spata31f1e	C	T	4: 42,793,027 (GRCm39)	M368I	probably benign	Het
St6galnac4	A	G	2: 32,484,216 (GRCm39)	H138R	probably benign	Het
Syne2	T	A	12: 76,143,768 (GRCm39)	M1045K	probably damaging	Het
Tbxas1	C	T	6: 39,004,800 (GRCm39)	T349M	probably damaging	Het
U2surp	T	G	9: 95,375,284 (GRCm39)	D146A	probably benign	Het
Usp38	T	C	8: 81,711,780 (GRCm39)	M752V	probably benign	Het

Other mutations in Dpp4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00492:Dpp4	APN	2	62,209,646 (GRCm39)	missense	probably damaging	1.00
IGL02205:Dpp4	APN	2	62,182,601 (GRCm39)	missense	probably damaging	1.00
IGL02276:Dpp4	APN	2	62,187,295 (GRCm39)	splice site	probably benign
IGL02335:Dpp4	APN	2	62,164,988 (GRCm39)	missense	probably benign	0.03
IGL02639:Dpp4	APN	2	62,182,584 (GRCm39)	missense	probably benign
IGL02972:Dpp4	APN	2	62,182,569 (GRCm39)	missense	probably damaging	1.00
IGL03366:Dpp4	APN	2	62,187,301 (GRCm39)	splice site	probably null
caribou	UTSW	2	62,178,245 (GRCm39)	missense	possibly damaging	0.69
PIT4449001:Dpp4	UTSW	2	62,186,988 (GRCm39)	missense	probably benign	0.00
R0502:Dpp4	UTSW	2	62,195,332 (GRCm39)	missense	probably damaging	0.99
R0581:Dpp4	UTSW	2	62,187,020 (GRCm39)	missense	probably benign
R1004:Dpp4	UTSW	2	62,162,984 (GRCm39)	missense	probably benign	0.08
R1075:Dpp4	UTSW	2	62,182,630 (GRCm39)	missense	probably benign	0.39
R1476:Dpp4	UTSW	2	62,178,245 (GRCm39)	missense	possibly damaging	0.69
R1702:Dpp4	UTSW	2	62,216,773 (GRCm39)	critical splice donor site	probably null
R1707:Dpp4	UTSW	2	62,189,679 (GRCm39)	splice site	probably benign
R1733:Dpp4	UTSW	2	62,203,213 (GRCm39)	critical splice acceptor site	probably null
R1899:Dpp4	UTSW	2	62,175,394 (GRCm39)	splice site	probably benign
R2264:Dpp4	UTSW	2	62,208,583 (GRCm39)	missense	possibly damaging	0.71
R2496:Dpp4	UTSW	2	62,217,477 (GRCm39)	missense	possibly damaging	0.90
R3765:Dpp4	UTSW	2	62,216,780 (GRCm39)	missense	probably benign	0.17
R4278:Dpp4	UTSW	2	62,209,667 (GRCm39)	missense	probably damaging	1.00
R4413:Dpp4	UTSW	2	62,217,484 (GRCm39)	missense	possibly damaging	0.89
R4432:Dpp4	UTSW	2	62,175,456 (GRCm39)	missense	probably damaging	1.00
R4647:Dpp4	UTSW	2	62,164,949 (GRCm39)	missense	probably damaging	1.00
R4710:Dpp4	UTSW	2	62,190,659 (GRCm39)	missense	probably benign	0.04
R4914:Dpp4	UTSW	2	62,178,236 (GRCm39)	missense	probably benign	0.20
R5173:Dpp4	UTSW	2	62,217,474 (GRCm39)	missense	probably damaging	1.00
R5283:Dpp4	UTSW	2	62,190,680 (GRCm39)	missense	probably damaging	1.00
R5698:Dpp4	UTSW	2	62,164,655 (GRCm39)	missense	probably damaging	1.00
R6621:Dpp4	UTSW	2	62,182,484 (GRCm39)	missense	probably damaging	1.00
R6681:Dpp4	UTSW	2	62,178,893 (GRCm39)	missense	probably benign	0.01
R6739:Dpp4	UTSW	2	62,217,439 (GRCm39)	missense	probably benign
R6962:Dpp4	UTSW	2	62,203,174 (GRCm39)	missense	probably benign	0.11
R7249:Dpp4	UTSW	2	62,215,547 (GRCm39)	missense	probably benign	0.14
R7268:Dpp4	UTSW	2	62,178,186 (GRCm39)	missense	probably damaging	1.00
R7343:Dpp4	UTSW	2	62,189,245 (GRCm39)	nonsense	probably null
R7357:Dpp4	UTSW	2	62,217,421 (GRCm39)	missense	probably benign
R7366:Dpp4	UTSW	2	62,184,943 (GRCm39)	missense	probably damaging	1.00
R7413:Dpp4	UTSW	2	62,187,333 (GRCm39)	missense	probably damaging	1.00
R7431:Dpp4	UTSW	2	62,182,582 (GRCm39)	missense	probably benign	0.01
R7642:Dpp4	UTSW	2	62,190,627 (GRCm39)	critical splice donor site	probably null
R8004:Dpp4	UTSW	2	62,189,172 (GRCm39)	missense	probably benign	0.00
R8197:Dpp4	UTSW	2	62,203,171 (GRCm39)	missense	probably benign	0.31
R8341:Dpp4	UTSW	2	62,178,234 (GRCm39)	missense	probably benign	0.10
R8706:Dpp4	UTSW	2	62,208,647 (GRCm39)	missense	probably benign	0.00
R8977:Dpp4	UTSW	2	62,204,747 (GRCm39)	missense	probably benign	0.29
R8997:Dpp4	UTSW	2	62,164,958 (GRCm39)	missense	probably damaging	0.99
R9100:Dpp4	UTSW	2	62,204,733 (GRCm39)	missense	possibly damaging	0.51
R9616:Dpp4	UTSW	2	62,217,429 (GRCm39)	missense	probably damaging	1.00
R9777:Dpp4	UTSW	2	62,195,340 (GRCm39)	missense	probably benign	0.04

Posted On

2015-04-16