Incidental Mutation 'R8314:Scgb2b18'
ID641564
Institutional Source Beutler Lab
Gene Symbol Scgb2b18
Ensembl Gene ENSMUSG00000100058
Gene Namesecretoglobin, family 2B, member 18
SynonymsGm4692, Abpbg18
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.327) question?
Stock #R8314 (G1)
Quality Score225.009
Status Not validated
Chromosome7
Chromosomal Location33171892-33173864 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 33173157 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Methionine at position 74 (I74M)
Ref Sequence ENSEMBL: ENSMUSP00000139701 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000186529]
Predicted Effect probably benign
Transcript: ENSMUST00000186529
AA Change: I74M

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000139701
Gene: ENSMUSG00000100058
AA Change: I74M

DomainStartEndE-ValueType
low complexity region 3 16 N/A INTRINSIC
Pfam:Feld-I_B 24 90 3.3e-34 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110059G10Rik T A 9: 122,948,928 T84S probably benign Het
4921501E09Rik C A 17: 33,067,064 A255S probably benign Het
4930533K18Rik A G 10: 70,875,276 T76A noncoding transcript Het
Adgrl1 C T 8: 83,938,389 T1235I probably damaging Het
Ak4 C T 4: 101,463,585 T197M possibly damaging Het
Alox12e T C 11: 70,316,172 M603V possibly damaging Het
Ap3d1 A T 10: 80,723,539 I267N possibly damaging Het
Arhgef2 T A 3: 88,621,293 I12N probably benign Het
Asnsd1 A T 1: 53,346,655 M520K probably damaging Het
B3galt5 T C 16: 96,315,449 L94P probably damaging Het
Birc3 T C 9: 7,872,941 probably benign Het
Cd177 T C 7: 24,750,588 S541G probably benign Het
Cdh8 T C 8: 99,171,379 D434G probably damaging Het
Ciita A T 16: 10,510,988 R379W probably damaging Het
Cntrl T A 2: 35,175,143 M2153K probably benign Het
Csmd1 A T 8: 16,158,244 D1232E probably benign Het
Cyp4a30b A C 4: 115,458,338 H252P probably benign Het
Dad1 G A 14: 54,253,812 R11W probably damaging Het
Ddit3 A G 10: 127,295,721 probably null Het
Dzank1 A G 2: 144,502,958 L293P probably damaging Het
Edf1 A G 2: 25,557,965 D5G probably damaging Het
Ep400 T A 5: 110,755,753 M327L unknown Het
Fam135a A T 1: 24,021,921 H1341Q possibly damaging Het
Fam150b G T 12: 30,884,851 G23V probably damaging Het
Fam189b T C 3: 89,188,146 probably null Het
Fbxl3 C T 14: 103,089,440 V169I probably benign Het
Gm4787 A G 12: 81,379,135 L83P probably damaging Het
Habp4 A G 13: 64,184,751 E392G probably damaging Het
Hspg2 C A 4: 137,539,675 P1997Q probably benign Het
Ints9 T C 14: 65,029,030 S444P probably damaging Het
Kif18b G A 11: 102,913,074 S420L probably benign Het
Klhl17 T A 4: 156,234,013 M51L probably benign Het
Kmt2b C T 7: 30,578,922 E1555K probably damaging Het
Malrd1 T A 2: 15,752,832 D972E unknown Het
Mapk8ip3 A T 17: 24,901,774 S805R probably benign Het
Mmp13 G A 9: 7,272,931 C97Y probably damaging Het
Moxd1 T A 10: 24,252,540 N163K possibly damaging Het
Nbea T C 3: 56,009,251 I863V probably damaging Het
Nectin4 A G 1: 171,384,727 T298A probably benign Het
Ntn1 T C 11: 68,385,624 D166G probably damaging Het
Olfr1137 A G 2: 87,711,202 F235L probably benign Het
Olfr140 T C 2: 90,052,097 T76A probably benign Het
Olfr391-ps T G 11: 73,799,742 N5T noncoding transcript Het
Olfr620 T C 7: 103,612,047 Q102R probably damaging Het
Olfr948 A G 9: 39,319,305 F103S probably damaging Het
Opa3 C A 7: 19,245,015 A135E possibly damaging Het
Osbpl5 T C 7: 143,695,096 I608V probably benign Het
Phc1 A C 6: 122,320,978 S782R unknown Het
Pip5k1b T A 19: 24,355,199 T374S probably benign Het
Prkaa1 A G 15: 5,178,873 S541G probably damaging Het
Ptpn20 A G 14: 33,622,547 N143D possibly damaging Het
Rabep1 A G 11: 70,893,660 D207G possibly damaging Het
Rbbp8 G A 18: 11,720,625 M296I probably benign Het
Recql4 C A 15: 76,710,180 R46L probably damaging Het
Shc4 A G 2: 125,655,616 I391T possibly damaging Het
Slc38a4 A G 15: 97,010,309 F184L probably benign Het
Smim13 G T 13: 41,272,634 G49* probably null Het
Tbc1d19 A G 5: 53,897,047 D459G probably damaging Het
Tnpo1 T C 13: 98,884,625 N82S possibly damaging Het
Tpp2 G A 1: 43,934,227 V47I probably benign Het
Umodl1 G T 17: 30,984,832 A540S probably damaging Het
Vmn2r83 G A 10: 79,481,479 V519I possibly damaging Het
Zfp641 T C 15: 98,290,583 I139V probably damaging Het
Zfyve21 A T 12: 111,823,281 I60F probably benign Het
Other mutations in Scgb2b18
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3806:Scgb2b18 UTSW 7 33173138 missense probably benign 0.00
R5333:Scgb2b18 UTSW 7 33173275 missense probably damaging 1.00
R5772:Scgb2b18 UTSW 7 33173830 missense unknown
R5975:Scgb2b18 UTSW 7 33173225 missense probably damaging 1.00
R6914:Scgb2b18 UTSW 7 33172139 missense possibly damaging 0.91
R6942:Scgb2b18 UTSW 7 33172139 missense possibly damaging 0.91
R7331:Scgb2b18 UTSW 7 33173256 nonsense probably null
R7542:Scgb2b18 UTSW 7 33173322 splice site probably null
R8349:Scgb2b18 UTSW 7 33173231 missense probably benign 0.00
R8449:Scgb2b18 UTSW 7 33173231 missense probably benign 0.00
Z1177:Scgb2b18 UTSW 7 33173272 nonsense probably null
Predicted Primers PCR Primer
(F):5'- GGCATGCTGCTTTACATGTAC -3'
(R):5'- GCAAGGAACATTGAGCCTCTG -3'

Sequencing Primer
(F):5'- CATGCTGCTTTACATGTACTAGGG -3'
(R):5'- ATTTTCTCTCTGTGTTTGCAGCAG -3'
Posted On2020-07-28