Incidental Mutation 'R5333:Scgb2b18'
ID423347
Institutional Source Beutler Lab
Gene Symbol Scgb2b18
Ensembl Gene ENSMUSG00000100058
Gene Namesecretoglobin, family 2B, member 18
SynonymsGm4692, Abpbg18
MMRRC Submission 042915-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.283) question?
Stock #R5333 (G1)
Quality Score173
Status Not validated
Chromosome7
Chromosomal Location33171892-33173864 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 33173275 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Histidine at position 35 (L35H)
Ref Sequence ENSEMBL: ENSMUSP00000139701 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000186529]
Predicted Effect probably damaging
Transcript: ENSMUST00000186529
AA Change: L35H

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000139701
Gene: ENSMUSG00000100058
AA Change: L35H

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
Pfam:Feld-I_B 24 90 3.3e-34 PFAM
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 97% (56/58)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930430A15Rik A T 2: 111,194,337 Y61N possibly damaging Het
4930505A04Rik C T 11: 30,426,349 V173M probably damaging Het
Abca14 T A 7: 120,289,546 Y1238* probably null Het
Abcb5 A T 12: 118,867,942 V1225D probably damaging Het
Arhgef15 A G 11: 68,947,196 probably benign Het
As3mt A G 19: 46,708,196 R58G probably null Het
Asap1 T G 15: 64,127,414 N525T possibly damaging Het
Bhmt2 A G 13: 93,671,430 V50A probably benign Het
Ccdc180 A T 4: 45,890,935 I36F possibly damaging Het
Cd209c A G 8: 3,944,976 S63P probably damaging Het
Cdc37 T C 9: 21,143,161 E56G possibly damaging Het
Cdkal1 T C 13: 29,326,152 Y541C probably benign Het
Cenph G T 13: 100,761,772 H208N probably benign Het
Cfap65 A T 1: 74,903,175 L1740Q probably benign Het
Cfap74 A G 4: 155,436,740 D623G probably damaging Het
Ckap4 C A 10: 84,527,610 V530L probably damaging Het
Cldn13 A T 5: 134,915,015 N105K probably benign Het
Ddn T C 15: 98,805,356 D685G possibly damaging Het
Fam155a T A 8: 9,770,762 Q86L possibly damaging Het
Fdxr T C 11: 115,272,258 I70V probably benign Het
Fn1 A T 1: 71,624,180 Y1050N probably damaging Het
Impad1 A C 4: 4,767,963 V271G possibly damaging Het
Iqcf3 A G 9: 106,553,661 I96T possibly damaging Het
Itgax A G 7: 128,142,283 Y822C probably damaging Het
Katnb1 A T 8: 95,095,606 I286L possibly damaging Het
Lrp2 A C 2: 69,525,228 I424R probably benign Het
Lrpprc C A 17: 84,790,393 A41S probably benign Het
Mast3 A G 8: 70,783,501 L761P probably benign Het
Mmp1b T C 9: 7,384,897 I251V possibly damaging Het
Mpp4 C A 1: 59,157,441 R44L probably benign Het
Nkain3 T A 4: 20,484,889 M63L probably benign Het
Nup88 A C 11: 70,945,016 probably benign Het
Obscn A T 11: 59,062,692 C3837S probably damaging Het
Ogdh T G 11: 6,352,126 L850V probably damaging Het
Olfr1131 A G 2: 87,629,114 Y217C probably damaging Het
Olfr1293-ps A G 2: 111,527,703 I148V probably benign Het
Panx2 T C 15: 89,068,539 I411T possibly damaging Het
Papss1 T A 3: 131,643,044 M585K probably damaging Het
Pcbp2 T G 15: 102,486,021 L180R possibly damaging Het
Pcdha7 A T 18: 36,974,566 T215S probably benign Het
Pcdhga4 C T 18: 37,685,424 R9C probably benign Het
Plin4 A G 17: 56,104,970 V687A probably benign Het
Psma6 A G 12: 55,407,428 probably benign Het
Rcn1 A T 2: 105,389,126 S241T probably benign Het
Slc11a1 A C 1: 74,384,145 D385A probably damaging Het
Stk31 T A 6: 49,469,152 C930S probably benign Het
Syt10 T A 15: 89,841,729 Q14L probably benign Het
Tnxb T G 17: 34,690,231 W1578G probably damaging Het
Triml1 C T 8: 43,130,290 A425T possibly damaging Het
Vil1 G A 1: 74,432,390 V777I probably benign Het
Vmn1r175 T C 7: 23,808,579 I208V possibly damaging Het
Other mutations in Scgb2b18
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3806:Scgb2b18 UTSW 7 33173138 missense probably benign 0.00
R5772:Scgb2b18 UTSW 7 33173830 missense unknown
R5975:Scgb2b18 UTSW 7 33173225 missense probably damaging 1.00
R6914:Scgb2b18 UTSW 7 33172139 missense possibly damaging 0.91
R6942:Scgb2b18 UTSW 7 33172139 missense possibly damaging 0.91
R7331:Scgb2b18 UTSW 7 33173256 nonsense probably null
R7542:Scgb2b18 UTSW 7 33173322 splice site probably null
Z1177:Scgb2b18 UTSW 7 33173272 nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACAGCCTTACAGCATCTGTTG -3'
(R):5'- ACCAAGGTCTGTCCACTCATG -3'

Sequencing Primer
(F):5'- CATCTGTTGCATGGGCGAG -3'
(R):5'- AAACCATGTTGTTTCTGGGAGGC -3'
Posted On2016-08-04