Incidental Mutation 'R4181:Clic4'
ID 319728
Institutional Source Beutler Lab
Gene Symbol Clic4
Ensembl Gene ENSMUSG00000037242
Gene Name chloride intracellular channel 4
Synonyms mc3s5, mtCLIC, D0Jmb3
MMRRC Submission 041017-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4181 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 134941280-135000071 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 134953350 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 98 (V98A)
Ref Sequence ENSEMBL: ENSMUSP00000041453 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037099]
AlphaFold Q9QYB1
Predicted Effect probably benign
Transcript: ENSMUST00000037099
AA Change: V98A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000041453
Gene: ENSMUSG00000037242
AA Change: V98A

DomainStartEndE-ValueType
Pfam:GST_N_3 31 103 7.3e-9 PFAM
Pfam:GST_C_2 134 223 2.7e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143370
Meta Mutation Damage Score 0.0616 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 92% (48/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for null mutations may display decreased survival, body weight and female fertility, impaired angiogenesis, increased suscpetibility to Listeria infection, increased resistance to LPS treatment, skin erosions and/or delayed wound healing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl T C 3: 116,540,279 (GRCm39) Y1445C probably damaging Het
Arhgap12 T C 18: 6,111,734 (GRCm39) D210G probably damaging Het
Atp11b A G 3: 35,854,714 (GRCm39) K284R probably benign Het
Atp11b A G 3: 35,843,707 (GRCm39) T185A probably damaging Het
Bcas1 A G 2: 170,260,547 (GRCm39) V44A probably benign Het
Carmil3 G A 14: 55,741,412 (GRCm39) D1066N probably benign Het
Cfap251 T C 5: 123,431,873 (GRCm39) I549T probably benign Het
Chil4 G A 3: 106,111,043 (GRCm39) P284S possibly damaging Het
Cmpk2 T C 12: 26,527,046 (GRCm39) V345A probably damaging Het
Col6a3 A T 1: 90,735,336 (GRCm39) I771N probably damaging Het
Cyp2d34 A T 15: 82,501,486 (GRCm39) probably null Het
Cyp7a1 C T 4: 6,271,205 (GRCm39) G317E probably benign Het
Ddx1 A T 12: 13,281,504 (GRCm39) L353* probably null Het
Dnhd1 T A 7: 105,343,161 (GRCm39) W1502R probably damaging Het
Drc1 T C 5: 30,513,057 (GRCm39) V377A probably benign Het
Fyb1 A G 15: 6,610,404 (GRCm39) N326D probably benign Het
Gapdh C T 6: 125,142,197 (GRCm39) probably benign Het
Gm973 A G 1: 59,590,399 (GRCm39) Y302C possibly damaging Het
Grsf1 G A 5: 88,812,015 (GRCm39) P271S probably benign Het
Gtpbp3 C T 8: 71,944,111 (GRCm39) T285I probably damaging Het
Hnrnpul1 T C 7: 25,426,237 (GRCm39) D538G probably damaging Het
Kif26b G A 1: 178,742,991 (GRCm39) S582N probably damaging Het
Lgals4 T C 7: 28,535,437 (GRCm39) V107A possibly damaging Het
Lmbr1l A T 15: 98,806,601 (GRCm39) L270Q possibly damaging Het
Loxl4 T A 19: 42,596,030 (GRCm39) Y141F probably benign Het
Lpcat3 C T 6: 124,680,187 (GRCm39) probably benign Het
Lrp1b G A 2: 40,501,446 (GRCm39) T219I probably damaging Het
Man2a2 T A 7: 80,001,487 (GRCm39) E1140V possibly damaging Het
Mapk8 T C 14: 33,104,177 (GRCm39) D413G probably damaging Het
Or11h4b C G 14: 50,918,507 (GRCm39) E195Q probably benign Het
Or7g30 C T 9: 19,353,031 (GRCm39) A274V possibly damaging Het
Or8k53 A T 2: 86,177,581 (GRCm39) H176Q probably damaging Het
Pdss1 T C 2: 22,805,517 (GRCm39) I265T probably damaging Het
Piezo2 T C 18: 63,257,801 (GRCm39) probably null Het
Rad50 T A 11: 53,592,832 (GRCm39) N106I probably benign Het
Rbbp6 A G 7: 122,593,958 (GRCm39) Y568C probably damaging Het
Rorc G A 3: 94,294,500 (GRCm39) C33Y probably damaging Het
Ssc4d T C 5: 135,990,778 (GRCm39) E470G possibly damaging Het
Tnxb T G 17: 34,928,428 (GRCm39) V2614G possibly damaging Het
Trip11 A T 12: 101,860,027 (GRCm39) D282E probably damaging Het
Ttn G T 2: 76,706,811 (GRCm39) probably benign Het
Vangl1 A T 3: 102,073,097 (GRCm39) probably benign Het
Wiz T C 17: 32,586,959 (GRCm39) E117G probably damaging Het
Zfp982 A G 4: 147,597,150 (GRCm39) K169R probably benign Het
Other mutations in Clic4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01564:Clic4 APN 4 134,944,504 (GRCm39) missense probably damaging 0.99
IGL01674:Clic4 APN 4 134,966,204 (GRCm39) missense probably benign 0.01
IGL03343:Clic4 APN 4 134,945,889 (GRCm39) missense possibly damaging 0.91
IGL03372:Clic4 APN 4 134,945,925 (GRCm39) missense probably damaging 0.99
R1643:Clic4 UTSW 4 134,966,206 (GRCm39) missense possibly damaging 0.69
R2201:Clic4 UTSW 4 134,950,850 (GRCm39) missense probably damaging 1.00
R4302:Clic4 UTSW 4 134,953,350 (GRCm39) missense probably benign 0.00
R4335:Clic4 UTSW 4 134,945,916 (GRCm39) missense probably benign 0.15
R4600:Clic4 UTSW 4 134,966,300 (GRCm39) splice site probably null
R4939:Clic4 UTSW 4 134,950,852 (GRCm39) missense probably benign 0.16
R5359:Clic4 UTSW 4 134,944,446 (GRCm39) missense probably benign 0.00
R5437:Clic4 UTSW 4 134,944,557 (GRCm39) missense probably damaging 1.00
R5902:Clic4 UTSW 4 134,999,869 (GRCm39) missense probably benign
R7670:Clic4 UTSW 4 134,944,516 (GRCm39) missense probably damaging 1.00
R9630:Clic4 UTSW 4 134,944,476 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCATTCTGCCACTGACTAAGC -3'
(R):5'- TCTCATTGCAGTGCTGTGC -3'

Sequencing Primer
(F):5'- AAGCATTACTCTTACAAGCGTGTCC -3'
(R):5'- GACTTGCCCCACTGAGAACTTG -3'
Posted On 2015-06-10