Incidental Mutation 'IGL02897:Dpp7'
ID363427
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dpp7
Ensembl Gene ENSMUSG00000026958
Gene Namedipeptidylpeptidase 7
SynonymsQPP
Accession Numbers

Genbank: NM_031843.2; Ensembl: ENSMUST00000028332

Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL02897
Quality Score
Status
Chromosome2
Chromosomal Location25352276-25356359 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 25353672 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 339 (Y339C)
Ref Sequence ENSEMBL: ENSMUSP00000028332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028332] [ENSMUST00000042390]
Predicted Effect probably damaging
Transcript: ENSMUST00000028332
AA Change: Y339C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028332
Gene: ENSMUSG00000026958
AA Change: Y339C

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:Peptidase_S28 48 475 2.3e-90 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000042390
SMART Domains Protein: ENSMUSP00000036996
Gene: ENSMUSG00000036646

DomainStartEndE-ValueType
low complexity region 3 11 N/A INTRINSIC
low complexity region 29 42 N/A INTRINSIC
transmembrane domain 49 71 N/A INTRINSIC
Pfam:Glyco_hydro_47 215 654 9.5e-167 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125248
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131665
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133253
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135473
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139108
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139971
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144218
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149953
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150305
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(4) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(1)

Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700093K21Rik T A 11: 23,517,308 E108D probably benign Het
Abca7 T C 10: 80,001,592 F437L probably damaging Het
Abi2 T C 1: 60,448,194 V134A probably damaging Het
Ablim2 T C 5: 35,833,126 I75T probably damaging Het
Aldh1a3 A G 7: 66,427,327 V29A probably benign Het
Bptf T C 11: 107,047,121 K2715E probably damaging Het
Cd163 A T 6: 124,325,527 S1017C probably damaging Het
Cdc14b T C 13: 64,247,253 I76V probably benign Het
Cers6 T A 2: 68,934,533 C63* probably null Het
Chd9 T C 8: 90,933,868 probably benign Het
Col19a1 T C 1: 24,534,098 N198D unknown Het
Cse1l T C 2: 166,919,708 C61R possibly damaging Het
Cubn T C 2: 13,318,312 T2815A possibly damaging Het
Cyp19a1 G T 9: 54,166,911 T453K possibly damaging Het
Dlg1 G T 16: 31,771,856 probably null Het
Dtl T C 1: 191,541,544 probably benign Het
Gm5591 T C 7: 38,520,042 E469G probably damaging Het
Ing3 T A 6: 21,969,326 V202E probably benign Het
Inpp5j A G 11: 3,500,619 L578P probably damaging Het
Irak4 A G 15: 94,553,991 N155S probably benign Het
Kif2b A T 11: 91,576,219 S413T probably damaging Het
L3mbtl1 A T 2: 162,965,772 Y490F probably damaging Het
Med17 T G 9: 15,267,534 D447A probably damaging Het
Med26 T C 8: 72,496,521 T245A probably benign Het
Nlrc3 A T 16: 3,964,074 S490R possibly damaging Het
Nme5 A G 18: 34,569,903 probably benign Het
Olfr611 T C 7: 103,518,130 R85G probably benign Het
Rnf10 G T 5: 115,248,641 Q530K probably benign Het
Robo3 A T 9: 37,427,502 Y281* probably null Het
Sclt1 T C 3: 41,675,387 I330V probably benign Het
Smim14 A T 5: 65,450,396 probably benign Het
Trank1 T G 9: 111,367,517 H1536Q probably damaging Het
Tspan18 A G 2: 93,220,173 L35P possibly damaging Het
Ubr4 G A 4: 139,472,508 V4568M probably damaging Het
Vmn1r63 A G 7: 5,802,745 V296A possibly damaging Het
Other mutations in Dpp7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01637:Dpp7 APN 2 25354613 missense probably benign 0.01
IGL02992:Dpp7 APN 2 25354577 missense possibly damaging 0.65
IGL03069:Dpp7 APN 2 25355723 critical splice acceptor site probably null
1mM(1):Dpp7 UTSW 2 25356140 missense probably benign 0.05
PIT4519001:Dpp7 UTSW 2 25352448 missense probably damaging 0.97
R0051:Dpp7 UTSW 2 25356095 missense possibly damaging 0.80
R0051:Dpp7 UTSW 2 25356095 missense possibly damaging 0.80
R0900:Dpp7 UTSW 2 25356299 missense probably damaging 0.99
R1889:Dpp7 UTSW 2 25353679 synonymous probably null
R1895:Dpp7 UTSW 2 25353679 synonymous probably null
R2055:Dpp7 UTSW 2 25354478 missense possibly damaging 0.84
R4697:Dpp7 UTSW 2 25354919 missense probably benign 0.00
R4832:Dpp7 UTSW 2 25352386 unclassified probably benign
R4887:Dpp7 UTSW 2 25352758 critical splice acceptor site probably null
R5114:Dpp7 UTSW 2 25352737 missense possibly damaging 0.51
R6976:Dpp7 UTSW 2 25354824 critical splice acceptor site probably null
R7577:Dpp7 UTSW 2 25355591 missense probably benign
X0058:Dpp7 UTSW 2 25354752 missense probably benign 0.05
Posted On2015-12-18