Incidental Mutation 'IGL02983:Vmn1r86'
ID 406632
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r86
Ensembl Gene ENSMUSG00000070816
Gene Name vomeronasal 1 receptor 86
Synonyms Gm10301
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL02983
Quality Score
Status
Chromosome 7
Chromosomal Location 13097531-13119917 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13102814 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 45 (D45G)
Ref Sequence ENSEMBL: ENSMUSP00000154549 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094828] [ENSMUST00000226604] [ENSMUST00000227220] [ENSMUST00000227700]
AlphaFold L7N213
Predicted Effect probably damaging
Transcript: ENSMUST00000094828
AA Change: D45G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092423
Gene: ENSMUSG00000070816
AA Change: D45G

DomainStartEndE-ValueType
Pfam:TAS2R 1 306 1.1e-14 PFAM
Pfam:V1R 35 301 4e-31 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210729
Predicted Effect probably damaging
Transcript: ENSMUST00000226604
AA Change: D45G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227220
AA Change: D45G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000227700
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020D05Rik A G 19: 5,503,181 F191L possibly damaging Het
Abca13 A G 11: 9,290,663 N842S probably benign Het
Acvr1b A G 15: 101,203,078 R374G probably damaging Het
Brip1 T C 11: 86,139,124 I565V probably benign Het
Camta2 C T 11: 70,672,022 R959Q probably damaging Het
Cbln2 A G 18: 86,713,379 E104G probably benign Het
Cdc42ep4 T C 11: 113,729,169 K132R probably benign Het
Clcnka T A 4: 141,390,131 I452F probably damaging Het
Clec4a3 T A 6: 122,967,567 probably null Het
Crat A C 2: 30,404,526 probably null Het
Cspp1 A G 1: 10,127,525 K227R probably benign Het
Ddx1 A T 12: 13,223,862 I588N probably damaging Het
Dip2b G T 15: 100,132,022 R98L possibly damaging Het
Dock5 G A 14: 67,764,670 P1617L probably damaging Het
Fa2h C T 8: 111,346,522 probably null Het
Fezf1 T A 6: 23,247,872 N68I probably damaging Het
Gabrb2 A T 11: 42,421,400 L17F probably benign Het
Gm17078 T C 14: 51,611,190 K30R probably benign Het
Gramd4 G A 15: 86,127,018 V249M probably damaging Het
Kcnd2 A C 6: 21,216,555 D86A probably damaging Het
Lrp1 T C 10: 127,550,199 E3486G probably damaging Het
Ltb A G 17: 35,194,670 D50G probably benign Het
Med18 A T 4: 132,459,686 Y167* probably null Het
Nat14 G A 7: 4,924,128 A100T probably damaging Het
Nxph2 T C 2: 23,400,362 V242A probably damaging Het
Olfr338 T A 2: 36,377,637 I287N probably damaging Het
Olfr443-ps1 T C 6: 43,094,648 noncoding transcript Het
Olfr54 T C 11: 51,027,380 V126A probably damaging Het
Olfr818 T A 10: 129,945,189 N291I probably damaging Het
Pramef20 T C 4: 144,373,127 E356G probably benign Het
Rad21l A G 2: 151,655,120 L358S probably damaging Het
Rasgef1c A G 11: 49,957,049 T4A possibly damaging Het
Spata31d1a A G 13: 59,703,694 S207P possibly damaging Het
Stxbp2 A T 8: 3,641,971 I538F probably benign Het
Szt2 T C 4: 118,365,779 probably benign Het
Taf6 T C 5: 138,178,880 T642A probably benign Het
Tmem30a A T 9: 79,771,443 M277K possibly damaging Het
Xkr5 T C 8: 18,933,832 I565V probably benign Het
Zfp526 C T 7: 25,224,415 A33V probably benign Het
Other mutations in Vmn1r86
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00492:Vmn1r86 APN 7 13102541 missense possibly damaging 0.91
IGL01124:Vmn1r86 APN 7 13102929 missense probably benign 0.04
IGL01291:Vmn1r86 APN 7 13102506 missense probably benign 0.14
IGL02347:Vmn1r86 APN 7 13102647 missense probably damaging 0.99
IGL02457:Vmn1r86 APN 7 13102780 missense probably benign
ANU05:Vmn1r86 UTSW 7 13102506 missense probably benign 0.14
R0304:Vmn1r86 UTSW 7 13102780 missense probably benign
R0525:Vmn1r86 UTSW 7 13102161 missense probably benign 0.13
R1958:Vmn1r86 UTSW 7 13102694 missense possibly damaging 0.94
R2227:Vmn1r86 UTSW 7 13102920 missense probably benign 0.00
R3149:Vmn1r86 UTSW 7 13102431 nonsense probably null
R3896:Vmn1r86 UTSW 7 13102166 missense probably benign 0.18
R4735:Vmn1r86 UTSW 7 13102294 missense probably damaging 1.00
R5219:Vmn1r86 UTSW 7 13102455 missense probably damaging 1.00
R6003:Vmn1r86 UTSW 7 13102198 nonsense probably null
R6457:Vmn1r86 UTSW 7 13102352 missense possibly damaging 0.70
R7442:Vmn1r86 UTSW 7 13102056 missense possibly damaging 0.70
R7622:Vmn1r86 UTSW 7 13102758 missense probably benign 0.07
R8436:Vmn1r86 UTSW 7 13102844 missense probably benign 0.25
R9141:Vmn1r86 UTSW 7 13102862 nonsense probably null
R9374:Vmn1r86 UTSW 7 13102854 missense possibly damaging 0.86
R9398:Vmn1r86 UTSW 7 13102334 missense probably damaging 0.98
Posted On 2016-08-02