Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02806:Tas2r135'

360434

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r135

Ensembl Gene

ENSMUSG00000056203

Gene Name

taste receptor, type 2, member 135

Synonyms

mt2r38, Tas2r35

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL02806

Quality Score

Status

Chromosome

Chromosomal Location

42382463-42383428 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 42383382 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 307 (F307S)

Ref Sequence

ENSEMBL: ENSMUSP00000070247 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000070178]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000070178
AA Change: F307S

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000070247
Gene: ENSMUSG00000056203
AA Change: F307S

Domain	Start	End	E-Value	Type
Pfam:TAS2R	22	320	1.3e-63	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acot4	A	G	12: 84,088,737 (GRCm39)	D195G	probably damaging	Het
Acsm1	G	A	7: 119,235,861 (GRCm39)	D194N	probably benign	Het
Akr1b1	T	C	6: 34,281,254 (GRCm39)	Y310C	probably damaging	Het
Aldh6a1	T	C	12: 84,486,414 (GRCm39)	D168G	probably damaging	Het
Ankrd29	A	C	18: 12,408,795 (GRCm39)	S166A	probably benign	Het
Ap1m2	T	G	9: 21,216,979 (GRCm39)	D119A	probably damaging	Het
Atp1a3	T	C	7: 24,681,297 (GRCm39)	K776R	probably damaging	Het
Bltp1	A	G	3: 37,000,643 (GRCm39)	D1274G	possibly damaging	Het
Cacna2d3	A	C	14: 29,073,907 (GRCm39)		probably null	Het
Ccdc51	T	C	9: 108,921,316 (GRCm39)	M401T	probably benign	Het
Cchcr1	A	G	17: 35,836,153 (GRCm39)		probably benign	Het
Cspg4	T	C	9: 56,797,543 (GRCm39)	S1336P	possibly damaging	Het
Ddx60	T	A	8: 62,409,156 (GRCm39)	D397E	probably benign	Het
Duox2	T	C	2: 122,115,147 (GRCm39)	H1110R	probably damaging	Het
Ephb3	C	A	16: 21,041,031 (GRCm39)	D696E	probably benign	Het
Ermap	T	C	4: 119,046,113 (GRCm39)	K6E	possibly damaging	Het
Gm3095	A	G	14: 15,170,388 (GRCm39)	D79G	possibly damaging	Het
Hnrnpab	A	G	11: 51,496,305 (GRCm39)	S126P	probably benign	Het
Hyou1	C	A	9: 44,300,180 (GRCm39)	S823*	probably null	Het
Klhl31	T	A	9: 77,563,056 (GRCm39)	V607E	probably damaging	Het
Klrc3	A	T	6: 129,616,065 (GRCm39)	C209S	possibly damaging	Het
Lhx4	G	A	1: 155,577,975 (GRCm39)	P389L	probably benign	Het
Lmntd2	T	C	7: 140,791,952 (GRCm39)	T264A	probably benign	Het
Mkx	T	C	18: 6,937,025 (GRCm39)	D302G	probably damaging	Het
Ms4a4d	T	C	19: 11,533,610 (GRCm39)	S164P	possibly damaging	Het
Myo1e	A	G	9: 70,269,552 (GRCm39)	E651G	probably benign	Het
Myo5b	G	A	18: 74,750,151 (GRCm39)		probably null	Het
Ncoa3	A	G	2: 165,894,352 (GRCm39)	I298V	probably benign	Het
Nek1	G	A	8: 61,497,120 (GRCm39)	M389I	probably benign	Het
Nid1	T	A	13: 13,642,897 (GRCm39)	D278E	probably benign	Het
Nkx2-9	C	T	12: 56,658,705 (GRCm39)	V170M	probably damaging	Het
Or51ag1	T	A	7: 103,155,210 (GRCm39)	K314N	probably benign	Het
Oxsr1	T	C	9: 119,070,260 (GRCm39)	D511G	possibly damaging	Het
Pramel14	T	A	4: 143,719,501 (GRCm39)		probably null	Het
Rbm44	T	C	1: 91,080,799 (GRCm39)	L329S	possibly damaging	Het
Setd7	A	T	3: 51,457,688 (GRCm39)	N46K	probably damaging	Het
Snx10	T	A	6: 51,565,329 (GRCm39)	F149I	probably damaging	Het
Sult2a3	T	A	7: 13,856,857 (GRCm39)	E21V	probably damaging	Het
Tmem131l	T	C	3: 83,836,123 (GRCm39)		probably benign	Het
Tnfsf18	T	G	1: 161,331,348 (GRCm39)	M166R	possibly damaging	Het
Toe1	C	T	4: 116,663,527 (GRCm39)	V88M	possibly damaging	Het
Ttk	T	A	9: 83,744,540 (GRCm39)	C577*	probably null	Het
Ush2a	T	A	1: 188,542,554 (GRCm39)	Y3373*	probably null	Het
Vwa8	A	G	14: 79,394,528 (GRCm39)	D1543G	probably benign	Het
Zfhx4	A	T	3: 5,455,468 (GRCm39)	H1154L	probably benign	Het

Other mutations in Tas2r135

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01357:Tas2r135	APN	6	42,383,078 (GRCm39)	missense	probably benign	0.00
IGL01395:Tas2r135	APN	6	42,382,846 (GRCm39)	nonsense	probably null
IGL02479:Tas2r135	APN	6	42,382,685 (GRCm39)	nonsense	probably null
IGL02526:Tas2r135	APN	6	42,383,214 (GRCm39)	missense	probably damaging	1.00
IGL02982:Tas2r135	APN	6	42,383,187 (GRCm39)	missense	probably benign
IGL03057:Tas2r135	APN	6	42,378,061 (GRCm39)	unclassified	probably benign
R0057:Tas2r135	UTSW	6	42,383,354 (GRCm39)	missense	probably benign	0.07
R0104:Tas2r135	UTSW	6	42,383,258 (GRCm39)	missense	possibly damaging	0.79
R1412:Tas2r135	UTSW	6	42,382,768 (GRCm39)	missense	probably benign	0.00
R4517:Tas2r135	UTSW	6	42,383,013 (GRCm39)	missense	probably benign
R4629:Tas2r135	UTSW	6	42,383,160 (GRCm39)	missense	probably benign	0.03
R5788:Tas2r135	UTSW	6	42,382,531 (GRCm39)	missense	probably damaging	1.00
R6021:Tas2r135	UTSW	6	42,383,321 (GRCm39)	missense	probably damaging	1.00
R6586:Tas2r135	UTSW	6	42,382,952 (GRCm39)	missense	probably benign	0.18
R7180:Tas2r135	UTSW	6	42,382,685 (GRCm39)	nonsense	probably null
R7458:Tas2r135	UTSW	6	42,382,881 (GRCm39)	missense	possibly damaging	0.95
R7850:Tas2r135	UTSW	6	42,383,072 (GRCm39)	missense	probably benign
R9113:Tas2r135	UTSW	6	42,383,315 (GRCm39)	missense	probably benign	0.00
Z1176:Tas2r135	UTSW	6	42,383,168 (GRCm39)	missense	probably benign	0.03

Posted On

2015-12-18