Incidental Mutation 'R5150:Or13c7c'
ID 395294
Institutional Source Beutler Lab
Gene Symbol Or13c7c
Ensembl Gene ENSMUSG00000111611
Gene Name olfactory receptor family 13 subfamily C member 7C
Synonyms MOR262-12, Olfr157, mOR37c, Olfr37c, OR37C, GA_x6K02T2N78B-16110014-16110970
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R5150 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 43834752-43837643 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43836301 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 63 (L63P)
Ref Sequence ENSEMBL: ENSMUSP00000150429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079234] [ENSMUST00000214281] [ENSMUST00000215442]
AlphaFold Q9QZ20
Predicted Effect probably damaging
Transcript: ENSMUST00000079234
AA Change: L63P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000078226
Gene: ENSMUSG00000110970
AA Change: L63P

DomainStartEndE-ValueType
Pfam:7tm_4 31 314 4.8e-58 PFAM
Pfam:7tm_1 41 296 2.9e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214281
AA Change: L63P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215442
AA Change: L63P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 93% (57/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam33 T C 2: 130,895,117 (GRCm39) probably benign Het
Ahnak T C 19: 8,988,268 (GRCm39) V3184A possibly damaging Het
Aoc1 A G 6: 48,883,084 (GRCm39) N320S possibly damaging Het
Bin2 T C 15: 100,543,244 (GRCm39) E313G probably damaging Het
Brd10 C A 19: 29,782,950 (GRCm39) A109S probably damaging Het
C9orf72 A G 4: 35,193,270 (GRCm39) S228P possibly damaging Het
Ccdc47 T C 11: 106,096,265 (GRCm39) D253G possibly damaging Het
Ccdc73 A G 2: 104,822,384 (GRCm39) T778A probably benign Het
Cops3 C A 11: 59,710,839 (GRCm39) D377Y probably damaging Het
Cyp4a14 A C 4: 115,350,806 (GRCm39) V156G probably damaging Het
D6Ertd527e C G 6: 87,088,506 (GRCm39) T223S unknown Het
Disp1 C A 1: 182,871,063 (GRCm39) M452I probably damaging Het
Fam210b T C 2: 172,193,468 (GRCm39) Y94H probably damaging Het
Fbxo45 C A 16: 32,065,524 (GRCm39) probably benign Het
Flrt2 T A 12: 95,745,977 (GRCm39) M105K possibly damaging Het
Gm26558 G A 2: 70,491,656 (GRCm39) probably benign Het
Gpr83 T G 9: 14,772,101 (GRCm39) L91R probably damaging Het
Greb1l TTTAATAACTT TTT 18: 10,555,950 (GRCm39) probably null Het
Hmces T A 6: 87,910,217 (GRCm39) probably null Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Ksr2 A C 5: 117,693,074 (GRCm39) E174A probably damaging Het
Lats1 A G 10: 7,588,415 (GRCm39) T1011A probably benign Het
Lrrc46 T C 11: 96,926,957 (GRCm39) D120G probably damaging Het
Ncstn C A 1: 171,895,151 (GRCm39) probably benign Het
Neb T C 2: 52,059,130 (GRCm39) T6118A probably benign Het
Nipsnap2 A C 5: 129,834,175 (GRCm39) M272L probably benign Het
Nlgn2 C T 11: 69,716,216 (GRCm39) R775H probably damaging Het
Or2n1c A C 17: 38,519,208 (GRCm39) E24A possibly damaging Het
Or4f15 T A 2: 111,814,366 (GRCm39) T18S probably benign Het
Or4f61 T A 2: 111,922,880 (GRCm39) L55F possibly damaging Het
Or4g17 T A 2: 111,209,598 (GRCm39) D84E probably damaging Het
Or5b118 A T 19: 13,448,794 (GRCm39) Q153H probably benign Het
Pold1 A G 7: 44,185,256 (GRCm39) V750A possibly damaging Het
Prdm11 C T 2: 92,805,817 (GRCm39) E378K probably damaging Het
Ptpn9 A G 9: 56,943,954 (GRCm39) D276G probably benign Het
Rlf A T 4: 121,005,369 (GRCm39) F1204I probably damaging Het
Robo1 C A 16: 72,769,192 (GRCm39) T537K possibly damaging Het
Sec31b T A 19: 44,508,970 (GRCm39) M670L probably benign Het
Sephs1 T A 2: 4,904,321 (GRCm39) V233E possibly damaging Het
Serpinb2 T C 1: 107,450,939 (GRCm39) probably null Het
Sf3b3 T C 8: 111,550,008 (GRCm39) Q670R possibly damaging Het
Slc8a2 A C 7: 15,879,101 (GRCm39) D529A possibly damaging Het
Sva A G 6: 42,019,093 (GRCm39) N88D probably benign Het
Tcf15 G T 2: 151,986,051 (GRCm39) R169L probably damaging Het
Tfr2 A G 5: 137,572,752 (GRCm39) T188A probably benign Het
Tshz1 T A 18: 84,031,340 (GRCm39) K1023* probably null Het
Ttc28 A G 5: 111,373,555 (GRCm39) N966S probably damaging Het
Unc5c T A 3: 141,463,554 (GRCm39) I225N probably damaging Het
Ush2a T C 1: 188,184,067 (GRCm39) L1457S possibly damaging Het
Zbtb34 G T 2: 33,301,133 (GRCm39) H469Q probably damaging Het
Zfp692 T C 11: 58,198,413 (GRCm39) M1T probably null Het
Other mutations in Or13c7c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01138:Or13c7c APN 4 43,835,617 (GRCm39) missense probably damaging 1.00
R1406:Or13c7c UTSW 4 43,835,582 (GRCm39) missense possibly damaging 0.69
R1406:Or13c7c UTSW 4 43,835,582 (GRCm39) missense possibly damaging 0.69
R4386:Or13c7c UTSW 4 43,836,124 (GRCm39) missense probably benign 0.44
R4673:Or13c7c UTSW 4 43,836,430 (GRCm39) missense probably benign 0.28
R5119:Or13c7c UTSW 4 43,836,433 (GRCm39) missense probably benign
R5379:Or13c7c UTSW 4 43,836,010 (GRCm39) missense probably benign
R6027:Or13c7c UTSW 4 43,835,842 (GRCm39) missense probably benign 0.03
R6542:Or13c7c UTSW 4 43,835,686 (GRCm39) missense probably benign 0.02
R8696:Or13c7c UTSW 4 43,836,193 (GRCm39) missense probably benign 0.00
R9360:Or13c7c UTSW 4 43,835,765 (GRCm39) missense probably benign 0.44
R9418:Or13c7c UTSW 4 43,835,879 (GRCm39) missense probably benign 0.21
Predicted Primers PCR Primer
(F):5'- GCCTTGTTCATGACCACAGG -3'
(R):5'- CAGACGACTGTAACAGAATTTGTCC -3'

Sequencing Primer
(F):5'- GTTGCAGATGGCCACATAACGATC -3'
(R):5'- AACAGAATTTGTCCTGTTGGGCC -3'
Posted On 2016-06-21